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River Quality: Dynamics and Restoration
by Antonius Laenen and David A. DunnetteWhat is involved in restoring a river? River Quality: Dynamics and Restoration answers this question through a series of articles and case studies written by some of the field's leading researchers and practitioners. The first part of the book covers the physical, chemical, and biological dynamics of a river system. The second part describes monitoring programs and remedial measures used to restore river systems back to healthy and functional states. The Willamette River in Oregon and the Vistula River in Poland are used to illustrate the dynamic and restoration processes. Each river is in a different stage of restoration and is subjected to different degrees of stress from agriculture, industry, and urbanization. The Willamette is an internationally cited example of a restored river, while the Vistula is a river that has just recently begun the restoration process. Contrasts and comparisons of the two river systems enable readers to learn the limitations of restoration processes and what is involved in the different stages of restoration.
The River Ran Red: Homestead, Eighteen Ninety-two
by Dave Demarest David MontgomeryCommemorates the 100th anniversary of the Homestead Strike (Pittsburgh, PA) of 1892. No index. Annotation copyrighted by Book News, Inc. , Portland, OR
River Republic: The Fall and Rise of America's Rivers
by Daniel McCoolDaniel McCool not only chronicles the history of water development agencies in America and the way in which special interests have abused rather than preserved the country's rivers, he also narrates the second, brighter act in this ongoing story: the surging, grassroots movement to bring these rivers back to life and ensure they remain pristine for future generations. The culmination of ten years of research and observation, McCool's book confirms the surprising news that America's rivers are indeed returning to a healthier, free-flowing condition. The politics of river restoration demonstrates how strong grassroots movements can challenge entrenched powers and win. Through passion and dedication, ordinary people are reclaiming the American landscape, forming a "river republic" of concerned citizens from all backgrounds and sectors of society. As McCool shows, the history, culture, and fate of America is tied to its rivers, and their restoration is a microcosm mirroring American beliefs, livelihoods, and an increasing awareness of what two hundred years of environmental degradation can do. McCool profiles the individuals he calls "instigators," who initiated the fight for these waterways and, despite enormous odds, have succeeded in the near-impossible task of challenging and changing the status quo. Part I of the volume recounts the history of America's relationship to its rivers; part II describes how and why Americans "parted" them out, destroying their essence and diminishing their value; and part III shows how society can live in harmony with its waterways while restoring their well-being—and, by extension, the well-being of those who depend on them.
The River Returns: An Environmental History of the Bow
by Christopher Armstrong Matthew Evenden H.V. NellesAlberta's iconic river has been dammed and plumbed, made to spin hydro-electric turbines, and used to cleanse Calgary. Artificial lakes in the mountains rearrange its flow; downstream weirs and ditches divert it to irrigate the parched prairie. Far from being wild, the Bow is now very much a human product: its fish are as manufactured as its altered flow, changed water quality, and newly stabilized and forested banks. The River Returns brings the story of the Bow River's transformation full circle through an exploration of the recent revolution in environmental thinking and regulation that has led to new limits on what might be done with and to the river. Rivers have been studied from many perspectives, but too often the relationship between nature and people, between rivers and the cultures that have grown up beside them, have been separated. The River Returns illuminates the ways in which humans, both inadvertently and consciously, have interacted with nature to make the Bow.
River Sand Mining Modelling and Sustainable Practice: The Kangsabati River, India (Environmental Science and Engineering)
by Raj Kumar Bhattacharya Nilanjana Das ChatterjeeWorldwide demand for sand and gravel is increasing daily, as the need for these materials continues to rise, for example in the construction sector, in land filling and for transportation sector based infrastructural projects. This results in over-extraction of sand from channel beds, and hampers the natural renewal of sediment, geological setup and morphological processes of the riverine system. In India, illegal sand mining (of alluvial channels) and gravel mining (of perennial channels) are two anthropogenic issues that negatively affect the sustainable drainage system. Along the Kangsabati River in India, the consequences of sand mining are very serious. The construction of Mukutmonipur Dam (1958) on the river causes huge sediment deposition along the middle and downstream areas, these same areas are also intensely mined for sand (instream and on the flood plain). Geospatial models are applied in order to better understand the state and the resilience of stream hydraulics, morphological and river ecosystem variables during pre-mining and post-mining stages, using micro-level datasets of the Kangsabati River. The book also includes practicable measures to minimize the environmental consequences of instream mining in respect to optimum sand mining. It discusses the threshold limits of each variable in stream hydraulics, morphological and river ecological regime, and also discusses the most affected variables. Consequently, all outputs will be very useful for students, researchers, academicians, decision makers and practitioners and will facilitate applying these techniques to create models for other river basins.
River, Sediment and Hydrological Extremes: Causes, Impacts and Management (Disaster Resilience and Green Growth)
by Manish Pandey Anil Kumar Gupta Giuseppe OlivetoThis edited book provides a platform for knowledge sharing in all areas related to the rivers, sediment and hydrological extremes. It explains the hypothesis that river flow and sediment transport are intimately linked to erosion, scour and sediment deposition. Sediment transport, erosion and deposition are driven by local base-level changes and are highly variable in space and time. These concepts have serious implication for understanding the recent development of the River, Sediment and Hydrological Extremes.The natural hazards posed by hydrologic events and river systems depend on the uncertainty of hydrological events. This ability is affected by change in climatic conditions. Climate change studies have revealed that the frequency of extreme weather phenomena with increasing damage to human assets has gradually grown worldwide. As a consequence, rainfall events concentrated in time and space are expected to lead to serious local flooding and sediment transport in many parts of the world. Floods are remarkable hydro-meteorological phenomena and forceful agents of geomorphic evolution in most physical geographical belts and, from the viewpoint of human society, among the most important environmental hazards. According to the Indian Environment Agency, floods rank as number one on the list of natural disasters in India over the past decade.This book is an attempt to fill the gap in literature and bring forth evidence based latest research about precise estimation of erosion and scour, which is essential to reduce the hazards. The book explains that lack of preparedness and appropriate adaptation strategy makes people more risk-prone. It highlights the vulnerability in South Asia region about the impacts of flood, sediments, and river hazards because a large portion of its population depends on sensitive sectors like agriculture and forestry for livelihoods and several other reasons.The book is relevant for academician, researchers and students of disaster management, hydrology and ecology.
River Sedimentation: Proceedings of the 13th International Symposium on River Sedimentation (Stuttgart, Germany, 19-22 September, 2016)
by Silke Wieprecht Stefan Haun Karolin Weber Markus Noack Kristina TerheidenSediment dynamics in fluvial systems is of great ecological, economic and human-health-related significance worldwide. Appropriate management strategies are therefore needed to limit maintenance costs as well as minimize potential hazards to the aquatic and adjacent environments. Human intervention, ranging from nutrient/pollutant release to physical modifications, has a large impact on sediment quantity and quality and thus on river morphology as well as on ecological functioning. Truly understanding sediment dynamics requires as a consequence a multidisciplinary approach.River Sedimentation contains the peer-reviewed scientific contributions presented at the 13th International Symposium on River Sedimentation (ISRS 2016, Stuttgart, Germany, 19-22 September 2016), and includes recent accomplishments in theoretical developments, numerical modelling, experimental laboratory work, field investigations and monitoring as well as management methodologies.
River Systems of West Bengal: Water and Environments (Springer Water)
by Gautam Kumar DasThe book explains the basic concepts of river water quality index, river environments, shifting of river courses, dams and barrages – their merits and demerits, mutual interdependence of river and society etc. in the typical geomorphic set up of West Bengal. In India, West Bengal is a riverine state due to the towering Himalayas to the north and the Bay of Bengal to the south. In between the mountain and sea, due to the location of the Gangetic delta region and its stability with space and time, the rivers of this state are gradually dying. In addition to the stability of the delta, the river channel is being filled with sediments carried along the river course from upstream. The role of dams, barrages and reservoirs in the normal flow of rivers at different geographical locations deserves discussion which is included in the book. It is to be expected that the rivers of West Bengal can be an outstanding example of mutual interdependence of science and society, all of which are included in the book.The use of different physicochemical parameters adopted for the water quality index of different rivers described in this book will provide new directions in this regard. With discussions like water quality index, river environments, shifting of river courses, reservoirs, dams and barrages, and mutual interdependence of river and society, it is the intention that this book, River Systems of West Bengal - Water and Environments, will be useful for the research and higher studies in the river related field. This book will be of interest to students and researchers of riverine environments.
Riverbank Erosion Hazards and Channel Morphodynamics: A Perspective of Fluvial Geomorphology
by Sourav Dey Sujit MandalThis book explores fluvial processes and their consequences on river dynamics in India. It discusses the integration of geomorphic, hydrologic, and socio-economic data with various policies and decisions regarding sustainable river basin management. The volume looks at the origin and development of streams, chronology of fluvial geomorphology, fluvial system concept, process–form interaction, river dynamics, channel migration, flow regime, channel types, and hydraulic and morphometric parameters; and explains how changing hydro-geomorphological dynamics have influenced land use patterns, nature of fluids, behaviour of floods, etc. It examines channel migration vulnerability and bank erosion hazard vulnerability of the Torsa River in the eastern region of India as a case study using channel migration zone and Bank Erosion Hazard Index models. The book presents a new research framework based on field surveys, scientific investigations, and analytical techniques and methods to interpret key geoinformatics data. With its extensive illustrations, this book will be useful to students, teachers, and researchers of geography, earth sciences, environmental geology, and environment and disaster management. It will also interest geographers, civil engineers, hydrologists, geomorphologists, planners, and other individuals and organizations working on fluvial processes and riverbank erosion problems globally.
Riverine Ecology Volume 1: Eco-functionality of the Physical Environment of Rivers
by Susanta Kumar ChakrabortyThis book is part of a two-volume set that offers an innovative approach towards developing methods and tools for assigning conservation categories of threatened taxa and their conservation strategies by way of different phases of eco-restoration in the context of freshwater river systems of tropical bio-geographic zones. The set provides a considerable volume of research on the biodiversity component of river ecosystems, seasonal dynamics of physical chemical parameters, geo-hydrological properties, types, sources and modes of action of different types of pollution, river restoration strategies and methodologies for the ongoing ecological changes of river ecosystems. Volume 1 provides an in-depth analysis of different theories with international relevance pertaining to the functioning of river ecosystems, shaping their structure and contributing ecological services, and includes the principles of riverine ecology such as biogeochemical cycles, physiography, hydrogeology, and physico-chemical parameters. It covers the basic concepts and principles of water within riverine ecosystems, and the underlying ecological principles operating to ensure ecological stability and sustainability of the fluvial ecosystem. The book explains the ecofunctionality of different geo-morphological, geo-hydrological and physico-chemical factors and processes in changing time scales and spaces, with special emphasis on the tropical fresh water rivers in India.
Riverine Ecology Volume 2: Biodiversity Conservation, Conflicts and Resolution
by Susanta Kumar ChakrabortyThis book is part of a two-volume set that offers an innovative approach towards developing methods and tools for assigning conservation categories of threatened taxa and their conservation strategies by way of different phases of eco-restoration in the context of freshwater river systems of tropical bio-geographic zones. The set provides a considerable volume of research on the biodiversity component of river ecosystems, seasonal dynamics of physical chemical parameters, geo-hydrological properties, types, sources and modes of action of different types of pollution, river restoration strategies and methodologies for the ongoing ecological changes of river ecosystems.Volume 2 highlights biodiversity potential in aiding the resistance and resilience of riverine ecosystem functioning and their synergistic effects on ongoing environmental perturbations. Comprehensive information on the conservation of river-associated-wildlife is provided, covering the impacts of pollution, land-use changes, river policies, and ecosystem restoration strategies. The book offers an innovative approach towards developing methods and tools for assigning conservation categories of threatened taxa, and covers their conservation strategies by way of different phases of eco-restoration in the context of freshwater river systems of tropical bio-geographic zones.
Riverine Ecosystem Management: Science For Governing Towards A Sustainable Future (Aquatic Ecology Series #8)
by Jan Sendzimir Stefan SchmutzThis open access book surveys the frontier of scientific river research and provides examples to guide management towards a sustainable future of riverine ecosystems. Principal structures and functions of the biogeosphere of rivers are explained; key threats are identified, and effective solutions for restoration and mitigation are provided. Rivers are among the most threatened ecosystems of the world. They increasingly suffer from pollution, water abstraction, river channelisation and damming. Fundamental knowledge of ecosystem structure and function is necessary to understand how human acitivities interfere with natural processes and which interventions are feasible to rectify this. Modern water legislation strives for sustainable water resource management and protection of important habitats and species. However, decision makers would benefit from more profound understanding of ecosystem degradation processes and of innovative methodologies and tools for efficient mitigation and restoration. The book provides best-practice examples of sustainable river management from on-site studies, European-wide analyses and case studies from other parts of the world. This book will be of interest to researchers in the field of aquatic ecology, river system functioning, conservation and restoration, to postgraduate students, to institutions involved in water management, and to water related industries.
Rivers: Form and Process in Alluvial Channels (Routledge Revivals)
by Keith RichardsOriginally published in 1982, this book presents a detailed review of alluvial river form and process and integrates the distinct but related approaches of geomorphologists, geologists and engineers to the subject. It outlines the environmental catchment factors that control the development of channel equilibrium and provides a detailed account of the sediment transport processes that represent the physical mechanisms by which channel adjustment occurs. Where possible it evaluates theoretical analyses in the context of the empirical evidence. Rivers should prove a valuable textbook for geomorphology students on advanced undergraduate courses on river behaviour and will also be of interest to students of hydraulics and sedimentology and to those concerned with civil and environmental engineering, river management and channel design, maintenance and management in the water industry
Rivers from Space!
by Liz HuyckWhen on land, rivers, lakes, and oceans appear flat. With the aid of satellites, these bodies of water appear to have many designs! Explore the art of nature and how satellites detect the temperature of the many bodies of water around the globe.
Rivers in Time
by Peter D. WardSeveral times in the distant past, catastrophic extinctions have swept the Earth, causing more than half of all species―from single-celled organisms to awe-inspiring behemoths―to suddenly vanish and be replaced by new life forms. Today the rich diversity of life on the Earth is again in grave danger―and the cause is not a sudden cataclysmic event but rather humankind's devastation of the environment. Is life on our planet teetering on the brink of another mass extinction? In this absorbing new book, acclaimed paleontologist Peter D. Ward answers this daunting question with a resounding yes. Elaborating on and updating Ward's previous work, The End of Evolution, Rivers in Time delves into his newest discoveries. The book presents the gripping tale of the author's investigations into the history of life and death on Earth through a series of expeditions that have brought him ever closer to the truth about mass extinctions, past and future. First describing the three previous mass extinctions―those marking the transition from the Permian to the Triassic periods 245 million years ago, the Triassic to the Jurassic 200 million years ago, and the Cretaceous to the Tertiary 65 million years ago―Ward assesses the present devastation in which countless species are coming to the end of their evolution at the hand of that wandering, potentially destructive force called Homo sapiens. The book takes readers to the Philippine Sea, now eerily empty of life, where only a few decades of catching fish by using dynamite have resulted in eviscerated coral reefs―and a dramatic reduction in the marine life the region can support. Ward travels to Canada's Queen Charlotte Islands to investigate the extinctions that mark the boundary between the Triassic and Jurassic periods. He ventures also into the Karoo desert of southern Africa, where some of Earth's earliest land life emerged from the water and stood poised to develop into mammal form, only to be obliterated during the Permian/Triassic extinction. Rivers of Time provides reason to marvel and mourn, to fear and hope, as it bears stark witness to the urgency of the Earth's present predicament: Ward offers powerful proof that if radical measures are not taken to protect the biodiversity of this planet, much of life as we know it may not survive.
Rivers of India: Past, Present and Future
by Shyam Kanhaiya Saurabh Singh Arohi Dixit Atul Kumar SinghThis volume presents geological, geographical, environmental, and agriculture related studies on rivers, focusing on basins of the three geomorphic divisions of India, i.e. peninsular India, Indo-Gangetic plain and extra-peninsular India. The book compiles data on both the small and large river systems of India, the large rivers include Jhelum, Ghaghara, Narmada, Son, Krishna and Godavari; and the small scale, rain-fed and groundwater-fed rivers such as Gomti have been studied. The chapters comprehensively provide assessments of geomorphological aspects, river sediment supply, clean water availability for human population, ground water recharge, flood management and irrigation. The information presented in this book will appeal to students, teachers, researchers and planners engaged in river development, management and conservation.
The Rivers of Montenegro (The Handbook of Environmental Chemistry #93)
by Vladimir Pešić Momir Paunović Andrey G. KostianoyThis book reviews the current state of knowledge on, recent advances in, and future prospects of Montenegrin river basins in the context of anthropogenic activities. Edited by three respected experts in the field, the book begins with an introduction to the specific hydrogeological conditions in Montenegro and critical reflections on the impact of hydropower projects. It then reviews the vulnerability of river ecosystems, exploring potential genotoxic effects and water quality, and explaining typology and monitoring of these aspects, and particularly highlighting mollusk assemblages and monitoring of intermittent rivers. The closing chapters focus on the impact of river flooding and discuss controversial projects aiming to find an approach mutually acceptable to all stakeholders. Given its scope, the book is an indispensable resource for scientists in academia and the water industry, as well as for decision-makers in the field investigating the interactions between land and water, limnology and biota, and natural and cultural resources.
Rivers of Power: How a Natural Force Raised Kingdoms, Destroyed Civilizations, and Shapes Our World
by Laurence C. SmithAn "eye-opening, sometimes alarming, and ultimately inspiring" natural history of rivers and their complex and ancient relationship with human civilization (Elizabeth Kolbert, Pulitzer Prize-winning author of The Sixth Extinction).Rivers, more than any road, technology, or political leader, have shaped the course of human civilization. They have opened frontiers, founded cities, settled borders, and fed billions. They promote life, forge peace, grant power, and can capriciously destroy everything in their path. Even today, rivers remain a powerful global force -- one that is more critical than ever to our future.In Rivers of Power, geographer Laurence C. Smith explores the timeless yet underappreciated relationship between rivers and civilization as we know it. Rivers are of course important in many practical ways (water supply, transportation, sanitation, etc). But the full breadth of their influence on the way we live is less obvious. Rivers define and transcend international borders, forcing cooperation between nations. Huge volumes of river water are used to produce energy, raw commodities, and food. Wars, politics, and demography are transformed by their devastating floods. The territorial claims of nations, their cultural and economic ties to each other, and the migrations and histories of their peoples trace back to rivers, river valleys, and the topographic divides they carve upon the world. And as climate change, technology, and cities transform our relationship with nature, new opportunities are arising to protect the waters that sustain us.Beautifully told and expansive in scope, Rivers of Power reveals how and why rivers have so profoundly influenced our civilization and examines the importance this vast, arterial power holds for the future of humanity."As fascinating as it is beautifully written."---Jared Diamond, Pulitzer Prize-winning author of Guns, Germs, and Steel, Collapse, and Upheaval
Rivers of Southern Chile and Patagonia: Context, Cascade Process, Geomorphic Evolution and Risk Management (The Latin American Studies Book Series)
by Carlos Oyarzún Bruno Mazzorana Pablo Iribarren Anacona Andrés IrouméThis book provides a comprehensive analysis of the evolution of rivers affected by natural and anthropogenic disturbances in the southern Chile and Patagonia. It presents a detailed description of the rivers affected by climatic extremes, volcanic eruptions, large-wood dynamics and impacts, sediment-laden flows, and Glacier Lake Outburst Floods (GLOFs). Moreover, it contains an in-depth discussion of a variety of topics encompassing the ecosystem function of Pacific Patagonia rivers, the geomorphic signatures of Glacier Lake Outburst Floods (GLOFs) and their impacts within river corridors, as well as the assessment of the associated natural hazards and risks. Further, it provides proposals for public and territorial policies that improve the management and sustainable strategies of the hazards and risks. This book is conceived by leading researchers of the Universidad Austral de Chile and includes contributions by distinguished scholars from around the world. It attracts a wide range of readers, including scientific community, researchers, undergraduate and graduate students, and policy makers from Chile and abroad.
Rivers of Sunlight: How the Sun Moves Water Around the Earth (Sunlight Series #4)
by Molly Bang Penny ChisholmA stunning, accessible explanation of the Earth's water cycle and its global effects. In this brightly illustrated narrative, readers will learn about the constant movement of water as it flows around the Earth and the sun's important role as water changes between liquid, vapor, and ice. From sea to sky, the sun both heats and cools water, ensuring that life can exist on Earth. How does the sun keep ocean currents moving, and lift fresh water from the seas? And what can we do to conserve one of our planet's most precious resources? Perfect for any young reader eager to learn more about his or her world, this is an invaluable addition to any classroom, library, or at-home collection. With stunning artwork and compelling scientific explanation, Bang and Chisholm have brought forth a masterpiece that is critically relevant in this environmentally tumultuous time. The newest book in the award-winning Sunlight Series is an important and beautiful exploration one of our planet's delicate geological cycles, clearly and simply presented for young readers.
Rivers of the Anthropocene
by Jason M. KellyA free ebook version of this title is available through Luminos, University of California Press’s Open Access publishing program. Visit www.luminosoa.org to learn more. This exciting volume presents the work and research of the Rivers of the Anthropocene Network, an international collaborative group of scientists, social scientists, humanists, artists, policy makers, and community organizers working to produce innovative transdisciplinary research on global freshwater systems. In an attempt to bridge disciplinary divides, the essays in this volume address the challenge in studying the intersection of biophysical and human sociocultural systems in the age of the Anthropocene, a new geological epoch of humans' own making. Featuring contributions from authors in a rich diversity of disciplines—from toxicology to archaeology to philosophy—this book is an excellent resource for students and scholars studying both freshwater systems and the Anthropocene.
Riveted: The Science of Why Jokes Make Us Laugh, Movies Make Us Cry, and Religion Makes Us Feel One with the Universe
by Jim DaviesWhy do some things pass under the radar of our attention, but other things capture our interest? Why do some religions catch on and others fade away? What makes a story, a movie, or a book riveting? Why do some people keep watching the news even though it makes them anxious?The past 20 years have seen a remarkable flourishing of scientific research into exactly these kinds of questions. Professor Jim Davies' fascinating and highly accessible book, Riveted, reveals the evolutionary underpinnings of why we find things compelling, from art to religion and from sports to superstition. Compelling things fit our minds like keys in the ignition, turning us on and keeping us running, and yet we are often unaware of what makes these "keys" fit. What we like and don't like is almost always determined by subconscious forces, and when we try to consciously predict our own preferences we're often wrong. In one study of speed dating, people were asked what kinds of partners they found attractive. When the results came back, the participants' answers before the exercise had no correlation with who they actually found attractive in person! We are beginning to understand just how much the brain makes our decisions for us: we are rewarded with a rush of pleasure when we detect patterns, as the brain thinks we've discovered something significant; the mind urges us to linger on the news channel or rubberneck an accident in case it might pick up important survival information; it even pushes us to pick up People magazine in order to find out about changes in the social structure.Drawing on work from philosophy, anthropology, religious studies, psychology, economics, computer science, and biology, Davies offers a comprehensive explanation to show that in spite of the differences between the many things that we find compelling, they have similar effects on our minds and brains.
Riveted Lap Joints in Aircraft Fuselage
by Andrzej Skorupa Małgorzata SkorupaFatigue of the pressurized fuselages of transport aircraft is a significant problem all builders and users of aircraft have to cope with for reasons associated with assuring a sufficient lifetime and safety, and formulating adequate inspection procedures. These aspects are all addressed in various formal protocols for creating and maintaining airworthiness, including damage tolerance considerations. In most transport aircraft, fatigue occurs in lap joints, sometimes leading to circumstances that threaten safety in critical ways. The problem of fatigue of lap joints has been considerably enlarged by the goal of extending aircraft lifetimes. Fatigue of riveted lap joints between aluminium alloy sheets, typical of the pressurized aircraft fuselage, is the major topic of the present book. The richly illustrated and well-structured chapters treat subjects such as: structural design solutions and loading conditions for fuselage skin joints; relevance of laboratory test results for simple lap joint specimens to riveted joints in a real structure; effect of various production and design related variables on the riveted joint fatigue behaviour; analytical and experimental results on load transmission in mechanically fastened lap joints; theoretical and experimental analysis of secondary bending and its implications for riveted joint fatigue performance; nucleation and shape development of fatigue cracks in riveted longitudinal lap joints; overview of experimental investigations into the multi-site damage for full scale fuselage panels and riveted lap joint specimens; fatigue crack growth and fatigue life prediction methodology for riveted lap joints; residual strength predictions for riveted lap joints in a fuselage structure. The major issues of each chapter are recapitulated in the last section.
RNA 3D Structure Analysis and Prediction
by Eric Westhof Neocles LeontisWith the dramatic increase in RNA 3D structure determination in recent years, we now know that RNA molecules are highly structured. Moreover, knowledge of RNA 3D structures has proven crucial for understanding in atomic detail how they carry out their biological functions. Because of the huge number of potentially important RNA molecules in biology, many more than can be studied experimentally, we need theoretical approaches for predicting 3D structures on the basis of sequences alone. This volume provides a comprehensive overview of current progress in the field by leading practitioners employing a variety of methods to model RNA 3D structures by homology, by fragment assembly, and by de novo energy and knowledge-based approaches.
RNA-Based Cancer Therapeutics: Techniques, Applications and Challenges in Prognosis
by Narendra Kumar Sharma Tikam Chand Dakal Pawan Kumar Maurya Gulshan WadhwaBy consistently dedicating efforts to multi-omic and other high-throughput technologies, it is expected that RNA therapies will have a vital role in future personalized medicine approaches for cancer therapy. Within this framework, analyzing the genetic sequence of a patient's tumor would allow for the detection of crucial driver mutations or changes that cause resistance to drugs. These mutations may then be targeted with RNA therapies that are particularly designed to treat those particular variations. Recent clinical trials have shown that RNA-based therapies hold great potential for treating several illnesses. However, further investigations are required to improve the delivery materials and understand the RNA alterations linked to these groundbreaking drugs, in order to facilitate their integration into clinical practice. Ideally, these therapeutic substances would be specifically administered to the tumor cells of interest using a targeted delivery agent. In this hypothetical situation, the choice of medications for cancer patients would differ depending on the precise abnormalities detected in each person, potentially including inhibitors that target circuits known to cause resistance to treatments. However, doing a more thorough assessment of the challenges and potential benefits discussed in each chapter would enhance the capacity to critically analyze this rapidly evolving field of therapies. This book largely examines the latest developments and clinical studies related to RNA-based medications, while also examining the challenges and future possibilities linked with them. This method shows potential for greatly improving the prognosis of cancer patients.