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Structure in Protein Chemistry
by Jack KyteThe second edition of Structure in Protein Chemistry showcases the latest developments and innovations in the field of protein structure analysis and prediction. The book begins by explaining how proteins are purified and describes methods for elucidating their sequences of amino acids and defining their posttranslational modifications. Comprehensive explanations of crystallography and of noncovalent forces-ionic interactions, hydrogen bonding, and the hydrophobic effect-act as a prelude to an exhaustive description of the atomic details of the structures of proteins. The resulting understanding of protein molecular structure forms the basis for discussions of the evolution of proteins, the symmetry of the oligomeric associations that produce them, and the chemical, mathematical, and physical basis of the techniques used to study their structures. The latter include image reconstruction, nuclear magnetic resonance spectroscopy, proton exchange, optical spectroscopy, electrophoresis, covalent cross-linking, chemical modification, immunochemistry, hydrodynamics, and the scattering of light, X-radiation, and neutrons. These procedures are applied to study the folding of polypeptides and the assembly of oligomers. Biological membranes and their proteins are also discussed. Structure in Protein Chemistry, Second Edition, bridges the gap between introductory biophysical chemistry courses and research literature. It serves as a comprehensive textbook for advanced undergraduates and graduate students in biochemistry, biophysics, and structural and molecular biology. Professionals engaged in chemical, biochemical, and molecular biological research will find it a useful reference.
Structure of Approximate Solutions of Optimal Control Problems
by Alexander J. ZaslavskiThis title examines the structure of approximate solutions of optimal control problems considered on subintervals of a real line. Specifically at the properties of approximate solutions which are independent of the length of the interval. The results illustrated in this book look into the so-called turnpike property of optimal control problems. The author generalizes the results of the turnpike property by considering a class of optimal control problems which is identified with the corresponding complete metric space of objective functions. This establishes the turnpike property for any element in a set that is in a countable intersection which is open everywhere dense sets in the space of integrands; meaning that the turnpike property holds for most optimal control problems. Mathematicians working in optimal control and the calculus of variations and graduate students will find this book useful and valuable due to its presentation of solutions to a number of difficult problems in optimal control and presentation of new approaches, techniques and methods.
The Structure of Evolutionary Theory
by Stephen Jay GouldThe world's most revered and eloquent interpreter of evolutionary ideas offers here a work of explanatory force unprecedented in our time--a landmark publication, both for its historical sweep and for its scientific vision. With characteristic attention to detail, Stephen Jay Gould first describes the content and discusses the history and origins of the three core commitments of classical Darwinism: that natural selection works on organisms, not genes or species; that it is almost exclusively the mechanism of adaptive evolutionary change; and that these changes are incremental, not drastic. Next, he examines the three critiques that currently challenge this classic Darwinian edifice: that selection operates on multiple levels, from the gene to the group; that evolution proceeds by a variety of mechanisms, not just natural selection; and that causes operating at broader scales, including catastrophes, have figured prominently in the course of evolution. Then, in a stunning tour de force that will likely stimulate discussion and debate for decades, Gould proposes his own system for integrating these classical commitments and contemporary critiques into a new structure of evolutionary thought. In 2001 the Library of Congress named Stephen Jay Gould one of America's eighty-three Living Legends--people who embody the "quintessentially American ideal of individual creativity, conviction, dedication, and exuberance." Each of these qualities finds full expression in this peerless work, the likes of which the scientific world has not seen--and may not see again--for well over a century.
The Structure of Interdisciplinary Science (New Directions in the Philosophy of Science)
by Rolf HvidtfeldtThis book presents a novel approach to the analysis of interdisciplinary science based on the contemporary philosophical literature on scientific representation. The basic motivation for developing this approach is that epistemic issues are insufficiently dealt with in the existing literature on interdisciplinarity. This means that when interdisciplinary science is praised (as it often is), it is far from clear to what extent this praise is merited – at least if one cares about various more or less standardised measures of scientific quality. To develop a more adequate way of capturing what is going on in interdisciplinary science, the author draws inspiration from the rich philosophical literature on modelling, idealisation, perspectivism, and scientific pluralism. The discussion hereof reveals a number of critical pitfalls related to transferring mathematical and conceptual tools between scientific contexts, which should be relevant and interesting for anyone actively engaged in funding, evaluating, or carrying out interdisciplinary science.
The Structure of Ionic Liquids
by Ruggero Caminiti Lorenzo GontraniThis volume describes the most recent findings on the structure of ILs interpreted through cutting-edge experimental and theoretical methods. Research in the field of ionic liquids (ILs) keeps a fast and steady pace. Since these new-generation molten salts first appeared in the chemistry and physics landscape, a large number of new compounds has been synthesized. Most of them display unexpected behaviour and possess stunning properties. The coverage in this book ranges from the mesoscopic structure of ILs to their interaction with proteins. The reader will learn how diffraction techniques (small and large angle X-Ray and neutron scattering, powder methods), X-Ray absorption spectroscopies (EXAFS/XANES), optical methods (IR, RAMAN), NMR and calorimetric methods can help the study of ILs, both as neat liquids and in mixtures with other compounds. It will enable the reader to choose the best method to suit their experimental needs. A detailed survey of theoretical methods, both quantum-chemical and classical, and of their predictive power will accompany the exposition of experimental ones. This book is a must read for postgraduate students, for post-docs, and for researchers who are interested in understanding the structural properties of ILs.
Structure of Materials: An Introduction to Crystallography, Diffraction and Symmetry
by Marc De Graef Michael E. MchenryThis highly readable, popular textbook for upper undergraduates and graduates comprehensively covers the fundamentals of crystallography and symmetry, applying these concepts to a large range of materials. New to this edition are more streamlined coverage of crystallography, additional coverage of magnetic point group symmetry and updated material on extraterrestrial minerals and rocks. New exercises at the end of chapters, plus over 500 additional exercises available online, allow students to check their understanding of key concepts and put into practice what they have learnt. Over 400 illustrations within the text help students visualise crystal structures and more abstract mathematical objects, supporting more difficult topics like point group symmetries. Historical and biographical sections add colour and interest by giving an insight into those who have contributed significantly to the field. Supplementary online material includes password-protected solutions, over 100 crystal structure data files, and Powerpoints of figures from the book.
Structure of Matter
by Pietro Carretta Attilio RigamontiThis textbook, now in its third edition, provides a formative introduction to the structure of matter that will serve as a sound basis for students proceeding to more complex courses, thus bridging the gap between elementary physics and topics pertaining to research activities. The focus is deliberately limited to key concepts of atoms, molecules and solids, examining the basic structural aspects without paying detailed attention to the related properties. For many topics the aim has been to start from the beginning and to guide the reader to the threshold of advanced research. This edition includes four new chapters dealing with relevant phases of solid matter (magnetic, electric and superconductive) and the related phase transitions. The book is based on a mixture of theory and solved problems that are integrated into the formal presentation of the arguments. Readers will find it invaluable in enabling them to acquire basic knowledge in the wide and wonderful field of condensed matter and to understand how phenomenological properties originate from the microscopic, quantum features of nature.
Structure of Medium Mass Nuclei: Deformed Shell Model and Spin-Isospin Interacting Boson Model
by V K Kota R SahuMedium heavy nuclei with mass number A=60-90 exhibit a variety of complex collective properties, provide a laboratory for double beta decay studies, and are a region of all heavy N=Z nuclei. This book discusses these three aspects of nuclear structure using Deformed Shell Model and the Spin-Isospin Invariant Interacting Boson Model naturally generated by fermionic SO(8) symmetry. Using these two models, the book describes properties of medium heavy nuclei with mass number A=60-90. It provides a good reference for future nuclear structure experiments using radioactive ion beam (RIB) facilities. Various results obtained by the authors and other research groups are also explained in this book.
Structure of Multielectron Atoms (Springer Series on Atomic, Optical, and Plasma Physics #112)
by Anders KastbergThis book is about the structure of multielectron atoms and predominantly adopts a perturbative approach to the total Hamiltonian. A key concept is the central-field approximation and, beyond the standard LS-coupling and jj-coupling schemes, intermediate cases are also treated. After that, the book covers hyperfine structure and other nuclear effects, as well as interactions with static external fields. Throughout the book, an analytical approach is adopted. Working knowledge of basic quantum mechanics (including the non-relativistic hydrogen atom, basic angular momentum and perturbation theory) is assumed, and it begins with a brief recap of the hydrogen orbitals, before turning towards the symmetry aspects of multi-electron atoms, spin-orbit interaction and couplings of angular momenta.
Structure of Nucleon Excited States from Lattice QCD (Springer Theses)
by Finn M. StokesQuantum Chromodynamics (QCD) describes the interactions between elementary quarks and gluons as they compose the nucleons at the heart of atomic structure. The interactions give rise to complexity that can only be examined via numerical simulations on supercomputers. This work provides an introduction to the numerical simulations of lattice QCD and establishes new formalisms relevant to understanding the structure of nucleons and their excited states. The research opens with an examination of the non-trivial QCD vacuum and the emergence of “centre domains.” The focus then turns to establishing a novel Parity-Expanded Variational Analysis (PEVA) technique solving the important problem of isolating baryon states moving with finite momentum. This seminal work provides a foundation for future calculations of baryon properties. Implementation of the PEVA formalism discloses important systematic errors in conventional calculations and reveals the structure of nucleon excited states from the first principles of QCD for the first time.
Structure Of The Nucleus
by M. A. PrestonA graduate-level one-volume textbook and reference work on the structure and physics of atomic nuclei. Throughout this book the underlying emphasis is on how a nucleus is constituted through the interaction between the nucleons. The book is structured into three parts: the first part contains a detailed treatment of the two-nucleon force and of basic model-independent nuclear properties the second part discusses the experimental results of nuclear models and their bases in fundamental theory the third part deals in some detail with alpha-decay and fission.
The Structure of Scientific Inference
by Mary HesseThis title is part of UC Press's Voices Revived program, which commemorates University of California Press’s mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1974.
The Structure of Scientific Revolutions
by Thomas S. KuhnA good book may have the power to change the way we see the world, but a great book actually becomes part of our daily consciousness, pervading our thinking to the point that we take it for granted, and we forget how provocative and challenging its ideas once were—and still are. The Structure of Scientific Revolutions is that kind of book. When it was first published in 1962, it was a landmark event in the history and philosophy of science. Fifty years later, it still has many lessons to teach.<P><P> With The Structure of Scientific Revolutions, Kuhn challenged long-standing linear notions of scientific progress, arguing that transformative ideas don’t arise from the day-to-day, gradual process of experimentation and data accumulation but that the revolutions in science, those breakthrough moments that disrupt accepted thinking and offer unanticipated ideas, occur outside of “normal science,” as he called it. Though Kuhn was writing when physics ruled the sciences, his ideas on how scientific revolutions bring order to the anomalies that amass over time in research experiments are still instructive in our biotech age.<P> Chosen for Mark Zuckerberg's "A Year of Books"
The Structure of Scientific Revolutions: 50th Anniversary Edition
by Thomas S. KuhnA good book may have the power to change the way we see the world, but a great book actually becomes part of our daily consciousness, pervading our thinking to the point that we take it for granted, and we forget how provocative and challenging its ideas once were—and still are. The Structure of Scientific Revolutions is that kind of book. When it was first published in 1962, it was a landmark event in the history and philosophy of science. Fifty years later, it still has many lessons to teach. With The Structure of Scientific Revolutions, Kuhn challenged long-standing linear notions of scientific progress, arguing that transformative ideas don’t arise from the day-to-day, gradual process of experimentation and data accumulation but that the revolutions in science, those breakthrough moments that disrupt accepted thinking and offer unanticipated ideas, occur outside of “normal science,” as he called it. Though Kuhn was writing when physics ruled the sciences, his ideas on how scientific revolutions bring order to the anomalies that amass over time in research experiments are still instructive in our biotech age. This new edition of Kuhn’s essential work in the history of science includes an insightful introduction by Ian Hacking, which clarifies terms popularized by Kuhn, including paradigm and incommensurability, and applies Kuhn’s ideas to the science of today. Usefully keyed to the separate sections of the book, Hacking’s introduction provides important background information as well as a contemporary context. Newly designed, with an expanded index, this edition will be eagerly welcomed by the next generation of readers seeking to understand the history of our perspectives on science.
The Structure of Spoken Language
by Philippe MartinUsing an innovative approach, this book focuses on a widely debated area of phonetics and phonology: intonation, and specifically its relation to metrics, its interface with syntax, and whether it can be attributed more to phonetics or phonology, or equally to both. Drawing on data from six Romance languages (French, Italian, Spanish, Portuguese, Catalan and Romanian), whose rich intonation patterns have long been of interest to linguists, J-Philippe Martin challenges the assumptions of traditional phonological approaches, and re-evaluates the data in favour of a new usage-based model of intonation. He proposes a unified description of the sentence prosodic structure, focusing on the dynamic and cognitive aspects of both production and perception of intonation in speech, leading to a unified grammar of Romance languages' sentence intonation. This book will be welcomed by researchers and advanced students in phonetics and phonology.
The Structure of the Universe
by Paul HalpernThe Structure of the Universe by Paul Halpern, Ph.D., originally published in 1996, is a tour of the knowledge of the deep reaches of space and predictions for its future.Technological marvels such as the Hubble Space Telescope are revealing a wealth of information about the deepest reaches of space. After decades of research, scientists now believe they are closer to discovering the 'missing matter,' the invisible stuff left over from the Big Bang that will determine the ultimate fate of the universe. With each discovery new light is shed on scores of old questions, and at the same time new questions arise.
Structure-preserving Integrators in Nonlinear Structural Dynamics and Flexible Multibody Dynamics
by Peter BetschThis book focuses on structure-preserving numerical methodsfor flexible multibody dynamics, including nonlinear elastodynamics andgeometrically exact models for beams and shells. It also deals with the newlyemerging class of variational integrators as well as Lie-group integrators. Itdiscusses two alternative approaches to the discretization in space ofnonlinear beams and shells. Firstly, geometrically exact formulations, whichare typically used in the finite element community and, secondly, the absolutenodal coordinate formulation, which is popular in the multibody dynamicscommunity. Concerning the discretization in time, the energy-momentum methodand its energy-decaying variants are discussed. It also addresses a number ofissues that have arisen in the wake of the structure-preserving discretizationin space. Among them are the parameterization of finite rotations, theincorporation of algebraic constraints and the computer implementation of thevarious numerical methods. The practical application of structure-preservingmethods is illustrated by a number of examples dealing with, among others,nonlinear beams and shells, large deformation problems, long-term simulationsand coupled thermo-mechanical multibody systems. In addition it links novel timeintegration methods to frequently used methods in industrial multibody systemsimulation.
Structure-Property Relationships in Non-Linear Optical Crystals II
by Xin-Tao Wu Ling ChenXiao-Ming Jiang, Sheng-Ping Guo, Hui-Yi Zeng, Ming-Jian Zhang, Guo-Cong Guo: Large Crystal Growth and New Crystal Exploration of Mid-Infrared Second-Order Nonlinear Optical Materials.- Kechen Wu: Simulation and Design of Infrared Second-Order Nonlinear Optical Materials in Metal Cluster Compounds.- Chaoyang Tu: The Recent Development Of SRS and SRS SF- conversion Laser Crystal.- Hua-Jun Zhao, Xin-Tao Wu, Li-Ming Wu: Exploration of New Second-Order Nonlinear Optical Compounds Containing Main Group Elements.
Structure–Activity Relationships for Development of Neurokinin-3 Receptor Antagonists: Reducing Environmental Impact (Springer Theses)
by Koki YamamotoThis book explores the possible development of neurokinin-3 receptor (NK3R) antagonists with reduced environmental impact. Pharmaceuticals are used to cure diseases and to alleviate symptoms in humans and animals. However, the stable, bioactive substances excreted by patients have unfavorable effects on non-target species. To overcome these disadvantages of these highly stable, potent substances, drug design to turn off bioactivity after release into the environment is needed. The book describes the development of eco-friendly NK3R antagonists by introducing a labile functional moiety and substituting a scaffold. This resulted in a novel NK3R antagonist that oxidized into its inactive form when exposed to air. Further, the book presents an efficient and easily achievable synthetic method of creating triazolopiperazine scaffolds, as well as a structure–activity relationship study involving scaffold hopping for decomposable motifs, which led to a novel photodegradable NK3R antagonist. Demonstrating that it is possible to develop compounds that convert into their inactive forms under environmental conditions, this book is useful for anyone interested in therapeutic agents with reduced environmental impact.
Structured and Modified Lipids
by Frank D. GunstoneThis text addresses critical topics in the expanding market and production for lipids. It combines novel and traditional methods from technological and biological perspectives to achieve the most effective pathways for production of modified lipids. The book is organized into three sections exploring development, new production methods and successful products and uses.Structured and Modified Lipids provides a comprehensive exploration of issues related to lipids production and marketing. It combines novel and traditional methods from technological and biological perspectives to achieve the most effective pathways for production of modified lipids. The book is organized into three sections highlighting development, new production methods
Structured Controllers for Uncertain Systems
by Rosario ToscanoStructured Controllers for Uncertain Systems focuses on the development of easy-to-use design strategies for robust low-order or fixed-structure controllers (particularly the industrially ubiquitous PID controller). These strategies are based on a recently-developed stochastic optimization method termed the "Heuristic Kalman Algorithm" (HKA) the use of which results in a simplified methodology that enables the solution of the structured control problem without a profusion of user-defined parameters. An overview of the main stochastic methods employable in the context of continuous non-convex optimization problems is also provided and various optimization criteria for the design of a structured controller are considered; H , H2, and mixed H2/H each merits a chapter to itself. Time-domain-performance specifications can be easily incorporated in the design.
Structured Decision Making: Case Studies in Natural Resource Management (Wildlife Management and Conservation)
by David R. SmithProvides and analyzes real examples of how structured decision making (SDM) can help solve complex problems involving natural resources.When faced with complicated, potentially controversial decisions that affect our environment, many resource management agencies have come to realize the value of structured decision making (SDM)—the systematic use of principles and tools of decision analysis. Few professionals, however, have extensive experience implementing SDM. Structured Decision Making provides key information to both current adopters of the method and those who are deploying it for the first time by demonstrating the formal use of decision analysis to support difficult, real-world natural resource management decisions. Drawing on case studies from multiple public agencies in the United States, Canada, Australia, and Mauritius, the editors present an overview of decision analysis, a classification of decision types, and a catalog of decision analysis methods. Dozens of detailed charts and maps help contextualize the material. These case studies examine a rich variety of topics, including• keeping forest birds free from disease• conserving imperiled freshwater mussels• managing water for oil sands mining• dealing with coastal wetlands in the face of sea-level rise• designing networks for prairie-dependent taxa• combatting invasive alpine shrubs• managing vernal pool habitats for obligate amphibian species • and much moreAimed at decision makers tackling natural resource challenges in government agencies around the world, as well as advanced undergraduate and graduate students preparing to work in natural resource management, Structured Decision Making shows how SDM can be implemented to achieve optimal outcomes that integrate social values and scientific understanding.Contributors: Taber D. Allison, Larissa L. Bailey, Ellen A. Bean, Clint W. Boal, Gregory Breese, Stefano Canessa, Jean Fitts Cochrane, Sarah J. Converse, Cami S. Dixon, John G. Ewen, Christelle Ferrière, Jill J. Gannon, Beth Gardner, Adam W. Green, Justin A. Gude, Victoria M. Hunt, Kevin S. Kalasz, Melinda G. Knutson, Jim Kraus, Graham Long, Eric V. Lonsdorf, James E. Lyons, Conor P. McGowan, Sarah E. McRae, Michael S. Mitchell, Clinton T. Moore, Joslin L. Moore, Steven Morey, Dan W. Ohlson, Charlie Pascoe, Andrew Paul, Eben H. Paxton, Lori B. Pruitt, Michael C. Runge, Sarah N. Sells, Terry L. Shaffer, Stephanie Slade, David R. Smith, Jennifer A. Szymanski, Terry Walshe, Nicolas Zuël
Structured Foods
by Prem Prakash Srivastav Eswaran U, Gnana Moorthy Brijesh SrivastavaStructured Foods is an important reference that discusses the recent research trends on structural development in various foods. This book covers different tools and food engineering techniques such as encapsulation, 3D and 4D printing, imaging techniques, and clean meat technology. It discusses how various foods can be broken down and manipulated at the molecular level to improve their quality, safety, and healthfulness. It describes the structuring of components like starch, proteins, and polysaccharides and the stability and bioavailability of different food structures. This is a useful reference for researchers and industry experts in food technology, food engineering, and food processing.The work addresses critical food-related issues that need to be tackled, including harvesting enough food to feed the global population, improving food sustainability, reducing food waste and pollution, and improving human health. Further, it focuses on the new scientific technologies being applied by scientists for an improved food system. The book is an important resource for all stakeholders in the debate about the future of our foods in the spheres of academic, industrial, and government policy.
Structured Glass-Fiber Catalysts
by Andrey Zagoruiko Sergey LopatinStructured Glass-Fiber Catalysts discusses the synthesis of advanced glass-fiber catalysts for various emerging applications, investigation of their properties, and development of the engineering basis required for their wide practical application. This book describes how to create and use such catalysts for different chemical reactions. It discusses how to efficiently arrange them into structured catalytic cartridges and gives examples of their successful application for purification of waste gases from different hazardous contaminants and environmentally safe combustion of fuels. It covers nanosize surface science fundamentals through large-scale commercial catalytic reactors. This book is aimed at researchers and engineers in the fields of chemical engineering, industrial engineering, and materials engineering.
Structured Light Fields
by Mike WördemannThe optical trapping of colloidal matter is an unequalled field of technology for enabling precise handling of particles on microscopic scales, solely by the force of light. Although the basic concept of optical tweezers, which are based on a single laser beam, has matured and found a vast number of exciting applications, in particular in the life sciences, there are strong demands for more sophisticated approaches. This thesis gives an introductory overview of existing optical micromanipulation techniques and reviews the state-of-the-art of the emerging field of structured light fields and their applications in optical trapping, micromanipulation, and organisation. The author presents established, and introduces novel concepts for the holographic and non-holographic shaping of a light field. A special emphasis of the work is the demonstration of advanced applications of the thus created structured light fields in optical micromanipulation, utilising various geometries and unconventional light propagation properties. While most of the concepts developed are demonstrated with artificial microscopic reference particles, the work concludes with a comprehensive demonstration of optical control and alignment of bacterial cells, and hierarchical supramolecular organisation utilising dedicated nanocontainer particles.