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The U.S. Combat Aircraft Industry, 1909-2000
by Mark A. LorellDrawing on primary and secondary sources on the aircraft industry, this report provides a brief survey of industry structure, innovation, and competition in the U.S. fixed-wing combat aircraft industry from its earliest days to the present. It supports a much larger research effort examining the future of the structure, innovation, and competition of the U.S. military aircraft industrial base that responds to congressional concerns about that future.
The U.S. Domestic Intelligence Enterprise: History, Development, and Operations
by Darren E. TromblayMuch has been written about U.S. intelligence operations. However, intelligence, as it is conducted in the U.S. domestic environment, has usually been treated in a fractured and sensationalistic manner. This book dispassionately assesses the U.S. domestically oriented intelligence enterprise by first examining its individual components and then sho
The UN Sustainable Development Goals for the Textile and Fashion Industry (Textile Science and Clothing Technology)
by Subramanian Senthilkannan Muthu Miguel Angel GardettiThis book highlights the Sustainable Development Goals (SDGs) as part of the 2030 Agenda for Sustainable Development. These universally agreed-upon aspirational goals for people, the planet, prosperity, and peace will not be achieved without all global and local actors – governments, the private sector, and civil society – playing their part. The SDGs offer a unique opportunity to align existing sustainability initiatives through a common framework and accelerate the industry’s efforts to address important challenges in the global textile value chain. Future sourcing models will largely be redefined by how this sector addresses the underlying themes as sourcing countries prioritize the goals and integrate them into their national plans. Stimulating discussion and exploring the many different ways in which the textile and clothing industry can implement the UN SDGs, this informative book provides readers with a comprehensive understanding of the topic, and presents various approaches, including reflexive, empirical, hands-on or applied theoretical.
The UN System and Cities in Global Governance
by Chadwick F. AlgerThis is the second volume to commemorate the 90th birthday of the distinguished scholar Chadwick F. Alger to honor his lifetime achievement in international relations and as President of the International Studies Association (1978-1979). After a brief introduction by Chad F. Alger this volume presents six of his key texts on The UN System and Cities in Global Governance, focusing on "Cities as arenas for participatory learning in global citizenship"; "The Impact of Cities on International Systems"; "Perceiving, Analysing and Coping With the Local-Global Nexus"; "The World Relations of Cities: Closing the Gap Between Social Science Paradigms and Everyday Human Experience"; "Japanese Municipal International Exchange and Cooperation in the Asia-Pacific: Opportunities and Challenges" and on "Searching for Democratic Potential in Emerging Global Governance: What Are the Implications of Regional and Global Involvements of Local Governments?".
The UNC-53-mediated Interactome
by Amita Pandey Girdhar K. PandeyThis book gives an overview of various interactomes involved in dorsal ventral (DV) and anterior posterior (AP) guidance, their mechanisms of action, subcellular localizations, and functional roles. It will provide readers a better understanding of the development of the nervous system, which in turn will help to find cures to various neural and other disorders. In nematodes there are two types of guidance systems, including DV and AP guidance. The signaling process that guides the growth cones along the DV axis has remained intact in both vertebrates and invertebrates. The adaptor protein UNC-53 appears to play a part in migration along the AP axis in both worms and their human homologs. "Neuron Navigators" (NAV) are also involved in nervous system development
The US Military Profession into the 21st Century: War, Peace and Politics (Cass Military Studies)
by Sam Sarkesian Robert ConnorThis brand new edition of The US Military Profession into the Twenty-First Century re-examines the challenges faced by the military profession in the aftermath of the international terrorist attack on the United States on September 11, 2001. While many of the issues facing the military profession examined in the first edition remain, the 'new war' and international terrorism have compounded the challenges. The US military must respond to the changed domestic and strategic landscapes without diminishing its primary function—a function that now many see that goes beyond success on the battlefield. Not only has this complicated the problem of reconciling the military professional ethos and raison d’etre with civilian control in a democracy, it challenges traditional military professionalism. This book also studies the notion of a US military stretched thin and relying more heavily on the US Federal Reserves and National Guard. These developments make the US military profession increasingly linked to public attitudes and political perspectives. In sum, the challenge faced by the US military profession can be termed a dual dilemma. It must respond effectively to the twenty-first century strategic landscape while undergoing the revolution in military affairs and transformation. At the same time, the military profession must insure that it remains compatible with civilian cultures and the US political-social system without eroding its primary function. This is an invaluable book for all students with an interest in the US Military, and of strategic studies and military history in general.
The Ubiquitin Code (Methods in Molecular Biology #2602)
by Manuel S. Rodriguez Rosa BarrioThis volume details novel and popular approaches to decipher the Ubiquitin Code. Chapters guide readers through ubiquitin chain complexity, methods to generate non-hydrolysable ubiquitin-NEDD8, a fully synthetic method for the linear synthesis of fluorescently labelled rhodamine LC3A and LC3B, a HECT ligase-mediated ubiquitylation in vitro, a RNAi-based screening to identify DUBs, a Yuh1 activity assay, a pull-down to isolate K48 and K63 chains using specific nanobodies, identification of NeDDylated protein based in a NEDD8R74K mutant, in vivo identification of NEDDylated proteins from liver diseases, UbL-ID method to identify ubiquitin-like modified proteins, a LC3/GABARAP capturing system, and methods to isolate peptides that are closely associated with proteasomes or trapped inside the core particle of proteasomes in eukaryotic cells, among others. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, The Ubiquitin Code aims to to be a useful practical guide to researches to help further their study in this field.
The Ubiquitin Proteasome System: Methods And Protocols (Methods in Molecular Biology #1844)
by Thibault Mayor Gary Kleiger“This volume explores numerous techniques used to study the ubiquitin proteasome system. The chapters in this book are organized into five parts and cover topics such as determining the mechanisms of action for E2s, E3s, and DUB enzymes; the latest advances to study the formation of poly-ubiquitin chains as well as their linkage types; the binding partners of proteins in the UPS; methods for structure determination by x-ray crystallography, cryo electron microscopy and SAXS; screening assays to select for degrons or modulators of E3s and DUBs; proteomics approaches in the ubiquitin field and methods to study 26S proteasome function. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and authoritative, The Ubiquitin Proteasome System: Methods and Protocols is a valuable resource for both experienced and novice scientists who are interested in expanding their knowledge in this field.
The Ubiquitin System in Health and Disease
by Bernhard Haendler Stefan JentschThe ubiquitin system plays an essential role in numerous cellular processes by controlling protein stability and function. A deregulation of this system has been reported in various pathologies including cancer, neurodegenerative diseases and immune disorders. Most of the enzymes involved in adding or removing ubiquitin chains have been identified, but often their direct substrate and the type of ubiquitylation remains to be clarified. A better understanding of the mechanisms governing these processes is likely to allow the identification of novel targets for pharmacological intervention and pave the way for improved therapies. The latest developments in this rapidly moving field are presented in this book.
The Ultimate Book of Saturday Science: The Very Best Backyard Science Experiments You Can Do Yourself
by Neil A. DownieThe best backyard experiments for hands-on science learningThe Ultimate Book of Saturday Science is Neil Downie's biggest and most astounding compendium yet of science experiments you can do in your own kitchen or backyard using common household items. It may be the only book that encourages hands-on science learning through the use of high-velocity, air-driven carrots.Downie, the undisputed maestro of Saturday science, here reveals important principles in physics, engineering, and chemistry through such marvels as the Helevator—a contraption that's half helicopter, half elevator—and the Rocket Railroad, which pumps propellant up from its own track. The Riddle of the Sands demonstrates why some granular materials form steep cones when poured while others collapse in an avalanche. The Sunbeam Exploder creates a combustible delivery system out of sunlight, while the Red Hot Memory experiment shows you how to store data as heat. Want to learn to tell time using a knife and some butter? There's a whole section devoted to exotic clocks and oscillators that teaches you how.The Ultimate Book of Saturday Science features more than seventy fun and astonishing experiments that range in difficulty from simple to more challenging. All of them are original, and all are guaranteed to work. Downie provides instructions for each one and explains the underlying science, and also presents experimental variations that readers will want to try.
The Ultimate Chemical Equations Handbook
by George R. Hague Jane D. SmithThis handbook is a must-have resource for Advanced Placement Chemistry students.
The Ultimate Engineer: The Remarkable Life of NASA's Visionary Leader George M. Low (Outward Odyssey: A People's History of Spaceflight)
by Richard JurekFrom the late 1950s to 1976 the U.S. manned spaceflight program advanced as it did largely due to the extraordinary efforts of Austrian immigrant George M. Low. Described as the &“ultimate engineer&” during his career at NASA, Low was a visionary architect and leader from the agency&’s inception in 1958 to his retirement in 1976. As chief of manned spaceflight at NASA, Low was instrumental in the Mercury, Gemini, and Apollo programs. Low&’s pioneering work paved the way for President Kennedy&’s decision to make a lunar landing NASA&’s primary goal in the 1960s. After the tragic 1967 Apollo 1 fire that took the lives of three astronauts and almost crippled the program, Low took charge of the redesign of the Apollo spacecraft, and he helped lead the program from disaster and toward the moon. In 1968 Low made the bold decision to go for lunar orbit on Apollo 8 before the lunar module was ready for flight and after only one Earth orbit test flight of the command and service modules. Under Low there were five manned missions, including Apollo 11, the first manned lunar landing. Low&’s clandestine negotiations with the Soviet Union resulted in a historic joint mission in 1975 that was the precursor to the Shuttle-Mir and International Space Station programs. At the end of his NASA career, Low was one of the leading figures in the development of the space shuttle in the early 1970s, and he was instrumental in NASA&’s transition into a post-Apollo world. Afterward, he embarked on a distinguished career in higher education as a transformational president of Rensselaer Polytechnic Institute, his alma mater. Chronicling Low&’s escape from Nazi-occupied Austria to his helping land a man on the moon, The Ultimate Engineer sheds new light on one of the most fascinating and complex personalities of the golden age of U.S. manned space travel.
The Ultimate Kid's Guide to Weather: At-Home Activities, Experiments, and More! (The Ultimate Kid's Guide to...)
by Jenny MarderWith stunning photos of Earth's wildest weather and easy at-home STEM activities, this is the only guide kids need on their journey of learning about all things meteorology.Buckle up and let Jenny Marder, a senior writer for NASA, be your guide through the Earth&’s atmosphere! First stop: the stratosphere!
The Ultimate Kid's Guide to the Universe: At-Home Activities, Experiments, and More! (The Ultimate Kid's Guide to...)
by Jenny MarderWith stunning photos of outer space and easy at-home experiments, this is the only guide kids need on their journey of learning about all things astronomy: the stars, the planets, the moon, and so much more!Buckle up and let Jenny Marder, a senior writer for NASA, be your guide to the universe! First stop: the moon!A perfect read for kids, just in time for the April 2024 total solar eclipse!
The Ultimate Quotable Einstein
by Albert Einstein Freeman Dyson Alice CalapriceHere is the definitive new edition of the hugely popular collection of Einstein quotations that has sold tens of thousands of copies worldwide and been translated into twenty-five languages. The Ultimate Quotable Einstein features 400 additional quotes, bringing the total to roughly 1,600 in all. This ultimate edition includes new sections--"On and to Children," "On Race and Prejudice," and "Einstein's Verses: A Small Selection"--as well as a chronology of Einstein's life and accomplishments, Freeman Dyson's authoritative foreword, and new commentary by Alice Calaprice. In The Ultimate Quotable Einstein, readers will also find quotes by others about Einstein along with quotes attributed to him. Every quotation in this informative and entertaining collection is fully documented, and Calaprice has carefully selected new photographs and cartoons to introduce each section.Features 400 additional quotations Contains roughly 1,600 quotations in all Includes new sections on children, race and prejudice, and Einstein's poetry Provides new commentary Beautifully illustrated The most comprehensive collection of Einstein quotes ever published
The Ultimate Quotable Einstein
by Albert EinsteinThis is the definitive edition of the hugely popular collection of Einstein quotations that has sold tens of thousands of copies worldwide and been translated into twenty-five languages.The Ultimate Quotable Einstein features roughly 1,600 quotes in all. This paperback edition includes sections unique to the ultimate collection--"On and to Children," "On Race and Prejudice," and "Einstein's Verses: A Small Selection"--as well as a chronology of Einstein’s life and accomplishments, Freeman Dyson’s authoritative foreword, and commentary and descriptive source notes by Alice Calaprice.
The Ultimate Shark Field Guide: The Ocean Explorer's Handbook (Sharks, Observations, Science, Nature, Field Guide, Marine Biology for Kids)
by Thomas NelsonSwim alongside your favorite underwater creatures with The Ultimate Shark Field Guide--created as if a marine biologist painted these illustrations and made these notes while out collecting research.Pick up the journal of a marine biologist and discover underwater mysteries with The Ultimate Shark Field Guide. Encounter sharks of all shapes and sizes and note observations on each species' appearance, size, diet, and more. Detailed watercolor illustrations will captivate young readers. This spectacular visual guide gets you up close and personal with some of the fiercest creatures on Earth, including the bull shark, the great white, the Ganges river shark, the whale shark, and the great hammerhead. Explore underwater landscapes with these incredible animals in The Ultimate Shark Field Guide!
The Ultimate Student’s Guide to Scientific Research
by Samuel J. Rubin Nir QvitA scientific career is a long and winding journey. Many factors assemble to determine the trajectory and products of scientific inquiry. This book addresses the scientific career path comprehensively, ranging from how to build a strong foundational knowledge and skill base, to training programs, composing winning research proposals and grants, conducting excellent research, writing papers and reports, collaborative research programs, bridging academia and industry, career advancement, and more. Guides where, how, and what to study in undergraduate, post-baccalaureate, graduate, and post-graduate training programs and addresses important crossroads throughout the continuum of training and beyond. Highlights best practices, techniques, and nuances for creating a successful scientific career. Provides critical insights for traversing major milestones and decision-points in a scientific career and serves as a resources for reference throughout stages of advancement. Discusses alternative career opportunities for individuals trained in sciences. Offers students, researchers, and other scientists across all stages of their careers with accessible, engaging, and useful insider tips.
The Ultimate Vaccine Timeline: A Fact-Packed History of Vaccines and Their Makers
by Shaz KhanDive deep into a comprehensive fact-packed history of vaccines that includes information on vaccine manufacturers and their evolution over time. Browse through an extensive series of verifiable and documented facts on vaccines. For well over a century, vaccines have been routinely recommended to billions of people worldwide, mostly children and babies. With an ever-increasing portfolio of vaccines using novel technologies on the global market, it is important now more than ever to consolidate a chronology of facts relating to human vaccination. Considering the current climate of censorship around vaccines, this publication will contribute to an expanded understanding of this important medical intervention. Spanning over fifteen hundred years, this thoroughly researched timeline is an educational tool for any researcher, student, doctor, scientist, parent, or curious human being wishing to gain a broader perspective and insight into the complex and vast landscape of human vaccination. From smallpox to shingles; tetanus to tuberculosis; hepatitis B to HPV, discover when, where, and by whom these vaccines were invented and marketed. Including a historical timeline of pharmaceutical company beginnings, mergers and acquisitions since the seventeenth century, this illustrated reference book shines a light on the controversial subject of vaccines and their makers.
The Uncertainty Analysis of Model Results: A Practical Guide
by Eduard HoferThis book is a practical guide to the uncertainty analysis of computer model applications. Used in many areas, such as engineering, ecology and economics, computer models are subject to various uncertainties at the level of model formulations, parameter values and input data. Naturally, it would be advantageous to know the combined effect of these uncertainties on the model results as well as whether the state of knowledge should be improved in order to reduce the uncertainty of the results most effectively. The book supports decision-makers, model developers and users in their argumentation for an uncertainty analysis and assists them in the interpretation of the analysis results.
The Uncertainty Business: Risks and Opportunities in Weather and Climate
by W. J. MaunderOriginally published in 1986, this book discusses the value of weather and climate information in government and business decision-making. It issues a strong manifesto for the development of new areas of research requiring the skills of weather scientists, geographers, economists, planners and political scientists. It offers a coherent and non-technical presentation of this climatology, supported with practical guidance on assessing the impacts of weather and climate on human affairs.
The Unconscious in Neuroscience and Psychoanalysis: On Lacan and Freud (The Routledge Neuropsychoanalysis Series)
by Marco Máximo BalzariniThe Unconscious in Neuroscience and Psychoanalysis presents a unique and provocative approach to the assimilation of these two disciplines while offering a thorough assessment of the unconscious from a neuropsychoanalytic and Lacanian perspective.Marco Máximo Balzarini offers a comprehensive overview of Freud’s theory of the unconscious and its importance within psychoanalysis, before looking to how it has been integrated into contemporary neuropsychoanalytic work. Paying close attention to the field-defining work of neuropsychoanalysts such as Mark Solms, Francois Ansermet, and Pierre Magistretti, Balzarini considers the dichotomy between neuroscience and psychoanalysis, and the omnipresent debate on if and how they should be integrated when working with the unconscious. Throughout, he provides a fascinating Lacanian interpretation, showing how the work of Lacan can offer a new way of developing the dialogue and understanding around this vital topic.Part of the Routledge Neuropsychoanalysis Series, this book will be of interest to any psychoanalyst seeking to explore the foundations of the relationship between neuropsychoanalytic and Lacanian ideas in their clinical and theoretical work.
The Unconstructable Earth: An Ecology of Separation (Meaning Systems)
by Frédéric NeyratWinner, Grand Prize, French Voices Award for Excellence in Publication and TranslationThe Space Age is over? Not at all! A new planet has appeared: Earth. In the age of the Anthropocene, the Earth is a post-natural planet that can be remade at will, controlled and managed thanks to the prowess of geoengineering. This new imaginary is also accompanied by a new kind of power—geopower—that takes the entire Earth, in its social, biological and geophysical dimensions, as an object of knowledge, intervention, and governmentality. In short, our rising awareness that we have destroyed our planet has simultaneously provided us not with remorse or resolve but with a new fantasy: that the Anthropocene delivers an opportunity to remake our terrestrial environment thanks to the power of technology.Such is the position we find ourselves in, when proposals for reengineering the earth’s ecosystems and geosystems are taken as the only politically feasible answer to ecological catastrophe. Yet far from being merely the fruit of geo-capitalism, this new grand narrative of geopower has also been activated by theorists of the constructivist turn—ecomodernist, postenvironmentalist, accelerationist—who have likewise called into question the great divide between nature and culture. With the collapse of this divide, a cyborg, hybrid, flexible nature has been built, an impoverished nature that does not exist without being performed by technologies that proliferate within the space of human needs and capitalist imperatives. Underneath this performative vision resides a hidden anaturalism denying all otherness to nature and the Earth, no longer by externalizing it as a thing to be dominated, but by radically internalizing it as something to be digested. Constructivist ecology thus finds itself in no position to confront the geoconstructivist project, with its claim that there is no nature and its aim to replace Earth with Earth 2.0.Against both positions, Neyrat stakes out the importance of the unconstructable Earth. Against the fusional myth of technology over nature, but without returning to the division between nature and culture, he proposes an “ecology of separation” that acknowledges the wild, subtractive capacity of nature. Against the capitalist, technocratic delusion of earth as a constructible object, but equally against an organicism marked by unacknowledged traces of racism and sexism, Neyrat shows what it means to appreciate Earth as an unsubstitutable becoming: a traject that cannot be replicated in a laboratory. Underway for billions of years, withdrawing into the most distant past and the most inaccessible future, Earth escapes the hubris of all who would remake and master it.This remarkable book, which will be of interest to those across the humanities, natural sciences, and social sciences, from theorists to shapers of policy, recasts the earth as a singular trajectory that invites humans to turn political ecology into a geopolitics.
The Undead: Organ Harvesting, the Ice-Water Test, Beating Heart Cadavers--How Medicine Is Blurring the Line Between Life and Death
by Dick TeresiImportant and provocative, The Undead examines why even with the tools of advanced technology, what we think of as life and death, consciousness and nonconsciousness, is not exactly clear and how this problem has been further complicated by the business of organ harvesting.Dick Teresi, a science writer with a dark sense of humor, manages to make this story entertaining, informative, and accessible as he shows how death determination has become more complicated than ever. Teresi introduces us to brain-death experts, hospice workers, undertakers, coma specialists and those who have recovered from coma, organ transplant surgeons and organ procurers, anesthesiologists who study pain in legally dead patients, doctors who have saved living patients from organ harvests, nurses who care for beating-heart cadavers, ICU doctors who feel subtly pressured to declare patients dead rather than save them, and many others. Much of what they have to say is shocking. Teresi also provides a brief history of how death has been determined from the times of the ancient Egyptians and the Incas through the twenty-first century. And he draws on the writings and theories of celebrated scientists, doctors, and researchers--Jacques-Bénigne Winslow, Sherwin Nuland, Harvey Cushing, and Lynn Margulis, among others--to reveal how theories about dying and death have changed. With The Undead, Teresi makes us think twice about how the medical community decides when someone is dead.