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Therapeutic Fc-Fusion Proteins
by Steven M. Chamow Thomas Ryll Henry B. Lowman Deborah FarsonEdited by three pioneers in the field, each with longstanding experience in the biotech industry, and a skilled scientific writer, this is the first book to cover every step in the development and production of immunoglobulin Fc-fusion proteins as therapeutics for human disease: from choosing the right molecular design, to pre-clinical characterization of the purified product, through to batch optimization and quality control for large-scale cGMP production. The whole of the second part is devoted to case studies of Fc-fusion proteins that are now commercially successful products. In this section, the authors, several of whom were personally involved in clinical development of the products themselves, detail the product?s background and give insight into issues that were faced and how these issues were overcome during clinical development. This section also includes a chapter on promising new developments for the future. An invaluable resource for professionals already working on Fc-fusion proteins and an excellent and thorough introduction for physicians, researchers, and students entering the field.
Therapeutic Monoclonal Antibodies
by Zhiqiang An70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies. First book to address the discovery and development of antibody therapeutics in their entirety.Most chapters contain experimental data to illustrate the principles described in them.Authors provide detailed methodologies that readers can take away with them and use in their own laboratories
Therapeutic Oligonucleotides
by John GoodchildThe field of oligonucleotide therapeutics research is ripe with the prospect of new discoveries. In Therapeutic Oligonucleotides: Methods and Protocols, a selection of established and emerging methods for the application of oligonucleotides as therapeutics are presented, all providing the tools needed to inspire great changes in the field. Divided into twenty-one chapters, this detailed volume meticulously describes vital protocols for optimizing and improving cell uptake, such as photochemical internalization, modified cell penetrating peptides, antibody conjugates, and nanoparticles. Other chapters address quantitation of RNA therapeutics in cells, assaying gene knockdown, selecting the best target site and synthesis of various modified oligonucleotides. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Therapeutic Oligonucleotides: Methods and Protocols serves as a timely resource for both professionals and novices pursuing research in this exciting and pioneering field.
Therapeutic Peptides
by Andrew E. NixonIn this volume we will cover technologies and associated methodologies that allow identification, characterization and application of therapeutic peptides. The section covering identification will cover areas such as display on the surface of filamentous or lytic phage, substrate phage display, ribosome display and the use of peptide library pools. Often the output from library selection is not a peptide but the sequence of a peptide. We will therefore discuss approaches to produce peptide ligands both synthetically and through recombinant techniques. This section will also include a discussion of how peptides may be produced such that their serum residence time can be extended to allow weekly dosing such as fusions to other larger proteins or through modification with PEG. The next section covers biophysical tools for characterization of peptide interactions with proteins. These include fluorescence polarization, equilibrium dialysis, radioligand binding assays, regular and array based SPR analysis. The remaining section outlines methods for preparation and application of peptides as: imaging agents; targeting agents for radionuclei; receptor antagonists, and as tools to mediate cell penetration
Therapeutic Peptides and Proteins: Formulation, Processing, and Delivery Systems, Third Edition
by Ajay K. BangaThere are more than 500 biopharmaceuticals on the market, including more than 200 therapeutic proteins, making biologics the fastest growing sector in the biopharmaceutical market. These products include more than 40 monoclonal antibodies, for indications ranging from treatment or mitigation of various types of cancer to rheumatoid arthritis. The c
Therapeutic Perspectives of Tea Compounds: Potential Applications against COVID-19 (Medicinal Plants and Natural Products for Human Health)
by Farnoosh Dairpoosh Kianoosh DairpooshThis unique volume provides an insight into bioactive compounds of tea from studies of both chemical structures and pharmacological aspects. Examples of the beneficial health effects of tea compounds in managing health problems and diseases are presented, with an emphasis on viral diseases such as COVID-19. Vaccines are not always available in many countries, thus simple and inexpensive measures which are easily available to help mitigate for example, the COVID-19 pandemic, are urgently needed. Dietary bioactive compounds could be alternative nutritional approaches in combating infection in addition to existing therapies and also upcoming vaccines and drugs, by enhancing their efficacy. Features : Emphasizes the antiviral activity of the tea compounds and the latest findings against Coronavirus and SARS-Cov-2. Provides a general overview of tea constituents, chemical structures of these compounds and their potential health benefits. Tea is one of the most commonly used beverages around the world and people with different backgrounds will be interested in reading about its health benefits. Correlating the therapeutic effect of tea components with COVID-19 is extremely beneficial for health care team members and general population. Assists the reader in understanding the therapeutic value of using tea to tackle COVID-19 symptoms, offering simple, inexpensive tips to help mitigate the virus.
Therapeutic potential of Cell Cycle Kinases in Breast Cancer
by Manzoor Ahmad MirThis book highlights the interrelation between cell cycle regulators and breast cancer phenotypes. It reviews the roles of Cyclin-Dependent Kinases (CDK) in driving cell cycle progression, cell cycle checkpoints and dysregulation in breast cancer. It also examines the prognostic significance of CDKs in breast cancer. and CDK inhibitors for the treatment of metastatic breast cancer. Further, the book discusses the role of different G1 cyclins in differentiation, chromosome stability, and transcriptional regulation in breast cancer. Additionally, it examines the role of immunogenic effects of CDK inhibitors, the mechanism of resistance and the current clinical trials in breast cancer treatment. Towards the end, the book explores cell cycle regulation as an attractive target for targeted drug therapy in breast cancer. This book is a comprehensive yet concise resource for oncologists and researchers interested in exploring the therapeutic potential of Cyclin-Dependent Kinases in breast cancer.
The Therapeutic Power of the Maggie’s Centre: Experience, Design and Wellbeing, Where Architecture meets Neuroscience
by Caterina FrisoneThis book is about the therapeutic environment of the Maggie’s centre and explores the many ways this is achieved. With an unconventional architecture as required by the design brief, combined with Maggie’s psychological support programme, this special health facility allows extraordinary therapeutic effects in people, to the point that one can speak of therapeutic power.After tracing the story of the Maggie’s centre, the book reveals its fundamentals: Maggie’s Therapeutikos (the-mind-as-important-as-the-body), the Architectural Brief and the ‘Client-Architect-Users’ Triad. It continues by unfolding Maggie’s synergy-that between people and place-which increases users’ psychological flexibility helping them tolerate what was intolerable before. Although comfort and atmospheres are paramount, they are not enough to define the therapeutic environment of the Maggie’s centre. Only by looking at neuroscience that can give us scientific explanations of empathy, feelings and emotions and only considering space neither neutral nor empty, but full of forces that envelop people in an embodied experience, can we explain what generates wellbeing in a Maggie’s centre.The book concludes by critically evaluating the Maggie’s centre as a model to be applied to other healthcare facilities and to architecture in general. It is essential reading for any student or professional working on therapeutic environments.
Therapeutic Processes for Communication Disorders: A Guide for Clinicians and Students
by Robert J. FourieWhy do many people with disorders of communication experience a sense of demoralization? Do these subjective experiences have any bearing on how such problems should be treated? How can professionals dealing with speech, language, hearing and other communication disorders analyse and respond to the subjective and relational needs of clients with such problems? In this book, authors in the fields of communication disorders analyse the psychological, social and linguistic processes and interactions that underpin clinical practice, from both client and clinician perspectives. The chapters demonstrate how it is possible to analyze and understand client-clinician discourse using qualitative research, and describe various challenges to establishing relationships such as cultural, gender and age differences. The authors go on to describe self-care processes, the therapeutic use of the self, and various psychological factors that could be important for developing therapeutic relationships. Also covered are the rarely considered topics of spirituality and transpersonal issues, which may at times be relevant to clinicians working with clients who have debilitating, degenerative and terminal illnesses associated with certain communication disorders. While this book is geared toward the needs of practicing and training speech, language and hearing clinicians, other professional such as teachers of the deaf, psychotherapists, nurses, and occupational therapists will find the ideas relevant, interesting and easily translatable for use in their own clinical practice.
Therapeutic Proteins
by David C. James C. Mark SmalesWorld-class researchers share their innovative and proven techniques for the production of therapeutic proteins downstream of the discovery stage. The methods use a variety of sources for producing therapeutic proteins, including bacterial and yeast expression systems, and insect and mammalian cells, and then cover the purification of the resulting protein using both state-of-the-art and traditional methods, such as those sourced from plasma. Additional chapters offer methods for the characterization of therapeutic proteins throughout the production process, along with methods and strategies for viral inactivation and protein formulation. The protocols follow the successful Methods in Molecular BiologyTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
Therapeutic Proteins: Strategies to Modulate Their Plasma Half-lives
by Roland KontermannFor this ready reference, the internationally renowned authority in the field, Roland Kontermann, has assembled a team of outstanding contributors from industry and academia to convey the worldwide knowledge on modifying therapeutic proteins in order to optimize their pharmacological potential. The result is a comprehensive work covering all approaches and aspects of the topic in one handy volume, making this indispensable reading for companies and research institutions working on the development of biopharmaceuticals.
Therapeutic Proteins: Methods and Protocols (Methods in Molecular Biology #2720)
by Millicent O. Sullivan Bryce Chackerian Wilfred ChenThis volume covers the latest key aspects of therapeutic protein applications. Chapters in this book cover topics such as the discovery, production, and conjugation of protein-proteins with discussions on the direction of future development and advancements; ways to use these engineering proteins for therapeutic and vaccine applications; and the use of modified protein nanocarriers. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and practical, Therapeutic Proteins: Methods and Protocols is a valuable resource for any researcher who are interested in learning more about the field of therapeutic proteins.
Therapeutic Proteins
by Vladimir Voynov Justin A. CaravellaAfter the identification of a potential protein drug, the next critical step is the production of sufficient authentic material for testing, characterization, and clinical trials, which, when successful, leads to the need for robust methodologies for large-scale production, purification, characterization, viral inactivation, and continued testing of the final protein product. Building on the valuable first edition, Therapeutic Proteins: Methods and Protocols, Second Edition aims to cover each of these key aspects of protein drug production through the contributions of authors from highly esteemed industrial and academic institutions around the world. Emphasizing the newest developments in the field, this second edition also includes additional emphasis on discovery, including new display and screening methods as well as the design and engineering of new types of therapeutic proteins. There is also discussion of computational and bioinformatics methods, and chapters on safety aspects of therapeutic protein development. Written in the highly successful Methods in Molecular BiologyTM format, protocol chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Fully updated and practical, Therapeutic Proteins: Methods and Protocols, Second Edition provides an essential resource to all scientists working in the field of therapeutic proteins.
Therapeutic Proteins Against Human Diseases
by Fahmida Khatoon Zahid BalouchThis book compiles updated research about the implications of therapeutic proteins in various human diseases. The initial chapters of the book provide basic information on the therapeutic proteins and discuss techniques for their formulation, production, and analytic approaches for their characterization. The subsequent chapters shed light on therapies based on therapeutic proteins against metabolic disorders, neurological disorders, cancer, autoimmune disorders, and infectious diseases. Importantly, it presents the factors influencing the immunogenicity of therapeutic proteins, including, genetic factors, disease type, and origin of therapeutic protein, dose frequency, administration route, and treatment duration. The book also reviews the strategies for reducing immunogenicity associated with therapeutic proteins, including PEGylation, site specific mutagenesis, exon shuffling, and humanizing of monoclonal antibodies. Further, it presents strategies for improving the typical drawback associated with protein therapeutics including instability and limited penetration through biological barriers. This book covers various computational methods that are commonly used for designing therapeutic proteins and in silico method for predicting and improving in vivo efficacy of the therapeutic molecules. Lastly, the book highlights the recent advances in developing nanosized delivery systems to improve safety and efficacy of protein therapeutics.This book caters to students and researchers of medicinal chemistry, pharmaceutical sciences and therapeutics. It is also useful to clinicians working with therapeutic proteins.
Therapeutic Revolutions: Pharmaceuticals and Social Change in the Twentieth Century
by Elizabeth Siegel Watkins Flurin Condrau Jeremy A. GreeneWhen asked to compare the practice of medicine today to that of a hundred years ago, most people will respond with a story of therapeutic revolution: Back then we had few effective remedies, but now we have more (and more powerful) tools to fight disease, from antibiotics to psychotropics to steroids to anticancer agents. This collection challenges the historical accuracy of this revolutionary narrative and offers instead a more nuanced account of the process of therapeutic innovation and the relationships between the development of medicines and social change. These assembled histories and ethnographies span three continents and use the lived experiences of physicians and patients, consumers and providers, and marketers and regulators to reveal the tensions between universal claims of therapeutic knowledge and the actual ways these claims have been used and understood in specific sites, from postwar West Germany pharmacies to twenty-first century Nigerian street markets. By asking us to rethink a story we thought we knew, Therapeutic Revolutions offers invaluable insights to historians, anthropologists, and social scientists of medicine.
Therapeutic Rhodium Complexes (SpringerBriefs in Molecular Science)
by Afzal Hussain Mohamed F. Alajmi Mushtaq Ahmad Lone Waseem A. WaniThis book describes the emergence and recent advances in the design and development of rhodium complexes as therapeutic agents. Different classes of anticancer rhodium complexes with particular emphasis on ligands containing nitrogen-oxygen donor atoms are presented. Anticancer rhodium complexes of N-heterocyclic carbenes are described, while half-sandwich, heterobimetallic, and multinuclear rhodium complexes are discussed. Therapeutic applications of rhodium complexes beyond cancer such as antibacterial agents or antiviral agents are also analyzed, among others. Their mechanism of action is overviewed in detail, and the authors thoroughly comment on the challenges and future outlooks of research in the development of rhodium metallodrugs. This title highlights the important research carried out in the development of therapeutic rhodium complexes and is of great interest to graduates and researchers working in the area of rhodium-based therapeutic drugs.
Therapeutic Ribonucleic Acids in Brain Tumors
by Volker A. Erdmann Guido Reifenberger Jan BarciszewskiIn the past few years nucleic acids technologies have grown into a powerful analytical and also increasingly therapeutic tool. It has been applied not only to the uncovering of gene functions in many organisms, but also to pathogenetic analysis and recently also for the treatment of human diseases. The book discusses in depth the potential of these innovative methods in the broad field of central nervous system and brain tumours particularly. Whereas there is currently no comprehensive overview on potential and challenges of nucleic acids technologies for basic brain tumours and for the clinical management of patients with brain tumours, this book does explicitly cover the many other aspects of the "RNA World" (pathogenic and therapeutic potential of microRNAs, aptamer technology, etc.), too. With this significantly broadened scope as compared to currently existing books it appears to be an urgently needed new publication.
The Therapeutic Use of Ayahuasca
by Beatriz Caiuby Labate Clancy CavnarThis book presents a series of perspectives on the therapeutic potential of the ritual and clinical use of the Amazonian hallucinogenic brew ayahuasca in the treatment and management of various diseases and ailments, especially its role in psychological well-being and substance dependence. Biomedical and anthropological data on the use of ayahuasca for treating depression, PTSD, and substance dependence in different settings, such as indigenous contexts, neo-shamanic rituals, contemporary therapeutic circles, and in ayahuasca religions, in both South and North America, are presented and critiqued. Though multiple anecdotal reports on the therapeutic use of ayahuasca exist, there has been no systematic and dense reflection on the topic thus far. The book brings the therapeutic use of ayahuasca to a new level of public examination and academic debate. The texts in this volume stimulate discussion on methodological, ethical, and political aspects of research and will enhance the development of this emergent field of studies.
Therapeutic Use of Medicinal Plants and their Extracts: Phytochemistry and Bioactive Compounds (Progress in Drug Research #74)
by A.N.M. AlamgirThis book starts with a general introduction to phytochemistry, followed by chapters on plant constituents, their origins and chemistry, but also discussing animal-, microorganism- and mineral-based drugs. Further chapters cover vitamins, food additives and excipients as well as xenobiotics and poisons. The book also explores the herbal approach to disease management and molecular pharmacognosy and introduces methods of qualitative and quantitative analysis of plant constituents.Phytochemicals are classified as primary (e.g. carbohydrates, lipids, amino acid derivations, etc.) or secondary (e.g. alkaloids, terpenes and terpenoids, phenolic compounds, glycosides, etc.) metabolites according to their metabolic route of origin, chemical structure and function. A wide variety of primary and secondary phytochemicals are present in medicinal plants, some of which are active phytomedicines and some of which are pharmaceutical excipients.
Therapeutic Uses of Cannabis
by British Medical AssociationAt the last Annual Representative Meeting of the British Medical Association a motion was passed that `certain additional cannabinoids should be legalized for wider medicinal use.'' This report supports this landmark statement by reviewing the scientific evidence for the therapeutic use of cannabinoids and sets the agenda for change. It will be welcomed by those who believe that cannabinoids can be used in medical treatment. The report discusses in a clear and readable form the use and adverse effects of the drug for nausea, multiple sclerosis, pain, epilepsy, glaucoma, and asthma.
Therapeutische Endoskopie im Gastrointestinaltrakt
by Georg Kähler Martin Götz Norbert SenningerAuch in der 2. Auflage des Buches ist die Vielfalt der etablierten und modernen endoskopisch-therapeutischen Interventionen von Experten aus Viszeralchirurgie und Gastroenterologie systematisch, umfassend und praxisnah dargestellt. Zahlreiche endoskopische Bilder und Schemazeichnungen illustrieren die Beschreibungen der Therapieverfahren.Zu jedem endoskopischen Verfahren sind beschrieben:- Indikationen- personelle, instrumentelle und technische Voraussetzungen- Durchführung- Ergebnisse- Limitationen, Komplikationen und deren Management.Alle Beiträge wurden aktualisiert; neu hinzugekommen ist ein eigenes Kapitel über Hygienemaßnahmen. Praktische Tipps und Hinweise auf alternative Vorgehensweisen sprechen den jungen Facharzt ebenso an wie den erfahrenen Endoskopiker und Endoskopie-Fachkräfte aus anderen Berufsgruppen.
Therapy and the Neural Network Model (Neural Network Model: Applications and Implications)
by Theodore Wasserman Lori Drucker WassermanThis innovative work explores integrating emerging research into how the brain processes information in applied therapeutic interventions. Typically, clinicians select therapeutic interventions based on their own training, personal experience or preference. This book aims to provide a new model, based upon the neural networks, to both understand the development of mental health issues and their persistence, and how and why to apply therapeutic interventions to impact the systems which are maintaining them.This work begins with a short and accessible overview of the neural network model, and the general aims of therapy. It elucidates components of the neural network model of learning such as reward recognition, automaticity, and memory reconsolidation, and how they apply to both general learning and new learning through the process in therapy. Next, the authors explore how the neural network model can be integrated across existing systems of therapy, including Cognitive Behavior therapy (CBT), Dialectical Behavior Therapy (DBT), third wave therapies and analytic therapies. Therapy and the Neural Network Model is an exciting resource for researchers and practitioners interested in understanding more about the applications of a neural network model for therapy and the how and why of building new mentally healthy cognitions, behaviors and emotions. Therapy and the Neural Network Model is also an essential theoretical foundation for both researchers and practitioners who wish to base their therapeutic practice on neuroscience and integrate their work with related fields such as behavioral medicine, health psychology, social work and public health.
Therapy of Viral Infections
by Wibke E. Diederich Holger SteuberMedicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e. g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.
There Are No Electrons: Electronics for Earthlings
by Kenn AmdahlThis book explains electricity in ways that the least scientific-minded of people will understand.
There Are Places in the World Where Rules Are Less Important Than Kindness: And Other Thoughts on Physics, Philosophy and the World
by Carlo RovelliA delightful intellectual feast from the bestselling author of Seven Brief Lessons on Physics and The Order of Time One of the world&’s most prominent physicists and fearless free spirit, Carlo Rovelli is also a masterful storyteller. His bestselling books have introduced millions of readers to the wonders of modern physics and his singular perspective on the cosmos. This new collection of essays reveals a curious intellect always on the move. Rovelli invites us on an accessible and enlightening voyage through science, literature, philosophy, and politics. Written with his usual clarity and wit, this journey ranges widely across time and space: from Newton's alchemy to Einstein's mistakes, from Nabokov&’s lepidopterology to Dante&’s cosmology, from mind-altering psychedelic substances to the meaning of atheism, from the future of physics to the power of uncertainty. Charming, pithy, and elegant, this book is the perfect gateway to the universe of one of the most influential minds of our age.