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Reviews of Physiology, Biochemistry and Pharmacology (Reviews of Physiology, Biochemistry and Pharmacology #177)
by Stine Helene Falsig PedersenLeading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.Chapter “Stationary and Non-Stationary Ion- and Water Flux Interactions in Kidney Proximal Tubule. Mathematical Analysis of Isosmotic Transport by a Minimalistic Model“ is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Reviews of Physiology, Biochemistry and Pharmacology (Reviews of Physiology, Biochemistry and Pharmacology #179)
by Stine Helene Falsig PedersenLeading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.
Reviews of Physiology, Biochemistry and Pharmacology (Reviews of Physiology, Biochemistry and Pharmacology #180)
by Stine Helene Falsig PedersenLeading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.
Reviews of Physiology, Biochemistry and Pharmacology (Reviews of Physiology, Biochemistry and Pharmacology #184)
by Stine Helene Falsig PedersenLeading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.
Reviews of Physiology, Biochemistry and Pharmacology (Reviews of Physiology, Biochemistry and Pharmacology #178)
by Stine Helene Falsig PedersenLeading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.
Reviews of Physiology, Biochemistry and Pharmacology 166
by Ole H. Petersen Stefan Offermanns Roland Lill Reinhard Jahn Thomas Gudermann Bernd NiliusThe highly successful Reviews of Physiology, Biochemistry and Pharmacology continue to offer high-quality, in-depth reviews covering the full range of modern physiology, biochemistry and pharmacology. Leading researchers are specially invited to provide a complete understanding of the key topics in these archetypal multidisciplinary fields. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.
Reviews of Physiology, Biochemistry and Pharmacology, Vol. 167
by Bernd Nilius Thomas Gudermann Reinhard Jahn Roland Lill Stefan Offermanns Ole H. PetersenThe highly successful Reviews of Physiology, Biochemistry and Pharmacology continue to offer high-quality, in-depth reviews covering the full range of modern physiology, biochemistry and pharmacology. Leading researchers are specially invited to provide a complete understanding of the key topics in these archetypal multidisciplinary fields. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.
Reviews of Physiology, Biochemistry and Pharmacology Vol. 169
by Bernd Nilius Thomas Gudermann Reinhard Jahn Roland Lill Ole H. Petersen Pieter P. de TombeLeading researchers are specially invited to provide a complete understanding of the key topics in these archetypal multidisciplinary fields. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.
Reviews of Physiology, Biochemistry and Pharmacology Vol. 170
by Bernd Nilius Pieter De Tombe Thomas Gudermann Reinhard Jahn Roland Lill Ole H. PetersenLeading researchers are specially invited to provide a complete understanding of the key topics in these archetypal multidisciplinary fields. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.
Reviews of Physiology, Biochemistry and Pharmacology, Vol. 171
by Bernd Nilius Pieter De Tombe Thomas Gudermann Reinhard Jahn Roland Lill Ole H. PetersenLeading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.
Reviews of Physiology, Biochemistry and Pharmacology, Vol. 172
by Bernd Nilius Pieter De Tombe Thomas Gudermann Reinhard Jahn Roland Lill Ole H. PetersenLeading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.
Reviews on Biomarker Studies in Aging and Anti-Aging Research (Advances in Experimental Medicine and Biology #1178)
by Paul C. GuestUsing both epidemiological and model organism approaches, we have gained new insights into the physiological and molecular aspects of aging, which has led to significant advancements in potential anti-aging strategies. Reviews on Biomarker Studies in Aging and Anti-Aging Research presents a series of reviews in various aspects of aging and age-related disease research along with several methods which have shown progress as potential anti-aging approaches. The book is aimed at researchers in the areas of aging and chronic disease, as well as to clinical scientists, physicians and major drug companies. It provides important information on disease mechanisms, and each chapter is presented in the context of the aging process, specific chronic diseases or different therapeutic areas.
Reviews on Biomarker Studies in Psychiatric and Neurodegenerative Disorders (Advances in Experimental Medicine and Biology #1118)
by Paul C. GuestThis book includes a series of reviews on general aspects of biomarker use in the study of psychiatric and neurodegenerative diseases and the development of medications involved in their treatment. It describes the pros and cons of the various approaches and covers the successes and failures in this research field. It is only by a thorough understanding of the shortcomings that progress can be made. The overall goal is to facilitate the understanding and treatment of these disorders, by providing a viable mechanism of catching up with other areas of modern medicine, such as diabetes and heart disease. Finally, it is anticipated that the development and application of valid biomarker tests and the leveraging of novel drug targets will help the fields of psychiatry on neurodegenerative disorders move into the area of personalized medicine where the right patients can receive the right medication at the right time for the best possible outcome.
Reviews on Biomarker Studies of Metabolic and Metabolism-Related Disorders (Advances in Experimental Medicine and Biology #1134)
by Paul C. GuestThe book recognizes that throughout the scientific, medical, and economic communities, new tests incorporating biomarkers are needed to improve the diagnosis of patients suffering from metabolic disorders. The early identification of those at risk of developing obesity will help to place these individuals on the best treatment course as early as possible for improved treatment outcomes. This will also help to cut costs incurred by the healthcare services. For all of this to occur, new research efforts are needed to identify novel biomarkers that can be used to predict the disease in the presymptomatic stage, for disease monitoring and for prediction of treatment response. It is also possible that new drug targets can be identified using these approaches which, in turn, can lead to the development of new treatment approaches. This volume also includes a series of reviews on biomarker discovery and usage in the study of diseases marked by perturbations in metabolism. It will describe the pros and cons of the various approaches and cover the successes and failures in this important research field.
Reviews on New Drug Targets in Age-Related Disorders (Advances in Experimental Medicine and Biology #1260)
by Paul C. GuestAging is an inevitable part of life and is becoming a worldwide social, economic and health problem. This is mainly due to the fact that the increasing proportion of individuals in the advanced age category have a higher probability of developing age-related disorders, such as type II diabetes mellitus, cardiovascular disorders, sarcopenia, and neurodegenerative conditions. New therapeutic approaches are still needed to decrease or slow the effects of such diseases. Advances in -omic technologies, such as genomics, transcriptomics, proteomics and metabolomics, have significantly advanced our understanding of disease in multiple medical areas, as the analysis of multiple molecular networks has simultaneously provided a more integrated view of disease pathways. It is hoped that emerging hits from these analyses might be prioritized for further screening as potential novel drug targets for increasing the human healthspan in line with the lifespan. In turn, this will lead to new therapeutic strategies as well as drug development projects by the pharmaceutical industry. This book presents a series of reviews describing studies that have resulted in identification of new potential drug targets for age-related disorders. Much of this information has come from -omic comparisons of healthy and disease states or from testing the effects of new therapeutic approaches. Authored by experts from around the globe, each chapter is presented in the context of specific chronic diseases or therapeutic strategies. This book is designed for researchers in the areas of aging and chronic disease, as well as clinical scientists, physicians and stakeholders in major drug companies.
Reviews on New Drug Targets in Age-Related Disorders: Part II (Advances in Experimental Medicine and Biology #1286)
by Paul C. GuestAging is an inevitable part of life, and is becoming a worldwide social, economic and health problem due to the fact that an increasing proportion of individuals in the advanced age category have a higher probability of developing age-related disorders. New therapeutic approaches are still in need to decrease or slow the effects of such diseases in this aging society. Advances in ‘omic technologies such as genomics, transcriptomics, proteomics and metabolomics have significantly advanced our understanding of diseases in multiple medical areas. It is hoped that emerging hits from these analyses might be prioritized for further screening as potential novel drug targets for increasing the human healthspan in line with the lifespan, which will in turn lead to new therapeutic strategies and drug development projects by the pharmaceutical industry. This new book presents a series of reviews describing studies which have resulted in the identification of potential new drug targets for age-related disorders. Much of this information has come from ‘omic comparisons of healthy and disease states or from testing the effects of potential new therapeutic approaches. Each chapter will be presented in the context of specific chronic diseases or different therapeutic strategies, providing important information on disease mechanisms related to the aging process. This book will be of interest to researchers in the areas of aging and chronic disease, as well as clinical scientists, physicians, and major drug companies. With contributors from Australia, Brazil, Canada, France, Germany, India, Iran, Iraq, South Africa, South Korea, Thailand, Ukraine, United Kingdom, United States of America, Uruguay and Vietnam, this is a timely follow up to Guest’s previous book Reviews on New Drug Targets in Age-Related Disorders.
A Revised Handbook of the Flora of Ceylon - Volume 7
by M.D DassanayakeSeventh volume (in no planned sequence) of the revision of the works of Trimen, Alston, Abeywickrama. A worthy successor to a great and extremely scarce work. We lament that this revision is printed on acidic paper. Annotation copyright Book News, Inc. Portland, Or.
A Revised Handbook to the Flora of Ceylon - Volume 10
by M. D. DassanayakeThis reference work on the flora of Ceylon describes every plant family, including: araliaceae; caricacae; dilleniaceae; fabaceae; loganiaceae; oleaceae; plataginaceae; portulacaceae; rhamnaceae; theaceae; tiliaceae; and violoaceae.
Revising Oral Pharmacokinetics, Bioavailability and Bioequivalence Based on the Finite Absorption Time Concept
by Panos Macheras Athanasios A. TsekourasThis book casts new light on the field of oral drug absorption. It outlines both the concept of the past and the novel concept of Finite Absorption Time (FAT). In addition, the authors explore the correlated need for re-definition of bioavailability, bioequivalence providing a plethora of experimental data. Accordingly, this book is intended for academics/students or scientists working in pharmaceutical industries, regulatory agencies, and contract research organizations. It can be used for teaching purposes in under- and post-graduate courses dealing with biopharmaceutics, pharmacokinetics and biomedical engineering.
Revising Smart Cities with Regenerative Design (Cities and Nature)
by Zaheer Allam Peter NewmanThis book presents a road map to urban regeneration through the contemporary concept of smart cities. It investigates why the concept has gained adoption as it has but until now it has been geared towards a profit-making venture by large corporations and ignoring the economic aspirations of smaller companies and city councils. The technologies can provide enhanced liveability levels if the concept is redefined. This work will be of interest to academics and policy makers looking at exploring how to drive urban regeneration in a sustainable and inclusive fashion while supporting local economies. It presents a case study of Port Louis, Mauritius, with unique insights and data. Academics, policy makers and urban developers could potentially adopt the model and calibrate it to various cities and quantify the economic and social benefits.
Revision of the Modified Mouthparts Species Group of Hawaiian Drosophila (Diptera: Drosophilidae)
by Karl N. Magnacca Patrick M. O'GradyThe modified mouthparts group is perhaps the largest of the four major Hawaiian Drosophila clades, yet has received relatively little taxonomic attention during the past 40 years. This study reviews unplaced species and the ceratostoma, freycinetiae, semifuscata, and setiger subgroups, with descriptions of 22 new species. We hope this work encourages greater study of the biology of this important group.
Revisiting Premodern Islamic Science and Experience (SpringerBriefs in History of Science and Technology)
by Hannah C. Erlwein Katja KrauseThis open access book takes a fresh look at the nature and place of experience in premodern Islamic science. It seeks to answer two questions: What kind of experience constituted premodern Islamic science? And in what ways did that experience constitute science? Answering these questions, the authors critique the trajectory of most existing histories of the period, which tend to reduce “experience” to empirical method or practice. This view reflects the emphasis that histories of modern science, especially of the Scientific Revolution, have placed on empiricism—the standard against which Islamic actors were then measured. This book offers a new historiography, arguing that experience had a far wider scope in the world of Islamic science. Combining an innovative theoretical framework with three case studies and a reflective epilogue by renowned experts in the field, this work offers the history of science a solid foundation on which to build its analyses of premodern science and the modality, scope, and role of experience therein. As a result, it speaks to specialists in the history of premodern Islamic science and historians of science in general to reconsider their historiographical assumptions.
Revisiting the Eclipse of Darwinism: A Historiographical and Philosophical Analysis (Evolutionary Biology – New Perspectives on Its Development #8)
by Michał Jakub WagnerThis book focuses on a critical reexamination of two prominent categories used in modern historiography of biology – “the eclipse of Darwinism” and the “modern synthesis”. The main objective is to critically analyze the main existing interpretations of the “eclipse of Darwinism” and emergence of the “modern synthesis”, with particular emphasis on the philosophical assumptions adopted in these interpretations. Thus, interpretations by Ernst Mayr, Peter Bowler, Mark Largent and modern historians who challenge these perspectives are discussed and critically evaluated The analysis of the above interpretations makes it possible to determine how the philosophy of science limits the interpretation of the history of a given field, and also serves as a starting point for proposing an original interpretation of the above period in the history of evolutionary biology. The ultimate goal will therefore be a proposal of a new interpretative perspective to answer following questions: Why did the “eclipse of the Darwinism” occur? How should its origins to be understood? Why did it end (and why did the “modern synthesis” emerge)? Main thesis of this book is that the “eclipse” was a direct response to inconsistent ontology upon which Darwin built his theory of evolution. Darwin referred to terms and concepts rooted in the philosophy of essentialism, which was problematic, because he tried to apply these essentialist concepts to his vision of the ever-changing nature. Therefore, all of the anti-Darwinian theories characteristic to the “eclipse of Darwinism” and later to the “modern synthesis” were produced in an attempt to reconcile essentialism with evolution and thus to correct Darwin's philosophical “error.” The book will appeal to biologists, philosophers and historians alike.
Revisiting the Regulation of Human Fertilisation and Embryology (Biomedical Law and Ethics Library)
by Kirsty HorseyThe Human Fertilisation and Embryology Act 2008 was a major update to the UK’s laws on the use and regulation of reproductive technology and assisted reproduction. Since the enactment of the new law, the sector’s regulatory body, the Human Fertilisation and Embryology Authority (HFEA), has also consulted on various related topics including barriers to egg and sperm donation in the UK, multiple births/single embryo transfer and using IVF technology to prevent mitochondrial disease. This book critically considers recent developments in human fertilisation legislation, asking whether the 2008 Act has achieved its stated aim of being fit for purpose. Bringing together a range of international experts, the book evaluates the fresh risks and challenges emerging from both established and existing technologies and techniques in the field of human fertilisation and embryology, as well as offering valuable insights into the social and regulatory challenges that lie ahead. Key topics include problems with DIY assisted conception; the lack of reform in respect of the regulation of surrogacy arrangements; and mitochondrial DNA transfer. As a review of the status of assisted reproduction legislation, this book will be of great use and interest to students, researchers and practitioners in medical law, bioethics, medicine and child welfare.
Revitalising Rural Communities (SpringerBriefs on Case Studies of Sustainable Development)
by Jessica M. Williams Vivian Chu Wai-Fung Lam Winnie W.Y. LawThis book highlights the challenges and opportunities of (re)constructing a sustainable rural community on the outskirts of the urban community. Based on knowledge and experience accumulated through implementing a rural revitalisation project in Hong Kong since 2013, the book provides an in-depth analysis of a case study along with related concepts from the literature. In particular, the concept of rural resilience is broken down and used to examine how communities at the urban-rural interface can leverage their position and connections to (re)create vibrant sustainable communities. The revitalisation project was showcased in the databases of the United Nations Development Programme (UNDP)’s Equator Initiative and the International Partnership for the Satoyama Initiative (IPSI) as well as achieving Special Recognition for Sustainable Development in the UNESCO Asia-Pacific Awards for Cultural Heritage Conservation in 2020. This book teases out the key issues in the process of revitalising a rural community in the peri-urban context and examines the complexities embedded in each issue and how they can be addressed in the quest for rural sustainability.