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Systemische Bionik: Impulse für eine nachhaltige gesellschaftliche Weiterentwicklung (essentials)
by E. W. Udo KüppersDieses Essential vermittelt einen grundlegenden Einblick in die Systemische Bionik als Grenzen überwindende Disziplin. Der Autor erläutert auf leicht verständliche Weise, welchen Wert die Bionik für ganzheitliche Problemlösungen bietet und welche Rolle eine intakte Natur dabei spielt. Wegweisend und zielführend bei diesem systembionischen Vorgehensmodell ist das Erkennen von Zusammenhängen in Natur und Technik.
Systemleichtbau für die Luftfahrt (essentials)
by Martin Wiedemannessentials liefern aktuelles Wissen in konzentrierter Form. Die Essenz dessen, worauf es als „State-of-the-Art“ in der gegenwärtigen Fachdiskussion oder in der Praxis ankommt. essentials informieren schnell, unkompliziert und verständlichals Einführung in ein aktuelles Thema aus Ihrem Fachgebietals Einstieg in ein für Sie noch unbekanntes Themenfeldals Einblick, um zum Thema mitreden zu könnenDie Bücher in elektronischer und gedruckter Form bringen das Fachwissen von Springerautor*innen kompakt zur Darstellung. Sie sind besonders für die Nutzung als eBook auf Tablet-PCs, eBook-Readern und Smartphones geeignet. essentials sind Wissensbausteine aus den Wirtschafts-, Sozial- und Geisteswissenschaften, aus Technik und Naturwissenschaften sowie aus Medizin, Psychologie und Gesundheitsberufen. Von renommierten Autor*innen aller Springer-Verlagsmarken.Dies ist ein Open-Access-Buch.
Systems Analysis And Design
by Alan Dennis Barbara Haley Wixom Roberta M. RothThe 6th Edition of Systems Analysis and Design continues to offer a hands-on approach to SAD while focusing on the core set of skills that all analysts must possess. Building on their experience as professional systems analysts and award-winning teachers, authors Dennis, Wixom, and Roth capture the experience of developing and analyzing systems in a way that students can understand and apply. With Systems Analysis and Design, 6th Edition, students will leave the course with experience that is a rich foundation for further work as a systems analyst.
Systems Analysis and Design
by Kenneth E. Kendall Julie E. KendallExpanded coverage of emerging technologies, such as agile methods, cloud computing, and mobile applications, complements this book’s traditional approaches to systems analysis and design. A wealth of real-world examples emphasizes critical thinking and IT skills in a dynamic, business-related environment. You will find numerous projects, insightful assignments, and helpful end-of-chapter exercises to help you refine the IT skills you need for success in today's intensely competitive business world.
Systems Analysis and Design in a Changing World
by John W. Satzinger Robert B. Jackson Stephen D. BurdReflecting the latest practices, trends, and developments from the field, SYSTEMS ANALYSIS AND DESIGN IN A CHANGING WORLD, 7E equips you with a solid foundation of the most important principles of systems analysis, systems design, project management, and new software development approaches. Using case driven techniques, the succinct 14-chapter book focuses on content that is key to your success in today's market. The book teaches both traditional (structured) and object-oriented (OO) approaches to systems analysis and design. It highlights use cases, use diagrams, and use case descriptions required for a modeling approach, while demonstrating their application to traditional, web development, object-oriented, and service-oriented architecture approaches. Content reflects Microsoft Project 2013 Professional and Microsoft Visio 2013.
Systems Analysis Approach for Complex Global Challenges
by Priscilla Mensah David Katerere Sepo Hachigonta Andreas RoodtThis book, which contains a collection of review articles as well as focus on evidence-based policy making, will serve as a valuable resource not just for all postgraduate students conducting research using systems analysis thinking but also for policy makers. To our knowledge, a book of this nature which also has a strong African focus is currently not available. The book examines environmental and socio-economic risks with the aim of providing an analytical foundation for the management and governance of natural resources, disasters, addressing climate change, and easing the technological and ecological transitions to sustainability. It provides scientific and strategic analysis to better understand the dynamics of future energy transitions, their main driving forces, enabling factors, barriers, as well as their consequences for the social, economic and environmental dimensions of human wellbeing. Science-based policy advice is achieved through an integrated assessment and modeling of how to simultaneously address the major energy policy challenges in the areas of environment (climate change and air pollution), energy poverty (or access to affordable and clean energy for the poor), energy security and reliability. It also aims to improve our understanding of ecosystems and their management in today’s changing world—in particular, the current state of ecosystems, and their ecological thresholds and buffering capacities. It provides support for policy makers in developing rational, realistic and science-based regional, national and global strategies for the production of fuel, food and fibre that sustain ecosystem services and safeguard food security. Finally, it addresses the human development dimension of global change based on comprehensive studies on the changing size and composition of human populations around the world by analyzing both their impacts and the differential vulnerabilities by age, gender and level of education.
Systems Analysis of Chromatin-Related Protein Complexes in Cancer
by Andrew Emili Shoshana Wodak Jack GreenblattEpigenetic modifications underlie all aspects of human physiology, including stem cell renewal, formation of cell types and tissues. They also underlie environmental impacts on human health, including aging and diseases like cancer. Consequently, cracking the epigenetic "code" is considered a key challenge in biomedical research. Chromatin structure and function are modified by protein complexes, causing genes to be turned "on" or "off" and controlling other aspects of DNA function. Yet while there has been explosive growth in the epigenetics field, human chromatin-modifying machines have only recently started to be characterized. To meet this challenge, our book explores complementary experimental tracks, pursued by expert international research groups, aimed at the physical and functional characterization of the diverse repertoire of chromatin protein machines - namely, the "readers, writers and erasers" of epigenomic marks. These studies include the identification of RNA molecules and drugs that interact selectively with components of the chromatin machinery. What makes this book distinctive is its emphasis on the systematic exploration of chromatin protein complexes in the context of human development and disease networks.
Systems Analysis of Human Multigene Disorders
by Natalia Maltsev Andrey Rzhetsky T. Conrad GilliamUnderstanding the genetic architecture underlying complex multigene disorders is one of the major goals of human genetics in the upcoming decades. Advances in whole genome sequencing and the success of high throughput functional genomics allow supplementing conventional reductionist biology with systems-level approaches to human heredity and health as systems of interacting genetic, epigenetic, and environmental factors. This integrative approach holds the promise of unveiling yet unexplored levels of molecular organization and biological complexity. It may also hold the key to deciphering the multigene patterns of disease inheritance.
Systems and Computer Science: Proceedings of a Conference held at the University of Western Ontario September 10-11, 1965
by John Hart Satoru TakasuThis book presents the papers delivered at the Conference on Systems and Computer Science held at the University of Western Ontario in September 1965. The primary purposes of the Conference were the promotion of research and the development of the teaching of computer science in Canadian universities. The papers focus attention on some of the concepts of Computer Science as a new field of study and at the same time provide a background for scientists looking at the subject for the first time. The chief developments in computer science have been concerned with the "applied" rather than the "pure" areas of the field: numerical analysis, applied statistics and operations research, and data processing. But there is something more to computers than the physical components and this book represents an attempt to correct the imbalance between "applied" and "pure" by drawing attention to certain theoretical aspects of computer and information science. Among the topics discussed are the theory of finite and infinite automata, aspects of formal language theory, heuristic and non-heuristic approaches to theorem proving and the mathematical formulation of the theory of general systems. There are also references to the problems of machine design, to software systems including higher-level languages, to multiple control computer models and to applied systems. This collection of papers will appeal first to graduate students and professors in Computer Science. It will also be of interest to computer scientists in industry and in government and university research groups and to the scientific public interested in discovering some of the principal ingredients and directions of the computer and information sciences.
Systems and Implemented Technologies for Data-Driven Innovation, addressing Data Spaces and Marketplaces Semantic Interoperability Needs: i3-MARKET Series - Part II: Data Economy, Models, Technologies and Solutions (River Publishers Series in Computing and Information Science and Technology)
by Martín Serrano Achille Zappa Waheed Ashraf Pedro Maló Márcio Mateus Edgar Fries Iván Martínez Alessandro Amicone Justina Bieliauskaite Marina CugurraIn the second i3-MARKET series book we review the basic technological principles, software best practices, and standards for implementing and deploying data spaces and data marketplaces. The book provides a definition for data-driven society as: The process to transform data production into data economy for the people using the emerging technologies and scientific advances in data science to underpin the delivery of data economic models and services. This book further discusses why data spaces and data marketplaces are the focus in today’s data-driven society as the trend to rapidly transform the data perception in every aspect of our activities. In this book, technology assets that are designed and implemented following the i3-MARKET backplane reference implementation (WebRI) that uses open data, big data, IoT and AI design principles is introduced. Moreover, the series of software assets grouped as sub-systems and composed by software artefacts are included and explained in full. Further, we describe i3-MARKET backplane tools and how these can be used for supporting marketplaces and its components including details of available data assets. Next, we provide descriptions of solutions developed in i3-MARKET as an overview of the potential for being the reference open-source solution to improve data economy across different data marketplaces.
Systems and Innovation Research in Transition: Research Questions and Trends in Historical Perspective (Sustainability and Innovation)
by Jakob Edler Rainer WalzIn the last decades it has become more and more imperative for our societies, and for decision makers in all areas of society, to understand the dynamics through which innovation systems develop and through which socio-technical systems transform themselves. As both innovation and transformation are strongly intertwined, it has equally become imperative to analyse their dynamics as well as their interplay. This open access volume reflects on the research fields that have developed in the last five decades to do exactly that. It defines and delineates research on systems and innovation as encompassing the scientific study of, first, the conditions, dynamics and impacts associated with the generation and uptake of innovations and, second, the development and transformation of functional systems satisfying essential needs such as the provision of energy or water. Further, the area of Systems and Innovation Research (SIR) is characterised by problem and stakeholder oriented research. We chose five decades as time frame because we noted that roughly 50 years ago a number of research institutes dedicated to SIR were founded and the SIR area started to grow significantly. We present a systematic history of nine selected fields within the area of SIR (Innovation policy, Innovation indicators, Foresight, Policy Evaluation, Technology Assessment, Production Paradigms, Renewable Energies, Energy Efficiency, Water Use). We also present a conceptual framework to understand the processes by which the research fields have developed. This allows to draw general lessons as to what drives fields throughout their development and how their role vis-à-vis policy, businesses and societies changes over time. It also allows to speculate about future challenges and trends in the SIR area. This is important because, if anything, the need to govern transformation through innovation will further grow in the future, and with it the need to understand the underlying dynamics.
Systems and Synthetic Biology
by Vikram Singh Pawan K. DharThis textbook has been conceptualized to provide a detailed description of the various aspects of Systems and Synthetic Biology, keeping the requirements of M. Sc. and Ph. D. students in mind. Also, it is hoped that this book will mentor young scientists who are willing to contribute to this area but do not know from where to begin. The book has been divided into two sections. The first section will deal with systems biology - in terms of the foundational understanding, highlighting issues in biological complexity, methods of analysis and various aspects of modelling. The second section deals with the engineering concepts, design strategies of the biological systems ranging from simple DNA/RNA fragments, switches and oscillators, molecular pathways to a complete synthetic cell will be described. Finally, the book will offer expert opinions in legal, safety, security and social issues to present a well-balanced information both for students and scientists.
Systems and Synthetic Immunology
by Shailza SinghSystems and Synthetic Immunology focuses on the similarities between biology and engineering at the systems level, which are important for applying engineering theories to biology problems. With the advent of new genomic techniques, there are numerous systematic investigations underway in the scientific world. This volume highlights techniques that can be used to effectively combine two of the most essential biological fields - Systems Biology and Synthetic Immunology.The respective chapters discuss the role of synthetic immunology in biotechnology, production of biomaterials, and their use in vaccine delivery. Further topics include the importance of cytokines; the use of genomic engineering tools in immunotherapy; immunosensors; nanotherapeutics; and bioinformatics tools in biomedical applications. Given its scope, the book offers readers an up-to-date and comprehensive review of this unique and dynamic field of research.
A Systems Approach to Agroecology
by Pablo TittonellAs agroecology gains momentum in the international research-for-development arena, there is an urgent need for methods and tools to support the codesign and evaluation of agroecological systems and their transitions. The social and ecological complexity of agroecosystems, their dynamics, uncertainties and sustainability, calls for a holistic, systemic approach to agroecology. As such, several questions arise for example: how do we deal with heterogeneity, landscapes, biodiversity or learning processes in agroecosystems analysis? How do we categorise diversity or analyse trade-offs in social-ecological interactions? How do we conceptualise, codesign and monitor agroecological transitions? This book sets out to answer these questions by building on the valuable ‘classics’ in agroecology. The book presents a systems perspective that underpins a combination of methodologies, ranging from participatory tools and field observations to mathematical simulation modelling. Researchers, advanced students and transdisciplinary practitioners will find in this book insights and methods to design research and (co-) innovation processes to foster agroecological transitions.
Systems Approach to Astrobiology
by Vera M. Kolb Benton C. ClarkSystems thinking/analysis is widely applied for solving complex problems in engineering and certain other fields. Astrobiology, which inherently involves complex problems, can benefit from such an approach.
A Systems Approach to the Environmental Analysis of Pollution Minimization
by Sven E. JorgensenThe environmental analysis of pollution problems always involves the use of mass and energy balances to quantify the extent of pollution and its sources. This same form of analysis can be applied to ecosystems, production systems, a whole country or a region. A Systems Approach to the Environmental Analysis of Pollution Minimization identifies and describes the common factors shared by these systems.The book is organized in twelve chapters and progresses from general concepts to specific assessment methods. Chapter one is a general introduction to environmental management principles. Chapter two discusses conservation principles and their applications to environmental health. Chapters three and four explore ecosystem health, properties and analysis. Chapters five through eleven present different methods of analysis including Green Accounting, Clean Technology, Life Cycle Analysis, and Risk Assessment. Editor Sven Jorgensen closes the book with a sweeping summary. Jorgensen is a internationally published authority on the use and analysis of ecosystem models. His new book is a comprehensive guide for both students and professionals. A Systems Approach to the Environmental Analysis of Pollution Minimization is an invaluable contribution.Features
Systems Approaches to Nuclear Fusion Reactors (Springer Series in Plasma Science and Technology)
by Frederick B. MarcusThis book offers an overall review, applying systems engineering and architecture approaches, of the design, optimization, operation and results of leading fusion experiments. These approaches provide a unified means of evaluating reactor design. Methodologies are developed for more coherent construction or evaluation of fusion devices, associated experiments and operating procedures. The main focus is on tokamaks, with almost all machines and their important results being integrated into a systems design space. Case studies focus on DIII-D, TCV, JET, WEST, the fusion reactor prototype ITER and the EU DEMO concept. Stellarator, Mirror and Laser inertial confinement experiments are similarly analysed, including reactor implications of breakeven at NIF.The book examines the engineering and physics design and optimization process for each machine, analysing their performance and major results achieved, thus establishing a basis for the improvement of future machines. The reader will gain a broad historical and up-to-date perspective of the status of nuclear fusion research from both an engineering and physics point of view. Explanations are given of the computational tools needed to design and operate successful experiments and reactor-relevant machines. This book is aimed at both graduate students and practitioners of nuclear fusion science and engineering, as well as those specializing in other fields demanding large and integrated experimental equipment. Systems engineers will obtain valuable insights into fusion applications. References are given to associated complex mathematical derivations, which are beyond the scope of this book. The general reader interested in nuclear fusion will find here an accessible summary of the current state of nuclear fusion.
Systems Biology (Rna Technologies Ser.)
by Jan Barciszewski Stefan Jurga Nikolaus RajewskyMany breakthroughs in experimental devices, advanced software, as well as analytical methods for systems biology development have helped shape the way we study DNA, RNA and proteins, on the genomic, transcriptional, translational and posttranslational level. This book highlights the comprehensive topics that encompass systems biology with enormous progress in the development of genome sequencing, proteomic and metabolomic methods in designing and understanding biological systems.Topics covered in this book include fundamentals of modelling networks, circuits and pathways, spatial and multi cellular systems, image-driven systems biology, evolution, noise and decision-making in single cells, systems biology of disease and immunology, and personalized medicine. Special attention is paid to epigenomics, in particular environmental conditions that impact genetic background. The breadth of exciting new data towards discovering fundamental principles and direct application of epigenetics in agriculture is also described.The chapter “Deciphering the Universe of RNA Structures and Trans RNA-RNA Interactions of Transcriptomes in vivo - from Experimental Protocols to Computational Analyses” is available open access under a CC BY 4.0 license via link.springer.com.
Systems Biology (Methods in Molecular Biology #2745)
by Mariano BizzarriThis second edition volume expands on the previous edition with discussions of the latest advancements and methods used by scientists to study systems biology. The chapters in this book are organized into four parts. Part One looks at models in systems biology and parameters identification such as short peptide analysis, metastasis models, and metabolomics. Part Two covers computational methods in the study of organisms, and cancer non-linear dynamics. Part Three discusses critical transition states across Waddington’s like landscapes such as understanding cell differentiation through single-cell approaches and modeling mammary organogenesis from biological first principles. Part Four talks about specific fields of investigation including inborn errors of metabolism, system biology approach in epithelial-mesenchymal transition, and an approach to understanding how COVID-19 spreads in the population. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and comprehensive, Systems Biology, Second Edition is a valuable tool for any researcher looking to learn more about this important and developing field.
Systems Biology
by Leszek Konieczny Irena Roterman-Konieczna Paweł SpólnikThe objective of this book is to present the strategies employed by living organisms on a molecular level and to help understand the basics of Systems Biology. Its content is organized in a way to meet the exponential growth in the volume of biological knowledge, and the need for a multidisciplinary approach in the practice of teaching modern biology. For this reason, the whole material is divided into five chapters, each devoted to a fundamental concept: Structure-Function, Energy, Information, Regulation and Interrelationships. The book describes generic mechanisms which occur in biology and promotes a simulation-based approach to the subject of Systems Biology. The use of basic knowledge as the background for presenting biological problems obligates the teachers to deal with generalized phenomena comprising the ever increasing volume of teaching materials. This book is intended for biologists and is informative for specialists in the areas of computer science, robotics and engineering.
Systems Biology: Functional Strategies of Living Organisms
by Leszek Konieczny Irena Roterman-Konieczna Paweł SpólnikThis open-access textbook is an excellent introduction to systems biology, which has developed rapidly in recent years. It discusses the processes in living organisms in an integrated way, enabling the reader to understand the fundamental principles and cause-effect relationships in biology and biochemistry. The authors have chosen an original but at the same time clear way of presenting the topics, repeatedly drawing comparisons and models from the macroscopic world and making the reader aware of the unity of the laws of physics, chemistry and biology. The fully updated 2nd edition also contains information that has only become available as a result of the increase in knowledge in recent years. This includes information on tumorigenesis, where significant progress has been made due to the explosive development of genetic knowledge as well as bioengineering with a highly effective technique adopted from the solutions of the bacterial world, such as CRISPR/CAS. This richly illustrated book is essential for postgraduate students and scientists of the following disciplines: biology, biotechnology, medicine, bioinformatics, robotics and automation, biocybernetics, and biomedical engineering. It is also an exciting read for anyone interested in biology.
Systems Biology: Principles, Methods, and Concepts
by Andrzej K. KonopkaWith extraordinary clarity,the Systems Biology: Principles, Methods, and Concepts focuses on the technical practical aspects of modeling complex or organic general systems. It also provides in-depth coverage of modeling biochemical, thermodynamic, engineering, and ecological systems. Among other methods and concepts based in logic, computer
Systems Biology: Modeling, Analysis, and Simulation (Lecture Notes on Mathematical Modelling in the Life Sciences)
by Jinzhi LeiThis book discusses the mathematical simulation of biological systems, with a focus on the modeling of gene expression, gene regulatory networks and stem cell regeneration. The diffusion of morphogens is addressed by introducing various reaction-diffusion equations based on different hypotheses concerning the process of morphogen gradient formation. The robustness of steady-state gradients is also covered through boundary value problems. The introduction gives an overview of the relevant biological concepts (cells, DNA, organism development) and provides the requisite mathematical preliminaries on continuous dynamics and stochastic modeling. A basic understanding of calculus is assumed. The techniques described in this book encompass a wide range of mechanisms, from molecular behavior to population dynamics, and the inclusion of recent developments in the literature together with first-hand results make it an ideal reference for both new students and experienced researchers in the field of systems biology and applied mathematics.
Systems Biology
by Ivan V. MalyThe rapidly developing methods of systems biology can help investigators to make inference and predictions from their data that intuition alone would not discern; however, the difficulty lies in the broad knowledge of mathematics and engineering that seems to be required to even evaluate the applicability of the methods to the problem at hand. In "Systems Biology", scientists who possess that mathematical knowledge and have applied it effectively to various biological problems contribute methods which reflect their experience, crystallized in a form very similar to typical biological laboratory protocols. In order to best aid researchers, the chapters supply the theory behind the method, its step-by-step implementation, and the pitfalls explained thoroughly and from the practical angle. As a volume of the highly successful Methods in Molecular BiologyTM series, this work provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Cutting-edge and easy to use, "Systems Biology" shatters the perceived insurmountable barrier between the laboratory and systems-biological research techniques.
Systems Biology
by Robert A. MeyersSystems biology is a relatively new biological study field that focuses on the systematic study of complex interactions in biological systems, thus using a new perspective (integration instead of reduction) to study them. Particularly from year 2000 onwards, the term is used widely in the biosciences, and in a variety of contexts. Systems biology is the study of the interconnected aspect of molecular, cellular, tissue, whole animal and ecological processes, and comprises mathematical and mechanistic studies of dynamical, mesoscopic, open, spatiotemporally defined, nonlinear, complex systems that are far from thermodynamic equilibrium.Containing a unique selection of new and updated, high-quality articles from the well-known Meyer's Encyclopedia of Molecular Cell Biology and Molecular Medicine, this two-volume handbook is an essential guide for students and researchers wishing to get an overview of the field.