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Role of Microbial Communities for Sustainability (Microorganisms for Sustainability #29)
by Gamini Seneviratne Junaida Shezmin ZavahirThis book is about the role played by microbes in their community mode in sustaining ecosystems. The descriptions given in its chapters indicate clearly that microbial communities are more effective in delivering multifaceted benefits to the soil-plant system than those offered by microbial monocultures in planktonic modes. The role these communities play in a multitude of microbe-microbe and plant-microbe interactions have not yet been fully exploited to gain benefits in this field as well as to achieve sustainability in agriculture practices. Amply discussed are the beneficial characteristics and metabolic capacities of specific microbial groups and the use of microbial traits for the benefit of plant growth. The book suggests the need to develop new microbial technologies to utilize plant-associated microbes for increased crop productivity and agroecosystem balance in order to ensure sustainability. This also provides an effective guidance to scientists, academics, researchers, students and policy makers of the sphere to achieve the above outcomes.
Role of Micronutrients in Brain Health (Nutritional Neurosciences)
by Wael Mohamed Toshihide YamashitaThis book comprehensively reviews the relationship between micronutrients and brain in health and diseases. It explains the relationship between micronutrients and brain functions, neurogenesis, and cognitive functions. The book also explores the relationship between micronutrients and brain disorders including depression, epilepsy, PD, and Autism. It further explores the recent advancements in understanding the important role of micronutrients as therapeutics in various brain disorders like TBI and AD. Lastly, it presents an overview of micronutrients as neuroprotective agents along with the main principles of nutrigenomics.
Role of Mulching in Pest Management and Agricultural Sustainability (SpringerBriefs in Plant Science)
by Khawar JabranThis book provides the concepts, techniques, and recent developments with regard to use of mulches in agriculture, utility of mulches for non-chemical pest control, and sustainability of crop production systems. Non-conventional means of improving the sustainability of crop production and pest control are required in the wake of environmental concerns over the use of conventional pesticides as well as the intensive use of land resources. Mulches have been used in agriculture for various purposes; however, there has been an increase in their use more recently, and scientists around the world have conducted more research to explore the benefits of mulching in various agricultural systems. Mulches have been found advantageous in non-chemical pest control, soil and water conservation, improving fertility, and improving microbial activities in the soil. While this is a topic of current importance, the information use of mulches in agricultural fields is rarely compiled in one comprehensive location to provide a full account of various aspects of mulches and their utility. This book will be helpful for researchers, growers, and students.
Role of Mutation Breeding In Floriculture Industry
by S.K DattaThis monograph provides a comprehensive review of many aspects of current interest and progress on mutation research on vegetatively propagated ornamentals. It covers almost all aspects of induced mutagenesis on ornamental plants. Chapters in this title provides information about mutation technology for the development of new ornamental varieties. Taking all aspects together, it is an excellent reference book of updated information on mutation breeding on vegetatively propagated ornamentals. Floriculture has become a very important industry in many countries as a result of science-based techniques and a steady supply of improved plant materials. The induced mutation is now recognized as well as a standardized valuable tool for the development of new varieties. The book provides an authoritative review account of all important aspects related to inducing mutagenesis in the field of ornamental crops. The primary objective of the book is to give a coherent and concise account of earlier work with an emphasis on recent developments. The knowledge generated so far has been reviewed in this book which can work as a knowledge base to prepare guidelines for future planning of successful application of mutation technology for the floriculture industry. The information in the book is an excellent informative document for researchers, teachers, students, and breeders for understanding the application of induced mutations and planning future strategies for the development of new ornamental varieties for the floriculture industry.
Role of Nutrients in Neurological Disorders (Nutritional Neurosciences)
by Senthilkumar Rajagopal Saravanan Ramachandran Geethalakshmi Sundararaman Swarnalatha Gadde VenkataThis book provides the latest research on the role of nutrients in the prevention and treatment of neurological disorders. It discusses dietary supplements and dietary restrictions for combating neurological disorders, including Alzheimer’s disease, Parkinson’s disease, stroke, and epilepsy. The book also explains the impact of different nutrients such as herbal products, algae, micronutrients in stimulating the brain and central nervous system during abnormal functions. It covers the effect of the nutrients on the function of neurotransmitters, their stimulatory effect in autism, dementia, Alzheimer’s, and other neuropathological states. The book also defines the mechanistic effects of neuroprotective and psycho protective effects of natural food in repairing brain damage. This book is essential reading for neuroscientists and neurologists, and healthcare professionals.
Role of Oxidative Stress in Pathophysiology of Diseases
by Pawan K. Maurya Kamal DuaThis book illustrates the importance and significance of oxidative stress in the pathophysiology of various human diseases. The book initially introduces the phenomenon of oxidative stress, basic chemical characteristics of the species involved and summarizes the cellular oxidant and anti-oxidant system and the cellular effects and metabolism of the oxidative stress. In addition, it reviews the current understanding of the potential impact of oxidative stress on telomere shortening, aging, and age-related diseases. It also examines the role of oxidative stress in chronic diseases, including cancer, diabetes, cardiovascular diseases, and neurodegenerative disorders. Further, the book presents novel technologies for the detection of oxidative stress biomarkers using nanostructure biosensors, as well as in vitro and in vivo models to monitor oxidative stress. Lastly, the book addresses the drug delivery carriers that can help in combating oxidative stress.
Role of Phenolic Phytochemicals in Diabetes Management: Phenolic Phytochemicals and Diabetes
by Mukesh Doble Muddasarul Hoda Shanmugam HemaiswaryaThis book summarizes the latest research trends in phytophenolic therapy for the management of diabetes. It discusses the various mechanisms of action of phytophenolics present in food, fruits and plants that can be used to control/reverse diabetic conditions. Further, it addresses the synergistic interactions of phytophenolics with anti-diabetic drugs, as understanding them can yield valuable insights for complementary and alternative medicine. In closing, it discusses the important aspects of nanotechnology-based targeted delivery and improving the bioavailability of phenolic phytochemicals, two major areas of research in phytotherapy of diabetes.
Role of Potassium in Abiotic Stress
by Shahid Umar Noushina IqbalThis book on potassium in abiotic stress tolerance deals with the ongoing trend in increasing abiotic stresses and interlinked issues food security. As mineral nutrient potassium holds an important place in agriculture and is involved in various physiological and biochemical processes. It takes part in protein synthesis, carbohydrate metabolism, enzyme activation, cation-anion balance, osmoregulation, water movement, energy transfer, and regulates stomata and photosynthesis. Potassium plays an important role as abiotic stress buster. This book will deal with potassium relevance to plant functions and adaptations, range of its biological functions, role of potassium in abiotic stress tolerance, analyses of mechanisms responsible for perception and signal transduction of potassium under abiotic stress, critical evaluation of and cross-talks on nutrients and phytohormones signaling pathways under optimal and stressful conditions, and interaction of potassium with other nutrients for abiotic stress tolerance. This book will be of interest to teachers, researchers, scientists working on abiotic stresses. Also the book serves as additional reading material for undergraduate and graduate students of agriculture, forestry, ecology, and environmental sciences. National and international agricultural scientists, policy makers will also find this to be a useful read.
Role of Potassium in Plants (SpringerBriefs in Plant Science)
by Girdhar K. Pandey Swati MahiwalPotassium (K+) is an essential mineral macronutrient abundantly present in the cytosol which, unlike other macronutrients, is not metabolized and does not integrate into macromolecules. Compared to animal cells, K+ is more abundantly present in plant cells. Overall performance of the plant, and operation of metabolic machinery depends upon intracellular K+ homeostasis (K+ uptake and efflux) via K+ channels and transporters acting as mediators of cellular responses during plant development. Unlike animals, plants lack sodium/K+ exchangers; plant cells have developed unique transport systems for K+ accumulation and release. In Arabidopsis thaliana, 71 K+ channels and transporters have been identified and categorized into six families. Plant adaptive responses to several abiotic and biotic stresses are mediated by regulation of intracellular K+ homeostasis. In this report, we highlight the role of K+ in abiotic and biotic stresses, features of channels and transporters responsible for its homeostasis along with its evolutionary relationship, perception and sensing mechanisms, and K+ deficiency triggering different signaling cascades. Overall, this book covers the role of K+ in plants would be significantly helpful to research, academic community as well as students to understand the one of the major attributes of plant biology.
Role of Procoagulant Activity in Health and Disease (Routledge Revivals)
by Gary A. LevyFirst published in 1994, Role of Procoagulant Activity in Health and Disease discusses different aspects of the pathobiology and consequences of the induction of cellular procoagulants. The first part of the book addresses the molecular and cellular biology of procoagulant activity induction (PCA). This includes the recent data on cellular pathways of induction of PCA and the molecular nature of the different procoagulants identified to date. The book addresses interactions between macrophages and endothelial cells, focusing on those aspects most relevant to induction of procoagulant activities, including the role of adhesion molecules. The second portion of the book describes the relevance of PCA to a number of human and experimental diseases, including infectious diseases, gastrointestinal diseases, liver disease, renal disease, neoplastic diseases, allograft rejection, and pulmonary disease. This book will not only be of value to the basic scientist, but also to pathologists and clinicians, and to others wishing to understand the role of immunologically mediated induction of cellular coagulants and their relevance to disease.
Role of Proteases in Cellular Dysfunction
by Naranjan S. Dhalla Sajal ChakrabortiIt is now well known that proteases are found everywhere, in viruses and bacteria as well as in all human, animal and plant cells, and play a role in a variety of biological functions ranging from digestion, fertilization, development to senescence and death. Under physiological conditions the ability of proteases is regulated by endogenous inhibitors. However, when the activity of proteases is not regulated appropriately, disease processes can result, as seen in Alzheimer's disease, cancer metastasis and tumor progression, inflammation and atherosclerosis. Thus it is evident that there is an absolute need for a tighter control of proteolytic activities in different cells and tissues. Aimed at graduate students and researchers with an interest in cellular proteolytic events, Role of Proteases in Cellular Dysfunctions is the second book on Proteases in this series. The book consists of three parts in specified topics based on current literatures for a better understanding for the readers with respect to their subject-wise interests. The first section of this book covers a brief idea about the neuronal disorders and the involvement of proteases such as calpains, caspases and matrix metalloproteases (MMPs). The second section covers the deadly disease cancer and its relation to ubiquitin-proteasome system, MMPs and serine proteases. The last section is about the role of proteases such as calpains, MMPs and serine protease as well as urokinase type plasminogen activator receptor (uPAR) in causing cardiovascular defects.
Role of Reservoir Operation in Sustainable Water Supply to Subak Irrigation Schemes in Yeh Ho River Basin: Learning From Experiences of Ancient Subak Schemes For Participatory Irrigation System Management in Bali
by Mawiti Infantri YektiA Subak irrigation scheme, primarily in Bali, Indonesia concerns an irrigation system of which the construction, operation and management are based on agreed principles of technology, management of agriculture and religious community. Subak systems have been well known since the 9th Century. As a manifestation of the Cultural Landscape of Bali Province the Subak schemes are since June, 2012 included in the World Heritage List of UNESCO. These systems are managed by a Subak Association based on the Tri Hita Karana philosophy - harmony between human beings and God, harmony between people and nature, and harmony between people and people. The problem of insufficient water in the dry season developed in the Yeh Ho River Basin. Because of this the main objective of this study was to develop an optimal reservoir operation strategy in relation to the water supply of the Subak irrigation schemes, capable to support agricultural productivity at upstream, midstream and downstream level. Based on a Generic Algorithm the RIBASIM model was applied using the dependable 80% of discharge and shifting the start of land preparation. The results provide evidence that the cropping pattern of the fifth scenario results in an overall optimal agriculture production of the Subak schemes. The recoverable flow considered in the river basin scheme model plays an important role in the optimisation. Nevertheless, if a normal hydro-climate occurs, the other scenarios, especially the first scenario, can be applied as well. This reflects the applicability of the Tri Hita Karana philosophy on harmony among people and harmony among people and nature.
Role of Rhizospheric Microbes in Soil: Volume 2: Nutrient Management And Crop Improvement
by Vijay Singh MeenaIn any ecosystem, plant and microbe interaction is inevitable. They not only co-exist but also support each other’s survival and provide sustenance in stressful environments. Agro-ecosystems in many regions around the globe are affected by high temperatures, soil salinity/alkalinity, low pH and metal toxicity. High salinity and severe draught are other major constraints affecting agricultural practices and also plants in the wild. A major limiting factor affecting global agricultural productivity is environmental stresses. Apart from decreasing yield, they also have a devastating impact on plant growth. Plants battle with various kind of stresses with the help of symbiotic associations with the rhizospheric microbes. Naturally occuring plant-microbe interactions facilitate the survival of plants under these stressful conditions.The rhizosphere consists of several groups of microbes, plant growth-promoting bacteria (PGPB) is one such group of microbes that assists plants in coping with multiple stresses and also promote plant growth. These efficient microbes support the stress physiology of the plants and can be extremely useful in solving agricultural as well food- security problems.This book provides a detailed, holistic description of plant and microbe interaction. It elucidates various mechanisms of nutrient management, stress tolerance and enhanced crop productivity in the rhizosphere, discussing The rhizospheric flora and its importance in enhancement of plant growth, nutrient content, yield of various crops and vegetables as well as soil fertility and health. Divided into two volumes, the book addresses fundamentals, applications as well as research trends and new prospects for agricultural sustainability. Volume 1: Stress Management and Agricultural Sustainability, includes chapters offering a broad overview of plant stress management with the help of microbes. It also highlights the contribution of enzymatic and molecular events occurring in the rhizosphere due to plant microbe interactions, which in turn help in the biological control of plant disease and pest attacks. Various examples of plant microbe interaction in rhizospheric soil are elaborated to facilitate the development of efficient indigenous microbial consortia to enhance food and nutritional security. Providing a comprehensive information source on microbes and their role in agricultural and soil sustainability, this timely research book is of particular interest to students, academics and researchers working in the fields of microbiology, soil microbiology, biotechnology, agronomy, and the plant protection sciences, as well as for policy makers in the area of food security and sustainable agriculture.
Role of Rhizospheric Microbes in Soil: Volume 2: Nutrient Management and Crop Improvement
by Vijay Singh MeenaIn any ecosystem, plant and microbe interaction is inevitable. They not only co-exist but also support each other’s survival and also provide for sustenance in stressful environment. Agro-ecosystems of many regions around the globe are affected by multi-stress. Major limiting factors affecting the agricultural productivity worldwide are environmental stresses. Apart from decreasing yield they introduce devastating impact on plant growth as well. Plants battle with various kind of stresses with the help of symbiotic association with the microbes in the rhizosphere. Naturally existing plant-microbe interaction facilitates survival of plants under these stressful conditions. Rhizosphere consists of many groups of microbes, plant growth-promoting bacteria (PGPB) is one such group of microbes which assist plants in coping with multiple stresses and in plant growth as well. These microbes help in stress physiology of the plants and can be extremely useful in solving agricultural as well food security problems. The proposed book is split into two parts, with an aim to provide comprehensive description and highlight a holistic approach. It elucidates various mechanisms in rhizosphere of nutrient management, stress tolerance and enhanced crop productivity. The book discusses rhizospheric flora and its importance in enhancement of plant growth, nutrient content, yield of various crops and vegetables as well as soil fertility and health. Both volumes of the book addresses fundamentals, applications as well as research trends and new prospects of agricultural sustainability. Volume 2: Nutrient Management and Crop Improvement, contains chapters which cover a broad overview of plant growth promoting activities of microbes. This proposed book also highlights the contribution of nitrogen, phosphorus, potassium, iron and zinc-solubilizing microbes from rhizospheric soil to develop efficient indigenous microbial consortia to enhance the food and nutritional security. With the given content and layout the proposed book will be an all-inclusive collection of information, which will be useful for students, academicians, researchers working in the field of rhizospheric mechanisms, agricultural microbiology, soil microbiology, biotechnology, agronomy and sustainable agriculture and also for policy makers in the area of food security and sustainable agriculture. It will be of special interest to both academics and professionals working in the fields of microbiology, soil microbiology, biotechnology and agronomy, as well as the plant protection sciences. Timely, this edited and research book provides an essential and comprehensive source of material from basic to advance findings on microbes and their role in agricultural and soil sustainability.
Role of Science and Technology for Sustainable Future: Volume 1: Sustainable Development: A Primary Goal
by Ranbir Chander SobtiThe book explores the pivotal role of science and technology in achieving the sustainable development goals (SDGs) outlined in the agenda 2030 for sustainable development. It emphasizes the importance of integrating science and technology into developing strategies to promote a sustainable and prosperous global future. The book highlights the universal acceptance of the SDGs by United Nations member states, subnational governing bodies, and international organizations. It emphasizes that all stakeholders, including governmental bodies, private enterprises, and civil society, have a responsibility to contribute to the achievement of the SDGs. Science, technology, and innovation are identified as the three pillars essential for achieving the SDGs. The book emphasizes the critical role of science and technology in addressing complex issues such as climate change, biodiversity loss, resource depletion, poverty reduction, health, education, gender equality, clean energy, sustainable cities, responsible consumption, and climate action. It helps to develop innovative solutions to promote economic growth, social inclusion, and environmental sustainability. And provide the necessary knowledge and tools to develop effective policies and strategies in these areas. Furthermore, the book highlights the potential of science and technology in promoting innovation and entrepreneurship, leading to the creation of new businesses and industries that align with sustainable development principles. This fosters economic growth, job creation, and environmental sustainability. It advocates for continued investment in science and technology and their integration into development strategies. The book aims to provide insights into the role of traditional and emerging areas of science and technology in meeting the goals outlined in the SDG document, with a specific focus on India. The book serves as a great source of information for researchers, teachers in basic and applied sciences /social sciences research and policymakers.
Role of Science and Technology for Sustainable Future: Volume 2- Applied Sciences and Technologies
by Ranbir Chander SobtiThis book discusses the role of science and technology in forging a sustainable and harmonious world. It delves into new horizons in healthcare, food security, climate change, energy, sustainable transportation, role of computational and data sciences in sustainability, and mental health and aims to cultivate innovative solutions that benefit both the planet and its inhabitants. The second volume is inspired by a unified objective: preserving our planet, fostering universal well-being, and envisioning a world where collective efforts drive positive change through an exploration of conventional and emerging technologies. The book chapters enrich the global discourse on sustainability, steering us toward a resilient and healthier future.With every chapter authored by dedicated experts, this book stands as a testament to the commitment to a better world and serves as a great resource for researchers, environmentalists, and students.
Role of Seismic Testing Facilities in Performance-Based Earthquake Engineering
by Michael N. Fardis Zoran T. RakicevicNowadays research in earthquake engineering is mainly experimental and in large-scale; advanced computations are integrated with large-scale experiments, to complement them and extend their scope, even by coupling two different but simultaneous tests. Earthquake engineering cannot give answers by testing and qualifying few, small typical components or single large prototypes. Besides, the large diversity of Civil Engineering structures does not allow drawing conclusions from only a few tests; structures are large and their seismic response and performance cannot be meaningfully tested in an ordinary lab or in the field. So, seismic testing facilities should be much larger than in other scientific fields; their staff has to be resourceful, devising intelligent ways to carry out simultaneously different tests and advanced computations. To better serve such a mission European testing facilities and researchers in earthquake engineering have shared their resources and activities in the framework of the European project SERIES, combining their research and jointly developing advanced testing and instrumentation techniques that maximize testing capabilities and increase the value of the tests. This volume presents the first outcomes of the SERIES and its contribution towards Performance-based Earthquake Engineering, i.e., to the most important development in Earthquake Engineering of the past three decades. The concept and the methodologies for performance-based earthquake engineering have now matured. However, they are based mainly on analytical/numerical research; large-scale seismic testing has entered the stage recently. The SERIES Workshop in Ohrid (MK) in Sept. 2010 pooled together the largest European seismic testing facilities, Europe's best experts in experimental earthquake engineering and select experts from the USA, to present recent research achievements and to address future developments. Audience: This volume will be of interest to researchers and advanced practitioners in structural earthquake engineering, geotechnical earthquake engineering, engineering seismology, and experimental dynamics, including seismic qualification.
Role of Signaling Pathways in Brain Tumorigenesis
by Mehdi Hayat ShahiThis book provides acomprehensive overview of cell signalling pathways and morphogens in the genesis of brain tumours. It also explains the role of brain tumour stem cells in the brain tumour progression. It also elucidates the novel early biomarkers that can be utilized to diagnose brain tumours. It presents the basic developmental pathways and morphogens, including retinoic acid and TGF-b that promote brain tumorigenesis. The chapters illustrate the role of stem cells and stem cells mediated cell signalling pathways including, Sonic hedgehog, Notch, Wnt in the brain tumour growth. The chapters also emphasize the role of transcription factors, mainlyNanog, Sox, BMI1, HIF1 and Pax6 in the brain tumouriogensis. It highlights the role of NF-kb, Myc and neurotrophins in the brain tumour development. Finally, the book summarizes the potential early therapeutic targets and targeted drug discovery for brain tumours.
Role of Transcription Factors in Gastrointestinal Malignancies
by Ganji Purnachandra Nagaraju Pallaval Veera BramhachariThis book illustrates the importance of transcription factors in gastrointestinal cancer progression and metastasis with regard to understanding the mechanism and target definition in drug discovery. Further, it describes the complex issues associated with cancer cell growth and metastasis. The respective chapters provide detailed information on the various types of transcription factors (NF-kB, HIF-1, STAT-3, E2F1, and Sp1) and gastric-associated cancers (esophagus, stomach, colorectal, liver and pancreatic cancers) in connection with specific functional studies like cell cycle, angiogenesis, migration, invasion and apoptosis. These transcription factors control the expression of several signaling pathways involved in tumor growth, making them ideal targets for gastrointestinal cancer therapy. In closing, the book provides comprehensive descriptions of the major challenges associated with gastrointestinal cancer therapy.
Role of Tyrosine Kinases in Gastrointestinal Malignancies
by Ganji Purnachandra NagarajuThe aim of this book is to provide comprehensive overview of the role of different tyrosine kinases in the progression and metastasis of various cancers of the gastrointestinal tract such as esophagus, liver, pancreas, stomach, and colorectal. Activation of various signaling pathways and tyrosine kinases are responsible for resistance to chemo and radiotherapy in these gastrointestinal malignancies. Targeting these tyrosine kinases, which regulate the activities of survival pathways in growth, and metastasis is a rational strategy in gastrointestinal cancer therapy. Each chapter embedded in this book covers information pertaining to a specific tyrosine kinase and its impact on various malignancies, which is not only significant for basic and clinical research investigations but will also be valued by students at advanced undergraduate to postgraduate levels.
Role of the Choroid Plexus in Health and Disease (Physiology in Health and Disease)
by Jeppe Praetorius Bonnie Blazer-Yost Helle DamkierThis book highlights the importance of the choroid plexus, which forms the blood-cerebrospinal fluid barrier and is the site of the major production of the cerebrospinal fluid (CSF). The authors show that this barrier is crucial for maintaining important compositional differences between the blood plasma and the CSF. The choroid plexus epithelial cells also prevent the spread of infectious agents and other blood-borne entities to the brain tissue. Chapter topics range from the production of CSF by electrolyte regulation in the choroid plexus, to details on the selectively transporting nature of this barrier. Further, the authors elaborate on the important roles of CSF in sustaining brain health by providing hydration, solutes, and nutrients to the brain tissue. Readers will also learn how CSF circulates signaling molecules within the compartments of the brain and removes waste products from the brain tissue. Elucidating the regulation of these processes in the choroid plexus is not only important for the readers’ understanding of normal brain development and function, but is also crucial for resolving a variety of cerebral challenges that lead to brain edema, as well as developing treatments for diseases. The book discusses disease models like hydrocephalus, sleep disorders, and age-related dementia. Its comprehensive coverage makes this volume a valuable resource for researchers in cell and neurophysiology, as well as graduate students of the neurosciences.
Roles of Copper in Lipid Metabolism
by Kai Y. LeiThe aim of this book is to provide a reference for researchers in the field of trace mineral and lipid metabolism. It addresses the influence of dietary copper status on cholesterol, lipoprotein and apolipoprotein metabolism as well as lipoprotein receptor characteristics. This fascinating volume critically reviews alterations in long chain fatty acid, prostaglandin and cardiac lipid metabolism, as well as arterial morphology induced by copper deficiency. Furthermore, it presents the theoretical relationship plus the anatomical, chemical and physiological similarities between copper deficiency and ischemic heart disease. This reading is indispensable for investigators interested in the role of copper in lipid metabolism.
Roles of Skeletal Muscle in Organ Development: Prenatal Interdependence among Cells, Tissues, and Organs (Advances in Anatomy, Embryology and Cell Biology #236)
by Boris KablarMuscle is the only tissue of the four basic types that make the body that can be completely ablated while allowing fetal survival. This book is a result of 25 years of research employing engineered mouse fetuses with no skeletal muscle, a model system that provides a unique opportunity to study body development holistically. A systematic anatomical analysis of such fetuses have shown that several anatomical locations are affected by the absence of the skeletal muscle. This book contains a summarized description of affected anatomical locations such as the alveolar lung epithelium, motor neurons and giant pyramidal cells in the CNS, cholinergic amacrine cells of the retina, and type I hair cells of the crista ampullaris. Several specific bioinformatics and systems biology interventions are also described. The book provides an update on skeletal muscle development, musculoskeletal developmental interactions, trophic relationships between the skeletal muscle and the motor neurons, mechanics of lung development, functional development of two special senses, eye and ear, and finally, skeletal muscle-related reasons for human fetal akinesia and its consequences. This volume in the Advances in Anatomy, Embryology and Cell Biology series stresses the need to think about the developing body and its organs in terms of their mutual interdependence, and to think about diseases, such as pulmonary hypoplasia, amyotrophic lateral sclerosis, or cleft palate, in terms of that interdependence. Directed to developmental biologists, neuroscientists, tissue engineers and health professionals, this book exposes the ideas of interorgan communication and interdependence in homeostasis and disease.
Rolling Circle Amplification (RCA)
by Vadim V. DemidovThis book covers the latest developments in rolling circle amplification (RCA) technology with applications in clinical diagnostic tests and molecular medicine. Topics covered include new enzymes useful in RCA, techniques involving RCA for enhanced signal amplification, novel RCA diagnostics, sensors for expediting RCA detection, and prospective RCA-based therapeutics. This is a valuable book for university professors and students in the field of biomedical engineering and biomolecular pharmacology as well as R&D managers of biotechnology and biopharmaceutical companies. Specifically, this book: Reviews prospective RCA-based therapeutics, including RCA-derived DNA nanoparticles that strongly bind to cancer cells Expands readers' understanding of sensor systems for expediting detection of RCA products by using probe-tagged magnetic nanobeads Maximizes reader insights into novel RCA diagnostics, such as PNA openers-assisted RCA for detection of single target cells and in situ RCA diagnosis of cancer cells and malignant tissues Presents innovative methods for quasi-exponential enhancement of RCA-generated signals, such as nicking enzyme-assisted cascade RCA and RCA coupled with loop-mediated amplification
Rolling of Advanced High Strength Steels: Theory, Simulation and Practice
by Jingwei Zhao Zhengyi JiangAdvanced high strength steels (AHSSs) for auto-making are primarily produced by rolling, plus heat treatment technologies if necessary. However, due to the metallurgical complexity of AHSSs, it is impossible to roll all of the AHSS grades in a rolling mill with the same rolling technology. Each of AHSSs has unique applications in vehicles, and specified rolling technologies are required to produce high quality AHSS products where they might be the best employed to meet performance demands of the automotive parts. Such background has prompted the publication of this scholarly book in the area of rolling of AHSSs with a purpose of providing readers with a valuable technical document that can be used in the research and development of AHSSs for automotive and other manufacturing industries. With contributors from USA, Germany, Poland, Italy, Spain, Austria, Australia, China, India and Iran, the book highlights the latest advances in rolling technologies of AHSSs. It focuses on the theory, simulation and practice of the rolling of AHSSs: The book introduces the history, types and advances of AHSSs and their processes; proposes new theory that is applicable to the rolling of AHSSs, presents mathematical and numerical modelling of AHSSs in rolling; covers thermomechanical processing technologies of AHSSs; provides case studies on the rolling practice of the most popular AHSSs and includes other rolling-related technologies of AHSSs. The book will be useful for both theoretical and applied research aimed at AHSSs rolling technologies, and will be a scientific and valuable literature for the metallurgists, engineers, materials scientists, academics and graduate students who are studying and working with AHSSs and their rolling technologies worldwide.