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Active Implants and Scaffolds for Tissue Regeneration (Studies in Mechanobiology, Tissue Engineering and Biomaterials #8)
by Meital ZilbermanActive implants are actually drug or protein-eluting implants that induce healing effects, in addition to their regular task, such as support. This effect is achieved by controlled release of the active agent to the surrounding tissue. This book will give a broad overview of biomaterial platforms used as basic elements of drug-eluting implants. It will include mainly coatings for vascular stents with controlled release of antiproliferative agents, wound dressings with controlled release of antibacterial agents, drug-eluting vascular grafts, protein-eluting scaffolds for tissue regeneration, drug-eluting platforms for dental and other applications. Thus, both internal and external implants are described. The drug-eluting implants will be described in terms of matrix formats and polymers, incorporated drugs and their release profiles from the implants, as well as implant functioning. Smart polymeric systems, such as crosslinked poly-lactones, thermo and pH-sensitive hydrogels and poly(amido-amines), as well as novel basic structural elements, such as composite fibers and films, and nanostructures will be thoroughly described. The effect of the processing parameters on the microstructure and on the resulting drug release profiles, mechanical and physical properties, and other relevant properties, will be emphasized. The described new biomaterials approaches for active implants enhance the tools available for creating clinically important biomedical applications.
Active Inference: The Free Energy Principle in Mind, Brain, and Behavior
by Thomas Parr Karl J. Friston Giovanni PezzuloThe first comprehensive treatment of active inference, an integrative perspective on brain, cognition, and behavior used across multiple disciplines. Active inference is a way of understanding sentient behavior—a theory that characterizes perception, planning, and action in terms of probabilistic inference. Developed by theoretical neuroscientist Karl Friston over years of groundbreaking research, active inference provides an integrated perspective on brain, cognition, and behavior that is increasingly used across multiple disciplines including neuroscience, psychology, and philosophy. Active inference puts the action into perception. This book offers the first comprehensive treatment of active inference, covering theory, applications, and cognitive domains. Active inference is a &“first principles&” approach to understanding behavior and the brain, framed in terms of a single imperative to minimize free energy. The book emphasizes the implications of the free energy principle for understanding how the brain works. It first introduces active inference both conceptually and formally, contextualizing it within current theories of cognition. It then provides specific examples of computational models that use active inference to explain such cognitive phenomena as perception, attention, memory, and planning.
Active Interrogation in Nuclear Security: Science, Technology and Systems (Advanced Sciences and Technologies for Security Applications)
by Igor Jovanovic Anna S. EricksonThis volume constitutes the state-of-the-art in active interrogation, widely recognized as indispensable methods for addressing current and future nuclear security needs. Written by a leading group of science and technology experts, this comprehensive reference presents technologies and systems in the context of the fundamental physics challenges and practical requirements. It compares the features, limitations, technologies, and impact of passive and active measurement techniques; describes radiation sources for active interrogation including electron and ion accelerators, intense lasers, and radioisotope-based sources; and it describes radiation detectors used for active interrogation. Entire chapters are devoted to data acquisition and processing systems, modeling and simulation, data interpretation and algorithms, and a survey of working active measurement systems. Active Interrogation in Nuclear Security is structured to appeal to a range of audiences, including graduate students, active researchers in the field, and policy analysts.The first book devoted entirely to active interrogationPresents a focused review of the relevant physicsSurveys available technologyAnalyzes scientific and technology trends Provides historical and policy context Igor Jovanovic is a Professor of Nuclear Engineering and Radiological Sciences at the University of Michigan and has previously also taught at Penn State University and Purdue University. He received his Ph.D. from University of California, Berkeley and worked as physicist at Lawrence Livermore National Laboratory. Dr. Jovanovic has made numerous contributions to the science and technology of radiation detection, as well as the radiation sources for use in active interrogation in nuclear security. He has taught numerous undergraduate and graduate courses in areas that include radiation detection, nuclear physics, and nuclear security. At University of Michigan Dr. Jovanovic is the director of Neutron Science Laboratory and is also associated with the Center for Ultrafast Optical Science. Anna Erickson is an Assistant Professor in the Nuclear and Radiological Engineering Program of the G.W. Woodruff School of Mechanical Engineering at Georgia Institute of Technology. Previously, she was a postdoctoral researcher in the Advanced Detectors Group at Lawrence Livermore National Laboratory. Dr. Erickson received her PhD from Massachusetts Institute of Technology with a focus on radiation detection for active interrogation applications. Her research interests focus on nuclear non-proliferation including antineutrino analysis and non-traditional detector design and characterization. She teaches courses in advanced experimental detection for reactor and nuclear nonproliferation applications, radiation dosimetry and fast reactor analysis.
Active Learning in College Science: The Case for Evidence-Based Practice
by Joel J. Mintzes Emily M. WalterThis book explores evidence-based practice in college science teaching. It is grounded in disciplinary education research by practicing scientists who have chosen to take Wieman’s (2014) challenge seriously, and to investigate claims about the efficacy of alternative strategies in college science teaching. In editing this book, we have chosen to showcase outstanding cases of exemplary practice supported by solid evidence, and to include practitioners who offer models of teaching and learning that meet the high standards of the scientific disciplines. Our intention is to let these distinguished scientists speak for themselves and to offer authentic guidance to those who seek models of excellence. Our primary audience consists of the thousands of dedicated faculty and graduate students who teach undergraduate science at community and technical colleges, 4-year liberal arts institutions, comprehensive regional campuses, and flagship research universities. In keeping with Wieman’s challenge, our primary focus has been on identifying classroom practices that encourage and support meaningful learning and conceptual understanding in the natural sciences. The content is structured as follows: after an Introduction based on Constructivist Learning Theory (Section I), the practices we explore are Eliciting Ideas and Encouraging Reflection (Section II); Using Clickers to Engage Students (Section III); Supporting Peer Interaction through Small Group Activities (Section IV); Restructuring Curriculum and Instruction (Section V); Rethinking the Physical Environment (Section VI); Enhancing Understanding with Technology (Section VII), and Assessing Understanding (Section VIII). The book’s final section (IX) is devoted to Professional Issues facing college and university faculty who choose to adopt active learning in their courses. The common feature underlying all of the strategies described in this book is their emphasis on actively engaging students who seek to make sense of natural objects and events. Many of the strategies we highlight emerge from a constructivist view of learning that has gained widespread acceptance in recent years. In this view, learners make sense of the world by forging connections between new ideas and those that are part of their existing knowledge base. For most students, that knowledge base is riddled with a host of naïve notions, misconceptions and alternative conceptions they have acquired throughout their lives. To a considerable extent, the job of the teacher is to coax out these ideas; to help students understand how their ideas differ from the scientifically accepted view; to assist as students restructure and reconcile their newly acquired knowledge; and to provide opportunities for students to evaluate what they have learned and apply it in novel circumstances. Clearly, this prescription demands far more than most college and university scientists have been prepared for.
Active Learning in Secondary and College Science Classrooms: A Working Model for Helping the Learner To Learn
by Joel Michael Harold I. ModellThe working model for "helping the learner to learn" presented in this book is relevant to any teaching context, but the focus here is on teaching in secondary and college science classrooms.Specifically, the goals of the text are to: *help secondary- and college-level science faculty examine and redefine their roles in the classroom; *define for science teachers a framework for thinking about active learning and the creation of an active learning environment; and *provide them with the assistance they need to begin building successful active learning environments in their classrooms. Active Learning in Secondary and College Science Classrooms: A Working Model for Helping the Learner to Learn is motivated by fundamental changes in education in response to perceptions that students are not adequately acquiring the knowledge and skills necessary to meet current educational and economic goals. The premise of this book is that active learning offers a highly effective approach to meeting the mandate for increased student knowledge, skills, and performance. It is a valuable resource for all teacher trainers in science education and high school and college science teachers.
Active Metamaterials: Terahertz Modulators and Detectors
by Saroj Rout Sameer SonkusaleThis book covers the theoretical background, experimental methods and implementation details to engineer for communication and imaging application, terahertz devices using metamaterials, in mainstream semiconductor foundry processes. This book will provide engineers and physicists an authoritative reference to construct such devices with minimal background. The authors describe the design and construction of electromagnetic (EM) devices for terahertz frequencies (108-1010 cycles/sec) using artificial materials that are a fraction of the wavelength of the incident EM wave, resulting in an effective electric and magnetic properties (permittivity and permeability) that are unavailable in natural materials.
Active Multiplexing of Spectrally Engineered Heralded Single Photons in an Integrated Fibre Architecture (Springer Theses)
by Robert J. A. Francis-JonesThis clearly written thesis discusses the development of a highly innovative single-photon source that uses active optical switching, known as multiplexing, to increase the probability of delivering photons into a single mode. Improving single-photon sources is critical in advancing the state of the art in photonic quantum technologies for information processing and communications.
Active Particles, Volume 1: Advances in Theory, Models, and Applications (Modeling and Simulation in Science, Engineering and Technology)
by Nicola Bellomo Pierre Degond Eitan TadmorThis volume collects ten surveys on the modeling, simulation, and applications of active particles using methods ranging from mathematical kinetic theory to nonequilibrium statistical mechanics. The contributing authors are leading experts working in this challenging field, and each of their chapters provides a review of the most recent results in their areas and looks ahead to future research directions. The approaches to studying active matter are presented here from many different perspectives, such as individual-based models, evolutionary games, Brownian motion, and continuum theories, as well as various combinations of these. Applications covered include biological network formation and network theory; opinion formation and social systems; control theory of sparse systems; theory and applications of mean field games; population learning; dynamics of flocking systems; vehicular traffic flow; and stochastic particles and mean field approximation. Mathematicians and other members of the scientific community interested in active matter and its many applications will find this volume to be a timely, authoritative, and valuable resource.
Active Particles, Volume 2: Advances in Theory, Models, and Applications (Modeling and Simulation in Science, Engineering and Technology)
by Nicola Bellomo Pierre Degond Eitan TadmorThis volume compiles eight recent surveys that present state-of-the-art results in the field of active matter at different scales, modeled by agent-based, kinetic, and hydrodynamic descriptions. Following the previously published volume, these chapters were written by leading experts in the field and accurately reflect the diversity of subject matter in theory and applications. Several mathematical tools are employed throughout the volume, including analysis of nonlinear PDEs, network theory, mean field approximations, control theory, and flocking analysis. The book also covers a wide range of applications, including:Biological network formationSocial systemsControl theory of sparse systemsDynamics of swarming and flocking systemsStochastic particles and mean field approximationsMathematicians and other members of the scientific community interested in active matter and its many applications will find this volume to be a timely, authoritative, and valuable resource.
Active Particles, Volume 3: Advances in Theory, Models, and Applications (Modeling and Simulation in Science, Engineering and Technology)
by Nicola Bellomo José Antonio Carrillo Eitan TadmorThis edited volume collects six surveys that present state-of-the-art results on modeling, qualitative analysis, and simulation of active matter, focusing on specific applications in the natural sciences. Following the previously published Active Particles volumes, these chapters are written by leading experts in the field and reflect the diversity of subject matter in theory and applications within an interdisciplinary framework. Topics covered include:Variability and heterogeneity in natural swarmsMultiscale aspects of the dynamics of human crowdsMathematical modeling of cell collective motion triggered by self-generated gradientsClustering dynamics on graphsRandom Batch Methods for classical and quantum interacting particle systemsThe consensus-based global optimization algorithm and its recent variantsMathematicians and other members of the scientific community interested in active matter and its many applications will find this volume to be a timely, authoritative, and valuable resource.
Active Particles, Volume 4: Theory, Models, Applications (Modeling and Simulation in Science, Engineering and Technology)
by José Antonio Carrillo Eitan TadmorThis edited volume collects nine surveys that present the state-of-the-art in modeling, qualitative analysis, and simulation of active particles, focusing on specific applications in the natural sciences. As in the preceding Active Particles volumes, it blends diverse applications that demonstrate the interdisciplinary nature of the subject and the various mathematical tools available. Contributions were selected with the aim of covering a variety of viewpoints, from modeling the interactions in collective dynamics of animals and in population dynamics; through neural-networks, semi-supervised learning, and Monte Carlo methods in optimization; to kinetic and continuum theories with applications to aggregations and birth-and-death processes. Mathematicians and other members of the scientific community interested in active matter and its many applications will find this volume to be a timely, authoritative, and valuable resource.
Active Pharmaceutical Ingredients: Development, Manufacturing, and Regulation, Second Edition (ISSN)
by Stanley H. NusimTo successfully bring an Active Pharmaceutical Ingredient (API) to market, many steps must be followed to ensure compliance with governmental regulations. This book is an unparalleled guide to the development, manufacturing, and regulation of the preparation and use of APIs globally. This secoond edition brings readers up-to-date with the quality control regulations for APIs that have been added or amended since the first edition. These updates help ensure that pharmaceutical professionals and drug manufacturers meet the established and required guidelines set forth by the US and international regulatory industries.
Active Pharmaceutical Ingredients in Synthesis: Catalytic Processes in Research and Development
by Gesine J. Hermann Nicholas J. Turner Carolina Silva Marques Anthony J. BurkePresents the most effective catalytic reactions in use today, with a special focus on process intensification, sustainability, waste reduction, and innovative methods This book demonstrates the importance of efficient catalytic transformations for producing pharmaceutically active molecules. It presents the key catalytic reactions and the most efficient catalytic processes, including their significant advantages over compared previous methods. It also places a strong emphasis on asymmetric catalytic reactions, process intensification (PI), sustainability and waste mitigation, continuous manufacturing processes as enshrined by continuous flow catalysis, and supported catalysis. Active Pharmaceutical Ingredients in Synthesis: Catalytic Processes in Research and Development offers chapters covering: Catalysis and Prerequisites for the Modern Pharmaceutial Industry Landscape; Catalytic Process Design - The Industrial Perspective; Hydrogenation, Hydroformylation and Other Reductions; Oxidation; ; Catalytic Addition Reactions; Catalytic Cross-Coupling Reactions; Catalytic Metathesis Reactions; Catalytic Cycloaddition Reactions: Coming Full-Circle; Catalytic Cyclopropanation Reactions; Catalytic C-H insertion Reactions; Phase Transfer Catalysis; and Biocatalysis. -Provides the reader with an updated clear view of the current state of the challenging field of catalysis for API production -Focuses on the application of catalytic methods for the synthesis of known APIs -Presents every key reaction, including Diels-Alder, CH Insertions, Metal-catalytic coupling-reactions, and many more -Includes recent patent literature for completeness Covering a topic of great interest for synthetic chemists and R&D researchers in the pharmaceutical industry, Active Pharmaceutical Ingredients in Synthesis: Catalytic Processes in Research and Development is a must-read for every synthetic chemist working with APIs.
Active Physical Science (Student Edition)
by Arthur Eisenkraft Gary FreeburyBook contains two units, Active Physics and Active Chemistry.
Active Physics: An Inquiry Approach to Physics
by Arthur EisenkrafPhysics should be experienced and make sense to you. Each chapter of Active Physics begins with a challenge--develop a sport that can be played on the Moon; build a home for people with a housing crisis; persuade your parents to lend you the family car; and so on. These are tough challenges, but you will learn the physics that will allow you to be successful at every one. Part of your education is to learn to trust yourself and to question others. When someone tells you something, can they answer your questions: "How do you know? Why should I believe you? and Why should I care?" After Active Physics, when you describe why seat belts are important, or why sports can be played on the moon, or why communication with extraterrestrials is difficult, and someone asks, "How do you know?" your answer will be, "I know because I did an experiment."
Active Physics: Medicine
by Arthur EisenkraftDr. Arthur Eisenkraft, project director, presents a short overview explaining how and why Active physics works. High School Physics Textbook.
Active Physics: Medicine
by Arthur EisenkraftDr. Arthur Eisenkraft, project director, presents a short overview explaining how and why Active physics works. High School Physics Textbook.
