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The Renin Angiotensin System in Cardiovascular Disease (Advances in Biochemistry in Health and Disease #24)
by Naranjan S. Dhalla Sukhwinder K. Bhullar Anureet K. ShahThis book on “Renin-Angiotensin System in Cardiovascular Disease” includes 25 chapters, which are organized in three sections, namely (i) modulatory aspects, (ii) pathophysiological aspects, and (iii) pharmacotherapeutic aspects. It includes an updated as well as comprehensive knowledge about molecular and cellular aspects for the role of the renin-angiotensin system (RAS) in the pathophysiology and therapy of cardiovascular diseases such as hypertension, atherosclerosis, ischemic heart disease, and heart failure. This book emphasizes the molecular and cellular mechanisms, signaling transduction pathways involved in the development of different cardiovascular diseases due to the prolonged activation of RAS. Furthermore, biochemical mechanisms are outlined for the inhibition of this system by the blockade of angiotensin converting enzyme as well as angiotensin II type 1 receptors in patients suffering from cardiovascular abnormalities. Since cardiovascular disease is the number one cause of death worldwide, leading to approximately 17.9 million deaths each year, there is a keen interest in understanding the pathogenesis and improving its therapy. In this regard, we can attest that this book provides ample information about essential components of RAS and their role in the development of cardiovascular disease.From the selection of recognized global experts in their area of investigation, this book can be seen to cover diverse cardiovascular aspects and molecular and cellular mechanisms of angiotensin II action for the development of different cardiovascular abnormalities. It is our contention that this book will be most suitable for promoting knowledge in the field of RAS biology and will be of great interest to health professionals involved in both experimental and clinical cardiology as well as academic investigators and cardiovascular scientists, graduate students, and fellows worldwide.
Renormalization Group Analysis of Equilibrium and Non-equilibrium Charged Systems
by Evgeny BarkhudarovThis thesis has two parts, each based on an application of the renormalization-group (RG). The first part is an analysis of the d-dimensional Coulomb gas. The goal was to determine if the Wilson RG could provide input into particle-in-cell simulations in plasma physics, which are the main family of simulation methods used in this field. The role of the RG was to identify the effect of coarse-graining on the coupling constants as a function of the cut-offs. The RG calculation reproduced established results, but in a more concise form, and showed the effect of the cut-offs on the Debye screening length. The main part of the thesis is the application of the dynamic RG to turbulence in magnetohydrodynamics. After transformation to Elsasser variables, which is a symmetrisation of the original equations, the solution is presented as a functional integral, which includes stirring forces, their conjugates and functional Jacobian. The coarse-graining of the functional integral is represented as a diagrammatic expansion, followed by rescaling, and casting the results into differential equations for the analysis of RG trajectories. Detailed comparisons are made with the Navier-Stokes limit and with previous calculations for MHD.
Renormalization Group Analysis of Nonequilibrium Phase Transitions in Driven Disordered Systems (Springer Theses)
by Taiki HagaThis book investigates phase transitions and critical phenomena in disordered systems driven out of equilibrium. First, the author derives a dimensional reduction property that relates the long-distance physics of driven disordered systems to that of lower dimensional pure systems. By combining this property with a modern renormalization group technique, the critical behavior of random field spin models driven at a uniform velocity is subsequently investigated. The highlight of this book is that the driven random field XY model is shown to exhibit the Kosterlitz–Thouless transition in three dimensions. This is the first example of topological phase transitions in which the competition between quenched disorder and nonequilibrium driving plays a crucial role. The book also includes a pedagogical review of a renormalizaion group technique for disordered systems.
Renormalization Group and Fixed Points
by Timothy J HollowoodThis Brief presents an introduction to the theory of the renormalization group in the context of quantum field theories of relevance to particle physics. Emphasis is placed on gaining a physical understanding of the running of the couplings. The Wilsonian version of the renormalization group is related to conventional perturbative calculations with dimensional regularization and minimal subtraction. An introduction is given to some of the remarkable renormalization group properties of supersymmetric theories.
Reoccupy Earth: Notes toward an Other Beginning (Groundworks: Ecological Issues in Philosophy and Theology)
by David WoodHabit rules our lives. And yet climate change and the catastrophic future it portends, makes it clear that we cannot go on like this. Our habits are integral to narratives of the good life, to social norms and expectations, as well as to economic reality. Such shared shapes are vital. Yet while many of our individual habits seem perfectly reasonable, when aggregated together they spell disaster. Beyond consumerism, other forms of life and patterns of dwelling are clearly possible. But how can we get there from here? Who precisely is the ‘we’ that our habits have created, and who else might we be? Philosophy is about emancipation—from illusions, myths, and oppression. In Reoccupy Earth, the noted philosopher David Wood shows how an approach to philosophy attuned to our ecological existence can suspend the taken-for-granted and open up alternative forms of earthly dwelling. Sharing the earth, as we do, raises fundamental questions about space and time, place and history, territory and embodiment—questions that philosophy cannot directly answer but can help us to frame and to work out for ourselves. Deconstruction exposes all manner of exclusion, violence to the other, and silent subordination. Phenomenology and Whitehead’s process philosophy offer further resources for an ecological imagination. Bringing an uncommon lucidity, directness, and even practicality to sophisticated philosophical questions, Wood plots experiential pathways that disrupt our habitual existence and challenge our everyday complacency. In walking us through a range of reversals, transformations, and estrangements that thinking ecologically demands of us, Wood shows how living responsibly with the earth means affirming the ways in which we are vulnerable, receptive, and dependent, and the need for solidarity all round.If we take seriously values like truth, justice, and compassion we must be willing to contemplate that the threat we pose to the earth might demand our own species’ demise. Yet we have the capacity to live responsibly. In an unfashionable but spirited defense of an enlightened anthropocentrism, Wood argues that to deserve the privileges of Reason we must demonstrably deploy it through collective sustainable agency. Only in this way can we reinhabit the earth.
Reordering Life: Knowledge and Control in the Genomics Revolution (Inside Technology)
by Stephen HilgartnerHow the regimes governing biological research changed during the genomics revolution, focusing on the Human Genome Project.The rise of genomics engendered intense struggle over the control of knowledge. In Reordering Life, Stephen Hilgartner examines the “genomics revolution” and develops a novel approach to studying the dynamics of change in knowledge and control. Hilgartner focuses on the Human Genome Project (HGP)—the symbolic and scientific centerpiece of the emerging field—showing how problems of governance arose in concert with new knowledge and technology. Using a theoretical framework that analyzes “knowledge control regimes,” Hilgartner investigates change in how control was secured, contested, allocated, resisted, justified, and reshaped as biological knowledge was transformed. Beyond illuminating genomics, Reordering Life sheds new light on broader issues about secrecy and openness in science, data access and ownership, and the politics of research communities. Drawing on real-time interviews and observations made during the HGP, Reordering Life describes the sociotechnical challenges and contentious issues that the genomics community faced throughout the project. Hilgartner analyzes how laboratories control access to data, biomaterials, plans, preliminary results, and rumors; compares conflicting visions of how to impose coordinating mechanisms; examines the repeated destabilization and restabilization of the regimes governing genome databases; and examines the fierce competition between the publicly funded HGP and the private company Celera Genomics. The result is at once a path-breaking study of a self-consciously revolutionary science, and a provocative analysis of how knowledge and control are reconfigured during transformative scientific change.
Repair: When and How to Improve Broken Objects, Ourselves, and Our Society
by Péter Érdi Zsuzsa SzvetelszkyThis book propagates a new way of thinking about managing our resources by integrating the perspectives of complex systems theory and social psychology. By resources, the authors mean objects, such as cell phones and cars, and human resources, such as family members, friends, and the small and large communities they belong to. As we all face the "replace or repair" dichotomy, readers will understand how to repair themselves, their relationships, and communities, accept the "new normal," and contribute to repairing the world. The book is offered to Zoomers, growing up in a world where it seems everything is falling apart; people in their 30s and 40s, who are thinking about how to live a fulfilling life; people from the Boomers generation, who are thinking back on life and how to repair relationships. The Reader will enjoy the intellectual adventure of connecting the natural and social worlds and understanding the transition's pathways from a "throwaway society" to a "repair society.
Repairing the Climate: A Plea for Carbon Capture
by L.J. ReindersClimate change is triggered by a too high concentration of greenhouse gases in the air, carbon dioxide in particular, primarily originating from fossil fuel-burning. Since such burning will not stop any time soon, the concentration will undoubtedly rise further, exacerbating climate change. There is no escape from this. That is where carbon capture comes in: direct air capture (DAC) scrubs the surplus carbon dioxide out of the air for actually lowering this concentration. At the same time emission levels must be drastically lowered by fitting point-source emitters with carbon capture installations. This book sets out the case for such carbon capture, which is a must, without which the climate cannot be repaired.
Repeated Measurements and Cross-Over Designs
by Lakshmi Padgett Damaraju RaghavaraoAn introduction to state-of-the-art experimental design approaches to better understand and interpret repeated measurement data in cross-over designs.Repeated Measurements and Cross-Over Designs:Features the close tie between the design, analysis, and presentation of resultsPresents principles and rules that apply very generally to most areas of research, such as clinical trials, agricultural investigations, industrial procedures, quality control procedures, and epidemiological studiesIncludes many practical examples, such as PK/PD studies in the pharmaceutical industry, k-sample and one sample repeated measurement designs for psychological studies, and residual effects of different treatments in controlling conditions such as asthma, blood pressure, and diabetes.Utilizes SAS(R) software to draw necessary inferences. All SAS output and data sets are available via the book's related website.This book is ideal for a broad audience including statisticians in pre-clinical research, researchers in psychology, sociology, politics, marketing, and engineering.
Repeated Measures Design for Empirical Researchers
by J. P. VermaThis book focuses on repeated measures designs, and while other books on design of experiments typically only explain the computation involved in each design, this book provides comprehensive solutions to each repeated measures design (RMD) discussed beginning with the formation of research questions to step-by-step analysis using IBM SPSS to the interpretation of the findings. The author uniquely discusses how to conceptualize research problems as well as identify appropriate repeated measures designs for research purposes. Examples have been carefully chosen from a multitude of domains, including psychology, the social sciences, management, and sports science, to aid readers in understanding both the associated theories and methodologies. The book contains eight chapters, the first three of which deal with various fundamental concepts involved in the design of experiments, basic statistical designs, computational details, differentiating independent and repeated measures designs, testing assumptions, and the introduction of SPSS softwar. The remaining chapters address five important repeated measures designs that are frequently used by researchers, namely two-way repeated measures design, two-way mixed design, one-way repeated measures ANOVA, and mixed design with two-way MANOVA.
Repetitorium Transplantationsbeauftragte
by Axel Rahmel Klaus Hahnenkamp Claus-Dieter MiddelKompakt und übersichtlich fasst das Buch die Wissensinhalte zusammen, die Ärzte und Pflegefachpersonal als Transplantationsbeauftragte auf einer Intensivstation benötigen. Es kann als anschauliche Einführung in das Aufgabenfeld ebenso verwendet werden wie als Nachschlagewerk für den erfahrenen Transplantationsbeauftragten. Alle Inhalte des Curriculums der Bundesärztekammer sind berücksichtigt, damit eignet es sich auch als Begleitbuch für die curricularen Kurse. Der inhaltliche Schwerpunkt liegt auf den Fragestellungen, die für die praktische Tätigkeit als Transplantationsbeauftragter besonders wichtig sind, wie die Voraussetzungen für eine Organspende und ihre Durchführung. Doch auch organisatorische, rechtliche und ethische Fragestellungen kommen nicht zu kurz. Die Links zu wichtigen Adressen und Arbeitsmaterialien können über integrierte QR-Codes direkt aufgerufen werden.
Replacing Animal Models
by Jamie DaviesOver the last decade, in vitro models have become more sophisticated and are at a stage where they can provide an effective alternative to in vivo experiments. Replacing Animal Models provides scientists and technicians with a practical, integrated guide to developing culture-based alternatives to in vivo experiments.The book is neither political nor polemical: it is technical, illustrating by example how alternatives can be developed and used and providing useful advice on developing others. After looking at the reasons for and potential benefits of alternatives to animal experiments, the book covers a range of methods and examples emphasising the design considerations that went into each system. The chapters also include 'case studies' that illustrate the ways in which culture models can be used to answer a range of important biological questions of direct relevance to human development, physiology, disease and healing.The thesis of this book is not that all animal experimentation can be replaced, now or in the near future, by equally effective or superior alternatives. Rather, the premise is that there is substantial opportunity, here and now, to do some common types of experiment better in vitro than in vivo, and that doing so will result in both scientific and ethical gains.
Replacing Darwin: The NEW Origin of Species
by Nathaniel T JeansonIf Darwin were to examine the evidence today using modern science, would his conclusions be the same? Charles Darwin’s On the Origin of Species, published over 150 years ago, is considered one of history’s most influential books and continues to serve as the foundation of thought for evolutionary biology. Since Darwin’s time, however, new fields of science have immerged that simply give us better answers to the question of origins. With a Ph.D. in cell and developmental biology from Harvard University, Dr. Nathaniel Jeanson is uniquely qualified to investigate what genetics reveal about origins. The Origins Puzzle Comes Together If the science surrounding origins were a puzzle, Darwin would have had fewer than 15% of the pieces to work with when he developed his theory of evolution. We now have a much greater percentage of the pieces because of modern scientific research. As Dr. Jeanson puts the new pieces together, a whole new picture emerges, giving us a testable, predictive model to explain the origin of species. A New Scientific Revolution Begins Darwin’s theory of evolution may be one of science’s “sacred cows,” but genetics research is proving it wrong. Changing an entrenched narrative, even if it’s wrong, is no easy task. Replacing Darwin asks you to consider the possibility that, based on genetics research, our origins are more easily understood in the context of . . . In the beginning . . . God, with the timeline found in the biblical narrative of Genesis. There is a better answer to the origins debate than what we have been led to believe. Let the revolution begin! About the Author Dr. Nathaniel Jeanson is a scientist and a scholar, trained in one of the most prestigious universities in the world. He earned his B.S. in Molecular Biology and Bioinformatics from the University of Wisconsin-Parkside and his PhD in Cell and Developmental Biology from Harvard University. As an undergraduate, he researched the molecular control of photosynthesis, and his graduate work involved investigating the molecular and physiological control of adult blood stem cells. His findings have been presented at regional and national conferences and have been published in peer-reviewed journals, such as Blood, Nature, and Cell. Since 2009, he has been actively researching the origin of species, both at the Institute for Creation Research and at Answers in Genesis.
Replication and Transcription of Chromatin
by Roumen G. Tsanev George Russev Iliya Pashev Jordanka S. ZlatanovaReplication and Transcription of Chromatin summarizes the main structural features of chromatin and presents results on replication and transcription gained over the last 20 years. The book emphasizes DNA-histone complexes and their importance in restricting genetic information encoded in DNA. Figures are used to illustrate many of the most important concepts of chromatin replication and transcription, and promising hypotheses and models are discussed to promote further research. Replication and Transcription of Chromatin is an important reference for biochemists, biophysicists, molecular biologists, cell biologists, and other researchers interested in this topic.
Replication of Chaos in Neural Networks, Economics and Physics
by Marat Akhmet Mehmet Onur FenThis book presents detailed descriptions of chaos for continuous-time systems. It is the first-ever book to consider chaos as an input for differential and hybrid equations. Chaotic sets and chaotic functions are used as inputs for systems with attractors: equilibrium points, cycles and tori. The findings strongly suggest that chaos theory can proceed from the theory of differential equations to a higher level than previously thought. The approach selected is conducive to the in-depth analysis of different types of chaos. The appearance of deterministic chaos in neural networks, economics and mechanical systems is discussed theoretically and supported by simulations. As such, the book offers a valuable resource for mathematicians, physicists, engineers and economists studying nonlinear chaotic dynamics.
Report of a Workshop of Pedagogical Aspects of Computational Thinking
by The National Academy of SciencesIn 2008, the Computer and Information Science and Engineering Directorate of the National Science Foundation asked the National Research Council (NRC) to conduct two workshops to explore the nature of computational thinking and its cognitive and educational implications. The first workshop focused on the scope and nature of computational thinking and on articulating what "computational thinking for everyone" might mean. A report of that workshop was released in January 2010. Drawing in part on the proceedings of that workshop, Report of a Workshop of Pedagogical Aspects of Computational Thinking, summarizes the second workshop, which was held February 4-5, 2010, in Washington, D. C. , and focuses on pedagogical considerations for computational thinking. This workshop was structured to gather pedagogical inputs and insights from educators who have addressed computational thinking in their work with K-12 teachers and students. It illuminates different approaches to computational thinking and explores lessons learned and best practices. Individuals with a broad range of perspectives contributed to this report. Since the workshop was not intended to result in a consensus regarding the scope and nature of computational thinking, Report of a Workshop of Pedagogical Aspects of Computational Thinking does not contain findings or recommendations.
Report of a Workshop on Science, Technology, Engineering, and Mathematics (STEM) Workforce Needs for the U.S. Department of Defense and the U.S. Defense Industrial Base
by Committee on Science Technology Engineering Mathematics Workforce Needs for the U.S. Department of Defense the U.S. Defense Industrial Base"Report of a Workshop on Science, Technology, Engineering, and Mathematics (STEM) Workforce Needs for the U. S. Department of Defense and the U. S. Defense Industrial Base" is the summary of a workshop held August 11, 2011, as part of an 18-month study of the issue. This book assesses the STEM capabilities that the Department of Defense (DOD) needs in order to meet its goals, objectives, and priorities; to assess whether the current DOD workforce and strategy will meet those needs; and to identify and evaluate options and recommend strategies that the department could use to help meet its future STEM needs.
Report of a Workshop on the Scope and Nature of Computational Thinking
by National Research Council of the National AcademiesReport of a Workshop on the Scope and Nature of Computational Thinking presents a number of perspectives on the definition and applicability of computational thinking. For example, one idea expressed during the workshop is that computational thinking is a fundamental analytical skill that everyone can use to help solve problems, design systems, and understand human behavior, making it useful in a number of fields. Supporters of this viewpoint believe that computational thinking is comparable to the linguistic, mathematical and logical reasoning taught to all children. Various efforts have been made to introduce K-12 students to the most basic and essential computational concepts and college curricula have tried to provide a basis for life-long learning of increasingly new and advanced computational concepts and technologies. At both ends of this spectrum, however, most efforts have not focused on fundamental concepts. The book discusses what some of those fundamental concepts might be. Report of a Workshop on the Scope and Nature of Computational Thinking explores the idea that as the use of computational devices is becoming increasingly widespread, computational thinking skills should be promulgated more broadly. The book is an excellent resource for professionals in a wide range of fields including educators and scientists.
Report of the Committee on Proposal Evaluation for Allocation of Supercomputing Time for the Study of Molecular Dynamics: Second Round
by Board on Life SciencesThe Committee on Proposal Evaluation for Allocation of Supercomputing Time for the Study of Molecular Dynamics evaluated submissions received in response to a Request for Proposals (RFP) for Biomolecular Simulation Time on Anton, a supercomputer specially designed and built by D.E. Shaw Research (DESRES) that allows for dramatically increased molecular dynamics simulations compared to other currently available resources. Over the past year (October 1, 2010 -- September 30, 2011), DESRES has made available to the non-commercial research community 3,000,000 node-hours on an Anton system housed at the Pittsburgh Supercomputing Center (PSC), based on the advice of a previous National Research Council committee convened in the fall of 2010. The goal of the second RFP for Biomolecular Simulation Time on Anton has been to continue to facilitate breakthrough research in the study of biomolecular systems by providing a massively parallel system specially designed for molecular dynamics simulations. These special capabilities allow multi-microsecond to millisecond simulation timescales, which previously had been unobtainable. The program seeks to continue to support research that addresses important and high impact questions demonstrating a clear need for Anton's special capabilities. The Anton RFP described the three criteria against which the committee was asked to evaluate proposals: Scientific Merit, Justification for Requested Time Allocation, and Investigator Qualifications and Past Accomplishments.
Report of the Committee on Proposal Evaluation for Allocation of Supercomputing Time for the Study of Molecular Dynamics: Third Round
by National Research Council of the National AcademiesThe committee evaluated submissions received in response to a request for proposals (RFP) for Biomolecular Simulation Time on Anton, a supercomputer specially designed and built by D.E. Shaw Research (DESRES) that allows for dramatically increased molecular dynamics simulations compared to other currently available resources. During the past 2 years, DESRES has made available to the non-commercial research community node-hours on an Anton system housed at the Pittsburgh Supercomputing Center (PSC), based on the advice of previous National Research Council committees convened in the falls of 2010 and 2011.
Report of the Panel on Implementing Recommendations from the New Worlds, New Horizons Decadal Survey
by Panel on Implementing Recommendations from New Worlds New Horizons Decadal SurveyThe 2010 Astronomy and Astrophysics Decadal Survey report, "New Worlds, New Horizons in Astronomy and Astrophysics" (NWNH), outlines a scientifically exciting and programmatically integrated plan for both ground- and space-based astronomy and astrophysics in the 2012-2021 decade. However, late in the survey process, the budgetary outlook shifted downward considerably from the guidance that NASA had provided to the decadal survey. And since August 2010--when NWNH was released--the projections of funds available for new NASA Astrophysics initiatives has decreased even further because of the recently reported delay in the launch of the James Webb Space Telescope (JWST) to no earlier than the fourth quarter of 2015 and the associated additional costs of at least $1. 4 billion. These developments jeopardize the implementation of the carefully designed program of activities proposed in NWNH. In response to these circumstances, NASA has proposed that the United States consider a commitment to the European Space Agency (ESA) Euclid mission at a level of approximately 20 percent. This participation would be undertaken in addition to initiating the planning for the survey's highest-ranked, space-based, large-scale mission, the Wide-Field Infrared Survey Telescope (WFIRST). The Office of Science and Technology Policy (OSTP) requested that the National Research Council (NRC) convene a panel to consider whether NASA's Euclid proposal is consistent with achieving the priorities, goals, and recommendations, and with pursuing the science strategy, articulated in NWNH. The panel also investigated what impact such participation might have on the prospects for the timely realization of the WFIRST mission and other activities recommended by NWNH in view of the projected budgetary situation. The panel convened a workshop on November 7, 2010. The workshop presentations identified several tradeoffs among options: funding goals less likely versus more likely to be achieved in a time of restricted budgets; narrower versus broader scientific goals; and U. S. -only versus U. S. -ESA collaboration. The panel captured these tradeoffs in considering four primary options: Option A: Launch of WFIRST in the Decade 2012-2021; Option B: A Joint WFIRST/Euclid Mission; Option C: Commitment by NASA of 20 percent Investment in Euclid prior to the M-class decision; or Option D: No U. S. Financing of an Infrared Survey Mission This Decade.
Report of the Treasurer of the National Academy of Sciences
by National Academy of Science the National AcademiesThis Report of the Treasurer of the National Academy of Sciences presents the financial position and results of operations, as well as a review of the endowment, trust, and other long-term investments pool activities of the Academy for the year ended December 31, 2008.
Report of the Treasurer of the National Academy of Sciences
by National Academy of Sciences of the National AcademiesThis Report of the Treasurer of the National Academy of Sciences presents the financial position and results of operations, as well as a review of the endowment, trust, and other long-term investments pool activities of the Academy for the year ended December 31, 2009.
Report of the Treasurer of the National Academy of Sciences for the Year Ended December 31, 2015
by National Academies of Sciences Engineering MedicineThe income that supports the activities of the National Academy of Sciences (NAS) comes from two major sources: program revenue received from sponsors to pay for the myriad studies and other activities undertaken each year by the National Academies of Sciences, Engineering, and Medicine, and a much smaller sum that is obtained from our endowment under the endowment spending policies adopted by the Council. The goal of the endowment is to provide stable support for the Academy’s programs and activities. To achieve this goal, the Council, acting on the recommendations of the Finance Committee, has historically authorized spending from the portfolio at a rate designed to maintain the purchasing power of the endowment over time. This Report of the Treasure of the National Academy of Sciences presents the financial position and results of operations as well as a review of the endowment, trust, and other long-term investments portfolio activities of our Academy for the year ended December 31, 2015. While this book provides essential financial summary to key personnel, it also serves as a vital informative resource for various members of the public, private, and governmental sectors.
Report on Green Development of Cities in the Yangtze River Economic Belt (2021)
by Linzi Li Xiaomin Li Liwen Zhan Yuting ZhaoThe report aims to help the cities in the Yangtze River Economic Belt of China identify their potentials for green development, especially to find their own suitable green development paths. Based on the evaluation, six green development models that can be replicated and promoted are initially established by selecting typical cities as pilot. The report is the first volume of its series and will be updated annually with more abundant green development models.