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The Initiation of DNA Replication in Eukaryotes
by Daniel L. KaplanEvery time a cell divides, a copy of its genomic DNA has to be faithfully copied to generate new genomic DNA for the daughter cells. The process of DNA replication needs to be precisely regulated to ensure that replication of the genome is complete and accurate, but that re-replication does not occur. Errors in DNA replication can lead to genome instability and cancer. The process of replication initiation is of paramount importance, because once the cell is committed to replicate DNA, it must finish this process. A great deal of progress has been made in understanding how DNA replication is initiated in eukaryotic cells in the past ten years, but this is the first one-source book on these findings. The Initiation of DNA Replication in Eukaryotes will focus on how DNA replication is initiated in eukaryotic cells. While the concept of replication initiation is simple, its elaborate regulation and integration with other cell processes results in a high level of complexity. This book will cover how the position of replication initiation is chosen, how replication initiation is integrated with the phases of the cell cycle, and how it is regulated in the case of damage to DNA. It is the cellular protein machinery that enables replication initiation to be activated and regulated. We now have an in-depth understanding of how cellular proteins work together to start DNA replication, and this new resource will reveal a mechanistic description of DNA replication initiation as well.
The Inner Clock: Living in Sync with Our Circadian Rhythms
by Lynne PeeplesHow the groundbreaking science of circadian rhythms can help you sleep better, feel happier, and improve your overall health Your body contains a symphony of tiny timepieces, synchronized to the sun and subtle signals in your environment and behavior. But modern insults like artificial light, contrived time zones, and late-night meals can wreak havoc on your internal clocks. Armed with advances in biology and technology, a circadian renaissance is reclaiming those lost rhythms. The Inner Clock explores the emerging science and its transformative applications: How could taking a walk in the morning and going to bed at the same time each night keep your body in sync? Why are some doctors prescribing treatments at specific times of day? And how might a better understanding of our circadian rhythms improve educational outcomes, optimize sports performance, and support the longevity of our planet? Science journalist Lynne Peeples seeks out the scientists, astronauts, athletes, and patients at the forefront of a growing movement. Along the way, she sleeps in a Cold War-era bunker, chases the midnight sun, spits into test tubes, and wears high-tech light sensors to decipher what makes our internal clocks tick and how we can reset them for the better.
The Inner Life of Cats: The Science And Secrets Of Our Mysterious Feline Companions
by Thomas McnameeOur feline companions are much-loved but often mysterious. In The Inner Life of Cats, Thomas McNamee blends scientific reportage with engaging, illustrative anecdotes about his own beloved cat, Augusta, to explore and illuminate the secrets and enigmas of her kind. As it begins, The Inner Life of Cats follows the development of the young Augusta while simultaneously explaining the basics of a kitten's physiological and psychological development. As the narrative progresses, McNamee also charts cats' evolution, explores a feral cat colony in Rome, tells the story of Augusta's life and adventures, and consults with behavioral experts, animal activists, and researchers, who will help readers more fully understand cats. McNamee shows that with deeper knowledge of cats' developmental phases and individual idiosyncrasies, we can do a better job of guiding cats' maturation and improving the quality of their lives. Readers' relationships with their feline friends will be happier and more harmonious because of this book.
The Innovation Butterfly
by Nitin R. Joglekar Edward G. Anderson Jr.Product and service innovations are the result of mutually interacting creative and coordination tasks within a system that has to balance technical decisions, marketplace taste, personnel management, and stakeholder commitment. The constituent elements of such systems are often scattered across multiple firms and across the globe and constitute a complex system consisting of many interacting parts. In the spirit of the "butterfly effect", metaphorically describing the sensitivity to initials conditions of chaotic systems, this book builds an argument that "innovation butterflies" can, in the short term, take up significant amounts of effort and sap efficiencies within individual innovation projects. Such "innovation butterflies" can be prompted by external forces such as government legislation or unexpected spikes in the price of basic goods (such as oil), unexpected shifts in market tastes, or from a company manager's decisions or those of its competitors. Even the smallest change, the smallest disruption, to this system can steer a firm down an unpredictable and irreversibly different path in terms of technology and market evolution. In the long term, they can shift the balance of the entire innovation portfolio into unplanned directions. More importantly, we describe how innovation leaders can influence the emergent behavior of the system for good or ill. The first half of the book draws parallels from physics, economics, and sociology as well as evidence from multiple industries to describe the structural and behavioral causes of emergent phenomena in innovation settings as well as their often negative impacts. In the second half of the book, we turn to distributed management of innovation under emergence. We show that innovation butterflies, if improperly managed, most often lead to negative outcomes. On the other hand, it is also argued that while the complexity of the innovation system and the desire to experiment and try new and emergent alternatives precludes precise planning, innovation leaders can actually tame innovation butterflies through the design and implementation of appropriate processes, strategies, tools and leadership choices.
The Innovator's Cookbook
by Steven JohnsonEssential reading-and progressive thinking-on the subject of innovation, from the national bestselling author. Steven Johnson, an acknowledged bestselling leader on the subject of innovation, gathers-for a foundational text on the subject of innovation-essays, interviews, and cutting-edge insights by such exciting field leaders as Peter Drucker, Richard Florida, Eric Von Hippel, Dean Keith Simonton, Arthur Koestler, John Seely Brown, and Marshall Berman. Johnson also provides new material from Marisa Mayer of Google, Twitter's Biz Stone and Jack Dorsey, and Ray Ozzie, Microsoft's former Chief Software Architect. With additional commentary by Johnson himself, this book reveals the innovation found in a wide range of fields, including science, technology, energy, transportation, education, art, and sociology, making it vital, fresh, and fascinating reading for our time, and for the future.
The Innovator's Dilemma: When New Technologies Cause Great Firms to Fail
by Clayton M. ChristensenThe book describes why excellent companies did everything right in spite of the competition, listened to customers and invested assertively in new technologies but still lost their market leadership when confronted with disruptive changes.
The Innovators Behind Leonardo: The True Story of the Scientific and Technological Renaissance
by Plinio InnocenziThis engaging book places Leonardo da Vinci’s scientific achievements within the wider context of the rapid development that occurred during the Renaissance. It demonstrates how his contributions were not in fact born of isolated genius, but rather part of a rich period of collective advancement in science and technology, which began at least 50 years prior to his birth.Readers will discover a very special moment in history, when creativity and imagination were changing the future—shaping our present. They will be amazed to discover how many technological inventions had already been conceived or even designed by the engineers and inventors who preceded Leonardo, such as Francesco di Giorgio and Taccola, the so-called Siena engineers. This engaging volume features a wealth of illustrations from a variety of original sources, such as manuscripts and codices, enabling the reader to see and judge for him or herself the influence that other Renaissance engineers and inventors had on Leonardo.
The Inquisition of Climate Science
by James PowellModern science is under the greatest and most successful attack in recent history. An industry of denial, abetted by news media and "info-tainment" broadcasters more interested in selling controversy than presenting facts, has duped half the American public into rejecting the facts of climate science—an overwhelming body of rigorously vetted scientific evidence showing that human-caused, carbon-based emissions are linked to warming the Earth. The industry of climate science denial is succeeding: public acceptance has declined even as the scientific evidence for global warming has increased. It is vital that the public understand how anti-science ideologues, pseudo-scientists, and non-scientists have bamboozled them. We cannot afford to get global warming wrong—yet we are, thanks to deniers and their methods.The Inquisition of Climate Science is the first book to comprehensively take on the climate science denial movement and the deniers themselves, exposing their lack of credentials, their extensive industry funding, and their failure to provide any alternative theory to explain the observed evidence of warming. In this book, readers meet the most prominent deniers while dissecting their credentials, arguments, and lack of objectivity. James Lawrence Powell shows that the deniers use a wide variety of deceptive rhetorical techniques, many stretching back to ancient Greece. Carefully researched, fully referenced, and compellingly written, his book clearly reveals that the evidence of global warming is real and that an industry of denial has deceived the American public, putting them and their grandchildren at risk.
The Insect & Spider Collections of the World (CRC Press Revivals)
by Ross H. Arnett, Jr. G. Allan Samuelson Gordon M. NishidaFirst published in 1993, completely rewritten, this second edition includes a list of all 210 countries of the world and all of the islands, with comments on the existence of insect and spider collections, both public and private. These listings are arranged alphabetically by country, state/province, and city, with private collections listed under the public collection with which they are registered. Part II of the directory is an alphabetical list of the codes assigned to each of the collections described in Part I. This list is also cross-referenced to variations of the codes used in other works, which will eliminate any confusion over this duplication. This classic work provides a ready reference to all collections and is required by all insect and spider systematists.
The Insect Cookbook
by Marcel Dicke Françoise Takken-Kaminker Arnold Van Huis Henk Van Gurp Diane Blumenfeld-SchaapInsects will be appearing on our store shelves, menus, and plates within the decade. In The Insect Cookbook, two entomologists and a chef make the case for insects as a sustainable source of protein for humans and a necessary part of our future diet. They provide consumers and chefs with the essential facts about insects for culinary use, with recipes simple enough to make at home yet boasting the international flair of the world's most chic dishes.Insects are delicious and healthy. A large proportion of the world's population eats them as a delicacy. In Mexico, roasted ants are considered a treat, and the Japanese adore wasps. Insects not only are a tasty and versatile ingredient in the kitchen, but also are full of protein. Furthermore, insect farming is much more sustainable than meat production. The Insect Cookbook contains delicious recipes; interviews with top chefs, insect farmers, political figures, and nutrition experts (including chef René Redzepi, whose establishment was elected three times as "best restaurant of the world"; Kofi Annan, former secretary-general of the United Nations; and Daniella Martin of Girl Meets Bug); and all you want to know about cooking with insects, teaching twenty-first-century consumers where to buy insects, which ones are edible, and how to store and prepare them at home and in commercial spaces.
The Insect Cookbook: Food for a Sustainable Planet (Arts and Traditions of the Table: Perspectives on Culinary History)
by Marcel Dicke Arnold van Huis Henk van GurpThe Definitive Guide to Insects as a Sustainable Food SourceIn The Insect Cookbook, two entomologists and a chef make the case for insects as a sustainable source of protein for humans and a necessary part of our future diet. They provide consumers and chefs with the essential facts about insects for culinary use, with recipes simple enough to make at home yet boasting the international flair of the world's most chic dishes."Invite politicians to dinner and let them tell the world how delicious it is.... They will proudly go around and say, 'I ate crickets, I ate locusts, and they were delicious.'"—Kofi Annan The Insect Cookbook features delicious recipes and interviews with top chefs, insect farmers, political figures, and nutrition experts, including chef René Redzepi, whose establishment was elected three times as "best restaurant of the world"; Kofi Annan, former secretary-general of the United Nations; and Daniella Martin of Girl Meets Bug. The book contains all you need to know about cooking with insects, where to buy them, which ones are edible, and how to store and prepare them at home and in commercial spaces.
The Insect Crisis: The Fall of the Tiny Empires That Run the World
by Oliver MilmanA devastating examination of how collapsing insect populations worldwide threaten everything from wild birds to the food on our plate. From ants scurrying under leaf litter to bees able to fly higher than Mount Kilimanjaro, insects are everywhere. Three out of every four of our planet’s known animal species are insects. In The Insect Crisis, acclaimed journalist Oliver Milman dives into the torrent of recent evidence that suggests this kaleidoscopic group of creatures is suffering the greatest existential crisis in its remarkable 400-million-year history. What is causing the collapse of the insect world? Why does this alarming decline pose such a threat to us? And what can be done to stem the loss of the miniature empires that hold aloft life as we know it? With urgency and great clarity, Milman explores this hidden emergency, arguing that its consequences could even rival climate change. He joins the scientists tracking the decline of insect populations across the globe, including the soaring mountains of Mexico that host an epic, yet dwindling, migration of monarch butterflies; the verdant countryside of England that has been emptied of insect life; the gargantuan fields of U.S. agriculture that have proved a killing ground for bees; and an offbeat experiment in Denmark that shows there aren’t that many bugs splattering into your car windshield these days. These losses not only further tear at the tapestry of life on our degraded planet; they imperil everything we hold dear, from the food on our supermarket shelves to the medicines in our cabinets to the riot of nature that thrills and enlivens us. Even insects we may dread, including the hated cockroach, or the stinging wasp, play crucial ecological roles, and their decline would profoundly shape our own story. By connecting butterfly and bee, moth and beetle from across the globe, the full scope of loss renders a portrait of a crisis that threatens to upend the workings of our collective history. Part warning, part celebration of the incredible variety of insects, The Insect Crisis is a wake-up call for us all.
The Insect Epiphany: How Our Six-Legged Allies Shape Human Culture
by Barrett KleinFrom entomologist Barrett Klein comes a buzz-worthy exploration of the many ways insects have affected human society, history, and culture Insects surround us. They fuel life on Earth through their roles as pollinators, predators, and prey, but rarely do we consider the outsize influence they have had on our culture and civilization. Their anatomy and habits inform how we live, work, create art, and innovate. Featuring nearly 250 color images—from ancient etchings to avant-garde art, from bug-based meals to haute couture—The Insect Epiphany proves that our world would look very different without insects, not just because they are crucial to our ecosystems, but because they have shaped and inspired so many aspects of what makes us human.
The Insects
by P. J. Gullan P. S. CranstonInsects represent over half of the planet's biological diversity. This popular textbook provides a comprehensive introduction to this extraordinary diversity, and places entomology central to the theory and practice of evolutionary and ecological studies.Fully revised, this fifth edition opens with a chapter concerning the popular side of insect studies, including insects in citizen science, zoos and butterfly houses, and insects as food for humans and animals. Key features of insectstructure, function, behaviour, ecology and classification are integrated with appropriate molecular studies. Much of the book is organized around major biological themes: living on the ground, in water, on plants, in colonies, and as predators, parasites/parasitoids and prey insects. A strong evolutionary theme is maintained throughout.There is major revision to the chapter on systematics and a new chapter, Insects in a Changing World, includes insect responses to, and the consequences of, both climate change and human-assisted global alterations to distributions. Updated 'Taxoboxes' demonstrate topical issues and provide concise information on all aspects of each of the 28 major groupings (orders) of insects, plus the three orders of non-insect hexapods. New boxes describe a worrying increase in insect threats to landscape and commercial trees (including eucalypts, palms and coffee) and explain the value of genetic data, including evolutionary developmental biology and DNA barcoding, in insect biodiversity studies.The authors maintain the clarity and conciseness of earlier editions, and extend the profuse illustrations with new hand-drawn figures. Over 50 colour photographs, together with the informative text and an accompanying website with links to video clips, appendices, textboxes and further reading lists, encourage a deeper scientific study of insects. The book is intended as the principal text for students studying entomology, as well as a reference text for undergraduate and graduate courses in the fields of ecology, agriculture, fisheries and forestry, palaeontology, zoology, and medical and veterinary science.
The Inside Story: Understanding the Power of Feelings
by The Editors at HeartMathWith exercises in each chapter, the book explores our 3 brains and how they produce our emotions.
The Instinct to Heal: Curing Stress, Anxiety, and Depression without Drugs and Without Talk Therapy
by David Servan-SchreiberRecent discoveries about the emotional brain show we can heal naturally from stress and depression. Award-winning psychiatrist and neuroscientist David Servan-Schreiber, M.D., Ph.D., presents seven methods for faster, more dramatic, and permanent results for patients who want to leave suffering behind and live joyful, happy lives.<P> The methods presented in this book, taken from case histories, have all been proven to work in clinical tests. They are based on the self-healing mechanisms of the emotional brain, which controls the body, as opposed to the cognitive brain, which manipulates symbols and language. Dr. Servan-Schreiber considers the influence of the heart upon the brain, explores the use of EMDR (eye-movement desensitization and reprocessing) to recover from trauma, and explains how to reset your biological clock to avoid symptoms from seasonal depression.<P> We learn how the biochemistry of touch and love can heal emotional wounds, and we also learn how to use acupuncture, nutrition, and exercise to control our moods. An international bestseller, this is the first book on the market to answer the public's questions about the new alternatives to conventional psychopharmaceuticals, as well as traditional talk therapy. By reprogramming their emotional brains, people struggling with stress, anxiety, and depression can rediscover the balance and well-being needed to transform their lives.
The Institution of Science and the Science of Institutions
by Marcel HerbstThe present anthology, edited by Marcel Herbst, is partially based on a conference, held in 2009, to reflect on the legacy of Ben-David, and contains a selection of substantially revised papers, plus four contributions specifically written for this volume. The book focuses on three major lines of Ben-David's research, namely "Center and Periphery" (Part I), "Role and Ethos" (Part II), and "Organization and Growth" (Part III). In addition, comprehensive introductory ("Prologue") and concluding chapters ("Epilogue", Part IV) by Marcel Herbst are provided. The volume addresses the following disciplines: higher education, history and sociology of science, philosophy of science, history of medicine, public administration, policy studies, Jewish studies, and economics. The anthology is one of two new publications on Joseph Ben-David after the special Minerva edition Vol. 25, Numbers 1-2, March 1987, and Gad Freudenthal's collection of Ben-David's writings [1991]. The text can be used in graduate studies, it addresses higher education professionals or public officials, and serves as a gateway to researchers in the field of higher education, science studies, or policy sciences.
The Instructional Design Trainer’s Guide: Authentic Practices and Considerations for Mentoring ID and Ed Tech Professionals
by Jill E. Stefaniak Rebecca M. ReeseThe Instructional Design Trainer’s Guide provides foundational concepts and actionable strategies for training and mentoring instructional design and educational technology students to be effective across contexts. ID faculty are charged with bridging the gap between research and practice preparing graduate students for the real-world workforce. This book provides trainers and university programs with authentic learning experiences that better articulate the practices of and demands on design and technology professionals in the field. Through this enhanced perspective, learners will be better positioned to confidently embrace constraints, work among changing project expectations, interact with multiple stakeholders, and convey to employers the skills and competencies gleaned from their formal preparation.
The Instructional Design Trainer’s Guide: Authentic Practices and Considerations for Mentoring ID and Ed Tech Professionals
by Jill E. Stefaniak Rebecca M. ReeseThe Instructional Design Trainer’s Guide provides foundational concepts and actionable strategies for training and mentoring instructional design and educational technology students to be effective across contexts. ID faculty are charged with bridging the gap between research and practice preparing graduate students for the real-world workforce. This book provides trainers and university programs with authentic learning experiences that better articulate the practices of and demands on design and technology professionals in the field. Through this enhanced perspective, learners will be better positioned to confidently embrace constraints, work among changing project expectations, interact with multiple stakeholders, and convey to employers the skills and competencies gleaned from their formal preparation.
The Instrument of Science: Scientific Anti-Realism Revitalised (Routledge Studies in the Philosophy of Science)
by Darrell P. RowbottomRoughly, instrumentalism is the view that science is primarily, and should primarily be, an instrument for furthering our practical ends. It has fallen out of favour because historically influential variants of the view, such as logical positivism, suffered from serious defects. In this book, however, Darrell P. Rowbottom develops a new form of instrumentalism, which is more sophisticated and resilient than its predecessors. This position—‘cognitive instrumentalism’—involves three core theses. First, science makes theoretical progress primarily when it furnishes us with more predictive power or understanding concerning observable things. Second, scientific discourse concerning unobservable things should only be taken literally in so far as it involves observable properties or analogies with observable things. Third, scientific claims about unobservable things are probably neither approximately true nor liable to change in such a way as to increase in truthlikeness. There are examples from science throughout the book, and Rowbottom demonstrates at length how cognitive instrumentalism fits with the development of late nineteenth- and early twentieth-century chemistry and physics, and especially atomic theory. Drawing upon this history, Rowbottom also argues that there is a kind of understanding, empirical understanding, which we can achieve without having true, or even approximately true, representations of unobservable things. In closing the book, he sets forth his view on how the distinction between the observable and unobservable may be drawn, and compares cognitive instrumentalism with key contemporary alternatives such as structural realism, constructive empiricism, and semirealism. Overall, this book offers a strong defence of instrumentalism that will be of interest to scholars and students working on the debate about realism in philosophy of science.
The Integrated Nervous System: A Systematic Diagnostic Case-Based Approach, Second Edition
by Walter J. Hendelman Christopher R. Skinner Peter HumphreysThis innovative textbook is modelled on problem-based learning. It bridges the gap between academic neuroanatomy and clinical neurology and effectively takes the reader from the classroom to the clinic, so that learning can be applied in practice. This second edition has been updated and expanded to include many more clinical cases within both the book and the accompanying Wweb site. Significant additions include abbreviated presentation of the history and neurologic examination of all the cases on the web site (now numbering over 50) within the text at the end of each of the clinical chapters. new ‘maps’ -- visual representations of the clinical motor, sensory and reflex findings. the web site further expands the cases – presenting them in detail, and providing an ‘expert’ commentary to discuss the reasoning for the localization and etiological diagnosis. This book and the associated Web site will be of practical value to all the professionals who deal with people who have neurological conditions, as well as being invaluable to medical students and residents. This includes physiatrists (rehabilitation medicine specialists), physiotherapists, occupational therapists and speech therapists, and nurses who specialize in the care of neurological patients. We think that this text will also be of value for family physicians and specialists in internal medicine and pediatrics, all of whom must differentiate between organic pathology of the nervous system and other conditions.
The Integrated Stress Response: Methods and Protocols (Methods in Molecular Biology #2428)
by Daniel Matějů Jeffrey A. ChaoThis volume provides an up-to-date collection of protocols describing some of the key methods to investigate the integrated stress response (ISR), a vital evolutionarily conserved mechanism that enables eukaryotic cells to adapt to stress conditions and alter their gene expression programs. The content of the book is split between techniques to analyze mRNA translation regulation and methods to analyze interaction networks and ribonucleoprotein (RNP) granules. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, The Integrated Stress Response: Methods and Protocols serves as an ideal guide to help accelerate research into the complex and fascinating biology of the ISR.
The Integration of Internet of Toys in Early Childhood Education: Research from Australia, England, and Norway (Evolving Families)
by Ioanna Palaiologou Sarika Kewalramani Maria DardanouThis book offers a fresh look at recent developments in policy, curricula and pedagogical discourse around children’s play with Internet of Toys (IoToys). By expanding the notion of digital and smart play perspectives in early childhood education, the authors critique and develop the broader subject area of IoToys play to better serve its end users. The book brings together research from across three different countries: Australia, Norway and England. It offers tangible examples of how one can use IoToys to build children’s social skills, emotional intelligence, sense of achievement, collaboration and aspects of STEM and design play thinking processes. The learning stories of children’s IoToys play will deliver a comprehensive review of how practitioners and parents can come together to build communities of practice for (re)enhancing children’s learning and growth using evolving technology-based play and engage in paradigmatic debates. Readers as a result will better appreciate the growth in pragmatic applications of technologies together with theoretical perspectives. The book will be a valuable resource for any academic or practitioner just beginning to understand the complexities and success stories of integrating IoToys for children’s playful learning.
The Integration of the Humanities and Arts with Sciences, Engineering, and Medicine in Higher Education: Branches From The Same Tree
by Engineering Medicine National Academies of SciencesIn the United States, broad study in an array of different disciplines —arts, humanities, science, mathematics, engineering— as well as an in-depth study within a special area of interest, have been defining characteristics of a higher education. But over time, in-depth study in a major discipline has come to dominate the curricula at many institutions. This evolution of the curriculum has been driven, in part, by increasing specialization in the academic disciplines. There is little doubt that disciplinary specialization has helped produce many of the achievement of the past century. Researchers in all academic disciplines have been able to delve more deeply into their areas of expertise, grappling with ever more specialized and fundamental problems. Yet today, many leaders, scholars, parents, and students are asking whether higher education has moved too far from its integrative tradition towards an approach heavily rooted in disciplinary “silos”. These “silos” represent what many see as an artificial separation of academic disciplines. This study reflects a growing concern that the approach to higher education that favors disciplinary specialization is poorly calibrated to the challenges and opportunities of our time. The Integration of the Humanities and Arts with Sciences, Engineering, and Medicine in Higher Education examines the evidence behind the assertion that educational programs that mutually integrate learning experiences in the humanities and arts with science, technology, engineering, mathematics, and medicine (STEMM) lead to improved educational and career outcomes for undergraduate and graduate students. It explores evidence regarding the value of integrating more STEMM curricula and labs into the academic programs of students majoring in the humanities and arts and evidence regarding the value of integrating curricula and experiences in the arts and humanities into college and university STEMM education programs.
The Integrative Functions of The Basal Ganglia
by Henry YinThis volume is the first comprehensive and single-authored book on the functions of the basal ganglia. The goal is to provide a new synthesis of diverse areas of research on the basal ganglia, from cellular mechanisms of synaptic transmission and plasticity to neural circuit mechanisms underlying behavior. A global theory of basal ganglia function incorporating research from the last 40 years is presented. I hope to explain for the first time how the basal ganglia generate behavior, how they contribute to learning and memory, and how impairments in basal ganglia function can lead to neurological and psychiatric disorders. Features The only single-authored book on the basal ganglia with coverage of the latest literature. Spans multiple levels of analysis, from cellular physiology to behavior. Includes coverage of clinical symptoms, encompassing neuropsychology, movement disorders, and psychiatric disorders. Discusses the role of the basal ganglia in learning and memory.