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Redox-Genome Interactions in Health and Disease (Oxidative Stress and Disease #Vol. 10)
by Jürgen Fuchs Maurizio PoddaAt the nexus of advances in molecular genetics and findings in redox biology, this volume elaborates on the dynamics governing cellular redox states and aggregates the body of evidence linking oxidative stress and redox modulation with a host of monogenetic and polygenetic diseases.
Redox-Mediated Signal Transduction
by John T. HancockOnce believed to be involved mainly with energetics, including the production of ATP, knowledge of the role of redox in the control of cellular activity has been expanded over recent years. In Redox-Mediated Signal Transduction: Methods and Protocols, experienced researchers with backgrounds in both the plant and animal sciences contribute timely methods and techniques that can be used to study this important aspect of biology. Beginning with an overview and methods for measuring compounds that affect redox and the redox state of cells, the book continues with reviews of the use of GFP and its derivatives, methods to study the impact of changing redox on proteins, and methods to study the exact molecular changes that may underlie the mechanisms of action of altering redox, among other subjects. As a volume in the highly successful Methods in Molecular BiologyTM series, chapters include step-by-step, readily reproducible protocols, lists of the necessary materials and reagents, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and easy to use, Redox-Mediated Signal Transduction: Methods and Protocols is an ideal reference for those who wish to enter this exciting area of research as well as for those who simply wish for a more thorough understanding of the dramatic impact of redox in the control of cellular function.
Redox-Mediated Signal Transduction: Methods and Protocols (Methods in Molecular Biology #1990)
by John T. Hancock Myra E. ConwayThis volume explores the scope of the cellular redox analysis and the importance of not being limited by frequently changing and evolving technology. The chapters in this book cover a wide range of topics such as redox components in animal and plant cells and the role of reactive oxygen species, reactive nitrogen species, and hydrogen sulphide in cell signaling; measuring modifications using Flow Cytometry, ELISA assays, and Western blot analysis; measurement of oxidative stress in mitochondira and biological systems; and the use of the genetically encoded fluorescent probe HyPer. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and informative, Redox-Mediated Signal Transduction: Methods and Protocols, Second Edition is a valuable resource for both novice and expert researchers who want to expand their studies into new areas and new systems in the evolving redox field.
Redox Metabolism and Longevity Relationships in Animals and Plants: Vol 62 (Society for Experimental Biology)
by Christine Foyer Richard Faragher Paul ThornalleyRedox Metabolism and Longevity Relationships in Animals and Plants focuses on the recent issues that have emerged in ageing research in both the animal and plant kingdoms. This volume reviews current concepts concerning cellular redox homeostatis and ageing in animals and plants, relationships to programmed cell death, the production of oxidants and dicarbonyls, the ways that different organisms perceive and respond to oxidative, nitration and glycation challenges, and how this might be intricately connected to ageing and lifespan.
Redox Regulation and Therapeutic Approaches in Cancer
by Mohinder Pal BansalThis book aims to provide an association of the major redox-sensitive pathways and networks involved in cancer. The initial chapter of the book discusses basic information about oxidative stress, its generation, and regulation (redox regulation or redox homeostasis) via cell signaling in normal and cancer cells. The book also explores antioxidants and metabolic events in cancer cells compared to normal cells. It further covers the application of nanoparticles in redox regulation in cancer cells. The role of redox regulation in cancer therapy, its influence, and its involvement in programmed cell death (PCD), metastasis, immune system, p53, and cell cycle/DNA damage repair pathways have been discussed in separate chapters. It further reviews the importance of dietary phytochemicals in redox regulation in normal and cancer pathophysiology. Towards the end, the book focuses on the role of redox balance, especially in ROS-dependent cellular processes in cancer stem cells.
Redox Regulation of Cell Signaling and Its Clinical Application (Oxidative Stress and Disease)
by Lester Packer Junji YodoiPresents recent developments in the rapidly expanding field of redox regulation research. The book examines insights into intracellular communication and new techniques for diagnosing and treating diseases associated with oxidation and reduction. It focuses on important cellular mechanisms, such as redox reactions related to thioredoxin (TRX)/adult
Redox Regulation of Differentiation and De-differentiation (Oxidative Stress and Disease #48)
by Carsten Berndt Christopher Horst LilligCell differentiation and the development of multicellular organisms are processes of self-assembly, controlled and driven by signaling molecules and cascades including redox regulation. These reactions may have provided the energy for the first metabolic steps in the evolution of life. Today, redox modifications are established as important regulatory events in cellular functions including differentiation and development. Redox modifications of single cysteines regulate differentiation of stem cells, formation of functioning organs, and de-differentiation such as formation of cancer cells. Current cancer therapy is based on redox events as well and regeneration often reactivates developmental pathways. Understanding differentiation and de-differentiation on a molecular level is therefore a prerequisite for the continuing development of new medical therapies. This book summarizes the roles of redox regulation in development by bringing together different concepts and comparing similarities and differences between various cell types and species. An international team of contributors presents several new aspects of redox-regulated differentiation and de-differentiation, including aspects of redox medicine. Key Features Provides the first summary on this important topic Reviews redox-dependent development of model organisms and single organs Highlights the redox-regulated pathways important for differentiation processes Illustrates the potential of redox medicine Combines state-of-the-art knowledge in differentiation/development, aging/longevity, and repair/regeneration Written by leading experts in the field Related Titles Ayyanathan, K., ed. Cancer Cell Signaling: Targeting Signaling Pathways Toward Therapeutic Approaches to Cancer (ISBN 978-1-77188-067-1) Clarke, M. & J. Frampton. Stem Cells: Biology and Application (ISBN 9780-8153-4511-4) Lim, W. & B. Mayer. Cell Signaling: Principles and Mechanisms (ISBN 978-0-8153-4244-1) Wong, E., ed. Autophagy and Signaling (ISBN 978-0-367-65772-7)
Redox Signaling and Biomarkers in Ageing (Healthy Ageing and Longevity #15)
by Ufuk ÇakatayThis book aims to present the age-related alterations in redox signaling networks and their diagnostic biomarkers in aging cells using multidisciplinary approach. Establishing sensitive and specific biomarkers of dynamic redox homeostasis is crucially important in the development of effective antiaging and senolytic interventions. Recent years have seen tremendous advances in the understanding of redox signaling events which highlight the process of aging and age-related pathologies. A major challenge in biological aging research is developing reliable biomarkers to determine the consequences of disrupted redox signaling networks long before the clinical diagnosis of age-related diseases is made. Therefore, we have chosen to concentrate on aging-induced aberrant redox signaling networks, their biomarkers, and pathological consequences in this book. Although oxidation is a natural metabolic process, the imbalance in the level of oxidants and antioxidants causes oxidative stress and eventually leads to inflammatory conditions, diabetes, neurodegenerative diseases, and cancer. Novel redox-sensitive biomarkers for the evaluation of aging-induced proteinopathies such as amyloid ß and tau proteins in Alzheimer's disease, α-synuclein in Parkinson's disease, and islet amyloid polypeptides in type 2 diabetes mellitus recently drew the attention of researchers. Inside this textbook, readers will find comprehensive perspectives on the association between redox homeostasis and the aging process both at the molecular and clinical levels. Due to the inherent relationship between impaired metabolic activities and oxidative stress, the temporal interaction between intermediary metabolism and disturbed redox status can lead to greater susceptibility to aging-induced diseases and disorders, such as cardiovascular diseases, hypertension, and diabetes. This knowledge could be a key to continued research toward improving medication regimens such as in cancer and cardiovascular therapies, and procedural outcomes for patients. This book brings together current research evidence and knowledge on redox signaling and biomarkers in aging in chapters written by leading global experts in this rapidly evolving field. We hope that this textbook is of interest to a wide group of researchers, advanced students, scientifically curious non-specialist readers and clinicians alike.
Redox State as a Central Regulator of Plant-Cell Stress Responses
by Dharmendra K. Gupta José M. Palma Francisco J. CorpasThis book provides an up-to-date overview of redox signaling in plant cells and its key role in responses to different stresses. The chapters, which are original works or reviews, focus on redox signaling states; cellular tolerance under different biotic and abiotic stresses; cellular redox homeostasis as a central modulator; redox homeostasis and reactive oxygen species (ROS); redox balance in chloroplasts and mitochondria; oxidative stress and its role in peroxisome homeostasis; glutathione-related enzyme systems and metabolism under metal stress; and abiotic stress-induced redox changes and programmed cell death. The book is an invaluable source of information for plant scientists and students interested in redox state chemistry and cellular tolerance in plants.
REDUCE for Physicists
by N MacDonaldThe use of computer algebra systems in science and engineering has grown rapidly as more people realize their potential to solve tedious and extensive mathematical problems. REDUCE for Physicists provides a comprehensive introduction to one of the most widely available and simple to use computer algebra systems, focusing primarily on the needs of physicists. As a means of performing symbolic computation, REDUCE reduces tedious manual algebraic calculations and the dangers of casual errors. Each chapter introduces some aspects of REDUCE and illustrates them with applications from various branches of physics including mechanics, dynamics, dimensional analysis, quantum mechanics, and plasma physics. Emphasizing hands-on work with REDUCE to tackle real physical problems, the book includes exercises to test understanding throughout. Students and researchers in the physical sciences and engineering using REDUCE for the first time will find this book an invaluable aid to learning.
Reduced Inequalities (Encyclopedia of the UN Sustainable Development Goals)
by Walter Leal Filho Anabela Marisa Azul Luciana Brandli Amanda Lange Salvia Pinar Gökçin Özuyar Tony WallThe problems related to the process of industrialisation such as biodiversity depletion, climate change and a worsening of health and living conditions, especially but not only in developing countries, intensify. Therefore, there is an increasing need to search for integrated solutions to make development more sustainable. The United Nations has acknowledged the problem and approved the “2030 Agenda for Sustainable Development”. On 1st January 2016, the 17 Sustainable Development Goals (SDGs) of the Agenda officially came into force. These goals cover the three dimensions of sustainable development: economic growth, social inclusion and environmental protection. The Encyclopedia of the UN Sustainable Development Goals comprehensively addresses the SDGs in an integrated way. The Encyclopedia encompasses 17 volumes, each one devoted to one of the 17 SDGs. This volume addresses SDG 10, namely "Reduce inequality within and among countries", but also includes inequalities in income as well as those based on age, sex, disability, race, ethnicity, origin, religion or economic or other status within a country. The Goal also addresses inequalities among countries, including those related to representation, migration and development assistance. This volume contains the description of a range of terms, to allow a better understanding and foster knowledge about it.Concretely, the identified targets are:Progressively achieve and sustain income growth of the bottom 40 per cent of the population at a rate higher than the national averageEmpower and promote the social, economic and political inclusion of all, irrespective of age, sex, disability, race, ethnicity, origin, religion or economic or other statusEnsure equal opportunity and reduce inequalities of outcome, including by eliminating discriminatory laws, policies and practices and promoting appropriate legislation, policies and action in this regardAdopt policies, especially fiscal, wage and social protection policies, and progressively achieve greater equalityImprove the regulation and monitoring of global financial markets and institutions and strengthen the implementation of such regulationsEnsure enhanced representation and voice for developing countries in decision-making in global international economic and financial institutions in order to deliver more effective, credible, accountable and legitimate institutionsFacilitate orderly, safe, regular and responsible migration and mobility of people, including through the implementation of planned and well-managed migration policiesImplement the principle of special and differential treatment for developing countries, in particular least developed countries, in accordance with World Trade Organization agreementsEncourage official development assistance and financial flows, including foreign direct investment, to states where the need is greatest, in particular least developed countries, African countries, small island developing states and landlocked developing countries, in accordance with their national plans and programmesReduce to less than 3 per cent the transaction costs of migrant remittances and eliminate remittance corridors with costs higher than 5 per centEditorial BoardMd. Mahmudul Alam, Olga Bialostocka, José Baltazar Salgueirinho Osório de Andrade Guerra, Narasimha Reddy Donthi, Ulla A. Saari, Daniele Vieira, Amanda Lange Salvia
Reducing Climate Impacts in the Transportation Sector
by James S. Cannon Daniel SperlingMore than 250 experts from around the world gathered at the Asilomar Transportation and Energy Conference in August 2007 to tackle what many agree is the greatest environmental challenge the world faces: climate change. This 11th Biennial Conference, organized under the auspices of the Energy and Alternative Fuels Committees of the U.S. Transportation Research Board, examined key climate change policy issues and strategies to combat climate impacts from the transportation sector, a leading source of greenhouse gas emissions. This book includes chapters by leading presenters at the Asilomar Conference that reflect the most current views of the world's experts about a critical and rapidly evolving energy and environmental problem. The chapters in this book examine increasing worldwide emissions of greenhouse gases, uncertain oil supply, evolving climate change science, public attitudes toward climate change, and the implications for the U.S. of growth in China, India and elsewhere. They propose methods to reduce growth in vehicle travel through alternative fuel, new technologies, and land use planning. They examine the costs and the potential for greenhouse gas reduction through deployment of advanced technology and alternative fuels and propose strategies to motivate consumers to buy fuel efficient and alternative fuel vehicles, including heavy duty trucks.
Reducing Drug Attrition
by James R. Empfield Michael P ClarkMedicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e. g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.
Reducing Inequalities Towards Sustainable Development Goals: Multilevel Approach
by Medani P. BhandariThe Sustainable Development Goals (SDGs) are a set of global goals that meet some of the most pressing challenges facing our world today. Goal 10 concerns reducing global inequalities. Inequality is currently seen in the social, political, and economic structures of communities at both the national and international level. The United Nation’s approach to sustainable development is to create a set of goals and targets try to minimize the accelerating gaps of inequality. The book presents new insights for evaluating the progress on SDGs (especially goal 10), it also boldly sets new economic, social and environmental targets for reducing inequality. Using case studies, this book encourages readers to view economic development through the lens of growing inequalities and disparities. Such inequalities are clearly becoming more obvious as the world is better connected, and information is quickly shared. The books main aim is therefore to direct the efforts of scholars, practitioners and policymakers to swiftly find the balance between the three pillars of sustainable development. The main challenges and focus of each chapter are different and collectively they give an integrated understanding of the phenomenon of sustainable development and its diverse aspects. This book will be useful for policymakers, social and environmental activists, agencies, educators and practitioners in the sphere of social or environmental economics. The methodology of the research can be replicated and taken forward by future researchers in the field.
Reducing Lightning Injuries Worldwide (Springer Natural Hazards)
by Mary Ann Cooper Ronald L. HolleThis book is a resource for understanding why Lightning continues to be a major health hazard, especially in the developing world, and equips researchers, governments, and public health advocates with the knowledge and techniques needed to reduce lightning casualties worldwide.
Reducing Operational Costs in Composites Manufacturing
by Karen Snyder TravisReducing Operational Costs in Composites Manufacturing provides organization-specific principles for managers working in the composites industry. It utilizes a "how to" format for reducing operational costs and provides examples for each principle. In the first two sections, readers learn how to evaluate the existing environment to determine the best course of action when developing a plan to achieve goals. This is followed by a deeper understanding of why character strengths are important, and how to effectively manage employees in section three. Section four helps the new manager to think outside the box by bringing in other managers to evaluate and offer suggestions. Finally, section five teaches the reader how to sustain and continually enhance what they have put in place. Uniquely aimed at the composites industry, this book helps professionals and managers implement process change, gain control of struggling facilities, enhance the strengths of more efficient organizations, and consider manufacturing costs of in a new light.
Reducing the Logistics Burden for the Army After Next: Doing More with Less
by National Research CouncilInformation on Reducing the Logistics Burden for the Army After Next
Reducing the Time from Basic Research to Innovation in the Chemical Sciences: A Workshop Report to the Chemical Sciences Roundtable
by Chemical Sciences RoundtableInnovation, the process by which fundamental research becomes a commercial product, is increasingly important in the chemical sciences and is changing the nature of research and development efforts in the United States. The workshop was held in response to requests to speed the R&D process and to rapidly evolve the patterns of interaction among industry, academe, and national laboratories. The report contains the authors' written version of the workshop presentations along with audience reaction.
Reduction and Emergence in Science and Philosophy
by Carl GillettGrand debates over reduction and emergence are playing out across the sciences, but these debates have reached a stalemate, with both sides declaring victory on empirical grounds. In this book, Carl Gillett provides new theoretical frameworks with which to understand these debates, illuminating both the novel positions of scientific reductionists and emergentists and the recent empirical advances that drive these new views. Gillett also highlights the flaws in existing philosophical frameworks and reorients the discussion to reflect the new scientific advances and issues, including the nature of 'parts' and 'wholes', the character of aggregation, and thus the continuity of nature itself. Most importantly, Gillett shows how disputes about concrete scientific cases are empirically resolvable and hence how we can break the scientific stalemate. Including a detailed glossary of key terms, this volume will be valuable for researchers and advanced students of the philosophy of science and metaphysics, and scientific researchers working in the area.
The Reduction of Physical Theories: A Contribution to the Unity of Physics Part 1: Foundations and Elementary Theory (Fundamental Theories of Physics #207)
by Erhard ScheibeUsing simple physical examples, this work by Erhard Scheibe presents an important and powerful approach to the reduction of physical theories. Novel to the approach is that it is not based, as usual, on a single reduction concept that is fixed once and for all, but on a series of recursively constructed reductions, with which all reductions appear as combinations of very specific elementary reductions. This leaves the general notion of theory reduction initially open and is beneficial for the treatment of the difficult cases of reduction from the fields of special and general relativity, thermodynamics, statistical mechanics,and quantum mechanics, which are treated in the second volume. The book is systematically organized and intended for readers interested in philosophy of science as well as physicists without deep philosophical knowledge.
Reductionism: A Beginner's Guide (Beginner's Guides)
by Alastair RaeEver since the ancient Greeks conceived of the atom, humans have sought the smallest ingredients of our existence. In the past century, the use of reductionism to understand behavior has gained steam as the quantum universe and the workings of the human mind have been uncovered; still there are those who say that reductionists are oversimplifying our world. Here, acclaimed physicist Alastair Rae spells out how the powerful tool of reductionism works, from the level of subatomic particles, up through molecular chemistry, and beyond to our neural networks. How does physics explain consciousness? Can quantum mechanics be applied to the brain or mind? Rae's exploration is an indispensable guide to one of the most fundamental ideas of science and the perfect companion for anyone considering how scientific findings reach into human life.
Reductionism, Emergence and Levels of Reality
by Sergio Chibbaro Lamberto Rondoni Angelo VulpianiScientists have always attempted to explain the world in terms of a few unifying principles. In the fifth century B. C. Democritus boldly claimed that reality is simply a collection of indivisible and eternal parts or atoms. Over the centuries his doctrine has remained a landmark, and much progress in physics is due to its distinction between subjective perception and objective reality. This book discusses theory reduction in physics, which states that the whole is nothing more than the sum of its parts: the properties of things are directly determined by their constituent parts. Reductionism deals with the relation between different theories that address different levels of reality, and uses extrapolations to apply that relation in different sciences. Reality shows a complex structure of connections, and the dream of a unified interpretation of all phenomena in several simple laws continues to attract anyone with genuine philosophical and scientific interests. If the most radical reductionist point of view is correct, the relationship between disciplines is strictly inclusive: chemistry becomes physics, biology becomes chemistry, and so on. Eventually, only one science, indeed just a single theory, would survive, with all others merging in the Theory of Everything. Is the current coexistence of different sciences a mere historical venture which will end when the Theory of Everything has been established? Can there be a unified description of nature? Rather than an analysis of full reductionism, this book focuses on aspects of theory reduction in physics and stimulates reflection on related questions: is there any evidence of actual reduction? Are the examples used in the philosophy of science too simplistic? What has been endangered by the search for (the) ultimate truth? Has the dream of reductionist reason created any monsters? Is big science one such monster? What is the point of embedding science Y within science X, if predictions cannot be made on that basis?
Reductionism in Art and Brain Science: Bridging the Two Cultures
by Eric KandelAre art and science separated by an unbridgeable divide? Can they find common ground? In this new book, neuroscientist Eric R. Kandel, whose remarkable scientific career and deep interest in art give him a unique perspective, demonstrates how science can inform the way we experience a work of art and seek to understand its meaning. Kandel illustrates how reductionism—the distillation of larger scientific or aesthetic concepts into smaller, more tractable components—has been used by scientists and artists alike to pursue their respective truths. He draws on his Nobel Prize-winning work revealing the neurobiological underpinnings of learning and memory in sea slugs to shed light on the complex workings of the mental processes of higher animals. In Reductionism in Art and Brain Science, Kandel shows how this radically reductionist approach, applied to the most complex puzzle of our time—the brain—has been employed by modern artists who distill their subjective world into color, form, and light. Kandel demonstrates through bottom-up sensory and top-down cognitive functions how science can explore the complexities of human perception and help us to perceive, appreciate, and understand great works of art. At the heart of the book is an elegant elucidation of the contribution of reductionism to the evolution of modern art and its role in a monumental shift in artistic perspective. Reductionism steered the transition from figurative art to the first explorations of abstract art reflected in the works of Turner, Monet, Kandinsky, Schoenberg, and Mondrian. Kandel explains how, in the postwar era, Pollock, de Kooning, Rothko, Louis, Turrell, and Flavin used a reductionist approach to arrive at their abstract expressionism and how Katz, Warhol, Close, and Sandback built upon the advances of the New York School to reimagine figurative and minimal art. Featuring captivating drawings of the brain alongside full-color reproductions of modern art masterpieces, this book draws out the common concerns of science and art and how they illuminate each other.
Reductive Explanation in the Biological Sciences
by Marie I. KaiserThis book develops aphilosophical account that reveals the major characteristics that make anexplanation in the life sciences reductive and distinguish them fromnon-reductive explanations. Understanding what reductive explanations areenables one to assess the conditions under which reductive explanations are adequateand thus enhances debates about explanatory reductionism. The account of reductiveexplanation presented in this book has three major characteristics. First, itemerges from a critical reconstruction of the explanatory practice of the lifesciences itself. Second, the account is monistic since it specifies one set ofcriteria that apply to explanations in the life sciences in general. Finally,the account is ontic in that it traces the reductivity of anexplanation back to certain relations that exist between objects in theworld (such as part-whole relations and level relations), rather than to thelogical relations between sentences. Beginning with a disclosure of themeta-philosophical assumptions that underlie the author's analysis of reductiveexplanation, the book leads into the debate about reduction(ism) in thephilosophy of biology and continues with a discussion on the twoperspectives on explanatory reduction that have been proposed in thephilosophy of biology so far. The author scrutinizes how the issue of reductionbecomes entangled with explanation and analyzes two concepts, the conceptof a biological part and the concept of a level of organization. The results ofthese five chapters constitute the ground on which the author bases herfinal chapter, developing her ontic account of reductive explanation.
Reef Fish Spawning Aggregations: Biology, Research and Management
by Patrick L. Colin Yvonne Sadovy de MitchesonReef fish spawning aggregations, ranging from small groups to many tens of thousands of individuals, are spectacular but poorly known natural phenomena whereby fish assemble at specific times and locations to spawn. For some species these large groups may be the only form of reproduction, the high fish numbers briefly giving a false impression of stability and abundance--an 'illusion of plenty'. They are often a focus for intensive seasonal fishing because of their predictability and because many important commercial fishes form them. Highly vulnerable to overexploitation, many aggregations and their associated fisheries, have disappeared or are in decline. Few are effectively managed or incorporated into protected areas. Aggregations are not well understood by fishery scientists, managers and conservationists and their significance little appreciated by fishers or the wider public. To ensure their persistence to replenish important fisheries in coral ecosystems, maintain their ecosystem function and continue to delight divers, a significant change in perspective is needed to foster protection and management. This book provides comprehensive and practical coverage of the biology, study and management of reef fish aggregations, exploring their how, when, where, and why. It explores ways to better protect, study, manage and conserve them, while identifying key data gaps and questions. The text is extensively illustrated with many unique, never before published, photographs and graphics. Case studies on over 20 interesting and important fishes are included, outlining their biology and fisheries and highlighting major concerns and challenges.