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Sarcopenia: Molecular, Cellular, and Nutritional Aspects

by Dominique Meynial-Denis

Sarcopenia: Molecular, Cellular, and Nutritional Aspects describes the progressive loss of skeletal muscle mass and strength, defined by Rosenberg in 1997 as a hallmark of aging and referred to as &“sarcopenia.&” As life expectancy continues to increase worldwide, sarcopenia has become a major public health issue. The condition worsens in the presence of chronic diseases accelerating its progression. Sarcopenia is not considered to be &“a process of normative aging&” but according to the International Classification of Disease, Tenth Revision, Clinical Modification (ICD-10-CM), as a disease. As sarcopenia is an ineluctable process, prevention and management are the only options to promote healthy aging; these actions should perhaps be taken during youth. <p><p>Included in this book: <li>Features essential information on sarcopenia, its current definition, and molecular and cellular aspects of this disease <li>Discusses the development of physical frailty, a complication of sarcopenia, and predicts its occurrence in the older population <li>Presents alterations in muscle protein turnover and mitochondrial dysfunction in the aging process <li>Provides data on the negative involvement of sarcopenia in certain chronic diseases <li>Describes presbyphagia or age-related changes in the swallowing mechanism in older people <li>Details possible strategies to combat muscle wasting in healthy older adults and their limits <p><p>This book features information collected from pioneers or experts on human aging from around the globe, including Europe, Brazil, Canada, Japan and the United States. It is a valuable source of information for nutritional scientists, medical doctors, sports scientists, food scientists, dietitians, students in these fields, and for anyone interested in nutrition. We hope this book provides a better understanding of sarcopenia which inevitably occurs with aging without weight loss. Moreover, this book will supply information outlining strategies to prevent or limit muscle wasting due to normal aging in order to promote successful aging.

Sarcopenia: Research and Clinical Implications (Practical Issues in Geriatrics)

by Nicola Veronese Charlotte Beaudart Shaun Sabico

This book offers a concise and updated guide for all readers (physicians and non-physicians) interested in gaining a comprehensive and precise understanding of sarcopenia. Over the last several years, sarcopenia has increasingly developed from being a concept known only in research settings to one that is commonly explored in journals and scientific meetings for various disciplines, such as geriatrics, rheumatology and rehabilitation medicine. Thus, all domains of sarcopenia, from molecular aspects to clinical management, represent highly active areas of research and clinical practice for health professionals in a variety of fields, including geriatric medicine, nutrition, and epidemiology. Despite being a relatively new concept in medicine, sarcopenia is increasingly being recognized as an important determinant of other health conditions, including mortality and disability. This book, written by experts from around the globe, covers several core aspects of sarcopenia management, from molecular mechanisms to genetics, epidemiology, diagnosis and finally treatment, including the clinical impact of sarcopenia as a risk factor, the known genetic and molecular aspects that can aid in predicting sarcopenia, and selected treatment and therapy concepts, including indications for nutrition and physical exercise. Sharing data from the latest studies, it will be of considerable interest not only for geriatricians, but also for a wide range of other readers.

Sarcopenia – Age-Related Muscle Wasting and Weakness

by Gordon S. Lynch

Some of the most serious consequences of aging are its effects on skeletal muscle. 'Sarcopenia', the progressive age-related loss of muscle mass and associated muscle weakness, renders frail elders susceptible to serious injury from sudden falls and fractures and at risk for losing their functional independence. Not surprisingly, sarcopenia is a significant public health problem throughout the developed world. There is an urgent need to better understand the neuromuscular mechanisms underlying age-related muscle wasting and to develop therapeutic strategies that can attenuate, prevent, or ultimately reverse sarcopenia. Significant research and development in academic and research institutions and in pharmaceutical companies is being directed to sarcopenia and to related health issues in order to develop and evaluate novel therapeutics. This book provides the latest information on sarcopenia from leading international researchers studying the cellular and molecular mechanisms underlying age-related changes in skeletal muscle and identifies strategies to combat sarcopenia and related muscle wasting conditions and neuromuscular disorders. The book provides a vital resource for researchers and practitioners alike, with information relevant to gerontologists, geriatricians, sports medicine physicians, physiologists, neuroscientists, cell biologists, endocrinologists, physical therapists, allied health and musculoskeletal practitioners, strength and conditioning specialists, athletic trainers, and students of the medical and biomedical sciences.

SARP-Driven Activation of Antibiotic Biosynthetic Gene Clusters in Actinomycetes (BestMasters)

by Oona Rössler

Actinomycetes are a group of Gram-positive bacteria of which many representatives are prominent for being prolific producers of bioactive natural products including antibiotics, fungicides, antitumor agents, or immunosuppressants. SARP transcriptional regulators are widely distributed among actinomycetes, especially in streptomycetes and are known to activate antibiotic biosynthesis. The set of genes responsible for the production of natural products, including pathway specific transcriptional regulators such as SARPs, are typically located in contiguous regions of the genome known as "biosynthetic gene clusters" (BGCs). In this book, Oona Rössler reports on the activation of antibiotic BGCs in selected actinomycetes strains upon heterologous expression of the SARP-type regulator PapR2 from Streptomyces pristinaespiralis. Applying a bioinformatic screening for the abundance of SARP genes and SARP consensus sequences as part of BGCs, the author has selected actinomycetes candidate strains from the DSMZ strain collection for heterologous SARP expression. It is shown that overexpression of papR2 increased the production of predominantly unknown antimicrobial compounds in more than half of the selected actinomycetes strains, as observed by bioassays against different microbial test strains including bacteria and fungi.

SARS-CoV-2 Spike Protein Convergent Evolution: Impact of Virus Variants on Efficacy of COVID-19 Therapeutics and Vaccines (SpringerBriefs in Microbiology)

by Daniele Focosi

This book reviews the current knowledge of the globally circulating SARS-CoV-2 variants, highlights their distinct genetic characteristics and associated conformational changes in the viral spike protein, and profoundly discusses the mechanisms of convergent evolution that led to the rise of these mutated strains at different geographic regions during the Covid-19 pandemic. Furthermore, the book explores how these variants do and may impact the efficacy of established neutralizing antibody-based (nAb) vaccines and therapeutics by analysing latest in vivo and in vitro clinical data. Finally, the author discusses ways on how nAb Covid-19 treatment derived immune escape of SARS-CoV-2 could be minimized in the future.

SAS Urban Survival Handbook: How to Protect Yourself Against Terrorism, Natural Disasters, Fires, Home Invasions, and Everyday Health and Safety Hazards

by John Lofty" Wiseman

John "Lofty" Wiseman is the author of the bestselling SAS Survival Handbook, the definitive guide to survival in the wild from Britain's Special Air Service. Now he has compiled a complete guide to survival in the urban jungle. Every year in America there are thousands of fatal accidents in the home—more than on the roads, and many more than in the great outdoors. Fire, electricity, water, gas, sharp knives, poisons, chemicals—these valuable tools can quickly become dangerous weapons when not treated with proper respect and understanding. Add to these the risks of travel, terrorism, muggings, rape, tsunamis, and earthquakes. We are constantly reminded that the world is a dangerous place. Wiseman shows readers how to think realistically and practically about these perils in order to avoid them, whether they are at home, on the street, in school, or in transit. From self-defense techniques to home security systems to coping with natural disasters, this book will teach readers to recognize risks, make quick decisions, and live confidently in the modern urban world.

The Sassafras Science Adventures: Anatomy

by Johnny Congo Paige Hudson

In this volume, the twins (and you) will learn all about the different systems of the human body as they zip to an ancient tomb in Ethiopia, a garbage landfill in Texas and more. Don’t miss a minute of their summer-long, science-filled zip line journey!

The Sassafras Science Adventures: Zoology

by Paige Hudson Johnny Congo

A guide that provides ideas for experiments, notebooking, vocabulary, memory work, and additional activities to enhance what your students are learning about animals!

The Sassafras Science Adventures: Volume 3: Botany

by Paige Hudson Johnny Congo

Inspire kids to love science with the Sassafras living books science curriculum series! Adventure stories integrate facts related to a major science topic into story-lines that children can't put down. <P><P>Each book can be read on its own (as a read-aloud or independently by students in 4th grade & up) or can be used alongside the activity book and logbook (not included and sold-separately) to create a full homeschool science curriculum. Designed for grades K-5.

SAT Biology E/M Test Prep Review: Exambusters Flash Cards and SAT II Exam Study Guide (Exambusters SAT 2 #1)

by Ace Inc.

<P><P><i>Advisory: Bookshare has learned that this book offers only partial accessibility. We have kept it in the collection because it is useful for some of our members. Benetech is actively working on projects to improve accessibility issues such as these.</i><P><P> SAT BIOLOGY E/M Study Guide:<P><P> 450 questions and answers. Essential definitions and concepts. Topics: Cells, Biochemistry and Energy, Evolution and Classification, Kingdoms: Bacteria, Fungi, Protista; Kingdom: Plantae, Kingdom: Animalia, Human Locomotion, Human Circulation and Immunology, Human Respiration and Excretion, Human Digestion, Human Nervous System, Human Endocrinology, Reproduction and Development, Genetics, Ecology. <P> EXAMBUSTERS SAT II Prep Workbook:<P> Provides comprehensive SAT II review--one fact at a time--to prepare students to take practice SAT II tests. Each SAT II study guide focuses on fundamental concepts and definitions--a basic overview to begin studying for the SAT II exam. Up to 600 questions and answers, each volume in the SAT II series is a quick and easy, focused read. Reviewing SAT II flash cards is the first step toward more confident SAT II preparation and ultimately, higher SAT II exam scores!

SAT Subject Test Biology E/M

by Kaplan

Essential strategies, practice, and review to ace the SAT Subject Test Biology E/M Getting into a top college has never been more difficult. Students need to distinguish themselves from the crowd, and scoring well on an SAT Subject Test gives students a competitive edge. Kaplan’s SAT Subject Test Biology E/M is the most up-to-date guide on the market with complete coverage of both the content review and strategies students need for success on Test Day. Kaplan’s SAT Subject Test Biology E/M features: * A full-length diagnostic test * 2 full-length practice tests * Focused chapter summaries, highlights, and quizzes * Detailed answer explanations * Proven score-raising strategies * End-of-chapter quizzes Kaplan is serious about raising students’ scores—we guarantee students will get a higher score, or get their money back.

SAT Subject Test Chemistry

by Kaplan

Essential strategies, practice, and review to ace the SAT Subject Test Chemistry Getting into a top college has never been more difficult. Students need to distinguish themselves from the crowd, and scoring well on an SAT Subject Test gives students a competitive edge. Kaplan’s SAT Subject Test Chemistry is the most up-to-date guide on the market with complete coverage of both the content review and strategies students need for success on Test Day. Kaplan’s SAT Subject Test Chemistry features: * A full-length diagnostic test * 3 full-length practice tests * Focused chapter summaries, highlights, and quizzes * Detailed answer explanations * Proven score-raising strategies * End-of-chapter quizzes Kaplan is serious about raising students’ scores—we guarantee students will get a higher score, or get their money back.

SAT Subject Test Chemistry: with 7 Practice Tests (Barron's SAT)

by Joseph A. Mascetta M.S. Mark Kernion M.A.

The updated edition of Barron's SAT Subject Test: Chemistry includes:A full-length diagnostic test with explained answersFour practice tests that reflect the actual SAT Subject Test ChemistryAll questions answered and explainedDetailed reviews covering all test topicsAppendixes, which include the Periodic Table; important equation, constant, and data tables; and a glossary of chemistry termsBoth teachers and test-taking students have praised earlier editions of this manual for its wealth of well-organized detail. Subject reviewed include the basics—matter, energy, scientific method, and measurements; atomic structure and the periodic table; bonding; chemical formulas; gases and laws; stoichiometry; liquids, solids, and phase changes; chemical reactions and thermochemistry; chemical reactions; chemical equilibrium; acids, bases, and salts; oxidation-reduction; carbon and organic chemistry; and the laboratory.ONLINE PRACTICE TESTS: Students who purchase this book or package will also get access to two additional full-length online SAT Chemistry subject tests with all questions answered and explained.

SAT Subject Test Physics: With Online Tests (Barron's Test Prep)

by Robert Jansen M.A. Greg Young M.S. Ed.

Barron's SAT Subject Test Physics is updated to reflect the current test and features three full-length practice tests along with detailed content review and expert tips to help students improve their score.This edition includes:One diagnostic test to determine strengths and weaknessesThree complete SAT Subject Tests in Physics, which reflect the most recent actual tests in length, subject matter, and degree of difficultyAnswers and explanations for all questionsSelf-assessment guides after each test so students can measure their progressExtensive subject review covering all topics on the test, including mechanics, electricity and magnetism, waves and optics, thermodynamics, and more.Online Practice Test: Students also get access to one brand new, full-length online practice test with all questions answered and explained.Unique features include a &“What&’s the Trick?&” approach to solving problems quickly and effectively. Additional tips, called out with &“If You See…&” are included within the chapters to give test takers critical insight into difficult concepts, and QR codes are provided at &“Key Concept&” areas link to short videos to enhance instruction. The authors also provide general examination strategies and a detailed appendix with equations, physical constants, and a basic math review.

SAT Subject Test (Tenth Edition): Physics

by Hugh Henderson

Kaplan's SAT Subject Test Physics is the most up-to-date guide on the market with the essential content, practice, and strategies students need for success on Test Day. Kaplan's expert tips and focused review will help you ace the test and give your college applications a boost.<P><P> Contents: Essential Review; Three full-length practice tests with detailed answer explanations; A full-length diagnostic test identifies areas for score improvement so you can personalize your prep; Focused chapter summaries, highlights, and quizzes; End-of-chapter quizzes for additional practice; Proven score-raising strategies teach you how to tackle the test efficiently; Expert Guidance. <P>We know the test: Our Learning Engineers have put tens of thousands of hours into studying the SAT – using real data to design the most effective strategies and study plans. Kaplan's expert psychometricians make sure our practice questions and study materials are true to the test.We invented test prep—Kaplan (www.kaptest.com) has been helping students for almost 80 years, and more than 95% of our students get into their top-choice schools. Our proven strategies have helped legions of students achieve their dreams.

SAT Test Prep Flash Cards: Chemistry Fast Facts (Exambusters SAT II Workbook #2)

by Ace Inc.

<P><P><i>Advisory: Bookshare has learned that this book offers only partial accessibility. We have kept it in the collection because it is useful for some of our members. Benetech is actively working on projects to improve accessibility issues such as these.</i><P><P> 700 questions and answers. Essential definitions, formulas, concepts, and sample problems. <P><P>Topics: Introduction, Matter, Atoms, Formulas, Moles, Reactions, Elements, Periodic Table, Electrons, Chemical Bonds, Heat, Gases, Phase Changes, Solutions, Reaction Rates, Equilibrium, Acids and Bases, Oxidation and Reduction, Introduction to Organic Chemistry, Radioactivity.<P> EXAMBUSTERS SAT II Prep Workbooks Provide comprehensive SAT II review--one fact at a time--to prepare students to take practice SAT II tests. Each SAT II study guide focuses on fundamental concepts and definitions--a basic overview to begin studying for the SAT II exam. Up to 600 questions and answers, each volume in the SAT II series is a quick and easy, focused read. Reviewing SAT II flash cards is the first step toward more confident SAT II preparation and ultimately, higher SAT II exam scores!

SAT Test Prep Review Flash Cards: Physics (Exambusters SAT II Workbook #2 of 3)

by Ace Inc.

<P><P><i>Advisory: Bookshare has learned that this book offers only partial accessibility. We have kept it in the collection because it is useful for some of our members. Benetech is actively working on projects to improve accessibility issues such as these.</i><P><P> 600 questions and answers. Essential definitions, formulas, concepts, and sample problems. <P><P>Topics: Measurement, Motion and Forces, Work and Energy, Heat and Gases, Atoms, Fluids, Sound, Light and Optics, DC Circuits, Magnetism, AC Circuits <P>EXAMBUSTERS SAT II Prep Workbooks provide comprehensive SAT II review--one fact at a time--to prepare students to take practice SAT II tests. Each SAT II study guide focuses on fundamental concepts and definitions--a basic overview to begin studying for the SAT II exam. Up to 600 questions and answers, each volume in the SAT II series is a quick and easy, focused read. Reviewing SAT II flash cards is the first step toward more confident SAT II preparation and ultimately, higher SAT II exam scores!

Satan, Cantor, And Infinity And Other Mind-bogglin

by Raymond M. Smullyan

Honorable knights, lying knaves, and other fanciful characters populate this unusual survey of the principles underlying the works of Georg Cantor. Created by a renowned mathematician, these engaging puzzles apply logical precepts to issues of infinity, probability, time, and change. They require a strong mathematics background and feature complete solutions.

Satellite-based Applications on Climate Change

by Alfred Powell John Qu M.V.K. Sivakumar

Climate and other environmental changes are drawing unprecedented concern and attention from national governments, international organizations and local communities. Global warming has left noticeable impacts on the environment and the ecosystems it supports (including humans), and has important implications for sustainable economic and social development in the future. Satellite observations of climate and environmental change have become an increasingly important tool in recent years in helping to shape the response of international communities to this critical global challenge. The book presents the latest advances in satellite-based remote sensing of the Earth's environment - ranging from applications in climate and atmospheric science to hydrology, oceanography, hydrology, geomorphology, ecology and fire studies. Introductory chapters also cover key technical aspects such as instrumentation, calibration, data analysis, and GIS tools for decision-making.

Satellite-Based Earth Observation: Trends And Challenges For Economy And Society

by Christian Brünner Georg Königsberger Hannes Mayer Anita Rinner

The book focuses on the topic of trends and challenges with regards to satellite-based earth observation. Contributors include legal experts in the field and representatives from institutions such as the European Space Agency, the European Space Policy Institute, academia and the private sector.

Satellite-Based Mitigation and Adaptation Scenarios for Sea Level Rise in the Lower Niger Delta (Ihe Delft Phd Thesis Ser.)

by Zahrah Naankwat Musa

The Niger delta with its gentle slope and low elevation is extremely sensitive to effects of climate change. Its adaptive capacity is the second lowest in terms of socio-economic development in Nigeria. Quantitative studies on developing measures for coastal planning and management in the lower Niger delta have been limited by data availability and inaccessibility of parts of the delta. The use of satellite data can help bridge the data gap by providing ancillary data (imagery, elevation, altimetry etc.) that can be used to quantify the effects of SLR in the Niger delta. This thesis uses satellite data as the main source for hydrodynamic modelling and GIS analysis. Until recently such data might not have the accuracy and precision of directly measured data. However recent innovative approaches have enabled better exploitation of satellite data to overcome these limitations and produce adequate results to assess the impact of SLR on the Niger delta in an integrated way that will lead to practical recommendations for adaptation. Using projected global eustatic SLR values in combination with land subsidence, this thesis estimated SLR levels for the Niger delta and its effect on inundation areas and flood extent. The results indicate that the Niger delta is very vulnerable to inundation and that even minimal SLR will affect flooding in the lower Niger delta since the area continues to subside. A new coastal vulnerability index was developed in this thesis by evaluating physical, social and human influence indicators of exposure, susceptibility and resilience. The results show that parts of the Niger delta are highly vulnerable to SLR and need adequate mitigation/adaptation measures to protect them. It is recommended that sustainable local resilience practices already being used in parts of the Niger delta should be included in adaptation planning.

Satellite Boy: The International Manhunt for a Master Thief That Launched the Modern Communication Age

by ANDREW AMELINCKX

Spanning the underworld haunts of Montreal to Havana and Miami in the early days of the Cold War, Satellite Boy reveals the unlikely connection between an audacious bank heist and the &“other Space Race&” that gave birth to the modern communication ageOn April 6, 1965, Georges Lemay was relaxing on his yacht in a south Florida marina following one of the largest and most daring bank heists in Canadian history. For four years, the roguishly handsome criminal mastermind hid in plain sight, eluding capture and the combined efforts of the FBI, Interpol, and the Royal Canadian Mounted Police. His future appeared secure.What Lemay didn&’t know was that less than two hundred miles away at Cape Canaveral, a brilliant engineer named Harold Rosen was about to usher in the age of global live television with the launch of the world&’s first twenty-four-hour commercial communications satellite. Rosen&’s extraordinary accomplishment would not only derail Lemay&’s cushy life but change the world forever.Brimming with criminal panache and technological intrigue, and set against a turbulent and iconic period that includes the moon landing and the civil rights movement, Satellite Boy tells the largely forgotten, high-stakes story of the two equally driven men who inadvertently launched the modern era.

Satellite Communications

by Joseph N. Pelton

The field of satellite communications represents the world's largest space industry. Those who are interested in space need to understand the fundamentals of satellite communications, its technology, operation, business, economic, and regulatory aspects. This book explains all this along with key insights into the field's future growth trends and current strategic challenges. Fundamentals of Satellite Communications is a concise book that gives all of the key facts and figures as well as a strategic view of where this dynamic industry is going. Author Joseph N. Pelton, PhD, former Dean of the International Space University and former Director of Strategic Policy at Intelstat, presents a readable book about the entire essence of the satellite communication field.

Satellite Communications: Self Study Course

by Timothy Pratt Jeremy E. Allnutt

Extensive revision of the best-selling text on satellite communications — includes new chapters on cubesats, NGSO satellite systems, and Internet access by satellite There have been many changes in the thirty three years since the first edition of Satellite Communications was published. There has been a complete transition from analog to digital communication systems, withanalog techniques replaced by digital modulation and digital signal processing. While distribution of television programming remains the largest sector of commercial satellite communications, low earth orbit constellations of satellites for Internet access are set to challenge that dominance. In the third edition, chapters one through three cover topics that are specific to satellites, including orbits, launchers, and spacecraft. Chapters four through seven cover the principles of digital communication systems, radio frequency communications, digital modulation and multiple access techniques, and propagation in the earth’s atmosphere, topics that are common to all radio communication systems. Chapters eight through twelve cover applications that include non-geostationary satellite systems, low throughput systems, direct broadcast satellite television, Internet access by satellite, and global navigation satellite systems. The chapter on Internet access by satellite is new to the third edition, and each of the chapters has been extensively revised to include the many changes in the field since the publication of the second edition in 2003. Two appendices have been added that cover digital transmission of analog signals, and antennas. An invaluable resource for students and professionals alike, this book: Focuses on the fundamental theory of satellite communications Explains the underlying principles and essential mathematics required to understand the physics and engineering of satellite communications Discusses the expansion of satellite communication systems in areas such as direct-broadcast satellite TV, GPS, and internet access Introduces the rapidly advancing field of small satellites, referred to as SmallSats or CubeSats Provides relevant practice problems based on real-world satellite systems Satellite Communications is required reading for undergraduate and postgraduate students in satellite communications courses and an authoritative reference for engineers working in communications, systems and networks, and satellite operations and management.

Satellite Communications Payload and System

by Teresa M. Braun

This is the first book primarily about the satellite payload of satellite communications systems. It represents a unique combination of practical systems engineering and communications theory. It tells about the satellites in geostationary and low-earth orbits today, both the so-called bent-pipe payloads and the processing payloads. The on-orbit environment, mitigated by the spacecraft bus, is described. The payload units (e.g. antennas and amplifiers), as well as payload-integration elements (e.g. waveguide and switches) are discussed in regard to how they work, what they do to the signal, their technology, environment sensitivity, and specifications. At a higher level are discussions on the payload as an entity: architecture including redundancy; specifications--what they mean, how they relate to unit specifications, and how to verify; and specification-compliance analysis ("budgets") with uncertainty. Aspects of probability theory handy for calculating and using uncertainty and variation are presented. The highest-level discussions, on the end-to-end communications system, start with a practical introduction to physical-layer communications theory. Atmospheric effects and interference on the communications link are described. A chapter gives an example of optimizing a multibeam payload via probabilistic analysis. Finally, practical tips on system simulation and emulation are provided. The carrier frequencies treated are 1 GHz and above. Familiarity with Fourier analysis will enhance understanding of some topics. References are provided throughout the book for readers who want to dig deeper.Payload systems engineers, payload proposal writers, satellite-communications systems designers and analysts, and satellite customers will find that the book cuts their learning time. Spacecraft-bus systems engineers, payload unit engineers, and spacecraft operators will gain insight into the overall system. Students in systems engineering, microwave engineering, communications theory, probability theory, and communications simulation and modelling will find examples to supplement theoretical texts.

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