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Stem Cells in Regenerative Medicine
by Nasib Qureshi Lee E. Babiss Arnold I. Caplan Alain A. VertesThis book is a unique guide to emerging stem cell technologies and the opportunities for their commercialisation. It provides in-depth analyses of the science, business, legal, and financing fundamentals of stem cell technologies, offering a holistic assessment of this emerging and dynamic segment of the field of regenerative medicine.* Reviews the very latest advances in the technology and business of stem cells used for therapy, research, and diagnostics* Identifies key challenges to the commercialisation of stem cell technology and avenues to overcome problems in the pipeline* Written by an expert team with extensive experience in the business, basic and applied science of stem cell researchThis comprehensive volume is essential reading for researchers in cell biology, biotechnology, regenerative medicine, and tissue engineering, including scientists and professionals, looking to enter commercial biotechnology fields.logy and avenues to overcome problems in the pipelineWritten by an expert team with extensive experience in the business, basic and applied science of stem cell researchThis comprehensive volume is essential reading for researchers in cell biology, biotechnology, regenerative medicine, and tissue engineering, including scientists and professionals, looking to enter commercial biotechnology fields. It is valuable for R&D staff in academia, biotechnology and pharmaceutical companies,and professionals from consulting firms, regulatory agencies, and patenting offices, also to business and scientific managers, venture capitalists, business development professionals, corporate strategists, policy makers, patient advocates, and healthcare payers. It also constitutes a useful resource as a textbook to support science andbusiness students looking into courses in the field of regenerative medicine.
Stem Cells in Regenerative Medicine
by William L. Stanford Julie AudetAs regenerative medicine involves replacing diseased cells, tissues or organs, or repairing tissues in vivo, the manipulation of stem cells underlie its goals. In Stem Cells in Regenerative Medicine: Methods and Protocols, leading experts in the field provide an updated representation of the landscape of stem cell-based therapies in a wide spectrum of tissue systems and ontogenic stages, from the isolation and culture of stem cells to their actual use in vivo. Written in the highly successful Methods in Molecular BiologyTM series format, these chapters include brief introductions to the topic, lists of the necessary materials and reagents, readily reproducible, step-by-step laboratory protocols, and tips for troubleshooting and avoiding known pitfalls. Comprehensive and easy-to-use, Stem Cells in Regenerative Medicine: Methods and Protocols is certain to contribute greatly to the definition of standardized procedures for the manipulation of somatic and embryonic stem cells in research and clinical applications.
Stem Cells in Reproductive Tissues and Organs: From Fertility to Cancer (Stem Cell Biology and Regenerative Medicine #70)
by Irma Virant-KlunThis contributed volume gathers the latest knowledge in the field of stem cells in human reproductive organs, as well as animal models, and to consider the possibility of using this knowledge for clinical purposes. The scope of the book covers both clinical and basic knowledge of stem cells in both reproductive medicine (gynecology and obstetrics) and regenerative medicine as well as cellular and molecular medicine and reproductive biology. Chapters on basic stem cell knowledge in human reproductive tissues and organs or animal models are included, as well as clinical knowledge on their role in the manifestation of infertility and cancer and their clinical use.
Stem Cells in the Respiratory System
by Mauricio RojasIn this state-of-the-art exploration of a hugely dynamic and fast-evolving field of research, leading researchers share their collective wisdom on the role that stem cells could play in the context of physiological stress and lung injury. The text focuses on reviewing the most relevant--and recent--ideas on using local, endogenous, and exogenous progenitor/stem cells in preventing and treating injury to the lung. The lungs are one of the most complex organs in the human body, with a mature adult lung boasting at least 40 morphologically differentiated cell lineages. Our entire blood supply passes through the lung's alveolar units during oxygenation. This interaction with the outside world, along with the intricacies of its structure, makes the lung a highly susceptible organ that is vulnerable to numerous types of injury and infection. This means that the mechanisms of lung repair are in themselves correspondingly complex. Because of their multipotentiality, as well as the fact of the lung's relatively rapid cell turnover, stem cells are thought to be an important alternative cell-base therapy in lung injury. Despite the controversial nature of stem cell research, there has been growing interest in both local and endogenous stem cells in the lung. This highly topical book with chapters on everything from using mesenchymal stem cells in lung repair to the effect of physical activity on the mobilization of stem and progenitor cells, represents an exciting body of work by outstanding investigators and will be required reading for those with an interest in the subject.
Stem Cells in Toxicology and Medicine
by Saura C. SahuA comprehensive and authoritative compilation of up-to-date developments in stem cell research and its use in toxicology and medicine Presented by internationally recognized investigators in this exciting field of scientific research Provides an insight into the current trends and future directions of research in this rapidly developing new field A valuable and excellent source of authoritative and up-to-date information for researchers, toxicologists, drug industry, risk assessors and regulators in academia, industry and government
Stem Cells in Urology
by Seyed Mohammad Kazem AghamirThis contributed volume emphasizes the potential of stem cells to be pertained in the urology field and attempts to disclose the history of the field up to the latest advances to date. It gathers the majority of papers that advocate utilizing stem cells as the best option for treating, diagnosing, and managing diseases related to urological system. This book covers a broad spectrum of issues, including mesenchymal stem cells, cancer stem cells, organoids, regenerative medicine, erectile dysfunction, bladder dysfunction, and kidney transplant. From several decades ago, as characteristic features of stem cells have been explored, it has attracted a great amount of interests. In view of their multiple capacity of differentiating into various lineages, many studies were conducted to assess their beneficial potential. Despite considerable progress into applying stem cells in animal models, for translating into clinical practices there are several obstacles to be resolved. However, few clinical studies have been performed in each field and outcomes were delightful. There is an ongoing hope for stem cells to someday, be the mainstream treatments of urological diseases, although stem cells treatments already exist they are not well-known. Indeed, this book is essential for anyone who is working with the purpose of employing stem cells to treat the urological diseases and discusses at length the latest advances as well as their limitations.
Stem Cells in Veterinary Science
by Ratan Kumar Choudhary Shanti ChoudharyThis book explores the potential applications of animal stem cells in veterinary medicine. It begins with an overview of stem cells and their application in treating various animal diseases, including mastitis. In turn, the book discusses the challenges of using stem cells in regenerative medicine and emphasizes the importance of understanding the action of stem cells and preclinical evidence for ensuring safety and therapeutic efficacy. It also presents methods for the identification, characterization, and quantification of stem cells. Further, it discusses the therapeutic applications of different stem cells, including milk-derived, testicular, and mesenchymal stem cells in veterinary medicine. Lastly, it discusses strategies for and therapeutic applications of genome editing by CRISPER/Cas9 in mammary stem cells. As such, the book offers a valuable resource for students and scientists working in the veterinary sciences and veterinarians.
Stem Cells & Regenerative Medicine
by Raghu K. Appasani Krishnarao AppasaniDefined as, "The science about the development of an embryo from the fertilization of the ovum to the fetus stage," embryology has been a mainstay at universities throughout the world for many years. Throughout the last century, embryology became overshadowed by experimental-based genetics and cell biology, transforming the field into developmental biology, which replaced embryology in Biology departments in many universities. Major contributions in this young century in the fields of molecular biology, biochemistry and genomics were integrated with both embryology and developmental biology to provide an understanding of the molecular portrait of a "development cell." That new integrated approach is known as stem-cell biology; it is an understanding of the embryology and development together at the molecular level using engineering, imaging and cell culture principles, and it is at the heart of this seminal book. Stem Cells and Regenerative Medicine: From Molecular Embryology to Tissue Engineering is completely devoted to the basic developmental, cellular and molecular biological aspects of stem cells as well as their clinical applications in tissue engineering and regenerative medicine. It focuses on the basic biology of embryonic and cancer cells plus their key involvement in self-renewal, muscle repair, epigenetic processes, and therapeutic applications. In addition, it covers other key relevant topics such as nuclear reprogramming induced pluripotency and stem cell culture techniques using novel biomaterials. A thorough introduction to stem-cell biology, this reference is aimed at graduate students, post-docs, and professors as well as executives and scientists in biotech and pharmaceutical companies.
STEM Education Across the Learning Continuum: Early Childhood to Senior Secondary
by Steve Murphy Amy MacDonald Lena DanaiaThis is the first comprehensive book to consider STEM education from early childhood through to senior secondary education. It approaches STEM as a form of real-world, problem-based education that draws on the knowledge and skills of the science, technology, engineering and mathematics disciplines. Rather than presenting each of the separate disciplines to an equal extent, it focuses on STEM researchers’ perspectives on how their work contributes to effective STEM education in terms of building knowledge, skills and engagement. Gathering contributions by authors from various countries, the book explores effective STEM education from a range of perspectives within the international context. Moreover, it addresses critical issues in STEM education, including transition and trajectories, gender, rurality, socioeconomic status and cultural diversity. By doing so, it not only shares the current state of knowledge in this field, but also offers a source of inspiration for future research.
STEM Education by Design: Opening Horizons of Possibility
by Sharon Friesen Brent Davis Krista FrancisAn accessible text that assumes no prior knowledge, this book is grounded in the realization that "STEM" and "STEM Education" have not yet evolved into fully coherent fields of study, and fills this gap by offering an original model and strategy for developing coherences in a way that both honors the integrity of each of STEM’s constituent disciplines and explores the ways they can amplify one another when used together to address complex contemporary issues. This book demonstrates how STEM can and should be understood as more than a collection of disciplines; it is a transdisciplinary, possibility-rich domain that is much more than the sum of its parts. Building on the actual work of scientists, engineers, and other professionals, the authors disrupt preconceptions about STEM domains, and provide the tools and evidence-based approaches to create new possibilities for all learners. Covering historical influences, theoretical frameworks, and current debates and challenges, this book positions teachers and students as agents of change. Each chapter features In Brief openers to introduce the topic; Opening Anecdotes to reflect the chapter’s key themes; Sidebars to put core principles in context; Consolidating Key Points activities to summarize and highlight important details; and Challenges to build upon and extend topics explored in the chapter from different angles.
STEM Education by Design: Opening Horizons of Possibility
by Sharon Friesen Brent Davis Krista FrancisAn accessible text that assumes no prior knowledge, this book is grounded in the realization that "STEM" and "STEM Education" have not yet evolved into fully coherent fields of study, and fills this gap by offering an original model and strategy for developing coherences in a way that both honors the integrity of each of STEM’s constituent disciplines and explores the ways they can amplify one another when used together to address complex contemporary issues. This book demonstrates how STEM can and should be understood as more than a collection of disciplines; it is a transdisciplinary, possibility-rich domain that is much more than the sum of its parts. Building on the actual work of scientists, engineers, and other professionals, the authors disrupt preconceptions about STEM domains, and provide the tools and evidence-based approaches to create new possibilities for all learners. Covering historical influences, theoretical frameworks, and current debates and challenges, this book positions teachers and students as agents of change. Each chapter features In Brief openers to introduce the topic; Opening Anecdotes to reflect the chapter’s key themes; Sidebars to put core principles in context; Consolidating Key Points activities to summarize and highlight important details; and Challenges to build upon and extend topics explored in the chapter from different angles.
STEM Education for High-Ability Learners
by Bronwyn MacfarlaneSTEM Education for High-Ability Learners: Designing and Implementing Programming focuses on the rigorous articulation of quality STEM education programming to develop STEM talent among high-ability and gifted learners. The intent of this book is to provide a comprehensive resource for educators designing and implementing each of the supports within STEM education by providing a discussion of each critical component for inclusion in a planned, coherent, and high-quality sequenced system. This edited volume provides a cutting-edge discussion of best practices for delivering STEM education by experts in the field. The contributing authors provide a differentiated discussion and recommendations for the learning experiences of gifted students in STEM education programs.
STEM Education for the 21st Century (Springerbriefs In Education Ser.)
by Bryan Edward PenpraseThis book chronicles the revolution in STEM teaching and learning that has arisen from a convergence of educational research, emerging technologies, and innovative ways of structuring both the physical space and classroom activities in STEM higher education. Beginning with a historical overview of US higher education and an overview of diversity in STEM in the US, the book sets a context in which our present-day innovation in science and technology urgently needs to provide more diversity and inclusion within STEM fields. Research-validated pedagogies using active learning and new types of research-based curriculum is transforming how physics, biology and other fields are taught in leading universities, and the book gives profiles of leading innovators in science education and examples of exciting new research-based courses taking root in US institutions. The book includes interviews with leading scientists and educators, case studies of new courses and new institutions, and descriptions of site visits where new trends in 21st STEM education are being developed. The book also takes the reader into innovative learning environments in engineering where students are empowered by emerging technologies to develop new creative capacity in their STEM education, through new centers for design thinking and liberal arts-based engineering. Equally innovative are new conceptual frameworks for course design and learning, and the book explores the concepts of Scientific Teaching, Backward Course Design, Threshold Concepts and Learning Taxonomies in a systematic way with examples from diverse scientific fields. Finally, the book takes the reader inside the leading centers for online education, including Udacity, Coursera and EdX, interviews the leaders and founders of MOOC technology, and gives a sense of how online education is evolving and what this means for STEM education. This book provides a broad and deep exploration into the historical context of science education and into some of the cutting-edge innovations that are reshaping how leading universities teach science and engineering. The emergence of exponentially advancing technologies such as synthetic biology, artificial intelligence and materials sciences has been described as the Fourth Industrial Revolution, and the book explores how these technologies will shape our future will bring a transformation of STEM curriculum that can help students solve many the most urgent problems facing our world and society.
STEM Education from Asia: Trends and Perspectives (Routledge Critical Studies in Asian Education)
by Aik-Ling Tan Tang Wee Teo Paul TengAsia is the largest continent in the world. Five out of the top ten high performing economies in the Programme for International Student Assessment (PISA) 2018 are located in Asia. Why do Asian students perform so well in STEM-related subjects? This book answers this by examining the STEM education policies and initiatives in Asian economies, as well as the training programmes undertaken by STEM teachers in Asia. The book is broken into four sections, each accompanied by a passage of commentary that summarizes the key takeaways of the chapters. Section one focuses on STEM policy environments and how various countries have developed policies that promote STEM as an integral part of national economic development. Section two focuses on STEM teacher education in the Philippines and Thailand, while section three focuses on STEM curriculum design, context, and challenges in four Asian economies. The fourth and final section focuses on presenting snapshots of STEM education research efforts in Malaysia, South Korea, and Singapore. Written by Asian academics, this book will provide valuable insights to policy makers, educators, and researchers interested in the topic of STEM education, especially in the Asian context.
STEM Education in the Early Years: Thinking About Tomorrow
by Kevin Larkin Thomas LowrieThis book analyses and synthesises past and current approaches to STEM Education in the Early Years, particularly the role of digital technologies and play based pedagogies, and provides a look forward to a new way of conceiving STEM Education. It presents a literature review of existing best practice in STEM education, both in Australia and internationally. It also presents theoretical and pedagogical discussions that outlines a new approach to STEM Education, based on a four-year, longitudinal, Early Years project. It provides educational frameworks for educators' use to enhance student learning in STEM, both in formal school contexts and beyond. This book focuses on a number of core themes in the research literature, including STEM education policy (nationally and internationally); the economic, social and political implication of STEM Education; the nexus between digital technologies, STEM, and play based pedagogies; the confidence and competence of early childhood educators and their professional development requirements; STEM education beyond formal schooling; and a new pedagogical approach to STEM education.
STEM Education Reform in Urban High Schools: Opportunities, Constraints, Culture, and Outcomes
by Margaret A. Eisenhart Lois WeisSTEM Education Reform in Urban High Schools gives a nuanced view of the obstacles marginalized students face in STEM education—and explores how schools can better support STEM learners.Reporting the results of a nine-year ethnographic study, the book chronicles the outcomes of various STEM education reforms in eight public high schools with nonselective admissions policies and high proportions of low-income and minoritized students: four schools in Denver, Colorado, and four in Buffalo, New York.Margaret A. Eisenhart and Lois Weis follow the educational experiences of high-ability students from each school, tracking the students' high school-to-college-to-career trajectories. Through interviews with students, educators, and parents, as well as classroom and campus observations, the authors identify patterns in the educational paths of students who go on to great success in STEM occupations and those who do not. They discuss common mechanisms that undermine the stated goals of STEM programming—opportunity structures that are inequitable, erosion of program quality, and diversion of resources—as well as social and cultural constructs (the figured worlds of STEM) that exclude many minoritized students with potential for success from the STEM pipeline.On a broader scope, the book explores how and why STEM education reform efforts fail and succeed. With an eye toward greater access to STEM learning, the authors show how lessons of past measures can inform future STEM initiatives.
STEM Education with Robotics: Lessons from Research and Practice
by Purvee Chauhan Vikram KapilaThis book offers a synthesis of research, curriculum examples, pedagogy models, and classroom recommendations for the effective use of robotics in STEM teaching and learning. Authors Chauhan and Kapila demonstrate how the use of educational robotics can catalyze and enhance student learning and understanding within the STEM disciplines. The book explores the implementation of design-based research (DBR); technological, pedagogical, and content knowledge (TPACK); and the 5E instructional model; among others. Chapters draw on a variety of pedagogical scaffolds to help teachers deploy educational robotics for classroom use, including research-driven case studies, strategies, and standards-aligned lesson plans from real-life settings. This book will benefit STEM teachers, STEM teacher educators, and STEM education researchers.
STEM English in Japan: Education, Innovation, and Motivation
by Glen Hill Joseph Falout Matthew AppleThis book focuses on Japanese science, technology, engineering and mathematics (STEM) students and their experiences of learning English. Students majoring in STEM face unique circumstances regarding their English language education. Despite the global use of English in these fields, the authors argue that Japanese STEM students fail to take advantage of coursework, extracurricular materials, teachers, peers, and other resources to raise their communicative abilities to a sufficient level for the workplace. This book offers insights into how STEM students can learn English more effectively and purposefully. The chapters provide firsthand perspectives into the psychologies, educational programs, and future workplace situations of Japanese STEM students, who are the innovators, inventors, and researchers of the future. This book will appeal to applied linguists and language teachers wherever STEM English is taught.
STEM in the Technopolis: The Power of STEM Education in Regional Technology Policy
by Cliff Zintgraff Sang C. Suh Bruce Kellison Paul E. RestaThis book addresses how forward-thinking local communities are integrating pre-college STEM education, STEM pedagogy, industry clusters, college programs, and local, state and national policies to improve educational experiences, drive local development, gain competitive advantage for the communities, and lead students to rewarding careers. This book consists of three sections: foundational principles, city/regional case studies from across the globe, and state and national context. The authors explore the hypothesis that when pre-college STEM education is integrated with city and regional development, regions can drive a virtuous cycle of education, economic development, and quality of life.Why should pre-college STEM education be included in regional technology policy? When local leaders talk about regional policy, they usually talk about how government, universities and industry should work together. This relationship is important, but what about the hundreds of millions of pre-college students, taught by tens of millions of teachers, supported by hundreds of thousands of volunteers, who deliver STEM education around the world? Leaders in the communities featured in STEM in the Technopolis have recognized the need to prepare students at an early age, and the power of real-world connections in the process. The authors advocate for this approach to be expanded. They describe how STEM pedagogy, priority industry clusters, cross-sector collaboration, and the local incarnations of global development challenges can be made to work together for the good of all citizens in local communities. This book will be of interest to government policymakers, school administrators, industry executives, and non-profit executives. The book will be useful as a reference to teachers, professors, industry professional volunteers, non-profit staff, and program leaders who are developing, running, or teaching in STEM programs or working to improve quality of life in their communities.
STEM-Infusing the Elementary Classroom
by Miranda Talley ReaganMake learning relevant with STEM essential questions This engaging, teacher-friendly guide helps teachers quickly and confidently infuse STEM concepts into all content areas. Real-world vignettes, sample lesson templates, discussion questions and immediately applicable action steps help you seamlessly promote college and career ready skills. Use this inspiring guide to: Deepen all content areas, including English/ Language Arts Promote the 4Cs: communication, collaboration, critical thinking, and creativity Require students to take risks to solve problems Differentiate instruction and scaffold support Expand students’ specific measurable capabilities Incorporate design skills into the curricula Save valuable time and confidently develop standards-aligned STEM projects in all content areas!
STEM-Infusing the Elementary Classroom
by Miranda Talley ReaganMake learning relevant with STEM essential questions This engaging, teacher-friendly guide helps teachers quickly and confidently infuse STEM concepts into all content areas. Real-world vignettes, sample lesson templates, discussion questions and immediately applicable action steps help you seamlessly promote college and career ready skills. Use this inspiring guide to: Deepen all content areas, including English/ Language Arts Promote the 4Cs: communication, collaboration, critical thinking, and creativity Require students to take risks to solve problems Differentiate instruction and scaffold support Expand students’ specific measurable capabilities Incorporate design skills into the curricula Save valuable time and confidently develop standards-aligned STEM projects in all content areas!
STEM Inquiry and Its Practice in K-12 Classrooms: Activities, Characteristics, and Enactment (Routledge Research in STEM Education)
by Aik-Ling Tan Tang Wee Teo Jina Chang Ban Heng ChoyThrough examining the theoretical ideas of disciplinarity and disciplinary practices, the book presents instructional aspects for teachers to explore when engaged with integrated STEM inquiry.Are you interested to understand the difference between science inquiry and STEM inquiry? Do you want to introduce integrated STEM problem solving to your students but need help with the key features of STEM inquiry? This book presents in-depth discussions related to the features and affordances of integrated STEM inquiry. Written for K-12 teachers and teacher educators, this book conceptualises STEM inquiry and integrated STEM and their enactment, using three practical STEM instructional frameworks: problem-centric, solution/design-centric, and user-centric STEM. The three STEM instructional frameworks serve as a key anchor for teachers to interpret and apply when planning various STEM lessons in meaningful, practical, and coherent ways.Whether you are an aspiring K-12 STEM teacher or an in-service teacher teaching K-12 students, the ideas of integrated STEM inquiry presented in this book challenge educators to think about the principles of integrated STEM inquiry and how they can be incorporated into classroom practice and lessons.
STEM Integration in K-12 Education
by Margaret Honey"STEM Integration in K-12 Education" examines current efforts to connect the STEM disciplines in K-12 education. This report identifies and characterizes existing approaches to integrated STEM education, both in formal and after- and out-of-school settings. The report reviews the evidence for the impact of integrated approaches on various student outcomes, and it proposes a set of priority research questions to advance the understanding of integrated STEM education. "STEM Integration in K-12 Education" proposes a framework to provide a common perspective and vocabulary for researchers, practitioners, and others to identify, discuss, and investigate specific integrated STEM initiatives within the K-12 education system of the United States. "STEM Integration in K-12 Education" makes recommendations for designers of integrated STEM experiences, assessment developers, and researchers to design and document effective integrated STEM education. This report will help to further their work and improve the chances that some forms of integrated STEM education will make a positive difference in student learning and interest and other valued outcomes.
STEM Lab (DK Activity Lab)
by Jack ChallonerFrom racing wind up cars to making music with a homemade guitar, STEM Lab will excite and inspire curious young minds.STEM Lab is packed with 25 exciting STEM activities, perfect for firing up kids&’ imaginations. Explore and discover beautifully illustrated science activities with an easy to follow guide that will explain how science, technology, engineering and math shape the world around us. A perfect balance between education and fun, STEM Lab teaches young readers through each experiment, describing the science behind it and providing engaging STEM facts. The richly illustrated activities promote further thinking by suggested &“Test and Tweak&” notes. Encourage young readers to take their projects to the next level, while furthering their understanding of the science behind it. Each activity has its own &‘How It Works&” section covering STEM principles to help young minds understand answers to their science curiosity, exercising cognitive thinking and problem-solving skills.Learn The Science Behind 25 Amazing ProjectsScience activities for kids that can be done at home. Leap into the exciting world of STEM where Science, Technology, Engineering and Math combine in 25 fun and easy-to-do projects. STEM Lab teaches young readers how to make impressive insulating gloves, stunning spaghetti towers, amazing automations, and explores many more educational activities.STEM subjects are a crucial part of a child&’s education. STEM Lab helps kids to practice STEM principles in a fun and engaging manner, while exercising motor skills and cognitive thinking. The four subject areas this book is based on are interrelated, and by combining them new insights, ideas and solutions to problems emerge. STEM Lab will teach you the principles of engineering and the science behind it.This STEM filled activity book is organised into four sections:- Forces and Motion- Liquids and Reactions- Shapes and Structures - Light and SoundSTEM Lab combines fun and learning with hand-on activities that engages STEM principles.
STEM Learning
by Elsayed A. Orady Daniel B. Lawson Brahim Medjahed Margret Höft Mesut DuranThis book reports the results of a three-year research program funded by the National Science Foundation which targeted students and teachers from four Detroit high schools in order for them to learn, experience, and use IT within the context of STEM (IT/STEM), and explore 21st century career and educational pathways. The book discusses the accomplishment of these goals through the creation of a Community of Designers-- an environment in which high school students and teachers, undergraduate/graduate student assistants, and STEM area faculty and industry experts worked together as a cohesive team. The program created four project-based design teams, one for each STEM area. Each team had access to two year-round IT/STEM enrichment experiences to create high-quality learning projects, strategies, and curriculum models. These strategies were applied in after school, weekend, and summer settings through hands-on, inquiry-based activities with a strong emphasis on non-traditional approaches to learning and understanding. The book represents the first comprehensive description and analysis of the research program and suggests a plan for future development and refinement.