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Structure and Properties of Cell Membrane Structure and Properties of Cell Membranes: Volume I (Structure And Properties Of Cell Membranes Ser.)
by BengaThis book provides in-depth presentations in membrane biology by specialists of international repute. The volumes examine world literature on recent advances in understanding the molecular struc-ture and properties of membranes, the role they play in cellular physiology and cell-cell interactions, and the alterations leading to abnormal cells. Illustrations, tables, and useful appendices com-plement the text. Those professionals actively working in the field of cell membrane investigations as well as biologists, biochemists, biophysicists, physicians, and academicians, will find this work beneficial.
Structure and Properties of Conducting Polymer Composites
by V.E. GulThe development of the principles of electrically conductive polymer composites and the creation of a wide variety of such materials have had a significant influence on modern technology. This volume in the "New Concepts in Polymer Science" series is devoted to various aspects of the structure and properties of electrically conductive polymer composites. This monograph is an attempt to systematize modern ideas on the interconnection of the structure and properties of ECPCs. Specific attention is given to the influence of electric current on kinetics and the direction of chemical interactive processes between such systems and air oxygen. The book also contains a special chapter which is devoted to the practical applications of electrically conductive polymer composites. It should be of use and interest to researchers working in the field.
Structure and Properties of Fat Crystal Networks
by Alejandro G. Marangoni Leendert H. WesdorpLipid science and technology has grown exponentially since the turn of the millennium. The replacement of unhealthy fats in the foods we eat, and of petroleum-based ingredients in the cosmetics we use, is a top priority for consumers, government, and industry alike. Particularly for the food industry, removing trans fats and reducing saturated fat
Structure and Properties of Liquid Crystals
by Lev M. BlinovThis book introduces the most important concepts related to the structure and physical properties of liquid crystals, including some of the theoretical aspects. It consists of three parts: structure, physical properties, and electro-optic behavior.
Structure and Properties of Matter
by Janette SchusterMatter, States of Matter, Physical Properties of Matter, Mixtures, Physical and Chemical Changes, Conserving Matter, Science and Engineering Practices, Careers.
Structure and Properties of Matter Journal
by Battle CenterStudents explore matter in terms of measurable properties and as made up of particles too small to be seen. Students develop an understanding that the number of particles and weight of matter does not change regardless of the changes it goes through.
Structure and Reactions of Light Exotic Nuclei
by Yasuyuki Suzuki Kazuhiro Yabana Rezso G. Lovas Kalman VargaSince the mid-1980s increasing effort has been put into light exotic nuclei, that is light nuclei of unusual composition. The research of the exotic nuclei began with the advent of accelerated beams of such nuclei. This new technique has revitalized nuclear physics, and the facilities producing radioactive ion beams now offer opportunities for pion
Structure-Based Drug Design (Computer-Aided Drug Discovery and Design #2)
by Marcelo A. Marti Adrian Gustavo Turjanski Dario Fernández Do PortoThis volume focuses on target-oriented approximations to drug discovery, including target selection, binding pocket detection, and current uses and variants of molecular dynamics and molecular docking. The primary audience is PhD and graduates working in the field of molecular biology, structural biology, pharmaceutical sciences.
Structure-Based Drug Design
by Pandi VeerapandianIntroducing the most recent advances in crystallography, nuclear magnetic resonance, molecular modeling techniques, and computational combinatorial chemistry, this unique, interdisciplinary reference explains the application of three-dimensional structural information in the design of pharmaceutical drugs. Furnishing authoritative analyses by world-renowned experts, Structure-Based Drug Design discusses protein structure-based design in optimizing HIV protease inhibitors and details the biochemical, genetic, and clinical data on HIV-1 reverse transcriptase presents recent results on the high-resolution three-dimensional structure of the catalytic core domain of HIV-1 integrase as a foundation for divergent combination therapy focuses on structure-based design strategies for uncovering receptor antagonists to treat inflammatory diseases demonstrates a systematic approach to the design of inhibitory compounds in cancer treatment reviews current knowledge on the Interleukin-1 (IL-1) system and progress in the development of IL-1 modulators describes the influence of structure-based methods in designing capsid-binding inhibitors for relief of the common cold and much more!
Structure-Based Drug Discovery
by Leslie W. TariThe last decade has seen the confluence of several enabling technologies that have allowed protein crystallographic methods to live up to their true potential. Taken together, the numerous recent advances have made it possible to tackle difficult biological targets with a high probability of success: intact bacterial ribosomes have been structurally elucidated, as well as eukaryotic trans-membrane proteins like the potassium channel and GPCRs. It is now possible for medicinal chemists to have access to structural information on their latest small molecule candidates bound to the therapeutic target within days of compound synthesis, allowing structure guided ligand optimization to occur in "real time". Structure-Based Drug Discovery presents an array of methods used to generate crystal structures of biological macromolecules, how to leverage the structural information to design novel ligands anew, and how to iteratively optimize hits and convert them to leads. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Structure-Based Drug Discovery aims to provide scientists interested in adding SBDD to their arsenal of drug discovery methods with well-honed, up-to-date methodologies.
Structure, Bonding and Reactivity of Heterocyclic Compounds
by Frank Proft Paul GeerlingsThe series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field.
The Structure Dependent Energy of Organic Compounds (SpringerBriefs in Molecular Science)
by Árpád FurkaThis brief introduces readers to an alternative thermochemical reference system that makes it possible to use the heats of formation of organic compounds to deduce the energies that depend entirely on their structures, and which provides calculated values for most of the characteristic structures appearing in organic molecules. These structure-dependent energies are provided e.g. for selected compounds of normal and cyclic alkanes, open chain and cyclic olefins (including conjugated polyenes), alkynes, aromatic hydrocarbons and their substituted derivatives. The oxygen, sulfur and nitrogen derivatives of the above-mentioned compounds are also represented with calculated structure-dependent energies including alcohols, ethers, aldehydes and ketones, carboxylic acids, thiols, sulfides, amines, amides, heterocyclic compounds and others. Most organic reactions can be interpreted as the disappearance of certain structures and formation of others. If the structure-dependent energies are known, it can be shown how the disappearing and the newly formed structures contribute to the heat of reactions and to the driving forces. As experienced by the author, who pioneered the concept, structure dependent energies can help teachers to make organic chemistry more accessible for their students. Accordingly, the brief offers a valuable resource for all those who teach organic chemistry at universities, and for those who are learning it.
Structure Determination By Spectroscopic Methods: A Practical Approach
by Raul SanMartin Maria Teresa HerreroThe authors travel with the reader through the challenging maze of structure determination, showing how to distinguish between valuable and deceiving data from IR, NMR and MS spectra, extracting structural conclusions and putting all the pieces together to solve the structure elucidation puzzle. Indeed, human reasoning is key to combining the information contained in those bands, signals and peaks by a rationale that enables the makeup of a chemical structure. A number of increasingly more complex problems will act as trip segments and, in addition to the spectra themselves, each chapter is supplemented with figures and tables that decipher the above data and serve as maps for the journey.
Structure Determination by X-ray Crystallography
by Mark Ladd Rex PalmerThe advances in and applications of x-ray and neutron crystallography form the essence of this new edition of this classic textbook, while maintaining the overall plan of the book that has been well received in the academic community since the first edition in 1977. X-ray crystallography is a universal tool for studying molecular structure, and the complementary nature of neutron diffraction crystallography permits the location of atomic species in crystals which are not easily revealed by X-ray techniques alone, such as hydrogen atoms or other light atoms in the presence of heavier atoms. Thus, a chapter discussing the practice of neutron diffraction techniques, with examples, broadens the scope of the text in a highly desirable way. As with previous editions, the book contains problems to illustrate the work of each chapter, and detailed solutions are provided. Mathematical procedures related to the material of the main body of the book are not discussed in detail, but are quoted where needed with references to standard mathematical texts. To address the computational aspect of crystallography, the suite of computer programs from the fourth edition has been revised and expanded. The programs enable the reader to participate fully in many of the aspects of x-ray crystallography discussed in the book. In particular, the program system XRAY* is interactive, and enables the reader to follow through, at the monitor screen, the computational techniques involved in single-crystal structure determination, albeit in two dimensions, with the data sets provided. Exercises for students can be found int the book, and solutions are available to instructors.
Structure Determination of HIV-1 Tat/Fluid Phase Membranes and DMPC Ripple Phase Using X-Ray Scattering
by Kiyotaka AkaboriThis Thesis in biological physics has two components, describing the use of X-ray scattering techniques to study the structure of two different stacked lipid membrane systems. The first part focuses on the interaction between a short 11-mer peptide, Tat, which is part of the Tat protein in the HIV-1 virus. Although highly positively charged, the Tat protein has been shown to translocate through hydrocarbon lipid bilayers easily, without requiring the cell's energy, which is counter to its Born self-energy. In this work Tat's location in the headgroup region was demonstrated using a combined X-ray scattering and molecular dynamics approach. Bilayer thinning was observed as well as softening of different membrane mimics due to Tat. It was concluded that Tat's headgroup location, which increases the area/lipid, and its bilayer softening likely reduce the energy barrier for passive translocation. The second part is a rigorous investigation of an enigmatic phase in the phase diagram of the lipid dimyristoylphosphatidylcholine (DMPC). The ripple phase has fascinated many researchers in condensed matter physics and physical chemistry as an example of periodically modulated phases, with many theoretical and simulation papers published. Despite systematic studies over the past three decades, molecular details of the structure were still lacking. By obtaining the highest resolution X-ray data so far, this work revealed the complex nature of the chain packing, as well as confirming that the major side is thicker than the minor side of the saw-tooth ripple structure. The new model shows that the chains in the major arm are tilted with respect to the bilayer normal and that the chains in the minor arm are slightly more disordered than all-trans gel-phase chains, i. e. , the chains in the minor arm are more fluid-like. This work provides the highest resolution X-ray structure of the ripple phase to-date.
Structure Elucidation in Organic Chemistry
by Maria-Magdalena Cid Jorge BravoIntended for advanced readers, this is a review of all relevant techniques for structure analysis in one handy volume. As such, it provides the latest knowledge on spectroscopic and related techniques for chemical structure analysis, such as NMR, optical spectroscopy, mass spectrometry and X-ray crystallography, including the scope and limitation of each method. As a result, readers not only become acquainted with the techniques, but also the advantages of the synergy between them. This enables them to choose the correct analytical method for each problem, saving both time and resources. Special emphasis is placed on NMR and its application to absolute configuration determination and the analysis of molecular interactions. Adopting a practical point of view, the author team from academia and industry guarantees both solid methodology and applications essential for structure determination, equipping experts as well as newcomers with the tools to solve any structural problem.
Structure, Evidence, and Heuristic: Evolutionary Biology, Economics, and the Philosophy of Their Relationship (Routledge Studies in the Philosophy of Science)
by Armin W. SchulzThis book is the first systematic treatment of the philosophy of science underlying evolutionary economics. It does not advocate an evolutionary approach towards economics, but rather assesses the epistemic value of appealing to evolutionary biology in economics more generally. The author divides work in evolutionary economics into three distinct, albeit related, forms: a structural form, an evidential form, and a heuristic form. He then analyzes five examples of work in evolutionary economics falling under these three forms. For the structural form, he examines the parallelism between natural selection and economic decision making, and the parallelism between natural selection and market competition. For the evidential form, he looks at the relationship between animal and human economic decision making, and the evolutionary explanation of diversity in human economic decision making. Finally, for the heuristic form, he focuses on the plausibility of equilibrium modeling in evolutionary ecology and economics. In this way, he shows that linking evolutionary biology and economics can make for a powerful methodological tool that can enable progress in our understanding of various economics questions. Structure, Evidence, and Heuristic will be of interest to scholars and advanced students working in philosophy of science, philosophy of social science, evolutionary biology, and economics.
Structure Formation in Modified Gravity Cosmologies
by Alexandre BarreiraThis unique thesis covers all aspects oftheories of gravity beyond Einstein's General Relativity, from setting up theequations that describe the evolution of perturbations, to determining thebest-fitting parameters using constraints like the microwave backgroundradiation, and ultimately to the later stages of structure formation usingstate-of-the-art N-body simulations and comparing them to observations ofgalaxies, clusters and other large-scale structures. This truly ground-breakingwork puts the study of modified gravity models on the same footing as thestandard model of cosmology. Since the discovery of the accelerating expansionof the Universe, marked by the awarding of the 2011 Nobel Prize in Physics,there has been a growing interest in understanding what drives thatacceleration. One possible explanation lies in theories of gravity beyondEinstein's General Relativity. This thesis addresses all aspects of the problem,an approach that is crucial to avoiding potentially catastrophic biases in theinterpretation of upcoming observational missions.
Structure & Function of the Body
by Kevin T. Patton Gary A. ThibodeauGet a solid understanding of the human body! Using simple, conversational language and vivid animations and illustrations, Structure & Function of the Body, 16th Edition introduces the normal structure and function of the human body and what the body does to maintain homeostasis. To help make difficult A&P concepts easy to understand, this new edition features thoroughly revised content and review questions which reflect the most current information available and a unique 22-page, semi-transparent insert of the human body. Plus, Connect It! boxes throughout directly correlate to online content giving you additional clinical and scientific insights essential to patient care!
Structure & Function of the Body 13th Edition
by Gary A. Thibodeau Kevin T. PattonThis textbook concentrates on the normal structures and function of the human body and on what the body does to maintain homeostasis. Chapters discuss topics like biochemistry, cells and tissue, the various organ systems, the senses, blood, immunity, nutrition and metabolism, fluid and electrolyte balance, acid-base balance, and growth and development. Approximately 330 color illustrations and cadaver photographs visually represent the anatomy under discussion. Thibodeau taught biology at the University of Wisconsin-River Falls. Patton teaches life sciences at Saint Charles Community College. Annotation ©2004 Book News, Inc. , Portland, OR (booknews. com)
Structure in Protein Chemistry
by Jack KyteThe second edition of Structure in Protein Chemistry showcases the latest developments and innovations in the field of protein structure analysis and prediction. The book begins by explaining how proteins are purified and describes methods for elucidating their sequences of amino acids and defining their posttranslational modifications. Comprehensive explanations of crystallography and of noncovalent forces-ionic interactions, hydrogen bonding, and the hydrophobic effect-act as a prelude to an exhaustive description of the atomic details of the structures of proteins. The resulting understanding of protein molecular structure forms the basis for discussions of the evolution of proteins, the symmetry of the oligomeric associations that produce them, and the chemical, mathematical, and physical basis of the techniques used to study their structures. The latter include image reconstruction, nuclear magnetic resonance spectroscopy, proton exchange, optical spectroscopy, electrophoresis, covalent cross-linking, chemical modification, immunochemistry, hydrodynamics, and the scattering of light, X-radiation, and neutrons. These procedures are applied to study the folding of polypeptides and the assembly of oligomers. Biological membranes and their proteins are also discussed. Structure in Protein Chemistry, Second Edition, bridges the gap between introductory biophysical chemistry courses and research literature. It serves as a comprehensive textbook for advanced undergraduates and graduate students in biochemistry, biophysics, and structural and molecular biology. Professionals engaged in chemical, biochemical, and molecular biological research will find it a useful reference.
Structure of Approximate Solutions of Optimal Control Problems
by Alexander J. ZaslavskiThis title examines the structure of approximate solutions of optimal control problems considered on subintervals of a real line. Specifically at the properties of approximate solutions which are independent of the length of the interval. The results illustrated in this book look into the so-called turnpike property of optimal control problems. The author generalizes the results of the turnpike property by considering a class of optimal control problems which is identified with the corresponding complete metric space of objective functions. This establishes the turnpike property for any element in a set that is in a countable intersection which is open everywhere dense sets in the space of integrands; meaning that the turnpike property holds for most optimal control problems. Mathematicians working in optimal control and the calculus of variations and graduate students will find this book useful and valuable due to its presentation of solutions to a number of difficult problems in optimal control and presentation of new approaches, techniques and methods.
The Structure of Biological Membranes
by Philip L. YeagleBiological membranes provide the fundamental structure of cells and viruses. Because much of what happens in a cell or in a virus occurs on, in, or across biological membranes, the study of membranes has rapidly permeated the fields of biology, pharmaceutical chemistry, and materials science. The Structure of Biological Membranes, Third Edition pro