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Totalsynthese des Marinen Makrolids Palmerolid A
by Julia SünnerDer Naturstoff Palmerolid A wurde im Jahr 2006 erstmals isoliert und zeigte in zellbiologischen Untersuchungen eine sehr starke und außergewöhnlich selektive cytotoxische Aktivität gegenüber ausgewählten Krebszelllinien. Als 20-gliedriges Makrolacton mit fünf Stereozentren, mehreren isolierten und konjugierten Doppelbindungseinheiten und einer Dienamid-tragenden Seitenkette bietet der hochfunktionalisierte Naturstoff aus struktureller Sicht für den Synthesechemiker interessante Herausforderungen. Im Rahmen dieser Studie wurde eine Strategie entwickelt, die den totalsynthetischen Zugang zu diesem hochpotenten Molekül ermöglicht. Über die hier beschriebene Synthesesequenz konnte eine bemerkenswerte Menge des Naturstoffs zur Verfügung gestellt werden, um seine pharmakologischen und toxikologischen Eigenschaften ausführlich zu untersuchen.
Touch
by David J. LindenThe New York Times bestselling author examines how our sense of touch and emotion are interconnectedJohns Hopkins neuroscientist and bestselling author of The Compass of Pleasure David J. Linden presents an engaging and fascinating examination of how the interface between our sense of touch and our emotional responses affects our social interactions as well as our general health and development. Accessible in its wit and clarity, Touch explores scientific advances in the understanding of touch that help explain our sense of self and our experience of the world.From skin to nerves to brain, the organization of the body's touch circuits powerfully influences our lives--affecting everything from consumer choice to sexual intercourse, tool use to the origins of language, chronic pain to healing. Interpersonal touch is crucial to social bonding and individual development. Linden lucidly explains how sensory and emotional context work together to distinguish between perceptions of what feels good and what feels bad. Linking biology and behavioral science, Linden offers an entertaining and enlightening answer to how we feel in every sense of the word.From the Hardcover edition.
Touch and Blindness: Psychology and Neuroscience
by Morton A. Heller Soledad BallesterosResearch on touch and blindness has undergone rapid transformation in recent years, with dramatic developments in technology designed to provide assistance to those who are blind, and advancements in robotics that demand haptic interfaces. Touch and Blindness approaches the study of the topic from the perspectives of psychological methodology and the most sophisticated, state-of-the-art techniques in neuroscience. This book, edited by well-known leaders in the field, is derived from the discussions presented by speakers at a conference held in 2002, and presents current research in the field. The book is arranged in a logical, disciplinary fashion, first discussing touch and blindness from a psychological perspective, followed by an examination from the perspective of neuroscience. Some specific topics include:*processing spatial information from touch and movement;*form, projection, and pictures for the blind;*neural substrate and visual and tactile object representations; and*the role of visual cortex in tactile processing. Touch and Blindness is ideal for researchers in psychology and neuroscience, medicine, and special education.
Touch and Blindness: Psychology and Neuroscience
by Morton A. Heller Soledad BallesterosThis is a scholarly document concerning the neurological aspects of visual impairment.
Touch It: Materials, Matter and You
by Adrienne MasonThe book helps in introducing Physical sciences to children practically, by exploring materials - their colour, shape, size, mass, magnetism etc.
Touch Matters: Handshakes, Hugs, and the New Science on How Touch Can Enhance Your Well-Being
by Michael BanissyAn exploration of the new science behind our most underappreciated sense and why we need to harness the power of touch for our health and well-being.Every day, we use our sense of touch to navigate the world. A handshake, a pat on the shoulder, a hug—all essential touches that make up our daily lives. In Touch Matters, Professor Michael Banissy brings together diverse scientific insights from the world's largest study on touch with takeaways on how to enhance your levels of touch for a happier, healthier life. The book explains why touch is essential to our well-being, the role it plays in our relationships, friendships, in the bedroom, workplace, in team activities such as sports, and much more. Banissy's latest research explores:Our "touch personalities"Touch starvationHow touch defines our relationships and self-esteemThe impact of touch on our physical and mental health This is a fascinating window into one of our most important and basic senses and how to harness its power.FEATURES ORIGINAL RESEARCH FROM "THE TOUCH TEST": Touch Matters is based on one of Banissy's most recent projects—the Touch Test—a science and broadcast collaboration with the BBC and Wellcome Collection. This project explored attitudes and experiences of touch via the world's largest contemporary survey on the topic, public exhibitions, and a series of broadcast programs focused on the topic of touch that received worldwide attention. The project had approximately 40,000 participants from 113 countries.OFFERS GUIDANCE ON COMMUNICATING AND CONNECTING IN OUR DAILY AND PROFESSIONAL LIVES: As we return to office work and live in a world where touch has become loaded with meaning, this book will help people understand how important touch is and the role it plays in every aspect of our lives, from relationships and friendships to the workplace and team activities and much more.Perfect for:Readers interested in science, psychology, and self-helpFans of James Nestor's Breath, Marc Brackett's Permission to Feel, Bill Bryson's The Body, Mark Miodownik's Stuff MattersAdults and parents of children resuming in-person activities including going back to the office, returning to school, traveling, and socializingThose interested in learning more about the science of touch, touch starvation, and how important touch is to child/human developmentPeople struggling with depression or anxiety around physical contact
Touch The Sun: A NASA Braille Book
by Noreen GriceTouch the Sun is a universally designed book with colorful raised images and combined text in print and Braille that explores the dynamic nature of our Sun.Topics include: size comparison between Earth and the Sun, the interior layers of the Sun, sunspots and their motion, views of the Sun in visible and ultraviolet light, solar eruptions as seen from space based observatories, massive solar storms, and the effect of space weather on Earth.According to the author, "This book is hot!"
Touching a Nerve: Our Brains, Our Selves
by Patricia S. ChurchlandA trailblazing philosopher's exploration of the latest brain science--and its ethical and practical implications. What happens when we accept that everything we feel and think stems not from an immaterial spirit but from electrical and chemical activity in our brains? In this thought-provoking narrative--drawn from professional expertise as well as personal life experiences--trailblazing neurophilosopher Patricia S. Churchland grounds the philosophy of mind in the essential ingredients of biology. She reflects with humor on how she came to harmonize science and philosophy, the mind and the brain, abstract ideals and daily life. Offering lucid explanations of the neural workings that underlie identity, she reveals how the latest research into consciousness, memory, and free will can help us reexamine enduring philosophical, ethical, and spiritual questions: What shapes our personalities? How do we account for near-death experiences? How do we make decisions? And why do we feel empathy for others? Recent scientific discoveries also provide insights into a fascinating range of real-world dilemmas--for example, whether an adolescent can be held responsible for his actions and whether a patient in a coma can be considered a self. Churchland appreciates that the brain-based understanding of the mind can unnerve even our greatest thinkers. At a conference she attended, a prominent philosopher cried out, "I hate the brain; I hate the brain!" But as Churchland shows, he need not feel this way. Accepting that our brains are the basis of who we are liberates us from the shackles of superstition. It allows us to take ourselves seriously as a product of evolved mechanisms, past experiences, and social influences. And it gives us hope that we can fix some grievous conditions, and when we cannot, we can at least understand them with compassion.
Touching for Knowing
by Yvette Hatwell Arlette Streri Edouard GentazA number of articles exploring ways people learn. Learning through touch instead of vision is contrasted.
Tour of Duty: John Kerry and the Vietnam War
by Douglas BrinkleyOne of our most acclaimed historians explores the decorated military service of one of America’s most intriguing politicians—the leading Democratic presidential candidate for 2004—and its profound effects on his career and lifeIn Tour of Duty, Brinkley explores Senator John Kerry’s career and deftly deals with such explosive issues as U.S. atrocities in Vietnam and the bombing of Cambodia. Using new information acquired from the recently released Nixon tapes, Brinkley reveals how White House aides Charles Colson and H.R. Haldeman tried to discredit Kerry. Refusing to be intimidated, Kerry started running for public office, eventually becoming a U.S. Senator from Massachusetts. Covering more than four decades, this is the first full-scale definitive account of Kerry’s journey from war to peace. In writing this riveting, action-packed narrative, Brinkley has drawn on extensive interviews with virtually everyone who knew Kerry well in Vietnam. Kerry also relegated to Brinkley his letters home from Vietnam and his voluminous “war notes” journals, notebooks, and personal reminiscences written during and shortly after the war. This material was provided without restriction, to be used at Brinkley’s discretion, and has never before been published.
A Tour of the Human Body: Amazing Numbers--Fantastic Facts (Number Tours for Curious Kids)
by Jennifer BerneJennifer Berne takes children on a tour of the human body to reveal the wonders of how it works -- with some astonishing numbers and fascinating facts along the way.From our eyes to our toes, kids will find out what makes the human body tick. They&’ll discover that our hearts beat 100,000 times a day, which equals 36 MILLION times a year. And that our tongue&’s 8,000 taste buds can detect only 5 flavors. And that we have 60,000 miles of blood vessels, enough to circle the world more than twice!With such remarkable facts and numbers, and vivid informative illustrations by Dawn DeVries Sokol, this book takes your child on an entertainingly educational journey through the wonders of the human body.
A Tour of the Senses: How Your Brain Interprets the World
by John M. Henshaw2012 Outstanding Academic Title, Choice MagazineEver wonder why some people have difficulty recognizing faces or why food found delicious in one culture is reviled in another? John M. Henshaw ponders these and other surprising facts in this fascinating and fast-paced tour of the senses.From when stimuli first excite our senses to the near-miraculous sense organs themselves to the mystery of how our brain interprets senses, Henshaw explains the complex phenomena of how we see, feel, taste, touch, and smell. He takes us through the rich history of sensory perception, dating back to Aristotle’s classification of the five main senses, and helps us understand the science and technology behind sensory research today.A Tour of the Senses travels beyond our human senses. Henshaw describes artificial sensing technologies and instruments, unusual sensory abilities of the animal kingdom, and techniques for improving, rehabilitating, and even replacing sense organs. This entertaining introduction to sensory science is a clever mix of research findings and real-world stories that helps us understand the complex processes that turn sensory stimuli into sophisticated brain responses.
A Tour of the Senses: How Your Brain Interprets the World
by John M. Henshaw“A blend of research findings and real-world anecdotes about people’s sensory experiences enlivens this historical view of the science behind perception.” —Science NewsEver wonder why some people have difficulty recognizing faces or why food found delicious in one culture is reviled in another? John M. Henshaw ponders these and other surprising facts in this fascinating and fast-paced tour of the senses.From when stimuli first excite our senses to the near-miraculous sense organs themselves to the mystery of how our brain interprets senses, Henshaw explains the complex phenomena of how we see, feel, taste, touch, and smell. He takes us through the rich history of sensory perception, dating back to Aristotle’s classification of the five main senses, and helps us understand the science and technology behind sensory research today.A Tour of the Senses travels beyond our human senses. Henshaw describes artificial sensing technologies and instruments, unusual sensory abilities of the animal kingdom, and techniques for improving, rehabilitating, and even replacing sense organs.This entertaining introduction to sensory science is a clever mix of research findings and real-world stories that helps us understand the complex processes that turn sensory stimuli into sophisticated brain responses.“A Tour of the Senses is a fun book, which may be of interest to anyone who’s ever wondered how the eye or ear works.” —American Journal of Human Biology
Tourism and Climate Change: Impacts, Adaptation and Mitigation (Contemporary Geographies of Leisure, Tourism and Mobility)
by Daniel Scott C. Michael Hall Gossling StefanClimate change is the single most important global environmental and development issue facing the world today and has emerged as a major topic in tourism studies. Climate change is already affecting the tourism industry and is anticipated to have profound implications for tourism in the twenty-first century, including consumer holiday choices, the geographic patterns of tourism demand, the competitiveness and sustainability of destinations and the contribution of tourism to international development. Tourism and Climate Change: Impacts, Adaptation and Mitigation is the first book to provide a comprehensive overview of the theory and practice of climate change and tourism at the tourist, enterprise, destination and global scales. Major themes include the implications of climate change and climate policy for tourism sectors and destinations around the world, tourist perceptions of climate change impacts, tourism’s global contribution to climate change, adaptation and mitigation responses by all major tourism stakeholders, and the integral links between climate change and sustainable tourism. It combines a thorough scientific assessment of the climate-tourism interrelationships with discussion of emerging mitigation and adaptation practice, showcasing international examples throughout the tourism sector as well as actions by other sectors that will have important implications for tourism. Written by three leading academics in this field, this critical contribution highlights the challenges of climate change within the tourism community and provides a foundation for decision making for both reducing the risks, and taking advantage of the opportunities, associated with climate change. This comprehensive discussion of the complexities of climate change and tourism is essential reading for students, academics, business leaders and government policy makers.
Tourism and Conservation-based Development in the Periphery: Lessons from Patagonia for a Rapidly Changing World (Natural and Social Sciences of Patagonia)
by Trace Gale-Detrich Andrea Ednie Keith BosakThis open access book applies a social ecological systems (SES) lens to conservation-based development in Patagonia, bringing together authors with historical, contemporary, and future-oriented perspectives in order to increase understanding of the social and environmental implications of nature-based tourism and other forms of conservation-based territorial development. By focusing on Patagonia (as a region) and its various forms of conservation-based development, this book contributes one of the first collections of South American based lessons and will be valuable to researchers and practitioners, both locally and around the world, seeking to better understand complex interconnections between social and ecological environments, and pursue a similar path to resilience and sustainability.
Tourism and Global Environmental Change: Ecological, Economic, Social and Political Interrelationships (Contemporary Geographies of Leisure, Tourism and Mobility)
by C. Michael Hall Stefan GösslingThis fascinating book is the first comprehensive analysis of the economic, social and political interrelationships between tourism and global environmental change: one of the most significant issues facing humankind today. Its contributors argue that the impacts of these changes are potentially extremely serious both for the tourism industry, and for the communities dependent upon it. Integrating knowledge from the social and physical sciences, this significant book explores they key issues surrounding global environmental change, as well as government and industry willingness to meet the challenges posed by it. Divided into four main sections, it investigates: the tourism and global environmental change relationship in specific environments global issues related to environmental change differing perceptions of global environmental change held by tourists and the tourist industry. Comprehensive in scope, topical and integrative, this key text is essential reading for students, scholars and researchers in all aspects of tourism, geography and environmental studies.
Tourism and Responsibility: Perspectives from Latin America and the Caribbean
by Martin Mowforth Clive Charlton Ian MuntThis book discusses the responsibility, or otherwise, of tourism activities in Latin America and the Caribbean. It considers issues such as the reduction of poverty through tourism and the conflict between increasing volumes of air travel spent in our continuing search for pleasure and the resulting contribution to global warming. The authors believe that tourism can only be adequately assessed through a consideration of how it fits into the structure of power. It is also argued that tourism cannot be analyzed without a consideration of its impacts on and links with development. This relationship between tourism, responsibility, power and development is explored in chapters covering both the macro and the micro level of responsibility. The authors look at methods of practising tourism responsibly or irresponsibly at the personal, company, national and international levels. The questions and dilemmas of "placing" responsibility in the tourism industry are examined throughout. Widely illustrating all these themes and issues with examples and case studies from throughout the sub-continent, this book will be of importance to students and academics and to the work of practitioners of development and tourism-related projects run by both governmental and non-governmental aid and development agencies.
Tourism, Heritage and Commodification of Non-human Animals: A Posthumanist Reflection
by Tomas Arias Jean Azcatl Pineda Alicia Mariana Pérez Bobbie Chew Bigby Émilie Crossley Johan Edelheim Georgina Flores Carolin Funck Leonardo Garavito-González Yulei Guo Dr Jes Hooper Brenda Martínez Velasco Alejandro Morales Gustavo Ortiz-Millán Mateo Nicolás Medina Jorge Iván Barrera Javed Salim Estephania Sepúlveda Perdomo Rie Usui David A. Varela-Trejo Nusrat YasmeenHeritage is a social construction rooted in modern and contemporary societies. It is commonly a positive assessment of many elements of the physical and human environment (e.g. ecosystems and landscapes, monuments, customs, gender norms, religious practices, gastronomy, and livelihoods). Heritage and tourism are strongly related to each other in that heritage gives rise to tourist attractions and activities, and tourism enhances the designation of heritage sites. Non-human animals (hereafter 'animals') are present as implicit or explicit heritage elements through multiple tourist environments: animals may be themselves the heritage focus of tourist interest (visual arts, gastronomy, as charismatic and distinguished beings, as part of festivities or rituals), or it may be that animals are agents involved in heritage tourist environments such as working animals or in recreational activities. A post-humanist perspective the moral valuation of equality between humans and other animals demands that both are sentient beings and self-aware of their pain and pleasure. Thus, the involvement of animals as heritage elements by themselves or as an element of tourist consumption in heritage sites implies their commodification and lack of agency. As such, these practices are usually unethical, since they threaten the animals' primary interests: not to suffer, not to feel pain and to be able to live their freedom. This book contains chapters that reveal both the unethical interactions between humans and animals within heritage tourism, and those that show experiences in which efforts are made to minimize damage within the commercialization of animals involved as heritage themselves. It will be of interest to postgraduate students, academics, NGOs and tourism planners.
Tourism in Emerging Economies: The Way We Green, Sustainable, and Healthy
by Wei-Ta FangThis book bridges the gap between the vital issues of the tourism industry, practices and destinations, discussing various topics from Asian and African perspectives. Each chapter presents extensive research on tourism development and tourism education, people’s work and travel experiences, as well as broader philosophies concerning the global tourism industry’s practices and operations. In the context of Sustainable Development Goals (SDGs) 8, 12 and 14, the book highlights the potential of tourism to contribute to economic growth, social inclusion and environmental preservation. It discusses crucial issues confronting the travel and tourism industry, presenting achievable outlines and strategy plans, and evaluating general theories, practices, and applications of social, economic and environmental aspects of management structure to maximize the cultural, social and ecological diversity of destinations and enhance the tourism experience. Providing a comprehensive guide to tourism and its related disciplines, it offers students, professors, entrepreneurs, and travel and tourism organizations insights into the trends, practices. Further, it features case studies ranging from historical and contemporary tourism to forecasts for future tourism.
Tourism, Land Grabs and Displacement: The Darker Side of the Feel-Good Industry (Routledge Studies in Global Land and Resource Grabbing)
by Andreas NeefThis book examines the global scope of tourism-related grabbing of land and other natural resources. Tourism is often presented as a peaceful and benevolent sector that brings people from different cultural backgrounds together and contributes to employment, poverty alleviation, and global sustainable development. This book sheds light on the lesser known and much darker side of tourism as it unfolds in the Global South. While there is no doubt that tourism has been an engine of economic growth for many so-called developing countries, this has often come at the cost of widespread dispossession and displacement of Indigenous and non-indigenous communities. In many countries of the Global South, tourism development is increasingly prioritised by governments, businesses, international financial institutions and donors over the legitimate land and resource rights of local people. This book examines the actors, drivers, mechanisms, discourses and impacts of tourism-related land grabbing and displacement, drawing on more than thirty case studies from Latin America and the Caribbean, sub-Saharan Africa, South and Southeast Asia, the Middle East and the Southwest Pacific. The book provides solid grounds for an informed debate on how different actors are responsible for the adverse impacts of tourism on land rights infringements, what forms of resistance have been deployed against tourism-related land grabs and displacement, and how those who have violated local land and resource rights can be held accountable. Tourism, Land Grabs and Displacement will be essential reading for students and scholars of land and resource grabbing, tourism studies, development studies and sustainable development more broadly, as well as policymakers and practitioners working in those fields.
Tourism Management and Sustainable Development (Contributions to Economics)
by Goran Karanovic Persefoni Polychronidou Anastasios Karasavvoglou Helga Maskarin RibaricThis book investigates the various ties between tourism development and sustainability, revealing forces of change and current trends in tourism management performance in countries of Central and Southeast Europe. The contributions explore how the tourism industry is responding to numerous related challenges while managing risks with the aim of enhancing tourism management performance. In addition, it offers insights into the interconnections between tourism and other industries. In brief, the book offers an innovative, quantitative and qualitative scientific approach to the topic, along with conclusions and concrete policy recommendations.
Tourism, Recreation and Biological Invasions
by Agustina Barros, Ross Shackleton, Lisa J. Rew, Cristóbal Pizarro and Aníbal PauchardThe first section of the book includes information about how tourism-related infrastructure and activities promote biological invasions, including key pathways for non-native invasive species introductions. This section provides case studies of different organisms that are known to be introduced and/or promoted by tourism in different ecosystems or regions. The second section elaborates on known and potential impacts of invasive species on tourism and recreation, including how they may affect, positively or negatively, the economic revenue from tourism, tourist access, recreation, aesthetic values and tourists' perceptions. The last section focuses on management and policy, covering aspects of how visitors perceive invasive species and their willingness to manage them, biosecurity measures to prevent invasion related to tourism, as well as potential policy options moving forward. The book draws on a number of examples across multiple taxa, landscapes and regions of the world.
Tourism, Travel, and Hospitality in a Smart and Sustainable World: 9th International Conference, IACuDiT, Syros, Greece, 2022 - Vol. 2 (Springer Proceedings in Business and Economics)
by Vicky KatsoniThis book features the second volume of the proceedings of the 9th International Conference of the International Association of Cultural and Digital Tourism (IACuDiT). Held at the Syros Island in Greece in September 2022, the conference's lead theme was ‘Tourism, Travel, and Hospitality in a Smart and Sustainable World’.With a full appreciation of the contributions made by numerous writers toward the progress in tourism research, this book presents a critical academic discourse on sustainable practices in a smart tourism context, stimulating future debates and advancing knowledge and understanding in this critical area of knowledge. It also puts emphasis on the knowledge economy and smart destinations notion. It enacts new modes of tourism management and development and presents chapters on cultural heritage tourism, emerging technologies and tourism consumer behaviour, such as tourism education, location-based services, Internet of Things, smart cities, mobile services, gamification, digital collections and the virtual visitor, social media, social networking, and augmented reality.
Tourism, Travel, and Hospitality in a Smart and Sustainable World: 9th International Conference, IACuDiT, Syros, Greece, 2022 - Vol. 1 (Springer Proceedings in Business and Economics)
by Vicky KatsoniThis book features the second volume of the proceedings of the 9th International Conference of the International Association of Cultural and Digital Tourism (IACuDiT). Held at the Syros Island in Greece in September 2022, the conference's lead theme was ‘Tourism, Travel, and Hospitality in a Smart and Sustainable World’.With a full appreciation of the contributions made by numerous writers toward the progress in tourism research, this book presents a critical academic discourse on sustainable practices in a smart tourism context, stimulating future debates and advancing knowledge and understanding in this critical area of knowledge. It also puts emphasis on the knowledge economy and smart destinations notion. It enacts new modes of tourism management and development and presents chapters on emerging technologies, such as location-based services, Internet of Things, smart cities, mobile services, gamification, digital collections and the virtual visitor, social media, social networking, and augmented reality
Tourists in Space
by Erik SeedhouseForget Hawaii or the Mediterranean. Soon - very soon - you'll be able to add a much more exotic stamp to your passport: space. How will you get there, what will the trip be like and how much training will you need? All you need to know is right here in this guide. Tourists in Space: A Practical Guide supplies all the advice and information you need to make your spaceflight the most rewarding experience of your life. This definitive, real-world guide is packed with helpful facts and suggestions on everything from training, equipment, safety and in-flight procedures to techniques for avoiding space motion sickness and bone demineralization. You'll also find: * Advice on choosing your training agency * Techniques for minimizing the risk of space motion sickness * Information you need to prepare for your medical examination, training and flight * Tips on activities near your training location and much more.