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Varicella-zoster Virus: Genetics, Pathogenesis and Immunity (Current Topics in Microbiology and Immunology #438)
by Ann M. Arvin Jennifer F. Moffat Allison Abendroth Stefan L OliverThis edited volume provides insights about the molecular virology, pathoenesis of infection and host responses to varicella-zoster virus, which is a medically important human herpesvirus. The chapters not only discuss genetics and molecular evolution of the virus, but also new structure-based knowledge on the functions of viral glycoproteins. Further, the authors illustrate how mechanisms from the virus are used to take over and remodel host cells during pathogeneis. These mechanisms also enable viral modulation of host cells and evasion of the host immune response. Part of these evasion and survival strategies, is the reaction to triggered host cell responses like autophagy, the stress response, modulation of apoptosis and other cell death pathways. This hands-on knowledge is crucial for students and clinicians in Virology, Immunology, and Infectious Diseases.Chapter "Common features between stroke following varicella in children and stroke following herpes zoster in adults" is available open access under a Creative Commons Attribution 4.0 International License via Springerlink.com.
The Varieties of Religious Experience
by William JamesIn The Varieties of Religious Experience: A Study in Human Nature, Dr. William James takes aim at the nature of religion from a scientific/academic point of view-something that had, until this landmark work, been sorely missed. James believed that the study of the origin of an object or concept should not play a role in the study of its value. As an example, he alluded to the Quaker religion and its founder, George Fox. Many scientists immediately reject all aspects of the Quaker religion because evidence suggests that Fox was schizophrenic. Calling this rejection medical materialism, he insisted that the origin of Fox's notions about religion should not be considered when placing a value on them. He pointed out that many believed El Greco to have suffered from astigmatism, yet no one would dismiss his art based on this medical detail. "Scientific theories are organically conditioned just as much as religious emotions are; and if we only knew the facts intimately enough, we should doubtless see 'the liver' determining the dicta of the sturdy atheist as decisively as it does those of the Methodist under conviction anxious about his soul. When it alters in one way the blood that percolates it, we get the Methodist, when in another way, we get the atheist form of mind."- Dr. William James
The Varieties of Scientific Experience
by Carl Sagan Ann DruyanCarl Sagan's prophetic vision of the tragic resurgence of fundamentalism and the hope-filled potential of the next great development in human spirituality The late great astronomer and astrophysicist describes his personal search to understand the nature of the sacred in the vastness of the cosmos. Exhibiting a breadth of intellect nothing short of astounding, Sagan presents his views on a wide range of topics, including the likelihood of intelligent life on other planets, creationism and so-called intelligent design, and a new concept of science as "informed worship." Originally presented at the centennial celebration of the famous Gifford Lectures in Scotland in 1985 but never published, this book offers a unique encounter with one of the most remarkable minds of the twentieth century.
The Varieties of Scientific Experience: A Personal View of the Search for God
by Carl Sagan Ann DruyanCarl Sagan's prophetic vision of the tragic resurgence of fundamentalism and the hope-filled potential of the next great development in human spirituality <P> The late great astronomer and astrophysicist describes his personal search to understand the nature of the sacred in the vastness of the cosmos. Exhibiting a breadth of intellect nothing short of astounding, Sagan presents his views on a wide range of topics, including the likelihood of intelligent life on other planets, creationism and so-called intelligent design, and a new concept of science as "informed worship." Originally presented at the centennial celebration of the famous Gifford Lectures in Scotland in 1985 but never published, this book offers a unique encounter with one of the most remarkable minds of the twentieth century.
Varieties of Scientific Realism
by Evandro AgazziThis book offers a comprehensive update on the scientific realism debate, enabling readers to gain a novel appreciation of the role of objectivity and truth in science and to understand fully the various ways in which antirealist conceptions have been subjected to challenge over recent decades. Authoritative representatives of different philosophical traditions explain their perspectives on the meaning and validity of scientific realism and describe the strategies being adopted to counter persisting antirealist positions. The coverage extends beyond the usual discussion of realism within the context of the natural sciences, and especially physics, to encompass also its applicability in mathematics, logic, and the human sciences. The book will appeal to all with an interest in the recent realist epistemologies of science, the nature of current philosophical debate, and the ongoing rehabilitation of truth as the legitimate goal of scientific research.
The Varnish and the Glaze: Painting Splendor with Oil, 1100–1500
by Marjolijn BolA new history of the techniques, materials, and aesthetic ambitions that gave rise to the radiant verisimilitude of Jan van Eyck’s oil paintings on panel. Panel painters in both the middle ages and the fifteenth century created works that evoke the luster of precious stones, the sheen of polished gold and silver, and the colorful radiance of stained glass. Yet their approaches to rendering these materials were markedly different. Marjolijn Bol explores some of the reasons behind this radical transformation by telling the history of the two oil painting techniques used to depict everything that glistens and glows—varnish and glaze. For more than a century after his death, the fifteenth-century painter Jan van Eyck was widely credited with inventing varnish and oil paint, on account of his unique visual realism. Once this was revealed to be a myth, the verisimilitude of his work was attributed instead to a new translucent painting technique: the glaze. Today, most theories about how Van Eyck achieved this realism revolve around the idea that he was the first to discover or refine the glazing technique. Bol, however, argues that, rather than being a fifteenth-century refinement, varnishing and glazing began centuries before. Drawing from an extensive body of recipes, Bol pieces together how varnishes and glazes were first developed as part of the medieval art of material mimesis. Artisans embellished metalwork and wood with varnishes and glazes to imitate gold and gems; infused rock crystal with oil, resin, and colorants to imitate more precious minerals; and oiled parchment to transform it into the appearance of green glass. Likewise, medieval panel painters used varnishes and glazes to create the look of enamel, silk, and more. The explorations of materials and their optical properties by these artists stimulated natural philosophers to come up with theories about transparent and translucent materials produced by the earth. Natural historians, influenced by medieval artists’ understanding of refraction and reflection, developed theories about gems, their creation, and their optical qualities.
Varying Gravity
by Helge KraghThe main focus of this book is on the interconnection of two unorthodox scientific ideas, the varying-gravity hypothesis and the expanding-earth hypothesis. As such, it provides a fascinating insight into a nearly forgotten chapter in both the history of cosmology and the history of the earth sciences. The hypothesis that the force of gravity decreases over cosmic time was first proposed by Paul Dirac in 1937. In this book the author examines in detail the historical development of Dirac's hypothesis and its consequences for the structure and history of the earth, the most important of which was that the earth must have been smaller in the past.
Vascular Access in Neonates and Children
by Daniele G. Biasucci Nicola Massimo Disma Mauro PittirutiThis is a practical guide to pediatric vascular access. It covers how to use ultrasound appropriately, how to prevent and manage early and late complications, and how to correctly place the catheter tip using ECG or radiology. It includes all the most modern approaches and devices. In particular, the best approach for some specific populations is covered, including neonates and infants, complex patients, and children with cancer or renal failure requiring long term treatments. A guide on how to establish a vascular access team in a pediatric hospital is included, including the costs and benefits of having this hospital-based team. Vascular Access in Neonates and Children is aimed at pediatric anesthesists and surgeons, and radiologists, pediatricians and other specialities may also find it of interest.
Vascular Biology Protocols
by Jun Ren Nair SreejayanOver the past decades, the pathogenesis, diagnosis, treatment and prevention of cardiovascular diseases have been benefited significantly from intensive research activities. In order to provide a comprehensive "manual" in a field that has become as broad and deep as cardiovascular medicine, this volume of "Methods in Molecular Medicine" covers a wide spectrum of in vivo and in vitro techniques encompassing biochemical, pharmacological and molecular biology disciplines which are currently used to assess vascular disease progression. Each chapter included in this volume focuses on a specific vascular biology technique and describes various applications as well as caveats of these techniques. The protocols included here are described in detail, allowing beginners with little experience in the field of vascular biology to embark on new research projects.
Vascular Biomechanics: Concepts, Models, and Applications
by T. Christian GasserThis textbook serves as a modern introduction to vascular biomechanics and provides the comprehensive overview of the entire vascular system that is needed to run successful vascular biomechanics simulations. It aims to provide the reader with a holistic analysis of the vascular system towards its biomechanical description and includes numerous fully through-calculated examples. Various topics covered include vascular system descriptions, vascular exchange, blood vessel mechanics, vessel tissue characterization, blood flow mechanics, and vascular tissue growth and remodeling. This textbook is ideally suited for students and researchers studying and working in classical and computational vascular biomechanics. The book could also be of interest to developers of vascular devices and experts working with the regulatory approval of biomedical simulations.Follows the principle of “learning by doing” and provides numerous fully through-calculated examples for active learning, immediate recall, and self-examination;Provides a holistic understanding of vascular functioning and the integration of information from different disciplines to enable students to use sophisticated numerical methods to simulate the response of the vascular system;Includes several case studies that integrate the presented material. Case studies address problems, such as the biomechanical rupture risk assessment of Abdominal Aortic Aneurysms, Finite Element analysis of structural and blood flow problems, the computation of wall stress and wall shear stress in the aorta.
Vascular CT Angiography Manual
by Robert Pelberg Wojciech MazurDespite the exponential growth in the use of peripheral CTA in the diagnosis and follow-up of vascular disease patients, practical sources from which to gain valuable expertise in this field remain scarce. There is becoming a great need for experts in the field of peripheral CTA, yet learning this imaging modality may be intimidating and time consuming. Very few if any, small, concise and portable books exist to ease training in this field and current books in this field are overwhelming, difficult to manage, text books that often combine CTA and MRI. A so called " how to manual" and reference guide to explain this technique from beginning to end, which compiles valuable, and difficult to obtain clinical pearls and descriptions of disease processes will be of tremendous value. The Peripheral CT Angiography Manual aims to make learning this intimidating technique and the diseases for which it applies simple and fun.
Vascular Differentiation and Plant Hormones
by Roni AloniThe book is intended as a guide for molecular biology students, equipping them to successfully study plants. It pursues a holistic approach, viewing the whole plant as an integrated operating organism, and is written in a straightforward manner, making it appealing to anyone interested in plants. Further, it reflects the latest findings for scientists and students in the fields of plant sciences, biology, agriculture, forestry, ecology, vascular medicine and cancer, discussing e.g. how hormonal signals induce and regulate simple and complex patterns in plants vascular tissues, their adaptation and evolution. • written by a world-renowned expert who has worked in the field for 50 years • covers the field from the initial studies conducted more than a century ago up to recent studies with up-to-date explanations• describes in details the structure, development, physiology and basic molecular biology of plants’ vascular tissues, their function, regeneration and environmental adaptation• explores the controlling mechanisms of plant vascular differentiation by continuously moving hormonal signals and their precursors• discusses the regulation of stem cells and cambium, control of gradients in vascular cell size along the plant, juvenile-adult transition and rejuvenation, grafting, mechanisms of recovery from bending by reaction wood, evolution of vessels and fibers from tracheids, regulation of ring-porous wood evolution, protecting mechanisms against insects and pathogens, parasitism, plant cancer, and more• helps readers understand the scope and breadth of plant vascular systems in 20 detailed, high-quality chapters• includes a wealth of outstanding original color photographs and illustrations documenting the formation of vascular tissues• provides an in-depth understanding of plant biology by studying their vascular tissues
Vascular Effects of Hydrogen Sulfide: Methods and Protocols (Methods in Molecular Biology #2007)
by Jerzy BełtowskiThis book explores techniques for exploring hydrogen sulfide (H2S) and its effects on the vascular system through numerous experimental animal models and vascular preparations. Alterations of vascular H2S generation/signaling may be involved in the pathogenesis of systemic and pulmonary arterial hypertension, ischemic heart disease, ischemic stroke, preeclampsia, and erectile dysfunction, and H2S also serves as an attractive target for pharmacotherapy of cardiovascular diseases, as well as possible effects on cancer, wound healing, and diabetic retinopathy, among other pathologies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Vascular Effects of Hydrogen Sulfide: Methods and Protocols is an ideal aid for scientists working to extend our knowledge in this valuable and wide-ranging field of study.
Vascular Endothelium in Human Physiology and Pathophysiology
by Patrick J Vallance David J. WebbEndothelial dysfunction is now regarded as an early marker of vascular disease and therefore an important target for therapeutic intervention and discovery of novel treatments. Ideal for both basic and clinical scientists, whether in industry or academia, and physicians, Vascular Endothelium in Human Physiology and Pathophysiology provides an up-to
The Vascular Flora of the Bosco della Mesola Nature Reserve (Geobotany Studies)
by Alessandro Alessandrini Giampaolo Balboni Lisa Brancaleoni Renato Gerdol Giovanni Nobili Mauro Pellizzari Filippo Piccoli Michele RavaglioliThe Bosco della Mesola represents one of the few remnants of coastal woodlands in Italy. A nature reserve was established in this area in 1977. No detailed checklists of the vascular flora of the nature reserve have been compiled since then. So, there was an urgent need to fill this gap. This book contains a critical updated checklist of the vascular flora in the Bosco della Mesola Nature Reserve. It also allows quantitative comparisons with a previous checklist dating back to the 1960s in order to detect temporal changes in the vascular flora over 60 years. We believe that this book represents a milestone for scientists and all people involved in nature conservation and management in this area and in similar territories in other countries. The readerships can also include high-school students and non-professional botany amateurs.
The Vascular Flora of the National Park of Abruzzo, Lazio and Molise (Central Italy)
by Fabio Conti Fabrizio BartolucciThis book provides an updated list of the vascular flora of the National Park of Abruzzo, Lazio and Molise, incorporating the latest nomenclatural and floristic findings. The list of plants was extrapolated from a geographic database including all data from floristic or vegetational references and herbarium specimens concerning the Park area. This data storage tool was obtained from the database of Abruzzo vascular flora (Conti et al. 2010) and adapted to the study area by adding those areas of the Park falling in the regions of Lazio and Molise and their accompanying floristic and vegetational data. Analysis of the data has allowed gaps in the floristic knowledge of the Park, such as comparatively or completely unexplored areas, to be identified, together with those species records that still require confirmation and/or further study. On the basis of these deductions, fieldwork aimed at the collection of new floristic data was carried out. Verification of the correct identification of herbarium specimens collected in the past, as well as a systematic study of critical genera, were also important priorities.
Vascular Hyperpermeability: Methods and Protocols (Methods in Molecular Biology #2711)
by Binu TharakanThis volume focuses on the latest research methods and techniques used by researchers to study vascular permeability/hyperpermeability in a science laboratory setting. The chapters in this book cover topics such as determination of solute permeability of microvascular endothelial cell monolayers in vitro; evaluation of barrier integrity used in a two-layered microfluidic device mimicking the blood-brain barrier; isolation and culture of human umbilical vein endothelial cells; measurement of blood-brain barrier hyperpermeability using Evans Blue extravasation assay; lymphatic vascular permeability determined from direct measurements of solute flux; intravital imaging of leukocyte-endothelial interaction by intravital multiphoton microscopy; and evaluation of tight junction integrity in brain endothelial cells using confocal microscopy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Thorough and cutting-edge, Vascular Hyperpermeability: Methods and Protocols is a valuable resource that will aid novice researchers with creating new and affordable research projects, and for expert researchers to initiate new strategies and collaborations in their ongoing programs.
Vascular Interventional Radiology
by Mark G. CowlingThis new edition of Vascular Interventional Radiology: Current Evidence in Endovascular Surgery provides a thorough yet succinct and accessible review of the latest knowledge in the field of endovascular surgery. All chapters have been updated to reflect the advances that have occurred during the past five years, and new chapters are included on carotid artery stenting and day case intervention. The chapter on lower limb veno-occlusive disease has been expanded to include management of deep venous thrombosis. Among the other topics considered are the endovascular treatment options in different arterial territories, aneurysm repair techniques, and the management of venous stenosis and venous insufficiency. The aim throughout is to tackle issues of evidence-based practice in order to assist trainees and experienced practitioners in making and implementing treatment decisions. This book will be an invaluable source of information for both interventional radiologists and vascular surgeons with an interest in endovascular techniques.
Vascular Mechanobiology in Physiology and Disease (Cardiac and Vascular Biology #8)
by Markus Hecker Dirk J. DunckerThis volume of the series Cardiac and Vascular Biology presents the most relevant aspects of vascular mechanobiology along with many more facets of this fascinating, timely and clinically highly relevant field. Mechanotransduction, mechanosensing, fluid shear stress, hameodynamics and cell fate, are just a few topics to name. All important aspects of vascular mechanobiology in health and disease are reviewed by some of the top experts in the field. This volume, together with a second title on cardiac mechanobiology featured in this series, will be of high relevance to scientists and clinical researchers in the area of vascular biology, cardiology and biomedical engineering.
Vascular Morphogenesis: Methods and Protocols (Methods in Molecular Biology #2206)
by Domenico RibattiThis detailed new edition aims to provide a range of methods and protocols for studying vascular morphogenesis in vivo and in vitro to reflect up-to-date advances in the field. Of note, the book explores endothelial cell signaling is currently understood to promote fundamental cues for cell fate specification, embryo patterning, organ differentiation, and postnatal tissue remodeling. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and timely, Vascular Morphogenesis: Methods and Protocols, Second Edition will serve as an ideal guide to this area of study for a broad audience amongst cell biologists, anatomists, pathologists, and physiologists.
Vascular Organization of Angiosperms: A New Vision
by Jean-Pierre AndreThis study of plant anatomy is based on newly available data on the structure and spatial organization of the vascular system of plants. For the first time, by means of a new technique of intracellular moulding, the vascular system can be observed in its length. Many examples are chosen from among the major groups of the plant kingdom to illustrate
Vascular Plant Communities of Morocco: Phytosociology, Ecology And Geography (Geobotany Studies)
by Mohammed Sghir Taleb Mohamed FennaneThis book offers a comprehensive overview of the phytosociological information currently available in Morocco – a country famous for its floristic and landscape diversity. There has been little literature on the topic; however, in recent decades there have been a number of advances in the field of vegetation communities in the country, and several new phytosociological units have been described.
The Vascular Plant Communities of the Retezat National Park (Geobotany Studies)
by Gheorghe Coldea Vasile CristeaThe floristic studies carried out during the 19th and 20th centuries in the Retezat Massif identified 1,152 plant species and 104 subspecies within the Cormobionta sub-regnum. Of these, about 12% are endemic Carpathian and Dacian-Balkan taxa that induce a regional specificity to the hosting communities. The phytocoenological research led to the description of 67 plant associations, grouped in 28 alliances, 19 orders and 13 vegetation classes. These classes are: Asplenietea trichomanis, Thlaspietea rotundifolii, Salicetea herbaceae, Montio-Cardaminetea, Scheuchzerio-Caricetea fuscae, Oxycocco-Sphagnetea, Molinio-Arrhenatheretea, Caricetea curvulae, Loisleurio-Vaccinietea, Elyno-Seslerietea, Mulgedio-Aconitetea, Carpino-Fagetea and Vaccinio-Piceetea. The following plant associations herein described are new syntaxa: Phyteumo confusi-Junicetum trifidi, Salici kitaibelianae-Dryadetum octopetalae and Aconito taurici-Rumicetum alpine. For the protection of some rare plant species and vulnerable plant associations, two natural reserves are proposed to be created within the “Limestone Retezat” area.
Vascular Proteomics
by Fernando VivancoProteomics is a rapidly expanding investigation platform in cardiovascular medicine. Driven by major improvements in mass spectrometry (MS) instrumentation and data analysis, the proteomics field has flourished in recent years particularly in the study of complex diseases. These recent advances are characterized by the development of quantitative MS-based methods that promoted the field from primarily identifying proteins to also providing measurements of relative changes in protein levels between different cell states. This progress is reflected in the application of proteomic techniques to vascular pathology. Vascular Proteomics: Methods and Protocols provides up-to-date methods and protocols for the analysis of arteries, cells, lipoproteins, body fluids, and metabolites, with a particular focus on MS-based methods of protein and peptide quantification. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Vascular Proteomics: Methods and Protocols is a representative selection of methods that can be a useful resource for experienced proteomics practitioners as well as newcomers interested in becoming acquainted with the practice of proteomic techniques for cardiovascular research.
Vascular Surgery
by Jamal J. Hoballah Alan B. LumsdenVascular care has evolved from conservative therapy and open surgical therapy to a minimally invasive approach using endovascular techniques, laparoscopic or thoracoscopic techniques as well as hybrids of open and endovascular techniques. This volume provides up-to-the-minute information and details new developments and procedures.