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Steric and Stereoelectronic Effects in Organic Chemistry
by Veejendra K. YadavIn this second edition, the author has thoroughly updated each chapter and expanded the content with addition of three new chapters. This book comments on several key aspects of stereochemical control of organic reactions in measured detail to allow the reader easily grasp these concepts. In addition, emphasis is given to key information and important aspects of steric and stereoelectronic effects and their control on conformational profile and reactivity features. This book is not only an indispensable resource for advanced undergraduate and graduate students studying the stereochemical aspects of organic reactions, but also a good reference book for all organic chemists in both industry and academia.
Steric Aspects Of Biomolecular Interactions
by G.Naray- Naray-SzaboThe present volume deals with the application of the following techniques; computational chemistry, X-ray diffraction, and two-dimensional nuclear magnetic resonance. The book will discuss how these methods can be used to study steric aspects of biomolecular interactions.
Steric Effects in the Chemisorption of Vibrationally Excited Methane on Nickel
by Bruce L. YoderBruce Yoder's thesis outlines his investigation of the dissociative chemisorption of methane (CH4) on a nickel single crystal. In this work Bruce uses a molecular beam and infrared laser techniques to prepare methane in excited rovibrational states. The excited methane molecules are aligned relative to the target nickel surface. Bruce describes the discovery and exploration of a previously unknown steric effect in the dissociation reaction between a vibrationally excited methane molecule and a nickel crystal. From these studies we see that methane molecules are up to twice as reactive when the vibration is aligned parallel rather than perpendicular to the surface. This discovery will help guide the development of detailed predictive models of methane chemisorption, which in turn may lead to better catalysts for the synthesis of several industrially relevant chemicals, including hydrogen fuel from natural gas.
Sterile Filtration: A Practical Approach
by Maik W. JornitzThis book focuses on sterilizing grade filters in the biopharmaceutical industry, emphasizing practical applications of universal and dependable operational protocols, integrity testing, and troubleshooting to streamline the production and preparation of pharmaceuticals.Addresses the complexities of globalizing redundancy in filtration! <BR
Sterile Insect Technique: Principles And Practice In Area-Wide Integrated Pest Management
by V. A. DyckThe sterile insect technique (SIT) is an environment-friendly method of pest control that integrates well into area-wide integrated pest management (AW-IPM) programmes. This book takes a generic, thematic, comprehensive, and global approach in describing the principles and practice of the SIT. The strengths and weaknesses, and successes and failures, of the SIT are evaluated openly and fairly from a scientific perspective. The SIT is applicable to some major pests of plant-, animal-, and human-health importance, and criteria are provided to guide in the selection of pests appropriate for the SIT. In the second edition, all aspects of the SIT have been updated and the content considerably expanded. A great variety of subjects is covered, from the history of the SIT to improved prospects for its future application. The major chapters discuss the principles and technical components of applying sterile insects. The four main strategic options in using the SIT — suppression, containment, prevention, and eradication — with examples of each option are described in detail. Other chapters deal with supportive technologies, economic, environmental, and management considerations, and the socio-economic impact of AW-IPM programmes that integrate the SIT. In addition, this second edition includes six new chapters covering the latest developments in the technology: managing pathogens in insect mass-rearing, using symbionts and modern molecular technologies in support of the SIT, applying post-factory nutritional, hormonal, and semiochemical treatments, applying the SIT to eradicate outbreaks of invasive pests, and using the SIT against mosquito vectors of disease. This book will be useful reading for students in animal-, human-, and plant-health courses. The in-depth reviews of all aspects of the SIT and its integration into AW-IPM programmes, complete with extensive lists of scientific references, will be of great value to researchers, teachers, animal-, human-, and plant-health practitioners, and policy makers.
Sterile Pharmaceutical Products: Process Engineering Applications (Drug Manufacturing Technology Ser.)
by Kenneth E. AvisSterile Pharmaceutical Products: Process Engineering Applications addresses the key concepts and applications of the sterile pharmaceutical manufacturing industry. It covers elements of the design, installation, validation, and usage of critical processes associated with sterile product manufacture. From water systems to clean-in-place systems, to sterile powder handling and robotic applications in sterile production environments, this book addresses the issues of system implementation, integration, and operations. Written by recognized experts and peer reviewed for accuracy, all chapters include references to supplemental resources and numerous illustrations.
Sterile Processing of Pharmaceutical Products: Engineering Practice, Validation, and Compliance in Regulated Environments
by Sam A. HoutDescribes the methodologies and best practices of the sterile manufacture of drug products Thoroughly trained personnel and carefully designed, operated, and maintained facilities and equipment are vital for the sterile manufacture of medicinal products using aseptic processing. Professionals in pharmaceutical and biopharmaceutical manufacturing facilities must have a clear understanding of current good manufacturing practice (cGMP) and preapproval inspection (PAI) requirements. Sterile Processing of Pharmaceutical Products: Engineering Practice, Validation, and Compliance in Regulated Environments provides up-to-date coverage of aseptic processing techniques and sterilization methods. Written by a recognized expert with more than 20 years of industry experience in aseptic manufacturing, this practical resource illustrates a comprehensive approach to sterile manufacturing engineering that can achieve drug manufacturing objectives and goals. Topics include sanitary piping and equipment, cleaning and manufacturing process validation, computerized automated systems, personal protective equipment (PPE), clean-in-place (CIP) systems, barriers and isolators, and guidelines for statistical procedure. Offering authoritative guidance on the key aspects of sterile manufacturing engineering, this volume: Covers fundamentals of aseptic techniques, quality by design, risk assessment and management, and operational requirements Addresses various regulations and guidelines instituted by the FDA, ISPE, EMA, MHRA, and ICH Provides techniques for systematic process optimization and good manufacturing practice Emphasizes the importance of attention to detail in process development and validation Features real-world examples highlighting different aspects of drug manufacturing Sterile Processing of Pharmaceutical Products: Engineering Practice, Validation, and Compliance in Regulated Environments is an indispensable reference and guide for all chemists, chemical engineers, pharmaceutical professionals and engineers, and other professionals working in pharmaceutical sciences and manufacturing.
Sterile Product Development
by Parag Kolhe Mrinal Shah Nitin RathoreThis comprehensive book encompasses various facets of sterile product development. Key concepts relevant to the successful development of sterile products are illustrated through case studies and are covered under three sections in this book: * Formulation approaches that discuss a variety of dosage forms including protein therapeutics, lipid-based controlled delivery systems, PEGylated biotherapeutics, nasal dosage form, and vaccines * Process, container closure and delivery considerations including freeze-thaw process challenges, best practices for technology transfer to enable commercial product development, innovations and advancement in aseptic fill-finish operations, approaches to manufacturing lyophilized parenteral products, pen / auto-injector delivery devices, and associated container closure integrity testing hurdles for sterile product closures * Regulatory and quality aspects in the areas of particulate matter and appearance evaluation, sterile filtration, admixture compatibility considerations, sterilization process considerations, microbial contamination investigations and validation of rapid microbiological methods, and dry and moist heat sterilizers This book is a useful resource to scientists and researchers in both industry and academia, and it gives process and product development engineers insight into current industry practices and evolving regulatory expectations for sterile product development.
Sterilization of Medical Devices
by Anne BoothThis book presents vital information on international sterilization standards and guidance on practical application of these standards in the manufacturing process. It covers validation, industrial sterilization methods, emerging sterilization techniques, laboratory testing, manufacturing of sterile devices, and device reuse. Excerpted from The Validator, edited by Anne F. Booth, more than fifty experts share their knowledge of current technologies in easy-to-understand articles that establish methods to ensure compliance. Contents include reviews of ISO sterilization standards, industrial sterilization methods and technologies, and support testing methodologies.
Sterilized by the State
by Randall Hansen Desmond KingThis book is the first comprehensive analysis of eugenics in North America focused on the second half of the twentieth century. Based on new research, Randall Hansen and Desmond King show why eugenic sterilization policies persisted after the 1940s in the United States and Canada. Through extensive archival research, King and Hansen show how both superintendents at homes for the 'feebleminded' and pro-sterilization advocates repositioned themselves after 1945 to avoid the taint of Nazi eugenics. Drawing on interviews with victims of sterilization and primary documents, this book traces the post-1940s development of eugenic policy and shows that both eugenic arguments and committed eugenicists informed population, welfare, and birth control policy in postwar America. In providing revisionist histories of the choice movement, the anti-population growth movement, and the Great Society programs, this book contributes to public policy and political and intellectual history.
Sterling Test Prep: Practice Questions with detailed explanations 6th edition
by The Editors at the Sterling PrepThis book provides over 1,800 chemistry practice questions that test your knowledge of all CLEP Chemistry topics.
Sternegucken für Dummies (Für Dummies)
by Steve Owens"Sternegucken für Dummies" ist ein praktisches Einsteigerbuch, das vor allem die grundlegenden Fragen aller Anfänger "Wie finde ich das richtige Teleskop?", "Wie benutze ich ein Teleskop?", "Wie orientiere ich mich am Himmel?" leicht verständlich erklärt, bevor es alle 88 Sternbilder inklusive Illustrationen beschreibt. Nachdem Sie die richtige Ausrüstung gefunden und gelernt haben, sich am Himmel zu orientieren, führt Sie der Astronom Steve Owens durchs ganze Jahr und erklärt Ihnen, wann Sie welche Sterne beobachten können.
Stern's Introductory Plant Biology
by James E. Bidlack Shelley H. Jansky Kingsley R. SternThis introductory text assumes little prior scientific knowledge on the part of the student. It includes sufficient information for some shorter introductory botany courses open to both majors and nonmajors, and is arranged so that certain sections can be omitted without disrupting the overall continuity of the course. Stern emphasizes current interests while presenting basic botanical principles. This latest edition incorporates measurable learning outcomes and updated readings. Students will be introduced to the new classification of plants and plant-related species, integration of biotechnology into several chapters and inclusion of new text boxes addressing the areas of ecology, evolution and molecular biology. New photos have replaced older pictures or have been added also. <P><P> With this edition we introduce McGraw-Hill Connect® Botany, a web-based assignment and assessment platform that gives students the means to better connect with their coursework, with their instructors, and with the important concepts that they will need to know for success now and in the future. With McGraw-Hill Connect Botany, instructors can deliver interactive assignments, quizzes and tests online. Nearly all the questions from the text are presented in an autogradable format and tied to the text’s learning objectives.
Stern's Introductory Plant Biology
by James Bidlack Shelley Jansky Kingsley R. SternThis introductory text assumes little prior scientific knowledge on the part of the student. It includes sufficient information for some shorter introductory botany courses open to both majors and nonmajors, and is arranged so that certain sections can be omitted without disrupting the overall continuity of the course. Stern emphasizes current interests while presenting basic botanical principles. This latest edition incorporates measurable learning outcomes and updated readings. Students will be introduced to the new classification of plants and plant-related species, integration of biotechnology into several chapters and inclusion of new text boxes addressing the areas of ecology, evolution and molecular biology. New photos have replaced older pictures or have been added also.
Steroid Analysis
by D. B. Gower Hugh L. MakinThe second edition of this handbook concentrates on the analysis of steroids in biological fluids. It offers analysis of low levels of steroid analytes in biological fluids. This new edition also provides an extra chapter on pharmaceutical aspects of steroid analysis. Coverage details spectroscopic and other methods, including UV and IR absorption spectroscopy, NMR spectroscopy, mass spectrometry, X-ray diffraction, chromatography and immunoassay of steroids.
Steroid Biochemistry: Volume II
by R. HobkirkAn attempt has been made to attract contributions which illustrate the importance of certain enzymatic processes involved in steroid biosynthesis and metabolism and, in some cases, leading to steroidal action in target sites. Investigators actively engaged in research in such areas were invited to present their material in a manner which they considered fitting. It is hoped that as a result if this, the publication will possess sufficient depth to warrant approval. The blend of review material and experimental data originating in the author laboratories will, it is felt, make for useful reading.
Steroid Biochemistry: Volume I
by R. HobkirkAn attempt has been made to attract contributions which illustrate the importance of certain enzymatic processes involved in steroid biosynthesis and metabolism and, in some cases, leading to steroidal action in target sites. Investigators actively engaged in research in such areas were invited to present their material in a manner which they considered fitting. It is hoped that as a result if this, the publication will possess sufficient depth to warrant approval. The blend of review material and experimental data originating in the author laboratories will, it is felt, make for useful reading.
Steroid Chemistry at a Glance
by Daniel LednicerThe term steroid has become virtually synonymous with drug abuse in sport to the majority of the public. However these steroids - androgens - actually comprise only a single relatively small class of biologically active steroids, and are overshadowed by a large collection of compounds, a sizeable number of which are commercial drugs that share the same structural carbon skeleton. The development of these drugs has led to a large body of organic chemistry often denoted as "Steroid Chemistry".Steroid Chemistry At A Glance provides a concise overview of the main principles and reactions of steroid chemistry. Topics covered include:history, isolation and structure determination of steroidssteroid nomenclature and stereochemistrynatural sources of steroidssynthesis and reactions of aromatic a-ring steroids, androstanes, and pregnanessteroids with a spirolactone at position 17steroids with hetrocyclic ring Acompounds derived from cholesterolBased on the highly successful and student friendly "at a glance" approach, the information is presented in integrated, self contained double page spreads of text and illustrative material. Students of chemistry and pharmacy using Steroid Chemistry at a Glance will find they have a resource with which they can quickly, concisely and confidently acquire, regularly review and revise the basic facts that underpin the properties, synthesis and reactions of this important class of natural products. It will also serve as a handy bench reference for postgraduates and professional chemists.
Steroid Dimers
by Satyajit Sarker Lutfun NaharSteroid dimers are an important group of compounds produced by various marine organisms, and also synthesized in the laboratories. This group of compounds possesses various pharmacological and biological properties, and can also be used to create "molecular umbrellas" for drug delivery.Steroid Dimers: Chemistry and Applications in Drug Design and Delivery provides an up-to-date overview on the chemistry and applications of steroid dimers of natural and synthetic origins. The book includes easy-to-follow synthetic protocols for various classes of important dimeric steroids, source details, valuable spectroscopic data and depiction of unique structural features of natural steroidal dimers, and the Structure-Activity-Relationships (SARs) of some pharmacologically active dimeric steroids. Topics covered include:introduction to steroid dimers synthesis and chemistry of noncyclic and cyclic steroid dimersnaturally occurring steroid dimers - cephalostatins, ritterazines and crellastatinsbiological and pharmacological functions of steroid dimers and their application in drug design and discoverysteroid dimers as "molecular umbrellas" for drug deliverySteroid Dimers: Chemistry and Applications in Drug Design and Delivery is an essential guide to this important class of natural and synthetic compounds for researchers and students of natural products chemistry and biochemistry, synthetic organic and medicinal chemistry, and drug design, discovery and delivery.
Steroid Receptor Methods
by Benjamin A. LiebermanA distinguished team of principal investigators and their associates describe in step-by-step detail a cross-section of the latest research techniques available for studying the endocrine system. As a basis for sophisticated biochemical analysis of receptor properties, the contributors provide methods for the production and purification of a variety of receptors, including progesterone, glucocorticoid, and androgen. Other protocols allow the reader to experiment with DNA binding characteristics, hormone binding assays, and the use of combinatorial chemistry for drug discovery. A series of novel methods utilizing the latest advances in immunochemistry, yeast two-hybrid screening, and fluorescence are included for the detection and analysis of a variety of cellular proteins that influence steroid receptor effectiveness.
Steroid Receptors: Methods and Protocols (Methods in Molecular Biology #1204)
by Gabriella Castoria Ferdinando AuricchioSteroid Receptors: Methods and Protocols presents a selection of techniques that have been recently applied to the analysis of steroid receptors, powerful tools for the advancement of our understanding of both the mechanisms regulating gene transcription and the rapid signaling responses of tissues to signals. Research in this area has generated a wealth of data allowing the elucidation of steroid receptor mechanisms and improving the treatment of many endocrine disorders, above all cancers. Chapters cover methods to analyze gene transcription, chromatin and proteomic modifications, extra-nuclear signaling regulation, development of cell and animal models, and preparation of new antibodies. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Steroid Receptors: Methods and Protocols offers an updated view on a variety of modern methods that will hopefully contribute to improving our knowledge on the integration of steroid receptors in single or different functionally connected cellular contexts under a variety of physiological and pathological conditions, above all tumors.
Steuerung öffentlich geförderter Forschungs‐ und Entwicklungsprojekte
by Mathias HennemannBasierend auf einer empirischen Studie unter Projektträgern und Bundesministerien zeigt Mathias Hennemann alternative Lösungsansätze für das Management und die Steuerung von Zuwendungen für Forschungs- und Entwicklungsprojekte auf. Dabei betrachtet er die speziellen Anforderungen der Fördermittelverwaltung an die Wahrung von Effizienz und Effektivität ebenso wie die haushaltsrechtlichen Rahmenbedingungen. Ein zusätzlicher Fokus wird im Sinne des New Public Managements auf die Integration privatwirtschaftlicher Steuerungsinstrumente in das Verwaltungshandeln gelegt.
Steve Jobs: The Man Who Thought Different
by Karen BlumenthalThis is the story of Steve Jobs who changed our world. In this book, Karen Blumenthal takes us to the core of the complicated and legendary man while simultaneously exploring the evolution of computers.
Steve Jobs: Technology Innovator and Apple Genius (Gateway Biographies Ser.)
by Matt DoedenOn October 5, 2011, the news of the death of technology innovator Steve Jobs rocked the world. The failing health of the Apple cofounder and Pixar CEO was no secret. Jobs had given up his role as Apple's CEO just a few months prior because of his struggle with pancreatic cancer. But his death still drew a huge reaction. From Apple employees and fans to political and business leaders, people honored Jobs's passing by reflecting on his prolific life that greatly influenced the way technology is used. In 1976, Jobs founded Apple Computer with Steve Wozniak. As the leaders of Apple, they developed concepts—such as navigating by using a mouse to click screen icons—that shaped the way we use and interact with computers. Jobs's forward-thinking engineering also influenced pop culture, bringing us a music revolution with the iPod, the ultimate communication device with the iPhone, and some of the first computer-animated films through Pixar. Called by some "the da Vinci of our time," Jobs used his innovation and vision to help advance technology like no other. He lived his life following a simple premise: "The only way to be truly satisfied is to do what you believe is great work. And the only way to do great work is to love what you do."
Steve Jobs: Insanely Great
by Jessie HartlandWhether they&’ve seen Aaron Sorkin and Danny Boyle&’s Steve Jobs movie, read Walter Isaacson&’s biography, or just own an iPhone, this graphic novel retelling of the Apple innovator&’s life will capture the imaginations of the legions of readers who live and breathe the technocentric world Jobs created. Told through a combination of black-and-white illustrations and handwritten text, this fast-paced and entertaining biography in graphic format presents the story of the ultimate American entrepreneur, the man who brought us Apple Computer, Pixar, Macs, iPods, iPhones, and more. Jobs&’s remarkable life reads like a history of the personal technology industry. He started Apple Computer in his parents&’ garage and eventually became the tastemaker of a generation, creating products we can&’t live without. Through it all, he was an overbearing and demanding perfectionist, both impossible and inspiring. Capturing his unparalleled brilliance, as well as his many demons, Jessie Hartland&’s engaging biography illuminates the meteoric successes, devastating setbacks, and myriad contradictions that make up the extraordinary life and legacy of the insanely great Steve Jobs.Here's the perfect book for any teen interested in STEM topics, especially tech. A School Library Journal Best Book of the Year &“If a picture is worth a thousand words, then this comic tale can hang with the sprawling biographies.&” —Macworld.com &“An accessible take . . . undoubtedly valuable for kids who are growing up using Apple&’s products but knowing little about the man who created them.&” —GeekDad.com