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Theory of Vibration Protection
by Igor A. Karnovsky Evgeniy LebedThis text is an advancement of the theory of vibration protection of mechanical systems with lumped and distributed parameters. The book offers various concepts and methods of solving vibration protection problems, discusses the advantages and disadvantages of different methods, and the fields of their effective applications. Fundamental approaches of vibration protection, which are considered in this book, are the passive, parametric and optimal active vibration protection. The passive vibration protection is based on vibration isolation, vibration damping and dynamic absorbers. Parametric vibration protection theory is based on the Shchipanov-Luzin invariance principle. Optimal active vibration protection theory is based on the Pontryagin principle and the Krein moment method. The book also contains special topics such as suppression of vibrations at the source of their occurrence and the harmful influence of vibrations on humans. Numerous examples, which illustrate the theoretical ideas of each chapter, are included. This book is intended for graduate students and engineers. It is assumed that a reader has working knowledge of theory of vibrations, differential equations, andcomplex analysis. About the Authors. Igor A Karnovsky, Ph. D. , Dr. Sci. , is a specialist in structural analysis, theory of vibration and optimal control of vibration. He has 40 years of experience in research, teaching and consulting in this field, and is the author of more than 70 published scientific papers, including two books in Structural Analysis (published with Springer in 2010-2012) and three handbooks in Structural Dynamics (published with McGraw Hill in 2001-2004). He also holds a number of vibration-control-related patents. Evgeniy Lebed, Ph. D. , is a specialist in applied mathematics and engineering. He has 10 years of experience in research, teaching and consulting in this field. The main sphere of his research interests are qualitative theory of differential equations, integral transforms and frequency-domain analysis with application to image and signal processing. He is the author of 15 published scientific papers and a US patent (2015).
Theory, Techniques and Applications of Nanotechnology in Gene Silencing
by Surendra Nimesh Ramesh ChandraThis book focuses on various aspects of nanotechnology based gene silencing. The initial chapters detail the techniques available for in vitro and in vivo characterization of nanoparticles. In the later chapters, exhaustive details about various polymeric systems employed for gene silencing has been accounted.
The Theory That Changed Everything: "On the Origin of Species" as a Work in Progress
by Philip LiebermanFew people have done as much to change how we view the world as Charles Darwin. Yet On the Origin of Species is more cited than read, and parts of it are even considered outdated. In some ways, it has been consigned to the nineteenth century. In The Theory That Changed Everything, the renowned cognitive scientist Philip Lieberman demonstrates that there is no better guide to the world’s living—and still evolving—things than Darwin and that the phenomena he observed are still being explored at the frontiers of science.In an exploration that ranges from Darwin’s transformative trip aboard the Beagle to Lieberman’s own sojourns in the remotest regions of the Himalayas, this book relates fresh, contemporary findings to the major concepts of Darwinian theory, which transcends natural selection. Drawing on his own research into the evolution of human linguistic and cognitive abilities, Lieberman explains the paths that adapted human anatomy to language. He demystifies the role of recently identified transcriptional and epigenetic factors encoded in DNA, explaining how nineteenth-century Swedish famines alternating with years of plenty caused survivors’ grandchildren to die many years short of their life expectancy. Lieberman is equally at home decoding supermarket shelves and climbing with the Sherpas as he discusses how natural selection explains features from lactose tolerance to ease of breathing at Himalayan altitudes. With conversational clarity and memorable examples, Lieberman relates the insights that led to groundbreaking discoveries in both Darwin’s time and our own while asking provocative questions about what Darwin would have made of controversial issues today, such as GMOs, endangered species, and the God question.
The Theory That Would Not Die: How Bayes' Rule Cracked the Enigma Code, Hunted Down Russian Submarines, & Emerged Triumphant from Two Centuries of C
by Sharon Bertsch McGrayne"This account of how a once reviled theory, Baye&’s rule, came to underpin modern life is both approachable and engrossing" (Sunday Times). A New York Times Book Review Editors&’ Choice Bayes' rule appears to be a straightforward, one-line theorem: by updating our initial beliefs with objective new information, we get a new and improved belief. To its adherents, it is an elegant statement about learning from experience. To its opponents, it is subjectivity run amok. In the first-ever account of Bayes' rule for general readers, Sharon Bertsch McGrayne explores this controversial theorem and the generations-long human drama surrounding it. McGrayne traces the rule&’s discovery by an 18th century amateur mathematician through its development by French scientist Pierre Simon Laplace. She reveals why respected statisticians rendered it professionally taboo for 150 years—while practitioners relied on it to solve crises involving great uncertainty and scanty information, such as Alan Turing's work breaking Germany's Enigma code during World War II. McGrayne also explains how the advent of computer technology in the 1980s proved to be a game-changer. Today, Bayes' rule is used everywhere from DNA de-coding to Homeland Security. Drawing on primary source material and interviews with statisticians and other scientists, The Theory That Would Not Die is the riveting account of how a seemingly simple theorem ignited one of the greatest controversies of all time.
Theranostic Applications of Nanotechnology in Neurological Disorders
by Akash Gautam Vishal ChaudharyThis book comprehensively reviews the theranostic applications of nanomaterials against various neurological disorders. The initial chapters briefly introduce various neurological disorders, their molecular mechanism, available treatments, and the latest research. It further reviews the challenges associated with the current theranostics strategies, including blood-brain-barrier. This book examines the synthesis of nanoparticles, development of efficient biosensors, fabrication of nanomaterials, diagnosis through nano-chips, and their interaction with neuronal cells. The chapter also discusses the various nanoformulations or nanocarriers of natural therapeutics, including herbal products, peptides, nootropics, and dietary supplements used to prevent and delay neurological disorders. Additionally, the book provides information on the commonly used molecular imaging tools and biosensors, using different nanomaterials for the early detection of neurological disorders. Towards the end,the book covers the imaging techniques like gold nanocages and photoacoustic imaging for diagnosing and targeted drug delivery for neurological disorders. The chapter presents the current challenges in using nanotechnology for neurological disorders and their potential solutions.
Theranostic Iron-Oxide Based Nanoplatforms in Oncology: Synthesis, Metabolism, and Toxicity for Simultaneous Imaging and Therapy (Nanomedicine and Nanotoxicology)
by Mohammad-Nabil Savari Ali JabaliThis book highlights the most efficient and latest ways to deal with cancer, focusing on IONPs. The book describes some well-designed surface modifications performed through several functional materials over the surface of IONPs, which results in the development of multifunctional IONPs-based delivery nanoplatforms by enhancing solubility, stability, and avoiding side effects on healthy cells. Several types of stimuli-responsive IONPs-based strategies are also discussed. Owing to magnetic, structural, and thermal properties, IONPs themselves can be utilized for magnetic targeting, magnetic hyperthermia, and phototherapy. Significant advancements are presented in IONPs-based immunotherapy, radiotherapy, and sonodynamic therapy for the efficient treatment of cancer. Finally, the book presents RIONs which serve as the parent platform for the development of powerful DMCAs utilized in SPECT/MRI and PET/MRI applications.
Theranostics: Methods and Protocols (Methods in Molecular Biology #2054)
by Jyotsna Batra Srilakshmi SrinivasanThis volume explores disease diagnosis and therapy in developing theranostics. The chapters in this book are divided into four parts and cover various techniques used in studying bioengineering, molecular diagnostics, in vivo imaging, and imaging-guided therapy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Theranostics: Methods and Protocols is a valuable tool for novice and expert clinicians, researchers, and students working in this multidisciplinary field.
Theranostics Approaches to Gastric and Colon Cancer (Diagnostics and Therapeutic Advances in GI Malignancies)
by Ganji Seeta Rama Raju L. V. K. S. BhaskarThis book highlights the importance of understanding gastric and colon cancer metabolism in guiding diagnosis and drug discovery. It summarizes the correlation between adiponectin and matrix metalloproteinase with colorectal cancer. The book also evaluates the divergent role of hypoxia-inducible factor 1 in colorectal cancer growth and metastasis. After discussing the role of genetic polymorphisms in alcohol metabolizing enzymes and EPHX1 with the onset of colorectal cancer, it reviews the molecular mechanisms of chemoresistance in gastric cancer and novel therapeutic strategies to reverse the chemoresistance of tumors. In addition, the book explores the theranostic role of nanoparticles and therapeutic potential of phytochemicals with regard to colorectal cancer. Given its scope, the book offers a valuable guide for oncologists, academic researchers, pharmaceuticals practitioners, and students who are involved in research and treatment of cancer.
Theranostics, Gallium-68, and Other Radionuclides
by Frank Rösch Richard P. BaumThis book is based on contributions presented at the 1st World Congress on Gallium-68 and Peptide Receptor Radionuclide Therapy, which examined recent developments in theranostics - the emerging field of molecular targeting of vectors that can be used for both diagnosis and therapy, when modified accordingly. The focus of this book is on the rapidly developing research into and clinical applications of gallium-68 and other generator-produced PET radionuclides in the personalized diagnosis and treatment of neuroendocrine tumors and other diseases. In addition, new PET radiopharmaceuticals are considered, and the latest ideas and concepts, presented. Theranostics embodies both molecular and personalized medicine. It is at the cutting edge of medicine, and the contents of this volume will be of interest to chemists, physicians, and investigators dealing with generators, PET radiochemistry, molecular imaging, and radionuclide therapy.
Therapeutic and Nutritional Uses of Algae
by Leonel PereiraAlgae have been used since ancient times as food, fodder, fertilizer and as source of medicine. Nowadays seaweeds represent an unlimited source of the raw materials used in pharmaceutical, food industries, medicine and cosmetics. They are nutritionally valuable as fresh or dried vegetables, or as ingredients in a wide variety of prepared foods. In particular, seaweeds contain significant quantities of protein, lipids, minerals and vitamins. There is limited information about the role of algae and algal metabolites in medicine. Only a few taxa have been studied for their use in medicine. Many traditional cultures report curative powers from selected alga, in particular tropical and subtropical marine forms. This is especially true in the maritime areas of Asia, where the sea plays a significant role in daily activities. Nonetheless, at present, only a few genera and species of algae are involved in aspects of medicine and therapy. Beneficial uses of algae or algal products include those that may mimic specific manifestations of human diseases, production of antibiotic compounds, or improvement of human nutrition in obstetrics, dental research, thallassotherapy, and forensic medicine.
Therapeutic Angiogenesis for Vascular Diseases
by Mark SlevinAngiogenesis is the growth of new blood vessels and is a key process which occurs during pathological disease progression. Excessive and damaging angiogenesis occurs in diseases such as cancer, diabetic retinopathies, age-related macular degeneration and atherosclerosis. In other diseases such as stroke and myocardial infarction, insufficient or improper angiogenesis results in tissue loss and ultimately higher morbidity and mortality. In this book we will begin by providing the reader with an overview of the process of angiogenesis including normal embryological development of blood vessels. The following chapters will each focus on a key angiogenic disease incorporating current scientific knowledge concerning the causes of activation of the "angiogenic switch", pathological consequences, current treatment options and future perspectives. Where appropriate, results from pre-clinical trials, novel imaging modalities and nanotechnological approaches will be incorporated into these sections. Finally, since it is now believed that the process of angiogenesis operated via different signalling mechanisms in different vascular beds, we will discuss our current understanding of this phenomenon. The target audience for this book would include researchers in all the basic sciences; post-graduate students at Universities and Institutes; pharmaceutical industries; clinicians working in vascular biology or tissue imaging; pathologists; neurologists; tumour biologists; ophthalmologists and cardiologists.
Therapeutic Antibodies: Methods and Protocols (Methods in Molecular Biology #2313)
by Gunnar HouenThis detailed book covers methods for studying, producing, and analyzing therapeutic antibodies, measuring their concentration, developing neutralizing antibodies for them, and for predicting and monitoring their therapeutic efficacy and clinical effects. These biologics are the fastest growing pharmaceutical drug group and have had tremendous clinical and scientific impact in cancer, autoimmune diseases, infectious diseases, and other immune-related diseases, making the content of this volume essential. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible methods, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Therapeutic Antibodies: Methods and Protocols serves as an ideal guide for researchers working with the production of, research on, and development of therapeutic antibodies as well as for clinicians using therapeutic antibodies in daily work with patients.
Therapeutic Applications of Adenoviruses (Gene and Cell Therapy)
by Philip Ng and Nicola Brunetti-PierriAdenoviruses are double stranded DNA viruses that have been used to study the process of DNA replication. Studies of the mode of action of adenovirally produced tumors in rodents led to the discovery of tumour supressor genes. The adenoviral vector is now the most used vector in clinical gene therapy especially for some kinds of cancers. The chapters in this book focus on the most up-to-date developments in the therapeutic applications of adenoviruses. The intended audience is individuals in the Life Sciences interested in therapeutic applications of adenoviruses. This book reviews the life history and immune responses to adenoviruses and summarizes various therapies implemented with the use of adenoviruses.
Therapeutic Applications of Honey and its Phytochemicals: Volume II
by Muneeb U. Rehman Sabhiya MajidHoney typically has a complex chemical and biochemical composition that invariably includes complex sugars, specific proteins, amino acids, phenols, vitamins, and rare minerals. It is reported to be beneficial in the treatment of various diseases, such as those affecting the respiratory, cardiovascular, gastrointestinal, and nervous systems, as well as diabetes mellitus and certain types of cancers; however, there is limited literature describing the use of honey in modern medicine.This book provides evidence-based information on the pharmaceutical potential of honey along with its therapeutic applications and precise mechanisms of action. It discusses in detail the phytochemistry and pharmacological properties of honey, highlighting the economic and culturally significant medicinal uses of honey and comprehensively reviewing the scientific research on the traditional uses, chemical composition, scientific validation, and general pharmacognostical characteristics. Given its scope, it is a valuable tool for researchers and scientists interested in drug discovery and the chemistry and pharmacology of honey.
Therapeutic Applications of Honey and its Phytochemicals: Vol.1
by Muneeb U. Rehman Sabhiya MajidHoney typically has a complex chemical and biochemical composition that invariably includes complex sugars, specific proteins, amino acids, phenols, vitamins, and rare minerals. It is reported to be beneficial in the treatment of various diseases, such as those affecting the respiratory, cardiovascular, gastrointestinal, and nervous systems, as well as diabetes mellitus and certain types of cancers; however, there is limited literature describing the use of honey in modern medicine. This book provides evidence-based information on the pharmaceutical potential of honey along with its therapeutic applications and precise mechanisms of action. It discusses in detail the phytochemistry and pharmacological properties of honey, highlighting the economic and culturally significant medicinal uses of honey and comprehensively reviewing the scientific research on the traditional uses, chemical composition, scientific validation, and general pharmacognostical characteristics. Given its scope, it is a valuable tool for researchers and scientists interested in drug discovery and the chemistry and pharmacology of honey.
Therapeutic Applications of Mesenchymal Stem Cells in Veterinary Medicine
by Mudasir Bashir GugjooThis book reviews the potential therapeutic and reproductive applications of mesenchymal stem cells in veterinary regenerative and reproductive medicine. The systemic approach focuses on musculoskeletal structures like cartilage, bone, muscle, tendon, ligaments and nervous tissues. It also focuses on other body systems like gastrointestinal, cardiovascular, urogenital, respiratory and integumentary system. Besides, the special glands or organs like endocrine glands and eye and its adnexa are also focused. The book chapters discusses the problems and the need for regenerative medicine employing MSCs. It provides an ex vivo basis of MSCs therapeutics and reproductive potential followed by their in vivo applications. The book further provides an understanding on the behavior and mechanisms of action of mesenchymal stem cells. The book also abridges challenges and provides future prospects of mesenchymal stem cells in clinical and reproductive applications. As such, the book offers a valuable resource for students, veterinarians, and scientists working in the regenerative and reproductive sciences in human and veterinary medicine.
Therapeutic Applications of Monte Carlo Calculations in Nuclear Medicine (Series in Medical Physics and Biomedical Engineering)
by H. Zaidi G. SgourosTherapeutic Applications of Monte Carlo Calculations in Nuclear Medicine examines the applications of Monte Carlo (MC) calculations in therapeutic nuclear medicine, from basic principles to computer implementations of software packages and their applications in radiation dosimetry and treatment planning. With chapters written by recognized authorit
Therapeutic Applications of Ribozymes
by Kevin J. ScanlonExpert laboratory scientists describe in detail their methodologies for constructing ribozymes designed to elucidate the role of specific genes as key routes to the development of novel therapies for a wide variety of diseases. The authors review the many sites targeted with ribozymes in various diseases and provide specific accounts of the practical techniques required for the proper use of ribozymes in these systems. Their cutting-edge protocols demonstrate how to achieve ribozyme expression in distinct cellular systems, the preparation and use of high-efficiency ribozyme DNA or RNA delivery, and the studies required to prove the efficacy of ribozyme-mediated inhibition. Therapeutic Applications of Ribozymes contains all the technical support needed to make ribozyme technology a widely used and significant methodology.
Therapeutic Applications of Ribozymes and Riboswitches
by Daniel Lafontaine Audrey DubéIn Therapeutic Applications of Ribozymes and Riboswitches: Methods and Protocols, expert researchers in the field provide a complete overview of protocols used in the development of RNA molecule as drugs and drug target. These include methods and protocols on recent and precise RNA molecule approaches or studies in the development of an RNA therapeutic tool. We are convinced that these methods will help researchers from various domains of life sciences, including clinicians, biochemists and virologists. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Therapeutic Applications of Ribozymes and Riboswitches: Methods and Protocols seeks to aid scientists in the further development of new therapeutic applications implicating RNA molecules or directly targeting harmful RNA.
Therapeutic Applications of RNAi
by Cristina M. Rondinone John F. Reidhaar-OlsonThe phenomenon of RNA interference has rapidly moved from groundbreaking scientific discovery to promising therapeutic approach. However, even as RNAi-based drugs enter the clinic, significant challenges remain, particulary in the area of delivery. Therapeutic Applications of RNAi provides detailed protocols in key areas of current focus, including testing of delivery vehicles, identification of appropriate model systems, and evaluation of the effects of RNAi in vivo. Produced by a team of internationally renowned authors, the volume describes the therapeutic applications of RNAi and potential pitfalls in oncology, viral infections and CNS disease, using a variety of delivery methods, including liposomes, peptide-based nanoparticles, polycationic polymers, and viral vehicles. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Therapeutic Applications of RNAi is an ideal guide for scientists attempting to solve the numerous challenges in this field and revolutionize the treatment of disease.
Therapeutic Delivery Solutions
by Chung Chow Chan Kwok Chow Bill McKay Michelle FungProvides a comprehensive review of all types of medical therapeutic delivery solutions from traditional pharmaceutical therapy development to innovative medical device therapy treatment to the recent advances in cellular and stem cell therapy development • Provides information to potentially allow future development of treatments with greater therapeutic potential and creativity • Includes associated regulatory requirements for the development of these therapies • Provides a comprehensive developmental overview on therapeutic delivery solutions • Provides overview information for both the general reader as well as more detailed references for professionals and specialists in the field
Therapeutic Dressings and Wound Healing Applications (Advances in Pharmaceutical Technology)
by Joshua BoatengThe latest research on techniques for effective healing of chronic and difficult to heal wounds The healing of chronic wounds is a global medical concern, specifically for patients suffering from obesity and type II diabetes. Therapeutic Dressing and Wound Healing Applications is an essential text for research labs, industry professionals, and general clinical practitioners that want to make the shift towards advanced therapeutic dressing and groundbreaking wound application for better healing. This book takes a clinical and scientific approach to wound healing, and includes recent case studies to highlight key points and areas of improvement. It is divided into two key sections that include insight into the biochemical basis of wounds, as well as techniques and recent advancements. Chapters include information on: ● Debridement and disinfection properties of wound dressing ● Biofilms, silver nanoparticles, and honey dressings ● Clinical perspectives for treating diabetic wounds ● Treating mixed infections ● Wound healing and tissue regeneration treatments ● Gene based therapy, 3D bioprinting and freeze-dried wafers Anyone looking to update and improve the treatment of chronic wounds for patients will find the latest pertinent information in Therapeutic Dressing and Wound Healing Applications.
Therapeutic Drug Monitoring and Toxicology by Liquid Chromatography (Chromatographic Science Ser. #32)
by Steven H. Y. WongFirst Published in 2017. Routledge is an imprint of Taylor & Francis, an Informa company.
Therapeutic Endoscopy in the Gastrointestinal Tract
by Georg Kähler Martin Götz Norbert SenningerIn the second edition of the book, the diversity of established and modern endoscopic therapeutic interventions is systematically, comprehensively, and practically presented by experts in visceral surgery and gastroenterology. Numerous endoscopic images and schematic drawings illustrate the descriptions of therapeutic procedures. For each endoscopic procedure, the following is described: Indications Personnel, instrumental, and technical requirements Implementation Results Limitations, complications, and their management All contributions have been updated; a new chapter on hygiene measures has been added. Practical tips and references to alternative approaches appeal to both the young specialist and the experienced endoscopist, as well as endoscopy professionals from other fields.
Therapeutic Enzymes: Function and Clinical Implications (Advances in Experimental Medicine and Biology #1148)
by Nikolaos LabrouTherapeutic enzymes exhibit fascinating features and opportunities, and represent a significant and promising subcategory of modern biopharmaceuticals for the treatment of several severe diseases. Research and drug developments efforts and the advancements in biotechnology over the past twenty years have greatly assisted the introduction of efficient and safe enzyme-based therapies for a range of both rare and common disorders. The introduction and regulatory approval of twenty different recombinant enzymes has enabled effective enzyme-replacement therapy. This volume aims to overview these therapeutic enzymes, focusing in particular on more recently approved enzymes produced by recombinant DNA technology. This volume is composed of four sections. Section 1 provides an overview of the production process and biochemical characterization of therapeutic enzymes, while Section 2 focuses upon the engineering strategies and delivery methods of therapeutic enzymes. Section 3 highlights the clinical applications of approved therapeutic enzymes, including aspects on their structure, indications and mechanisms of action. Together with information on these mechanisms, safety and immunogenicity issues and various adverse events of the recombinant enzymes used for therapy are discussed. Section 4, provides discussion on the prospective and future developments of new therapeutic enzymes. This book is aimed at academics, researchers and students undertaking advanced undergraduate/postgraduate programs in the biopharmaceutical/biotechnology area who wish to gain a comprehensive understanding of enzyme-based therapeutic molecules.