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Vaccines for Neglected Pathogens: Focus on Leprosy, Leishmaniasis, Melioidosis and Tuberculosis
by Myron ChristodoulidesThis book reviews successes and (remaining) challenges in vaccine development for the selected Neglected Tropical Diseases (NTD) of Leprosy, Leishmaniasis, Meliodoisis and Tuberculosis, which are a continuous burden for millions of people in affected areas worldwide. Written by frontline researchers, the volume deep-dives into different vaccine strategies, provides biotechnological background information and also tackles animal models in NTD therapeutics research. By bringing together state-of-the-art expert knowledge, the book contributes to the aim of ultimately ending the epidemics of neglected tropical diseases, complying with UN Sustainable Development Goal 3, Health and Well-Being.The volume highlights the activities of the research network VALIDATE (VAccine deveLopment for complex Intracellular neglecteD pAThogEns), funded by the Medical Research Council in the UK. The four NTDs discussed in the book were selected as these are in the focus of VALIDATE’s research.The book targets scientists and clinicians working on NTDs, as well as all readers with a background in biomedicine and interest in vaccine development.This is an open access book.
Vaccines, Medicines and COVID-19: How Can WHO Be Given a Stronger Voice? (SpringerBriefs in Public Health)
by Germán VelásquezThis open access book is a collection of research papers on COVID-19 by Germán Velásquez from 2020 and early 2021 that help to answer the question: How can an agency like the World Health Organization (WHO) be given a stronger voice to exercise authority and leadership? The considerable health, economic and social challenges that the world faced at the beginning of 2020 with COVID-19 continued and worsened in many parts of the world in the second-half of 2020 and into 2021. Many of these countries and nations wanted to explore COVID-19 on their own, sometimes without listening to the main international health bodies such as WHO, an agency of the United Nations system with long-standing experience and vast knowledge at the global level and of which all countries in the world are members. In this single volume, the chapters present the progress of thinking and debate — particularly in relation to drugs and vaccines — that would enable a response to the COVID-19 pandemic or to subsequent crises that may arise. Among the topics covered:COVID-19 Vaccines: Between Ethics, Health and EconomicsMedicines and Intellectual Property: 10 Years of the WHO Global StrategyRe-thinking Global and Local Manufacturing of Medical Products After COVID-19Rethinking R&D for Pharmaceutical Products After the Novel Coronavirus COVID-19 ShockIntellectual Property and Access to Medicines and VaccinesThe World Health Organization Reforms in the Time of COVID-19Vaccines, Medicines and COVID-19: How Can WHO Be Given a Stronger Voice? is essential reading for negotiators from the 194 member countries of the World Health Organization (WHO); World Trade Organization (WTO) and World Intellectual Property Organization (WIPO) staff participating in these negotiations; academics and students of public health, medicine, health sciences, law, sociology and political science; and intergovernmental organizations and non-governmental organizations that follow the issue of access to treatments and vaccines for COVID-19.
Vacuum: Science, Technology and Applications
by Pramod NaikVacuum plays an important role in science and technology. The study of interaction of charged particles, neutrals and radiation with each other and with solid surfaces requires a vacuum environment for reliable investigations. Vacuum has contributed immensely to advancements made in nuclear science, space, metallurgy, electrical/electronic technology, chemical engineering, transportation, robotics and many other fields. This book is intended to assist students, scientists, technicians and engineers to understand the basics of vacuum science and technology for application in their projects. The fundamental theories, concepts, devices, applications, and key inventions are discussed.
Vacuum and Ultravacuum: Physics and Technology
by Igor BelloVacuum technology has enormous impact on human life in many aspects and fields, such as metallurgy, material development and production, food and electronic industry, microelectronics, device fabrication, physics, materials science, space science, engineering, chemistry, technology of low temperature, pharmaceutical industry, and biology. All decorative coatings used in jewelries and various daily products—including shiny decorative papers, the surface finish of watches, and light fixtures—are made using vacuum technological processes. Vacuum analytical techniques and vacuum technologies are pillars of the technological processes, material synthesis, deposition, and material analyses—all of which are used in the development of novel materials, increasing the value of industrial products, controlling the technological processes, and ensuring the high product quality. Based on physical models and calculated examples, the book provides a deeper look inside the vacuum physics and technology.
Vacuum Bubbling: Techniques and Applications
by Yong Du JunVacuum Bubbling introduces the background and applications for generating bubbles under a vacuum condition, accomplished through depressurization without the need to heat water. It presents the advantage of utilizing vapor bubble in deaeration applications because the diffusion for degassing happens between the water body and micro vapor bubbles without the need of membrane or packing.Instead of relying on massive heating, vacuum bubbling focuses on depressurization down to the level of saturated vapor pressure or below to secure vapor bubbles with virtually zero dissolved non-condensable gases, including oxygen. The book considers prospective applications, such as extracting high-oxygen-content air from water for underwater breathing, pretreatment of aircraft fuel before being pumped into a fuel tank system, and probable desalination applications through massive bubbling combined with low-grade renewable energy.The book is intended for researchers in thermal fluids, heat and mass transfer, process engineering, and water treatment fields and industry professionals working in power generation, plant and process engineering, transportation, and energy.
Vacuum Circuit Breaker for Aviation Variable Frequency Power System: Theory and Application of Arc in Electrical Apparatus (Power Systems)
by Qing Li Yuan JiangThis book introduces the concepts of more electric aircraft and aviation electrical appliances, as well as the aviation experimental platform of vacuum switches, the interruption characteristics, frequency characteristics and post-arc breakdown characteristics of intermediate frequency vacuum switches, etc. It is the first monograph on protection electrical appliances, vacuum interrupter in aviation variable frequency power system. This book includes a lot of experimental process and chart analysis for readers to understand and provides references for practical engineering problems. This book could be used as references for engineers and technicians working on electric power systems in aircrafts.
Vacuum in Particle Accelerators: Modelling, Design and Operation of Beam Vacuum Systems
by Oleg B. MalyshevA unique guide on how to model and make the best vacuum chambers Vacuum in Particle Accelerators offers a comprehensive overview of ultra-high vacuum systems that are used in charge particle accelerators. The book?s contributors ? noted experts in the field ? also highlight the design and modeling of vacuum particle accelerators. The book reviews vacuum requirements, identifies sources of gas in vacuum chambers and explores methods of removing them. In addition, Vacuum in Particle Accelerators offers an in-depth explanation of the control of the beam and the beam aperture. In the final part of the book, the focus is on the modelling approaches for vacuum chambers under various operating conditions. This important guide: -Offers a review of vacuum systems in charge particle accelerators -Contains contributions from an international panel of noted experts in the field -Highlights the systems, modelling, and design of vacuum particle accelerators -Includes information on vacuum requirements, beam-gas interactions, cryogenic temperatures, ion induced pressure instability, heavy ion machines -Presents the most up-to-date information on the topic for scientists and engineers Written for vacuum physicists, vacuum engineers, plasma physicists, materials scientists, and engineering scientists, Vacuum Particle Accelerators is an essential reference offering an in-depth exploration of vacuum systems and the modelling and design of charged particle accelerators.
The Vacuum Interrupter: Theory, Design, and Application
by Paul G. SladeTitle: The Vacuum Interrupter: Theory, Design, and ApplicationShelving guide: Electrical EngineeringDr. Paul Slade draws from his nearly six decades of active experience to develop this second edition of The Vacuum Interrupter: Theory, Design, and Application. This book begins by discussing the design requirements for high voltage vacuum interrupters and then the contact requirements to interrupt the vacuum arc. It then continues by describing the various applications in which the vacuum interrupter is generally utilized.Part 1 of this book begins with a detailed review of the vacuum breakdown process. It continues by covering the steps necessary for the design and the manufacture of a successful vacuum interrupter. The vacuum arc is then discussed, including how it is affected as a function of current. An overview of the development and use of practical contact materials, along with their advantages and disadvantages, follows. Contact designs that are introduced to control the high current vacuum arc are also analyzed.Part 2, on application, begins with a discussion of the arc interruption process for low current and high current vacuum arcs. It examines the voltage escalation phenomenon that can occur when interrupting inductive circuits. The occurrence of contact welding for closed contacts subjected to the passage of high currents, and for contacts when closing on high currents, is explored. The general requirements for the successful manufacture and testing of vacuum circuit breakers is then presented. The general application of vacuum interrupters to switch load currents, especially when applied to capacitor circuits, is also given. The interruption of high short circuit currents is presented along with the expected performance of the two major contact designs.Owing to the ever-increasing need for environmentally friendly circuit protection devices, the development and application of the vacuum interrupter will only increase in the future. At present the vacuum circuit breaker is the technology of choice for distribution circuits (5kV to 40.5kV). It is increasingly being applied to transmission circuits (72.5kV to 242kV). In the future, its application for protecting high voltage DC networks is assured.Audience This is a practical source book for engineers and scientists interested in studying the development and application of the vacuum interrupter Research scientists in industry and universities Graduate students beginning their study of vacuum interrupter phenomena Design engineers applying vacuum interrupters in vacuum switches, vacuum contactors, vacuum circuit breakers, and vacuum contactors It provides a unique and comprehensive review of all aspects of vacuum interrupter technology for those new to the subject and for those who wish to obtain a deeper understanding of its science and application Scientists and engineers, who are beginning their research into vacuum breakdown and aspects of the vacuum arc, will find the extensive bibliography and phenomenological descriptions to be a useful introduction
Vacuum Technology in the Chemical Industry
by Wolfgang JorischBased on the very successful German edition and a seminar held by the German Engineers` Association (VDI) on a regular basis for years now, this English edition has been thoroughly updated and revised to reflect the latest developments. It supplies in particular the special aspects of vacuum technology, applied vacuum pump types and vacuum engineering in the chemical, pharmaceutical and process industry application-segments. The text includes chapters dedicated to latest European regulations for operating in hazardous zones with vacuum systems, methods for process pressure control and regulation and leak detection. All of the authors work or did work at a selection of the most important German companies involved in vacuum technology, and their expertise is disseminated here for engineers working in vacuum technology, chemical process design, plant operation, and mechanical engineering.
Vadose Zone Hydrology
by Daniel B. StephensVadose Zone Hydrology describes the elements of the physical processes most often encountered by hydrogeologists and ground-water engineers in their vadose zone projects. It illustrates the application of soil physics to practical problems relevant to the characterization and monitoring of the vadose zone. It includes an introduction to physical processes, including basic flow theory, and provides examples of important field-scale processes that must be recognizable by hydrogeologists. Considerable attention is given to the concepts of recharge, including how it is most accurately evaluated in the vadose zone. Field and laboratory methods for characterizing hydraulic properties in the vadose zone are also covered, and case studies illustrating these methods are provided. New and emerging technologies for monitoring the vadose zone, particularly for the purpose of detecting contaminants, are highlighted. In the last section of the book, additional case studies are presented, demonstrating applications related to seepage detection, landfill monitoring, and soil gas investigations.This book is written from the perspective of hydrogeologists and is designed to be directly applicable and to maintain continuity and consistency between chapters. It will be an invaluable primer for environmental or geotechnical consultants, regulators, or students who have no prior formal academic training in unsaturated flow concepts. Because the text contains some of the latest advances in this field, it will be an excellent reference for geologists and engineers currently working on problems of vadose zone hydrology.
Vagina Obscura: An Anatomical Voyage
by Rachel E. GrossA myth-busting voyage into the female body. A camera obscura reflects the world back but dimmer and inverted. Similarly, science has long viewed woman through a warped lens, one focused narrowly on her capacity for reproduction. As a result, there exists a vast knowledge gap when it comes to what we know about half of the bodies on the planet. That is finally changing. Today, a new generation of researchers is turning its gaze to the organs traditionally bound up in baby-making—the uterus, ovaries, and vagina—and illuminating them as part of a dynamic, resilient, and ever-changing whole. Welcome to Vagina Obscura, an odyssey into a woman’s body from a fresh perspective, ushering in a whole new cast of characters. In Boston, a pair of biologists are growing artificial ovaries to counter the cascading health effects of menopause. In Melbourne, a urologist remaps the clitoris to fill in crucial gaps in female sexual anatomy. Given unparalleled access to labs and the latest research, journalist Rachel E. Gross takes readers on a scientific journey to the center of a wonderous world where the uterus regrows itself, ovaries pump out fresh eggs, and the clitoris pulses beneath the surface like a shimmering pyramid of nerves. This paradigm shift is made possible by the growing understanding that sex and gender are not binary; we all share the same universal body plan and origin in the womb. That’s why insights into the vaginal microbiome, ovarian stem cells, and the biology of menstruation don’t mean only a better understanding of female bodies, but a better understanding of male, non-binary, transgender, and intersex bodies—in other words, all bodies. By turns funny, lyrical, incisive, and shocking, Vagina Obscura is a powerful testament to how the landscape of human knowledge can be rewritten to better serve everyone.
Valerian: The Genus Valeriana
by Peter J. HoughtonValerian, is an up-to-date treatment of all aspects of this very important genus of plants, used in the traditional medicine of many parts of the world, particularly as a sedative. It includes material written by experts dealing with a variety of aspects including the ethnobotany, chemistry, pharmacology, cultivation, analysis and commercial aspects of Valeriana.This book will be of interest to all those concerned with the study and use of medicinal and aromatic plants and provides a comprehensive and contemporary overview of the status of this particular genus.
Validated Cleaning Technologies for Pharmaceutical Manufacturing
by Destin A. LeBlancWritten by an expert for those who must design validatable cleaning processes and then validate those processes, this book discusses interdependent topics from various technical areas and disciplines. It shows how each piece of the cleaning process fits into the validation program, making it more defensible in both internal quality audits and exter
Validating Medical Packaging
by Ronald PilchikAccording to the FDA Quality System Regulations, manufacturers must ensure that "device packaging and shipping containers are designed and constructed to protect the device from alteration or damage during the customary conditions of processing, storage, handling, and distribution." As specific as this statement is, the FDA does not provide instruc
Validation and Qualification in Analytical Laboratories
by Ludwig HuberThis Second Edition discusses ways to improve pharmaceutical product quality while achieving compliance with global regulatory standards. With comprehensive step-by-step instructions, practical recommendations, standard operating procedures (SOPs), checklists, templates, and graphics for easy incorporation in a laboratory. This title
Validation and Reconstruction of Remote Sensing Land Surface Temperature Products
by Wei Zhou Lei Fan Wenping Yu Yuechen Li Xujun Han Mingguo Ma Weiyu ShiThis book focuses on validation and reconstruction work on the land surface temperature (LST) products retrieved by thermal infrared remote sensing. The LST is a key parameter in the energy-water balance process and has been widely used in research on the global climate change, water cycle, vegetation growing, and drought detection. Remote sensing retrieving LST is the most important source for regional and even global application. However, there are several factors that limited their widespread use: (1) the thermal infrared remote sensing is easily influenced by clouds; therefore, there are lots of pixel with invalid LST; (2) LST products have not been sufficiently validated in global scale. This book arms to overcome above defects and guide the readers to estimate the LST of cloudy pixel and implement the general validation on the remote sensing LST. Furthermore, it helps to understand the scale mismatch between different observation and land surface heterogeneity. The book covers ground-based observation, validation and reconstruction theories, scale mismatch analysis, heterogeneity and representativeness evaluation for observations, and application cases. It is an essential reference to the quantitative retrieval of thermal infrared remote sensing technologies.
Validation Compliance Annual: 1995
by International Validation Forum"Offers an overview of validation and the current regulatory climate and provides a compendium of the regulations, guidance documents, issues, compliance tools, terminology, and literature involved in computer systems validation. Thoroughly examines regulations issued by the U.S. Food and Drug Administration, the U.S. Environmental Protection Agency, and the European Union. Furnishes case studies of real-world situations."
Validation for Medical Device and Diagnostic Manufacturers
by Carol V. Desain Charmaine V. SuttonImplementation of FDA's Design Control requirements (21 CFR 820.30) changed an entire industry. Quality System Requirements defined the approach to medical device validation. Product design, manufacturing process, and test method validation studies must be performed before or as a product is transferred to commercial production. Validation studies
Validation of Bioanalytical Methods (essentials)
by Patric U. Vogelthis book, the validation of bioanalytical methods is described. In the quality control of biological medicinal products, bioanalytical methods are frequently used to check important properties such as the content or possible impurities. The methods used must provide trustworthy results so that no false conclusions are drawn when evaluating the results. The trustworthiness is ensured by validation. The validation of bioanalytical methods is illustrated by means of some examples.
Validation of Computerized Analytical Systems
by Ludwig HuberValidation of Computerized Analytical and Networked Systems provides the definitive rationales, logic, and methodology for validation of computerized analytical systems. Whether you are involved with formulation or analytical development laboratories, chemical or microbiological quality control laboratories, LIMS installations, or any aspect of robotic in a healthcare laboratory, this book furnishes complete validation details.International and FDA regulations and requirements are discussed and juxtaposed with numerous practical examples that show you how to cost-effectively and efficiently accomplish validation acceptable to FDA GCP/GLP/GMP, NAMAS, and EN45001 standards. The templates included provide documentation examples and the many checklists found throughout the book assure that all aspects of covered in a logical sequence. The chapters describe and explain such topics as the Product Life Cycle revalidation, change control, documentation requirements, qualifications, testing, data validation and traceability, inspection, SOPs, and many other that help streamline the validation process.
Validierung bioanalytischer Methoden (essentials)
by Patric U. VogelIn diesem Buch wird die Validierung bioanalytischer Methoden beschrieben. Bei der Qualitätskontrolle von biologischen Arzneimitteln kommen häufig bioanalytische Methoden zum Einsatz, um wichtige Eigenschaften wie den Gehalt oder mögliche Verunreinigungen zu überprüfen. Die eingesetzten Methoden müssen vertrauenswürdige Ergebnisse liefern, damit bei der Bewertung der Ergebnisse keine falschen Schlüsse gezogen werden. Die Vertrauenswürdigkeit wird durch eine Validierung sichergestellt. Die Validierung von bioanalytischen Methoden wird anhand einiger Beispiele dargestellt.
Validierung in der Analytik (Die Praxis der instrumentellen Analytik)
by Stavros KromidasDie Validierung von Methoden und Geräten ist eine elementare Aufgabe in jedem analytischen Labor. Erstmals liegt mit diesem Band der Reihe eine praktische Einführung für den Anwender vor. In didaktisch bewährter Form werden die einzelnen Validierungsparameter ausführlich erklärt, kommentiert und ihre Verknüpfung erläutert. Der Leser wird sukzessiv durch die Validierungsschritte geführt, von der Fragestellung bis zur Bewertung der Ergebnisse und Plausibilitätsbetrachtung. Er erhält konkrete Hilfestellung in Form von Fallbeispielen, Checklisten und Diagrammen sowie durch Antworten auf typische Fragen und Hinweise zur Vermeidung typischer Fehler. Ergänzend dazu enthält das Buch ein Glossar und einen Anhang mit nützlichen weiterführenden Informationen. Es ist der Begleiter für alle Anwender, die validieren müssen. Aus Rezensionen bereits erschienener Bände: 'Das sehr empfehlenswerte Werk ist didaktisch geschickt formuliert und illustriert [...]. Es setzt die bewährte Reihe zur Praxis der instrumentellen Analytik fort und sollte in keiner einschlägigen Fachbibliothek fehlen.' (Die Pharmazeutische Industrie) 'Besonders lehrreich für den Anfänger ist die Vielzahl von praktischen Beispielen' (Die Nahrung)
Validity Assessment in Clinical Neuropsychological Practice: Evaluating and Managing Noncredible Performance (Evidence-Based Practice in Neuropsychology)
by Ryan W. Schroeder and Phillip K. MartinPractical and comprehensive, this is the first book to focus on noncredible performance in clinical contexts. Experts in the field discuss the varied causes of invalidity, describe how to efficiently incorporate validity tests into clinical evaluations, and provide direction on how to proceed when noncredible responding is detected. Thoughtful, ethical guidance is given for offering patient feedback and writing effective reports. Population-specific chapters cover validity assessment with military personnel; children; and individuals with dementia, psychiatric disorders, mild traumatic brain injury, academic disability, and other concerns. The concluding chapter describes how to appropriately engage in legal proceedings if a clinical case becomes forensic. Case examples and sample reports enhance the book's utility.
Valorisation of Agro-industrial Residues – Volume I: Biological Approaches (Applied Environmental Science and Engineering for a Sustainable Future)
by Zainul Akmar Zakaria Ramaraj Boopathy Julian Rafael DibAgriculture and industry are the two most important economic sectors for various countries around the globe, providing millions of jobs as well as being the main source of income for these countries. Nevertheless, with the increasing demand for agricultural and industrial produce, huge amounts of waste are also being produced. Without proper management, this waste (both liquid and solid) poses a serious threat to overall environmental quality, mainly due to its toxicity and slow degradation processes. Current approaches are effective but would normally require huge capital investments, are labour intensive and generate potential hazardous by-products. As such, there is a need for alternative approaches that are cheaper, easier-to-handle and have a minimum potential impact on environmental quality. This book presents up-to-date approaches using biological techniques to manage the abundance of waste generated from agricultural and industrial activities. It discusses techniques such as bioconversion, biodegradation, biotransformation, and biomonitoring as well as the utilization of these wastes. A number of chapters also include individual case studies to enhance readers’ understanding of the topics. This comprehensive book is a useful resource for anyone involved in agricultural and industrial waste management, green chemistry or biotechnology. It is also recommended as a reference work for graduate students and all agriculture and biotechnology libraries.