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Therapeutic Processes for Communication Disorders: A Guide for Clinicians and Students
by Robert J. FourieWhy do many people with disorders of communication experience a sense of demoralization? Do these subjective experiences have any bearing on how such problems should be treated? How can professionals dealing with speech, language, hearing and other communication disorders analyse and respond to the subjective and relational needs of clients with such problems? In this book, authors in the fields of communication disorders analyse the psychological, social and linguistic processes and interactions that underpin clinical practice, from both client and clinician perspectives. The chapters demonstrate how it is possible to analyze and understand client-clinician discourse using qualitative research, and describe various challenges to establishing relationships such as cultural, gender and age differences. The authors go on to describe self-care processes, the therapeutic use of the self, and various psychological factors that could be important for developing therapeutic relationships. Also covered are the rarely considered topics of spirituality and transpersonal issues, which may at times be relevant to clinicians working with clients who have debilitating, degenerative and terminal illnesses associated with certain communication disorders. While this book is geared toward the needs of practicing and training speech, language and hearing clinicians, other professional such as teachers of the deaf, psychotherapists, nurses, and occupational therapists will find the ideas relevant, interesting and easily translatable for use in their own clinical practice.
Therapeutic Proteins
by David C. James C. Mark SmalesWorld-class researchers share their innovative and proven techniques for the production of therapeutic proteins downstream of the discovery stage. The methods use a variety of sources for producing therapeutic proteins, including bacterial and yeast expression systems, and insect and mammalian cells, and then cover the purification of the resulting protein using both state-of-the-art and traditional methods, such as those sourced from plasma. Additional chapters offer methods for the characterization of therapeutic proteins throughout the production process, along with methods and strategies for viral inactivation and protein formulation. The protocols follow the successful Methods in Molecular BiologyTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
Therapeutic Proteins: Strategies to Modulate Their Plasma Half-lives
by Roland KontermannFor this ready reference, the internationally renowned authority in the field, Roland Kontermann, has assembled a team of outstanding contributors from industry and academia to convey the worldwide knowledge on modifying therapeutic proteins in order to optimize their pharmacological potential. The result is a comprehensive work covering all approaches and aspects of the topic in one handy volume, making this indispensable reading for companies and research institutions working on the development of biopharmaceuticals.
Therapeutic Proteins: Methods and Protocols (Methods in Molecular Biology #2720)
by Millicent O. Sullivan Bryce Chackerian Wilfred ChenThis volume covers the latest key aspects of therapeutic protein applications. Chapters in this book cover topics such as the discovery, production, and conjugation of protein-proteins with discussions on the direction of future development and advancements; ways to use these engineering proteins for therapeutic and vaccine applications; and the use of modified protein nanocarriers. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and practical, Therapeutic Proteins: Methods and Protocols is a valuable resource for any researcher who are interested in learning more about the field of therapeutic proteins.
Therapeutic Proteins
by Vladimir Voynov Justin A. CaravellaAfter the identification of a potential protein drug, the next critical step is the production of sufficient authentic material for testing, characterization, and clinical trials, which, when successful, leads to the need for robust methodologies for large-scale production, purification, characterization, viral inactivation, and continued testing of the final protein product. Building on the valuable first edition, Therapeutic Proteins: Methods and Protocols, Second Edition aims to cover each of these key aspects of protein drug production through the contributions of authors from highly esteemed industrial and academic institutions around the world. Emphasizing the newest developments in the field, this second edition also includes additional emphasis on discovery, including new display and screening methods as well as the design and engineering of new types of therapeutic proteins. There is also discussion of computational and bioinformatics methods, and chapters on safety aspects of therapeutic protein development. Written in the highly successful Methods in Molecular BiologyTM format, protocol chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Fully updated and practical, Therapeutic Proteins: Methods and Protocols, Second Edition provides an essential resource to all scientists working in the field of therapeutic proteins.
Therapeutic Proteins Against Human Diseases
by Fahmida Khatoon Zahid BalouchThis book compiles updated research about the implications of therapeutic proteins in various human diseases. The initial chapters of the book provide basic information on the therapeutic proteins and discuss techniques for their formulation, production, and analytic approaches for their characterization. The subsequent chapters shed light on therapies based on therapeutic proteins against metabolic disorders, neurological disorders, cancer, autoimmune disorders, and infectious diseases. Importantly, it presents the factors influencing the immunogenicity of therapeutic proteins, including, genetic factors, disease type, and origin of therapeutic protein, dose frequency, administration route, and treatment duration. The book also reviews the strategies for reducing immunogenicity associated with therapeutic proteins, including PEGylation, site specific mutagenesis, exon shuffling, and humanizing of monoclonal antibodies. Further, it presents strategies for improving the typical drawback associated with protein therapeutics including instability and limited penetration through biological barriers. This book covers various computational methods that are commonly used for designing therapeutic proteins and in silico method for predicting and improving in vivo efficacy of the therapeutic molecules. Lastly, the book highlights the recent advances in developing nanosized delivery systems to improve safety and efficacy of protein therapeutics.This book caters to students and researchers of medicinal chemistry, pharmaceutical sciences and therapeutics. It is also useful to clinicians working with therapeutic proteins.
Therapeutic Revolutions: Pharmaceuticals and Social Change in the Twentieth Century
by Elizabeth Siegel Watkins Flurin Condrau Jeremy A. GreeneWhen asked to compare the practice of medicine today to that of a hundred years ago, most people will respond with a story of therapeutic revolution: Back then we had few effective remedies, but now we have more (and more powerful) tools to fight disease, from antibiotics to psychotropics to steroids to anticancer agents. This collection challenges the historical accuracy of this revolutionary narrative and offers instead a more nuanced account of the process of therapeutic innovation and the relationships between the development of medicines and social change. These assembled histories and ethnographies span three continents and use the lived experiences of physicians and patients, consumers and providers, and marketers and regulators to reveal the tensions between universal claims of therapeutic knowledge and the actual ways these claims have been used and understood in specific sites, from postwar West Germany pharmacies to twenty-first century Nigerian street markets. By asking us to rethink a story we thought we knew, Therapeutic Revolutions offers invaluable insights to historians, anthropologists, and social scientists of medicine.
Therapeutic Rhodium Complexes (SpringerBriefs in Molecular Science)
by Afzal Hussain Mohamed F. Alajmi Mushtaq Ahmad Lone Waseem A. WaniThis book describes the emergence and recent advances in the design and development of rhodium complexes as therapeutic agents. Different classes of anticancer rhodium complexes with particular emphasis on ligands containing nitrogen-oxygen donor atoms are presented. Anticancer rhodium complexes of N-heterocyclic carbenes are described, while half-sandwich, heterobimetallic, and multinuclear rhodium complexes are discussed. Therapeutic applications of rhodium complexes beyond cancer such as antibacterial agents or antiviral agents are also analyzed, among others. Their mechanism of action is overviewed in detail, and the authors thoroughly comment on the challenges and future outlooks of research in the development of rhodium metallodrugs. This title highlights the important research carried out in the development of therapeutic rhodium complexes and is of great interest to graduates and researchers working in the area of rhodium-based therapeutic drugs.
Therapeutic Ribonucleic Acids in Brain Tumors
by Volker A. Erdmann Guido Reifenberger Jan BarciszewskiIn the past few years nucleic acids technologies have grown into a powerful analytical and also increasingly therapeutic tool. It has been applied not only to the uncovering of gene functions in many organisms, but also to pathogenetic analysis and recently also for the treatment of human diseases. The book discusses in depth the potential of these innovative methods in the broad field of central nervous system and brain tumours particularly. Whereas there is currently no comprehensive overview on potential and challenges of nucleic acids technologies for basic brain tumours and for the clinical management of patients with brain tumours, this book does explicitly cover the many other aspects of the "RNA World" (pathogenic and therapeutic potential of microRNAs, aptamer technology, etc.), too. With this significantly broadened scope as compared to currently existing books it appears to be an urgently needed new publication.
The Therapeutic Use of Ayahuasca
by Beatriz Caiuby Labate Clancy CavnarThis book presents a series of perspectives on the therapeutic potential of the ritual and clinical use of the Amazonian hallucinogenic brew ayahuasca in the treatment and management of various diseases and ailments, especially its role in psychological well-being and substance dependence. Biomedical and anthropological data on the use of ayahuasca for treating depression, PTSD, and substance dependence in different settings, such as indigenous contexts, neo-shamanic rituals, contemporary therapeutic circles, and in ayahuasca religions, in both South and North America, are presented and critiqued. Though multiple anecdotal reports on the therapeutic use of ayahuasca exist, there has been no systematic and dense reflection on the topic thus far. The book brings the therapeutic use of ayahuasca to a new level of public examination and academic debate. The texts in this volume stimulate discussion on methodological, ethical, and political aspects of research and will enhance the development of this emergent field of studies.
Therapeutic Use of Medicinal Plants and their Extracts: Phytochemistry and Bioactive Compounds (Progress in Drug Research #74)
by A.N.M. AlamgirThis book starts with a general introduction to phytochemistry, followed by chapters on plant constituents, their origins and chemistry, but also discussing animal-, microorganism- and mineral-based drugs. Further chapters cover vitamins, food additives and excipients as well as xenobiotics and poisons. The book also explores the herbal approach to disease management and molecular pharmacognosy and introduces methods of qualitative and quantitative analysis of plant constituents.Phytochemicals are classified as primary (e.g. carbohydrates, lipids, amino acid derivations, etc.) or secondary (e.g. alkaloids, terpenes and terpenoids, phenolic compounds, glycosides, etc.) metabolites according to their metabolic route of origin, chemical structure and function. A wide variety of primary and secondary phytochemicals are present in medicinal plants, some of which are active phytomedicines and some of which are pharmaceutical excipients.
Therapeutic Uses of Cannabis
by British Medical AssociationAt the last Annual Representative Meeting of the British Medical Association a motion was passed that `certain additional cannabinoids should be legalized for wider medicinal use.'' This report supports this landmark statement by reviewing the scientific evidence for the therapeutic use of cannabinoids and sets the agenda for change. It will be welcomed by those who believe that cannabinoids can be used in medical treatment. The report discusses in a clear and readable form the use and adverse effects of the drug for nausea, multiple sclerosis, pain, epilepsy, glaucoma, and asthma.
Therapeutische Endoskopie im Gastrointestinaltrakt
by Georg Kähler Martin Götz Norbert SenningerAuch in der 2. Auflage des Buches ist die Vielfalt der etablierten und modernen endoskopisch-therapeutischen Interventionen von Experten aus Viszeralchirurgie und Gastroenterologie systematisch, umfassend und praxisnah dargestellt. Zahlreiche endoskopische Bilder und Schemazeichnungen illustrieren die Beschreibungen der Therapieverfahren.Zu jedem endoskopischen Verfahren sind beschrieben:- Indikationen- personelle, instrumentelle und technische Voraussetzungen- Durchführung- Ergebnisse- Limitationen, Komplikationen und deren Management.Alle Beiträge wurden aktualisiert; neu hinzugekommen ist ein eigenes Kapitel über Hygienemaßnahmen. Praktische Tipps und Hinweise auf alternative Vorgehensweisen sprechen den jungen Facharzt ebenso an wie den erfahrenen Endoskopiker und Endoskopie-Fachkräfte aus anderen Berufsgruppen.
Therapy and the Neural Network Model (Neural Network Model: Applications and Implications)
by Theodore Wasserman Lori Drucker WassermanThis innovative work explores integrating emerging research into how the brain processes information in applied therapeutic interventions. Typically, clinicians select therapeutic interventions based on their own training, personal experience or preference. This book aims to provide a new model, based upon the neural networks, to both understand the development of mental health issues and their persistence, and how and why to apply therapeutic interventions to impact the systems which are maintaining them.This work begins with a short and accessible overview of the neural network model, and the general aims of therapy. It elucidates components of the neural network model of learning such as reward recognition, automaticity, and memory reconsolidation, and how they apply to both general learning and new learning through the process in therapy. Next, the authors explore how the neural network model can be integrated across existing systems of therapy, including Cognitive Behavior therapy (CBT), Dialectical Behavior Therapy (DBT), third wave therapies and analytic therapies. Therapy and the Neural Network Model is an exciting resource for researchers and practitioners interested in understanding more about the applications of a neural network model for therapy and the how and why of building new mentally healthy cognitions, behaviors and emotions. Therapy and the Neural Network Model is also an essential theoretical foundation for both researchers and practitioners who wish to base their therapeutic practice on neuroscience and integrate their work with related fields such as behavioral medicine, health psychology, social work and public health.
Therapy of Viral Infections
by Wibke E. Diederich Holger SteuberMedicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e. g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.
There Are No Electrons: Electronics for Earthlings
by Kenn AmdahlThis book explains electricity in ways that the least scientific-minded of people will understand.
There Are Places in the World Where Rules Are Less Important Than Kindness: And Other Thoughts on Physics, Philosophy and the World
by Carlo RovelliA delightful intellectual feast from the bestselling author of Seven Brief Lessons on Physics and The Order of Time One of the world&’s most prominent physicists and fearless free spirit, Carlo Rovelli is also a masterful storyteller. His bestselling books have introduced millions of readers to the wonders of modern physics and his singular perspective on the cosmos. This new collection of essays reveals a curious intellect always on the move. Rovelli invites us on an accessible and enlightening voyage through science, literature, philosophy, and politics. Written with his usual clarity and wit, this journey ranges widely across time and space: from Newton's alchemy to Einstein's mistakes, from Nabokov&’s lepidopterology to Dante&’s cosmology, from mind-altering psychedelic substances to the meaning of atheism, from the future of physics to the power of uncertainty. Charming, pithy, and elegant, this book is the perfect gateway to the universe of one of the most influential minds of our age.
There Is Life After the Nobel Prize
by Eric KandelOne day in 1996, the neuroscientist Eric R. Kandel took a call from his program officer at the National Institute of Mental Health, who informed him that he had been awarded a key grant. Also, the officer said, he and his colleagues thought Kandel would win the Nobel Prize. “I hope not soon,” Kandel’s wife, Denise, said when she heard this. Sociologists had found that Nobel Prize winners often did not contribute much more to science, she explained.In this book, Kandel recounts his remarkable career since receiving the Nobel in 2000—or his experience of proving to his wife that he was not yet “completely dead intellectually.” He takes readers through his lab’s scientific advances, including research into how long-term memory is stored in the brain, the nature of age-related memory loss, and the neuroscience of drug addiction and schizophrenia. Kandel relates how the Nobel Prize gave him the opportunity to reach a far larger audience, which in turn allowed him to discover and pursue new directions. He describes his efforts to promote public understanding of science and to put brain science and art into conversation with each other. Kandel also discusses his return to Austria, which he had fled as a child, and observes Austria’s coming to terms with the Nazi period. Showcasing Kandel’s accomplishments, erudition, and wit, There Is Life After the Nobel Prize is a candid account of the working life of an acclaimed scientist.
There Is No Planet B: A Handbook for the Make or Break Years
by Mike Berners-LeeFeeding the world, climate change, biodiversity, antibiotics, plastics – the list of concerns seems endless. But what is most pressing, what are the knock-on effects of our actions, and what should we do first? Do we all need to become vegetarian? How can we fly in a low-carbon world? Should we frack? How can we take control of technology? Does it all come down to population? And, given the global nature of the challenges we now face, what on Earth can any of us do? Fortunately, Mike Berners-Lee has crunched the numbers and plotted a course of action that is practical and even enjoyable. There is No Planet B maps it out in an accessible and entertaining way, filled with astonishing facts and analysis. For the first time you'll find big-picture perspective on the environmental and economic challenges of the day laid out in one place, and traced through to the underlying roots - questions of how we live and think. This book will shock you, surprise you - and then make you laugh. And you'll find practical and even inspiring ideas for what you can actually do to help humanity thrive on this – our only – planet.
There Is No Planet B: A Handbook for the Make or Break Years – Updated Edition
by Mike Berners-LeeFeeding the world, climate change, biodiversity, antibiotics, plastics, pandemics - the list of concerns seems endless. But what is most pressing, and what should we do first? Do we all need to become vegetarian? How can we fly in a low-carbon world? How can we take control of technology? And, given the global nature of the challenges we now face, what on Earth can any of us do, as individuals? Mike Berners-Lee has crunched the numbers and plotted a course of action that is full of hope, practical, and enjoyable. This is the big-picture perspective on the environmental and economic challenges of our day, laid out in one place, and traced through to the underlying roots - questions of how we live and think. This updated edition has new material on protests, pandemics, wildfires, investments, carbon targets and of course, on the key question: given all this, what can I do?
There Was An Old Astronaut Who Swallowed the Moon! (There Was an Old Lady)
by Lucille ColandroScholastic's bestselling OLD LADY becomes an astronaut in this adventure full of hilarious laughs and fun facts about space -- perfect for the 50th anniversary of the moon landing!There was an old astronaut who swallowed the moon. I don't know why she swallowed the moon. It happened at noon.Scholastic's bestselling OLD LADY returns in this adventure series with a nonfiction twist that will make you laugh AND learn! In this spin-off, the OLD LADY turns into an OLD ASTRONAUT who travels through space, swallowing a moon... along with a star, a planet, a comet, a meteor, a rocket, and a satellite... Why? Well, it went down just right, that bright satellite! Two new characters lead the reader through this hilarious adventure while exchanging some awesome facts about outer space for a light take on nonfiction that's perfect for this age. With expanded back matter about the solar system and a search-and-find game at the end, this OLD ASTRONAUT definitely shoots for the stars!
There's a Skeleton Inside You!
by Idan Ben-BarakFrom writer Idan Ben-Barak and illustrator Julian Frost, the creators of Do Not Lick This Book, comes a hilarious, interactive picture book that takes a look inside our bodies to show what humans are made of.Lay your hand flat out in front of you. Have you ever wondered what it's made of?What's beneath your skin?Your muscle?Your nerves?Find out in There's a Skeleton Inside You! Follow two friendly aliens named Quort and Oort as their spaceship breaks down on the way to their friend Kevin's birthday party. They realize they need a hand, but . . . they don't have hands! Don't worry. They have a great idea: They'll just grow some!What follows is an uproarious exploration of what makes up the human body, layer by layer.
There's No Place Like Space! All About Our Solar System: All About Our Solar System (The Cat in the Hat's Learning Library)
by Tish RabeLaugh and learn with fun facts about the sun, the moon, the planets, constellations, astronauts, and more—all told in Dr. Seuss&’s beloved rhyming style and starring The Cat in the Hat! &“The universe is a mysterious place. We are only just learning what happens in space.&” The Cat in the Hat&’s Learning Library series combines beloved characters, engaging rhymes, and Seussian illustrations to introduce children to non-fiction topics from the real world! On this adventure into outer space, readers will discover: • what makes each planet in our solar system unique• how a million Earths could fit inside the sun• how astronauts have driven a special car all over the moon• and much more! Perfect for story time and for the youngest readers, There&’s No Place Like Space: All About Our Solar System also includes an index, glossary, and suggestions for further learning. Look for more books in the Cat in the Hat&’s Learning Library series!Cows Can Moo! Can You? All About FarmsHark! A Shark! All About SharksIf I Ran the Dog Show: All About DogsOh Say Can You Say Di-no-saur? All About DinosaursOn Beyond Bugs! All About InsectsOne Vote Two Votes I Vote You VoteWho Hatches the Egg? All About EggsWhy Oh Why Are Deserts Dry? All About DesertsWish for a Fish: All About Sea Creatures
Thermal Analysis of Materials (Materials Engineering)
by Robert SpeyerDiscussing the design and optimum use of thermal analysis instrumentation for materials' property measurement, this work details how the instruments work, what they measure, potential pitfalls and the fitting of experimental results to theoretical models. It presents a tutorial on writing computer programs for data manipulation, advanced thermoanal
Thermal analysis of Micro, Nano- and Non-Crystalline Materials
by Jaroslav Šesták Peter SimonThermal Analysis of Micro-, Nano- and Non-Crystalline Materials: Transformation, Crystallization, Kinetics, and Thermodynamics complements and adds to volume 8 Glassy, Amorphous and Nano-Crystalline Materials by providing a coherent and authoritative overview of cutting-edge themes in this field. In particular, the book focuses on reaction thermodynamics and kinetics applied to solid-state chemistry and thermal physics of various states of materials. Written by an international array of distinguished academics, the book deals with fundamental and historical aspects of phenomenological kinetics, equilibrium background of processes, crystal defects, non-stoichiometry and nano-crystallinity, reduced glass-transition temperatures and glass-forming coefficients, determination of the glass transition by DSC, the role of heat transfer and phase transition in DTA experiments, explanation of DTA/DSC methods used for the estimation of crystal nucleation, structural relaxation and viscosity behaviour in glass and associated relaxation kinetics, influence of preliminary nucleation and coupled phenomenological kinetics, nucleation on both the strongly curved surfaces and nano-particles, crystallization of glassy and amorphous materials including oxides, chalcogenides and metals, non-parametric and fractal description of kinetics, disorder and dimensionality in nano-crystalline diamond, thermal analysis of waste glass batches, amorphous inorganic polysialates and bioactivity of hydroxyl groups as well as reaction kinetics and unconventional glass formability of oxide superconductors. Thermal Analysis of Micro-, Nano- and Non-Crystalline Materials: Transformation, Crystallization, Kinetics, and Thermodynamics is a valuable resource to advanced undergraduates, postgraduates, and researches working in the application fields of material thermodynamics, thermal analysis, thermophysical measurements, and calorimetry.