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Zebrafish
by Koichi Kawakami Graham J. Lieschke Andrew C. OatesIn the last 20 years, research activity using the zebrafish Danio rerio has increased dramatically, due in part to the ease of breeding and raising them, their genetic tractability, embryonic accessibility, and their imaging potential. In Zebrafish: Methods and Protocols, expert researchers provide a collection of experimental techniques for the genetic modification, manipulation, and in vivo live imaging of zebrafish. This volume collects sophisticated and practical techniques, including several not yet widely known, from laboratories around the world. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Zebrafish: Methods and Protocols seeks to aid and inspire scientists utilizing this versatile animal model in their research.
Zebrafish
by Patricia McgrathZebrafish: Methods for Assessing Drug Safety and Toxicity offers a practical guide for using zebrafish as a tool for toxicology studies. Consolidating key protocols and approaches to help researchers navigate the important and evolving field of zebrafish models for toxicity screening, this new title describes the methods for using the zebrafish as a model organism to assess compound-induced toxicity on all major organs. Individual chapters that concentrate on assays for each organ system are included and various analytical tools including microscopy, microplate readers, high content imaging systems, ECG, blood pressure monitors, high speed video and motion detectors are described.
Zebrafish: A Model for Marine Peptide Based Drug Screening
by Saravanan Ramachandran Senthilkumar RajagopalThis book offers a comprehensive overview of toxicology, highlighting the significance of peptide-based toxins from marine environments. It discusses the principles of protein-carbohydrate and domain-domain interactions to increase our understanding of toxicology in zebrafish models, as well as drug interaction mechanisms and target definition in drug discovery. It also reviews the structure of marine peptides/toxins and the toxicology of peptide secreting cells and cells that respond to these enzymes, and describes the normal and abnormal toxicology of marine peptides in zebrafish models. Offering insights into the field of proteomics, particularly current practice and research models for solving its many riddles, the book also explains the analytical principles of marine protein-protein and protein-carbohydrate interaction in the context of teratogenicity in target identification in peptide- based drug discovery. Lastly, the book methodically examines the preclinical research on marine proteins/peptides.
Zebrafish Models in Neurobehavioral Research
by Allan V. Kalueff Jonathan M. CachatAnimal models have traditionally played a crucial role in improving our understanding of brain pathogenesis. Zebrafish (Danio rerio) have generated considerable discoveries in the areas of genetics, embryology, endocrinology, and neuroscience. Zebrafish Models in Neurobehavioral Research emphasizes the growing importance of zebrafish in neurobehavioral research and portrays an extensive, thorough perspective on the emergence of zebrafish as robust and translational models. Written by leading international experts, the book covers major topics ranging from stress to learned recognition of environment, encompassing a wide spectrum of the utility of zebrafish within neurobiological disciplines. The chapters provide authoritative reviews of many zebrafish paradigms commonly used in the field today. This book will be a useful guide for zebrafish researchers, and will complement another related book from the popular Neuromethods series, Zebrafish Neurobehavioral Protocols. Comprehensive and up-to-date, Zebrafish Models in Neurobehavioral Research serves as an ideal resource for scientists new to the field as well as for established researchers seeking valuable insight into the growing utility of zebrafish in neuroscience.
Zebrafish Neurobehavioral Protocols
by Jonathan M. Cachat Allan V. KalueffAs a model organism, zebrafish (Danio rerio) offer an opportunity to perform steadfast scientific investigations in a robust and high-throughput manner. In Zebrafish Neurobehavioral Protocols, experts in the field provide a series of detailed behavioral protocols dealing with the major current research areas in the field of behavioral neuroscience. The chapters discuss the use and interpretation of video-aided quantification of zebrafish behaviors, describe novel assays commonly used to quantify emotionality, learning, memory, and social behaviors in zebrafish, and instruct how to quantify endocrine responses and correlate them with behavior. Written in the Neuromethods series format, the chapters provide authoritative reviews of many commonly used approaches in the field today. This "how to" book will be a useful practical guide for zebrafish researchers and will complement another related book from this series, Zebrafish Models in Neurobehavioral Research. Cutting-edge and timely, Zebrafish Neurobehavioral Protocols serves as an excellent compilation epitomizing the growing potential of zebrafish in modern scientific inquiry.
Zebrafish Protocols for Neurobehavioral Research
by Adam Michael Stewart Allan V. KalueffZebrafish (Danio rerio) play an integral role in biomedical research, enabling researchers to examine physiological mechanisms and pathways relevant to human pathogenesis and its therapy. That, along with their low cost, easy manipulation, short reproductive cycles, and physiological homology to humans, has made zebrafish a vital model organism for neuroscience research. Zebrafish Protocols for Neurobehavioral Research addresses protocols for both larval and adult models, written by the leading experts in the field of zebrafish research. Part I of this book takes advantage of the high-throughput nature of larval models to offer protocols for research requiring high output, easily manipulated screens. The second half of the book focuses on the robust and sophisticated behaviors of adult zebrafish, suitable for the neurophenotyping of complex traits and multi-domain disorders. Importantly, these models complement each other, working together to provide researchers with valuable insights into neurobiology of normal and pathological behavior. Thorough and cutting-edge, this volume is a useful, authoritative reference guide that should hold a coveted spot in zebrafish laboratories across the globe.
Zeig mir Health Data Science!: Ideen und Material für guten Biometrie-Unterricht mit datenwissenschaftlichem Fokus
by Carolin Herrmann Ursula Berger Christel Weiß Iris Burkholder Geraldine Rauch Jochen KruppaIn diesem Buch sind Lehrbeispiele gesammelt, die Dozierenden wertvolle Anregungen für ihre eigene Lehre liefern: Es werden Ideen für einzelne Übungen, Unterrichtseinheiten, Prüfungen oder ganze Kurse vorgestellt. Die benötigten Materialien sind für die Nutzer online frei verfügbar, um die Anwendung zu vereinfachen. Alle Beiträge dieses Buches wurden 2020 für den Preis für das beste Health-Data-Science-Lehrmaterial eingereicht, der von der Arbeitsgruppe Lehre und Didaktik der Biometrie der Deutschen Region der Internationalen Biometrischen Gesellschaft und der GMDS ausgeschrieben wurde. So entstand ein breiter Querschnitt an Beiträgen für lebendige Lehre in Biometrie, Epidemiologie, Public Health und ähnlichen Gebieten. Das Buch knüpft damit an die beiden Bände Zeig mir Biostatistik! und Zeig mir mehr Biostatistik! an, denen ähnliche Ausschreibungen vorausgingen. Die Herausgeber unterrichten Biometrie als Haupt- oder Nebenfach an verschiedenen Universitäten bzw. Hochschulen. Es verbindet sie das gemeinsame Ziel, den Austausch von Ideen und ausgereiftem Unterrichtsmaterial im Bereich Health Data Science zu fördern.
Zeitmanagement für Ingenieure (essentials)
by Ekbert HeringIngenieure in Führungsverantwortung sind in besonderer Weise Stress und Hektik ausgesetzt. Ein effektives und effizientes Zeitmanagement hilft dabei, die erforderlichen Ziele zu erreichen und ist ein wichtiger Schlüssel zu mehr Lebensqualität. Nach einer persönlichen Selbsteinschätzung werden die biologischen Gegebenheiten vorgestellt, wie die Leistungs-, Stör- und Konzentrationskurven. Zur Auswahl von Entscheidungen werden die Aufgaben je nach Dringlichkeit und Wichtigkeit in das Eisenhower-Portfolio eingetragen. Daraus lassen sich Prioritäten bestimmen. Als universell einsetzbare Methode für das Zeitmanagement wird die ALPEN-Methode ausführlich behandelt (A: Aktivitäten zusammenstellen; L: Länge der Aktivitäten abschätzen; P: Pufferzeiten reservieren: E: Entscheidungen fällen; N: Nachkontrolle). Wertvolle Tipps werden gegeben zum rationellen Arbeiten in Zeitblöcken, zum Besprechungs-, Telefon- und Besucher-Management sowie zum Umgang mit Zeiträubern und zum Zeitsparen. Zum Schluss wird gezeigt, dass das Zeitmanagement nur in der work-life-balance seinen sinnvollen Platz hat.
Zeke Bartholomew: Superspy!
by Jason PinterZeke Bartholomew has always dreamed of being a spy. But when a case of mistaken identity goes horribly wrong, he's thrust into a world of real-life espionage beyond his wildest dreams. Soon this 7th grade nobody finds himself hunted by the lava-powered behemoth Ragnarok, aided by a mysterious butt-kicking girl who goes only by the codename 'Sparrow', while trying to stop the evil mastermind Le Carré from unleashing a device that will turn millions of kids around the world into brainwashed zombie minions. Zeke has always been a zero, and unless he can fumble his way towards becoming a hero, the world is doomed...Full of action, humor, suspense, and more impractical spy gadgets than you can imagine, Zeke Bartholomew is a hero for a new generation. The fate of the world is in his hands! (uh oh...)
Zelda's Big Adventure
by Marie Alafaci Shane McGZelda has big plans—she wants to be the first chicken in space. She leaves nothing to chance as she builds her spaceship, plans her experiments, and packs for the journey. All she needs now is a little help from her friends, and if they won’t step up, Zelda will just have to manage on her own! Eye-popping art and a story of perseverance and ingenuity prove that for a plucky hen, the sky is never the limit.This modern twist on the traditional The Little Red Hen story features an endearing and resourceful chicken determined to fulfill her dream.
Zeldovich: Reminiscences
by R. A. SunyaevYa. B. Zeldovich was certainly one of the greatest physicists and cosmologists of the 20th century. This volume presents reminiscences of this exemplary academician, providing biographical and historical insights from colleagues who knew him best. Zeldovich's achievements are outlined, including those in relativistic astrophysics and cosmology, the
Zell- und Gewebekultur: Allgemeine Grundlagen und spezielle Anwendungen
by Gerhard Gstraunthaler Toni LindlDieses Lehr- und Methodenbuch soll Studierenden der Biologie, Medizin, Pharmazie oder Biotechnologie wie auch Wissenschaftler*innen und technischen Assistent*innen einen umfassenden Einblick in die Zell- und Gewebekultur vermitteln. Praktische Tipps und Tricks in einer labor- und leserfreundlichen Aufmachung dienen dazu, die tägliche Routine im Zellkulturlabor zu erleichtern. Es sind vor allem die leicht nachvollziehbaren "Man-nehme"-Vorschriften, die den praktischen Wert des Buches ausmachen und zu weiterführenden experimentellen Ansätzen anregen. Exemplarisch werden die wichtigsten Grundoperationen in der Zellkultur behandelt, sodass sich auch Anfänger bei der Kultivierung tierischer und pflanzlicher Zellen gut mithilfe des Buches einarbeiten und informieren können. Der Info-Anhang enthält stöchiometrische Rechenbeispiele, ein umfangreiches Glossar, weiterführende Literaturhinweise und Adressen von Lieferfirmen mit Internetadressen. Die 8. Auflage wurde wieder gründlich überarbeitet und auf den letzten Stand von Wissen und Technik gebracht. Die neuesten Entwicklungen in der Zell- und Gewebekultur, die dreidimensionale Zellkultur, die Kultivierung von Organoiden und Miniorganen wie auch mikrophysiologische Systeme "on Chips" werden in einem neu gestalteten Kapitel ausführlich beschrieben. Ebenfalls neu gestaltet und aktualisiert wurde der Abschnitt zur Kultivierung von Stammzellen. Der Abschnitt über die in vitro-toxikologischen Ansätze wurde ergänzt und aktualisiert. Sie finden ausführliche praktische Anleitungen zum einen zur Authentifizierung humaner Zelllinien, verbunden mit einem Qualitätsmanagement, um Kontaminationen mit Mycoplasmen und Kreuzkontaminationen zu vermeiden bzw. rechtzeitig zu entdecken, zum anderen für die Reduktion der Verwendung von fetalem Kälberserum oder um dieses gänzlich zu vermeiden.
Zen-Brain Horizons: Toward a Living Zen (The\mit Press Ser.)
by James H. AustinA neurologist and Zen practitioner clarifies the benefits of meditative training, drawing on classical Buddhist literature and modern brain research.In Zen-Brain Horizons, James Austin draws on his decades of experience as a neurologist and Zen practitioner to clarify the benefits of meditative training. Austin integrates classical Buddhist literature with modern brain research, exploring the horizons of a living, neural Zen. When viewed in the light of today, the timeless wisdom of some Zen masters seems almost to have anticipated recent research in the neurosciences. The keen attentiveness and awareness that we cultivate during meditative practices becomes the leading edge of our subsequent mental processing. Austin explains how our covert, involuntary functions can make crucial contributions to the subtle ways we learn, intuit, and engage in creative activities. He demonstrates why living Zen means much more than sitting quietly indoors on a cushion, and provides simplified advice that helps guide readers to the most important points.
Zen Science: Stop and Smell the Universe
by Institute of Zen ScienceAn inspirational collection of musings on the wonders of nature and the universe, Zen Science pairs the fun of popular science trivia with the benefits of mindfulness. It takes 30,000 years to create a single ray of sunlight. A pinch of soil contains 1 billion living organisms. For virtually all of the earth's existence -- 99.9994% of time -- there were no human beings. These simple reflections are also deeply profound, revealing how vast and awe-inspiring the natural world truly is. With more than 100 of the most surprising, thought-provoking facts about our planet, Zen Science leads readers towards mindfulness, wonder, and spiritual contemplation. This gentle guide is illustrated throughout with charming line drawings and can be read straight through or consulted periodically for a bite-sized piece of inspiration and joy.
Zenn Scarlett
by Christian SchoonZenn Scarlett is a bright, determined, occasionally a-little-too-smart-for-her-own-good 17-year-old girl training hard to become an exoveterinarian. That means she's specializing in the treatment of exotic alien life forms, mostly large and generally dangerous. Her novice year of training at the Ciscan Cloister Exovet Clinic on Mars will find her working with alien patients from whalehounds the size of a hay barn to a baby Kiran Sunkiller, a colossal floating creature that will grow up to carry a whole sky-city on its back.But after a series of inexplicable animal escapes from the school and other near-disasters, the Cloister is in real danger of being shut down by a group of alien-hating officials. If that happens, Zenn knows only too well the grim fate awaiting the creatures she loves.Now, she must unravel the baffling events plaguing her school, before someone is hurt or killed, before everything she cares about is ripped away from her and her family forever. To solve this mystery - and live to tell about it - Zenn will have to put her new exovet skills to work in ways she never imagined, and in the process learn just how powerful compassion and empathy can be.
Zenn Scarlett
by Christian SchoonZenn Scarlett is a bright, determined, occasionally a-little-too-smart-for-her-own-good 17-year-old girl training hard to become an exoveterinarian. That means she's specializing in the treatment of exotic alien life forms, mostly large and generally dangerous. Her novice year of training at the Ciscan Cloister Exovet Clinic on Mars will find her working with alien patients from whalehounds the size of a hay barn to a baby Kiran Sunkiller, a colossal floating creature that will grow up to carry a whole sky-city on its back.But after a series of inexplicable animal escapes from the school and other near-disasters, the Cloister is in real danger of being shut down by a group of alien-hating officials. If that happens, Zenn knows only too well the grim fate awaiting the creatures she loves.Now, she must unravel the baffling events plaguing her school, before someone is hurt or killed, before everything she cares about is ripped away from her and her family forever. To solve this mystery - and live to tell about it - Zenn will have to put her new exovet skills to work in ways she never imagined, and in the process learn just how powerful compassion and empathy can be.
Zeolite Catalysts: Principles and Applications
by Subhash BhatiaPresented in an easy-to-read form, this book on zeolite catalysis cover all aspects of the subject. It focuses on synthesis, structure, diffusion, deactivation, and industrial applications. This book is an ideal text for courses on catalysis or as a supplementary text for those studying applied or industrial chemistry. It is also a useful resource for anyone who works with zeolites as catalysts in the laboratory, pilot plants, or commercial installations.
Zeolite Characterization and Catalysis
by E. G. Derouane Arthur W. ChesterZeolites have been an important material in catalysis and other applications (adsorbents, detergents) for the last 50 years. While new types of porous materials (ordered mesopores, metal organic frameworks) are now attracting more R&D attention, zeolites are still the most important crystalline industrial catalysts. Zeolite Characterization and Catalysis: A Tutorial makes available a series of tutorials on zeolite characterization and catalysis. Topics covered include X-ray powder diffraction, infra-red and Raman spectroscopy, Electron microscopy, determination of acid/base properties, the important reactions of C1 building blocks over zeolites as well as zeolite catalysis in chemicals . An important chapter covers computational methods in zeolite science. Zeolite Characterization and Catalysis: A Tutorial is intended for graduate students, post-docs and experienced scientists entering the fields of synthesis, characterization and catalytic applications of porous materials.
Zeolites in Sustainable Chemistry
by Feng-Shou Xiao Xiangju MengThis book is devoted to the new development of zeolitic catalysts with an emphasis on new strategies for the preparation of zeolites, novel techniques for their characterization and emerging applications of zeolites as catalysts for sustainable chemistry, especially in the fields of energy, biomass conversion and environmental protection. Over the years, energy and the environment have become the most important global issues, while zeolitic catalysts play important roles in addressing them. With individual chapters written by leading experts, this book offers an essential reference work for researchers and professionals in both academia and industry. Feng-Shou Xiao is a Professor at the Department of Chemistry, Zhejiang University, China. Xiangju Meng is an Associate Professor at the Department of Chemistry, Zhejiang University, China.
Zeptosecond Dynamics of Transfer‐Triggered Breakup: Mechanisms, Timescales, And Consequences For Fusion (Springer Theses)
by Kaitlin Jennifer CookCombining incisive experiments with the latest theoretical advances, this book presents an extensive study of transfer-triggered breakup, the dominant process by which breakup occurs in reactions involving light, weakly bound nuclei. It demonstrates not only that lifetimes of resonant states shorter than a zeptosecond are crucially important for these reactions to suppress complete fusion, but also that such short lifetimes are experimentally accessible. By making quantitative predictions of the effect of breakup from short-lived resonant states on incomplete fusion at above-barrier energies, the book suggests that the extent to which near-target breakup can suppress complete fusion is much more limited than previously thought. With an impressive amount of complex data and state-of-the-art models, which were developed, modified, and tested over course of the Ph.D., it examines all aspects of nuclear reactions – nuclear models, modern detectors and spectrometers, as well as data analysis, and offers a detailed discussion of experimental results and technical developments like new radioactive beams. This excellent and beautifully written book presents outstanding quality experimental work that establishes a cornerstone in our understanding of the reaction dynamics of light weakly bound nuclei at energies around the Coulomb barrier.
Zero-Carbon Energy Kyoto 2012
by Takeshi YaoThe Global COE is setting out a zero-emission technology roadmap and is promoting socioeconomic studies of energy, studies of new technologies for renewable energies, and research for advanced nuclear energy. It has also established the Global COE Unit for Energy Science Education to support young researchers as they apply their skills and knowledge and a broad international perspective to respond to issues of energy and the environment in our societies. This book follows on the earlier volumes Zero-Carbon Energy Kyoto 2009, 2010, and 2011.
Zero Decibels
by George M FoyHave our noise-soaked lives driven us mad? And is absolute silence an impossible goal--or the one thing that can save us? A lively tale of one man's quest to find the grail of total quiet.---" I don't know at what point noise became intolerable for me," George Michelsen Foy writes as he recalls standing on a subway platform in Manhattan, hands clamped firmly over his ears, face contorted in pain. But only then does Foy realize how overwhelmed he is by the city's noise and vow to seek out absolute silence, if such an absence of sound can be discovered.Foy begins his quest by carrying a pocket-sized decibel meter to measure sound levels in the areas he frequents most--the subway, the local café, different rooms of his apartment--as well as the places he visits that inform his search, including the Parisian catacombs, Joseph Pulitzer's "silent vault," the snowy expanses of the Berkshires, and a giant nickel mine in Canada, where he travels more than a mile underground to escape all human-made sound. Along the way, Foy experiments with noise-canceling headphones, floatation tanks, and silent meditation before he finally tackles a Minnesota laboratory's anechoic chamber that the Guinness Book of World Records calls "the quietest place on earth," and where no one has ever endured even forty-five minutes alone in its pitch-black interior before finding the silence intolerable.Drawing on history, science, journalistic reportage, philosophy, religion, and personal memory, as well as conversations with experts in various fields whom he meets during his odyssey, Foy finds answers to his questions: How does one define silence? Did human beings ever experience silence in their early history? What is the relationship between noise and space? What are the implications of silence and our need for it--physically, mentally, emotionally, politically? Does absolute silenceactually exist? If so, do we really want to hear it? And if we do hear it, what does it mean to us?According to the Environmental Protection Agency, 30 million Americans suffer from environment-related deafness in today's digital age of pervasive sound and sensory overload. Roughly the same number suffer from tinnitus, a condition, also environmentally related, that makes silence impossible in even the quietest places. In this respect, Foy's quest for silence represents more than a simple psychological inquiry; both his queries and his findings help to answer the question "How can we live saner, healthier lives today?"Innovative, perceptive, and delightfully written, Zero Decibels will surely change how we perceive and appreciate the soundscape of our lives.
Zero Degrees: Geographies of the Prime Meridian
by Charles W. WithersCharles Withers explains how the choice of Greenwich to mark 0° longitude solved problems of global measurement that had engaged geographers, astronomers, and mariners since ancient times. This history is a testament to the power of maps, the challenges of global measurement, and the role of scientific authority in creating the modern world.
Zero Footprint: The true story of a private military contractor's secret wars in the world's most dangerous places
by Simon ChaseSimon Chase's life is a maze of burner phones, encrypted emails, secret meetings, and weaponry - all devoted to executing missions too sensitive for government acknowledgement. Working for shadowy British and American organisations, Chase has been on the trail of Bin Laden in Afghanistan, protected allied generals in Iraq, and been part of an operation directly related to the attack in 2012 on the US consulate in Benghazi.Zero Footprint takes us to this dangerous and thrilling world, and tells the true story of a private military contractor whose work forms the foundation for western security abroad, especially when the UK and US military, intelligence agencies, and departments of state need something done that they can't - or won't - do themselves.
The Zero-G Headache (AstroKids #2)
by Robert ElmerMeet the AstroKids--DeeBee, Buzz, Miko, Mir, and Tag--five friends learning biblical truth through out-of-this-world adventures aboard space station CLEO-7. "'DeeBee's a GEEN-ius.' Suffering satellites, that's all I ever hear! So I understand basic quantum theory. I mean, who doesn't, right? "Anyway, can you believe it? Zero-G, The most popular band in the galaxy, was coming to perform at CLEO-7. Now. . . I think Zero-G's music is pretty lame -- but don't tell that to the other AstroKids! I was more interested in finding out why my geeky cousin Phil was on Zero-G's shuttle. . . and what exactly he was hiding in that mysterious blue plasma barrel".