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Sphingosine-1-Phosphate
by Alice Pébay Kursad TurksenSphingosine-1-phosphate is a bioactive lysophospholipid which has become, in recent years, the focus of much research interest as it has widespread developmental and physio-pathological actions, controlling events within the nervous, reproductive, gastrointestinal, vascular, respiratory, and immune systems, in addition to having a prominent role in cancer, early mammalian embryogenesis, and stem cells. In Sphingosine-1-Phosphate: Methods and Protocols, worldwide experts in the S1P field describe in-depth techniques in an array of cell types and with various physiological applications, showcasing the important effects of S1P in development and in physiopathology. As a volume in the Methods in Molecular Biology(tm) series, chapters contain introductions to their respective topics, lists of the relevant materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips for troubleshooting and avoiding known pitfalls. Authoritative and timely, Sphingosine-1-Phosphate: Methods and Protocols is a key resource for scientists working in this expanding and dynamic field.
Sphingosine-1-Phosphate
by Alice Pébay Kursad TurksenSphingosine-1-phosphate is a bioactive lysophospholipid which has become, in recent years, the focus of much research interest as it has widespread developmental and physio-pathological actions, controlling events within the nervous, reproductive, gastrointestinal, vascular, respiratory, and immune systems, in addition to having a prominent role in cancer, early mammalian embryogenesis, and stem cells. In Sphingosine-1-Phosphate: Methods and Protocols, worldwide experts in the S1P field describe in-depth techniques in an array of cell types and with various physiological applications, showcasing the important effects of S1P in development and in physiopathology. As a volume in the Methods in Molecular BiologyTM series, chapters contain introductions to their respective topics, lists of the relevant materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips for troubleshooting and avoiding known pitfalls. Authoritative and timely, Sphingosine-1-Phosphate: Methods and Protocols is a key resource for scientists working in this expanding and dynamic field.
Sphingosine-1-Phosphate Signaling in Immunology and Infectious Diseases
by Michael B. A. Oldstone Hugh RosenThis volume focuses on the role of sphingosine-1-phosphate (S1P) and its analogs in the induced sequestration of lymphocytes in secondary lymphoid organs or in the microenvironment of tissues involved in infection or autoimmune disease. Initial chapters define the pathways to understand S1P signaling. They cover the organization of signaling systems, the structural biology of the S1P1 receptor, and the chemical and genetic tools that are available and useful to explore this area of research and therapeutics. The later chapters highlight S1P and endothelial integrity, lymphocyte migration in the spleen, and S1P agonist in controlling immunopathologic manifestations of acute respiratory influenza virus infection (in the lung), and its accompanying cytokine storm as well as immunopathologic disease of the central nervous system, including the beginning of treatments in multiple sclerosis. One chapter reveals the possible involvement of other lipid molecules, their use for better understanding lipid signaling, and their potential in the modulation of immune responses.
Spi-ku: A Clutter of Short Verse on Eight Legs
by Leslie BulionLeslie Bulion, award-winning educator favorite and master of science poetry, is back with a humorous exploration of the silk-spinning, bungee-jumping, hunting, trapping, trick-filled world of spiders!Meet spiders that spit silk, roll like wheels, scuba dive, hide under trap doors, strum tunes, and so much more. Watch as they find mates, find prey...or find mates that become prey!Award-winning poet Leslie Bulion and illustrator Robert Meganck team up again for this clutter (a collective noun for spiders) of short poems and humorously accurate illustrations celebrating the amazing attributes of Araneae. The book is also packed with helpful sidebars, call-outs, and back matter, including a glossary of science terms, a description of the poetic forms, a list of common and scientific names, a spider-hunting adventure how-to, resources for further study, and a relative-size chart. A feast for science and animal fans!
Spic-and-Span!: Lillian Gilbreth's Wonder Kitchen (Great Idea Series #6)
by Monica KullingBorn into a life of privilege in 1878, Lillian Moller Gilbreth put her pampered life aside for one of adventure and challenge. She and her husband, Frank, became efficiency experts by studying the actions of factory workers. They ran their home efficiently, too. When Frank suddenly died, Lillian was left to her own devices to raise their eleven children. Eventually, she was hired by the Brooklyn Borough Gas Company to improve kitchen design, which was only the beginning. Lillian Gilbreth was the subject of two movies (Cheaper by the Dozen and Belles on Their Toes), the first woman elected to the National Academy of Engineering, and the first female psychologist to have a U.S. postage stamp issued in her honor. A leading efficiency expert, she was also an industrial engineer, a psycologist, an author, a professor, and an inventor.
Spices: Leafy Spices
by V. PrakashLeafy Spices discusses the botany, cultivation, harvesting and processing, chemical composition, processing methods, varietal differences and end uses for the leaves and essential oils of leafy spices. The book emphasizes botany and cultivation, identifies which seasons are best for harvesting to achieve a maximum oil yield, and explains the care needed to ensure successful cultivation and oil extraction. Leaf and oil composition is discussed, and the medicinal uses of the leaves, as well as their use as food flavorings, are examined in detail. Species covered include basil, bay, bergamot, borage, burnet, capers, camomile, chervil, chives, coriander, costmary, curry leaf, marjoram, mint, oregano, parsley, rosemary, sage, savory, tarragon, and thyme. This book is an ideal reference volume for botanists, food scientists, technologists, and flavor chemists.
Spices, Scents and Silk: Catalysts of World Trade
by James HancockSpices, scents and silks were at the centre of world trade for millennia. Exotic luxuries such as cinnamon, ginger, pepper, saffron, clove, frankincense and myrrh. Through their international trade, humans were pushed to explore and then travel to the far corners of the earth. Almost from their inception, the earliest great civilizations - Egypt, Sumer and Harappa - became addicted to the luxury products of far-off lands and established long-reaching trade networks. Over time, great powers fought mightily for the kingdoms where silk, spices and scents were produced. The New World was accidentally discovered by Columbus in his quest for spices. What made trade in these products so remarkable was that the plants producing them grew in very restricted areas of the world, distant from the wealthy civilizations of northern Africa, Greece and Europe. These luxuries could be carried from mysterious locations on the backs of camels or in the holds of ships for months on end, and arrived at their final destination in nearly perfect condition. Once the western world discovered the intoxicating properties of these products, their procurement became a dominant force in the world economy. Nothing else compared with their possible profit returns. In this book, eminent horticulturist and author James Hancock examines the origins and early domestication and culture of spices, scents and silks and the central role they played in the lives of the ancients. The book also traces the development of the great international trade networks and explores how struggles for trade dominance and demand for such luxuries shaped the world. Recommended for academics, students and general readers with an interest in crop and agricultural development, world trade, economic botany, history of food, and global economics and public policy, Spices, Scents and Silk offers a fascinating and insightful history.
Spider Behaviour: Flexibility and Versatility
by Marie Elisabeth HerbersteinSpiders are often underestimated as suitable behavioural models because of the general belief that due to their small brains their behaviour is innate and mostly invariable. Challenging this assumption, this fascinating book shows that rather than having a limited behavioural repertoire, spiders show surprising cognitive abilities, changing their behaviour to suit their situational needs. The team of authors unravels the considerable intra-specific as well as intra-individual variability and plasticity in different behaviours ranging from foraging and web building to communication and courtship. An introductory chapter on spider biology, systematics and evolution provides the reader with the necessary background information to understand the discussed behaviours and helps to place them into an evolutionary context. Highlighting an under-explored area of behaviour, this book will provide new ideas for behavioural researchers and students unfamiliar with spiders as well as a valuable resource for those already working in this intriguing field.
Spider Ecophysiology
by Wolfgang NentwigWith over 43,000 species, spiders are the largest predacious arthropod group. They have developed key characteristics such as multi-purpose silk types, venoms consisting of hundreds of components, locomotion driven by muscles and hydraulic pressure, a highly evolved key-lock mechanism between the complex genital structures, and many more unique features. After 300 million years of evolutionary refinement, spiders are present in all land habitats and represent one of the most successful groups of terrestrial organisms. Ecophysiology combines functional and evolutionary aspects of morphology, physiology, biochemistry and molecular biology with ecology. Cutting-edge science in spiders focuses on the circulatory and respiratory system, locomotion and dispersal abilities, the immune system, endosymbionts and pathogens, chemical communication, gland secretions, venom components, silk structure, structure and perception of colours as well as nutritional requirements. Spiders are valuable indicator species in agroecosystems and for conservation biology. Modern transfer and application technologies research spiders and their products with respect to their value for biomimetics, material sciences, and the agrochemical and pharmaceutical industries.
Spider Homes (Rigby Sails #Red (Level 3-5))
by Ratu MatairaLearn more about all the different places spiders can live.
Spider Silk: Evolution and 400 Million Years of Spinning, Waiting, Snagging, and Mating
by Leslie Brunetta Catherine L. CraigSpiders, objects of eternal human fascination, are found in many places: on the ground, in the air, and even under water. Leslie Brunetta and Catherine Craig have teamed up to produce a substantive yet entertaining book for anyone who has ever wondered, as a spider rappelled out of reach on a line of silk, "How do they do that?" The orb web, that iconic wheel-shaped web most of us associate with spiders, contains at least four different silk proteins, each performing a different function and all meshing together to create a fly-catching machine that has amazed and inspired humans through the ages. Brunetta and Craig tell the intriguing story of how spiders evolved over 400 million years to add new silks and new uses for silk to their survival "toolkit" and, in the telling, take readers far beyond the orb. The authors describe the trials and triumphs of spiders as they use silk to negotiate an ever-changing environment, and they show how natural selection acts at the genetic level and as individuals struggle for survival.
Spider Webs: Behavior, Function, and Evolution
by William EberhardIn this lavishly illustrated, first-ever book on how spider webs are built, function, and evolved, William Eberhard provides a comprehensive overview of spider functional morphology and behavior related to web building, and of the surprising physical agility and mental abilities of orb weavers. For instance, one spider spins more than three precisely spaced, morphologically complex spiral attachments per second for up to fifteen minutes at a time. Spiders even adjust the mechanical properties of their famously strong silken lines to different parts of their webs and different environments, and make dramatic modifications in orb designs to adapt to available spaces. This extensive adaptive flexibility, involving decisions influenced by up to sixteen different cues, is unexpected in such small, supposedly simple animals. As Eberhard reveals, the extraordinary diversity of webs includes ingenious solutions to gain access to prey in esoteric habitats, from blazing hot and shifting sand dunes (to capture ants) to the surfaces of tropical lakes (to capture water striders). Some webs are nets that are cast onto prey, while others form baskets into which the spider flicks prey. Some aerial webs are tramways used by spiders searching for chemical cues from their prey below, while others feature landing sites for flying insects and spiders where the spider then stalks its prey. In some webs, long trip lines are delicately sustained just above the ground by tiny rigid silk poles. Stemming from the author’s more than five decades observing spider webs, this book will be the definitive reference for years to come.
Spiders
by Gail GibbonsThis book talks about the different types of spiders there are sizes,colors poisonous or not and that there are over 30,000 types of spiders and most of them are harmless.
Spiders and Other Arachnids (World Book's Animals of the World)
by Steven OtfinoskiQuestions and Answers about arachnids with a close up on the spider.
Spielwiese Internet: Sucht ohne Suchtmittel
by Kai MüllerInternetsucht ist eine moderne Form einer psychischen Problematik, die offensichtlich immer mehr Menschen etwas angeht, entweder direkt oder indirekt. Wie eine verschwommene Schimäre taucht dieses Schlagwort "Internetsucht" in den Medien auf. Zahlen von Betroffenen, Symptome und Auswirkungen dieses neuen Phänomens werden von unterschiedlichen Experten in unterschiedlicher Weise diskutiert und dennoch bleibt der Nicht-Fachmann nur allzu oft mit mehr Fragen als Antworten zurück. Dieses Buch soll dem Leser einen möglichst umfassenden Einblick vermitteln. Es vermittelt Antworten auf zentrale Fragen, wie z.B.: Was verbirgt sich hinter dem Begriff der Internetsucht? Wann ist ein Verhalten bereits Ausdruck einer Sucht? Welche Menschen sind als besonders gefährdet anzusehen? Welche Maßnahmen können ergriffen werden, um einer Internetsucht zu begegnen? Der aktuelle psychologische Kenntnisstand wurde hierzu nachvollziehbar aufbereitet und in einen engen praxisnahen Bezug gesetzt. Zielgruppen für dieses Werk sind alle, die sich über das Thema Spiel- und Internetsucht informieren möchten sowie alle, die selbst oder in ihrem familiären Umfeld oder Bekanntenkreis Menschen kennen, die davon betroffen sind. Nebenzielgruppe sind alle diejenigen, die im beruflichen Umfeld mit Betroffenen zu tun haben. Der Autor ist Diplompsychologe und arbeitet in der deutschlandweit einzigartigen Ambulanz für Spielsucht. Innerhalb seines beruflichen Umfeldes befasst er sich intensiv mit dem Thema der substanzungebundenen Abhängigkeitserkrankungen (Verhaltenssüchte), hier insbesondere mit der Internet- und Computerspielsucht sowie der Glücksspielsucht.
Spies and Shuttles: NASA's Secret Relationships with the DoD and CIA
by James E. DavidRevealing the connections between NASA and the United States defense communityIn this real life spy saga, James E. David reveals the extensive and largely hidden interactions between NASA and U.S. defense and intelligence departments. The story begins with the establishment of NASA in 1958 and follows the agency through its growth, not only in scope but also in complexity.In Spies and Shuttles, David digs through newly declassified documents to ultimately reveal how NASA became a strange bedfellow to the Department of Defense (DoD) and the Central Intelligence Agency (CIA). He tracks NASA’s early cooperation—supplying cover stories for covert missions, analyzing the Soviet space program, providing weather and other scientific data from its satellites, and monitoring missile tests—that eventually devolved into NASA’s reliance on DoD for political and financial support for the Shuttle. David also examines the restrictions imposed on such activities as photographing the Earth from space and the intrusive review mechanisms to ensure compliance.The ties between NASA and the intelligence community have historically remained unexplored, and David’s riveting book is the first to investigate the twists and turns of this labyrinthine relationship.
Spies in Disguise: Gadgets, Gizmos, and Gear (Spies in Disguise)
by Centum Books LtdSpies in Disguise hits the big screen on December 25, 2019. The all-star cast includes Will Smith, Tom Holland, Karen Gillan, Rashida Jones, and DJ Khaled!Explore the tech world of Spies in Disguise in this action-packed storybook featuring unique gadgets and devices that only Walter could invent.Super spy Lance Sterling and scientist Walter Beckett are almost exact opposites. Lance is smooth, suave and debonair. Walter is... not. But what Walter lacks in social skills he makes up for in smarts and invention, creating the awesome gadgets Lance uses on his epic missions.But when events take an unexpected turn, Walter and Lance suddenly have to rely on each other in a whole new way. And if this odd couple can't learn to work as a team, the whole world is in peril.
The Spike: How Our Lives Are Being Transformed by Rapidly Advancing Technologies
by Damien BroderickThe rate at which technology is changing our world--not just on a global level like space travel and instant worldwide communications but on the level of what we choose to wear, where we live, and what we eat--is staggeringly fast and getting faster all the time. The rate of change has become so fast that a concept that started off sounding like science fiction has become a widely expected outcome in the near future - a singularity referred to as The Spike. At that point of singularity, the cumulative changes on all fronts will affect the existence of humanity as a species and cause a leap of evolution into a new state of being. On the other side of that divide, intelligence will be freed from the constraints of the flesh; machines will achieve a level of intelligence in excess of our own and boundless in its ultimate potential; engineering will take place at the level of molecular reconstruction, which will allow everything from food to building materials to be assembled as needed from microscopic components rather than grown or manufactured; we'll all become effectively immortal by either digitizing and uploading our minds into organic machines or by transforming our bodies into illness-free, undecaying exemplars of permanent health and vitality. The results of all these changes will be unimaginable social dislocation, a complete restructuring of human society and a great leap forward into a dazzlingly transcendent future that even SF writers have been too timid to imagine.At the Publisher's request, this title is being sold without Digital Rights Management Software (DRM) applied.
The Spike: An Epic Journey Through the Brain in 2.1 Seconds
by Mark HumphriesThe story of a neural impulse and what it reveals about how our brains workWe see the last cookie in the box and think, can I take that? We reach a hand out. In the 2.1 seconds that this impulse travels through our brain, billions of neurons communicate with one another, sending blips of voltage through our sensory and motor regions. Neuroscientists call these blips “spikes.” Spikes enable us to do everything: talk, eat, run, see, plan, and decide. In The Spike, Mark Humphries takes readers on the epic journey of a spike through a single, brief reaction. In vivid language, Humphries tells the story of what happens in our brain, what we know about spikes, and what we still have left to understand about them.Drawing on decades of research in neuroscience, Humphries explores how spikes are born, how they are transmitted, and how they lead us to action. He dives into previously unanswered mysteries: Why are most neurons silent? What causes neurons to fire spikes spontaneously, without input from other neurons or the outside world? Why do most spikes fail to reach any destination? Humphries presents a new vision of the brain, one where fundamental computations are carried out by spontaneous spikes that predict what will happen in the world, helping us to perceive, decide, and react quickly enough for our survival.Traversing neuroscience’s expansive terrain, The Spike follows a single electrical response to illuminate how our extraordinary brains work.
Spike Timing: Mechanisms and Function
by Patricia M. DiLorenzo Jonathan D. VictorNeuronal communication forms the basis for all behavior, from the smallest movement to our grandest thought processes. Among the many mechanisms that support these functions, spike timing is among the most powerful and-until recently-perhaps the least studied. In the last two decades, however, the study of spike timing has exploded. The heightened
Spillover: Animal Infections And The Next Human Pandemic
by David Quammen"Science writing as detective story at its best." --Jennifer Ouellette, Scientific American A New York Times Notable Book of the Year, a Scientific American Best Book of the Year, and a Finalist for the National Book Critics Circle Award. Ebola, SARS, Hendra, AIDS, and countless other deadly viruses all have one thing in common: the bugs that transmit these diseases all originate in wild animals and pass to humans by a process called spillover. In this gripping account, David Quammen takes the reader along on this astonishing quest to learn how, where from, and why these diseases emerge and asks the terrifying question: What might the next big one be?
Spillover and Feedback Effects in Low Carbon Development
by Youguo ZhangThis book studies the pathways and policies of regional coordinated low carbon development from the perspective of regional spillover-feedback effects. How do regional economies interact with carbon emission? This phenomena, also known as spillover-feedback effects, is explained in depth with reference to datasets and real examples. As China adopts zero-carbon emissions policies within the context of regional disparities, this theoretical construct is gaining utility, and in this book, climate science researchers and political scientists will find it explicated as never before.
Spillway Design - Step by Step
by Geraldo Magela PereiraMost dam accidents with hydroelectric plants are due to under-dimensioning of the maximum floods of spillway design, causing extravasation and dam breaks (this occurs in 23% of the accidents). This work highlights the relationship between spillway design and potential dam failure and other important aspects of these structures and presents the methodology of design based on the international experience on the subject. The book covers river basin studies and floods (the geology, geomorphology, hydrology, hydraulics, and layouts of the works). Further, spillway function, capacity and design flood, layouts, or arrangements, of hydroelectric works and types of spillways are treated in the book. Finally, the book discusses examples of dams that broke due to insufficient spillway capacity. The book is intended for engineers and the companies that design dams and power plants around the world, as well as students in dam and hydraulic engineering. In short, people interested in producing electricity that is clean and potentially cheaper than other sources.
Spin: From Basic Symmetries to Quantum Optimal Control
by ILYA KUPROVThis monograph is a fundamental reference for scientists and engineers who encounter spin processes in their work. The author, Ilya Kuprov, derives the concept of spin from basic symmetries and gives an overview of theoretical and computational aspects of spin dynamics: from Dirac equation and spin Hamiltonian, through coherent evolution and relaxation theories, to quantum optimal control, and all the way to practical implementation advice for parallel computers.
Spin – Was ist das eigentlich?: Ein abstrakter quantenmechanischer Begriff, experimentelle Nachweise und Anwendungen (essentials)
by Hans Paetz gen. SchieckIn diesem Essential wird gezeigt, dass der Spin einer der fundamentalen Begriffe der Physik ist. Zugleich stellt er eine fundamentale Mess- und Beobachtungsgröẞe dar. Er wurde erst gegen Widerstände akzeptiert, da er nur nicht-klassisch, d.h. auch nur nicht-anschaulich zu verstehen ist. Das hinderte nicht daran, mit dem geeigneten, v.a. von Heisenberg, Schrödinger und Dirac entwickelten Formalismus der Quantentheorie die zunächst unerklärten Beobachtungen richtig zu beschreiben. Ein Beispiel ist das Periodensystem der Elemente, das nur durch den Spin und das Ausschließungsprinzip von Pauli erklärbar ist. Das hat auch eine Vielzahl von Anwendungen bis in die Medizin und Festkörperphysik ermöglicht.