- Table View
- List View
Translational Research and Onco-Omics Applications in the Era of Cancer Personal Genomics (Advances in Experimental Medicine and Biology #1168)
by Erika Ruiz-Garcia Horacio Astudillo-de la VegaBeing a complex disease that affects millions of people world over, cancer research has assumed great significance. Translational cancer research transforms scientific discoveries in the laboratory into clinical application to reduce incidence of cancer, morbidity and mortality. On the other hand, personalized medicine in cancer is the concept that selection of a treatment should be tailored according to the individual patient’s specific genomic characteristics, including mutations, chromosomal aberrations, protein interactions, and SNPs, and even more, taking into account the inmume system, the metabolism and maybe in the next future also the microbiome.
Translational Research in Breast Cancer (Advances in Experimental Medicine and Biology #1187)
by Dong-Young Noh Wonshik Han Masakazu ToiThis book describes recent advances in translational research in breast cancer and presents emerging applications of this research that promise to have meaningful impacts on diagnosis and treatment. It introduces ideas and materials derived from the clinic that have been brought to "the bench" for basic research, as well as findings that have been applied back to "the bedside". Detailed attention is devoted to breast cancer biology and cell signaling pathways and to cancer stem cell and tumor heterogeneity in breast cancer. Various patient-derived research models are discussed, and a further focus is the role of biomarkers in precision medicine for breast cancer patients. Next-generation clinical research receives detailed attention, addressing the increasingly important role of big data in breast cancer research and a wide range of other emerging developments. An entire section is also devoted to the management of women with high-risk breast cancer. Translational Research in Breast Cancer will help clinicians and scientists to optimize their collaboration in order to achieve the common goal of conquering breast cancer.
Translational Research in Environmental and Occupational Stress
by Shashi Bala Singh Nanduri R. Prabhakar Srinivas N. PentyalaCutting edge technologies can propel a simple finding in basic science to a concept that can be of immense value to the society. While applying novel techniques to unravel the mysteries of biological processes, an offshoot of applied branch emerged. This field, which is now widely referred to as Translational Research utilizes basic science findings and translates these findings into innovative concepts for the benefit of mankind. This branch of science has evolved into a multidisciplinary juggernaut encompassing all known fields of science as varied as biomedicine, environment, law, economics, sociology, etc. With the ever increasing interest in this branch and the dreams and aspirations that this field can bring, basic science researchers are now taking a bold step into this new realm, merging different fields of knowledge to come up with novel inventions. This book "Translational research in environmental and occupational stress" provides and insight into the research that led to discoveries, inventions and development of novel technologies which will have a tremendous impact on the future of mankind.
Translational Research in Pain and Itch
by Chao Ma Yuguang HuangThis book provides a comprehensive review of the latest advances in translational pain and itch research, and presents the cutting-edge developments in the study of our two principal, yet most mysteries sensations. Despite the slow progress in the discovery of effective therapies for chronic pain and pruritus, scientists around the globe now have a better understanding of why and how these conditions occur. Based on these findings, a series of novel treatment strategies are currently under development, and hopefully in a few years, medical practitioners will become more confident and optimistic when facing patients with these annoying and sometimes severe disorders. The contributing authors are world-renowned research scientists, who have made significant discoveries. The book is of interest to neuroscientists, neurologists and pharmacologists in both clinical and basic medical research field. In this second edition of the book, five existing chapters have been updated. Five new chapters have been added to reflect the lasted developments in the related field of research.
Translational Research in Traumatic Brain Injury (Frontiers In Neuroscience Ser.)
by Daniel Laskowitz Gerald GrantTraumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme
Translational Stem Cell Research
by Göran Hermerén Kristina HugFor many years, the ethical discussion surrounding human embryonic stem cell research has focused on the moral status of the embryo. This text takes a wider moral berth and focuses on numerous ethical, legal and social aspects involved in translating the results of stem cell research into diagnostic and therapeutic applications. Translational Stem Cell Research is broken into ten sections. It opens with an overview of the latest in stem cell research, focusing on specific diseases and the treatment of burn victims. Part II discusses the issues involved in the many steps from bench to bedside, ranging from first research in vitro to clinical trials. Part III covers scientific, regulatory and ethical challenges to basic research, and Part IV details issues regarding stem cell banks. Part V explores ethical, economic and strategic issues involved in collaboration between universities and industry, and Part VI addresses legal problems raised by patents on human stem-cell based inventions plus the extent to which there can be technological solutions to a moral dilemma. Part VII presents imaginative ways of communicating research to the general public and how to create conditions for a constructive dialogue. Part VIII probes psychosocial and cultural factors affecting judgment and decisions about translational stem cell research, and Part IX explores problems and procedures raised by an examination of the evaluation of stem cell research projects in research ethics committees. The book closes with a look into the future of translational stem cell research and stem cell-based therapeutic applications.
Translational Stroke Research
by Paul A. Lapchak John H. ZhangThis volume sets a basis for effective translational research. Authored by experts in the field of translational stroke research, each chapter specifically addresses one or more components of preclinical stroke research. The emphasis is placed on target identification and drug development using state-of-the-art in vitro and in vivo assays, in combination with in vitro toxicology assays, AMDE and clinical design.
Translational Toxicology and Therapeutics: Windows of Developmental Susceptibility in Reproduction and Cancer
by Michael D. Waters Claude L. HughesWritten by leading research scientists, this book integrates current knowledge of toxicology and human health through coverage of environmental toxicants, genetic / epigenetic mechanisms, and carcinogenicity. Provides information on lifestyle choices that can reduce cancer risk Offers a systematic approach to identify mutagenic, developmental and reproductive toxicants Helps readers develop new animal models and tests to assess toxic impacts of mutation and cancer on human health Explains specific cellular and molecular targets of known toxicants operating through genetic and epigenetic mechanisms
Translational Urinomics (Advances in Experimental Medicine and Biology #1306)
by Hugo Miguel Baptista Carreira dos SantosTranslational Urinomics provides an overview of urine analysis using proteomics, metabolomics, transcriptomics or any combination thereof for the diagnosis and prognosis of diseases related to the urinary system and the kidneys. The text approaches urine biomarkers from a new perspective, incorporating up-to-date studies of mass-spectrometry-based biomarker discovery as well as the latest advances in personalized medicine. The integration of technology-driven techniques, such as OMICS also provides a unique opportunity for improved diagnostics accuracy of urinary-related diseases. For nephrologists and urologists looking for new approaches to well-known problems, this edited volume serves as a valuable guide.
Transmembrane β-Barrel Proteins: Methods and Protocols (Methods in Molecular Biology #2778)
by Raffaele IevaThis detailed volume explores experimental strategies and protocols for the expression, assembly, characterization, and exploitation of transmembrane β-barrel proteins. Beginning with methodologies to study their assembly, the book continues with protocols for characterizing the landscape of transmembrane β-barrel protein interactions with other cellular factors, dissecting processes of protein transport in bacteria and mitochondria, examining structural characterization, determination, and prediction, and more. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Transmembrane β-Barrel Proteins: Methods and Protocols serves as an ideal guide for researchers seeking to expand our knowledge of these vital membrane-spanning proteins.
Transmembrane Dynamics of Lipids (Wiley Series in Protein and Peptide Science #9)
by Andreas HerrmannThe first and only book devoted entirely to MEMBRANE LIPID ASYMMETRY AND ITS BIOLOGICAL IMPLICATIONS Transmembrane Dynamics of Lipids is comprised of contributions from expert authors from leading research groups that present up-to-date quantitative data on the formation, stability, and biological consequences of the asymmetrical organization of lipids in cell membranes. Incorporating an impressive amount of new, previously uncollected data, the book examines transmembrane asymmetry and movement of lipids in biological membranes, and methods for the measurement of transmembrane lipid motion, emphasizing the role of lipid flippases and discusses biological functions associated with lipid asymmetry. In addition, it draws attention to important new discoveries in the field, such as the correlation between malfunction of lipid flippases and human diseases such as thrombosis and cancer. The book also addresses the manifold methods that are used to measure the rate of transmembrane movement of lipids in biological and model systems. The only guide to new discoveries regarding lipids in cell membranes, Transmembrane Dynamics of Lipids is designed to appeal to biophysicists, biochemists, and cellular and molecular biologists working in the growing field of membrane research.
Transmembrane Signaling Protocols
by Hydar Ali Haribabu BodduluriThis fully updated and expanded second edition of Transmembrane Signaling Protocols demonstrates the use of such techniques as single cell imaging, bioluminecence resonance energy transfer, and global proteomics in the study of transmembrane signaling events. Highlights include the functional expression and genetic selection of mutant mammalian transmembrane receptors in yeast, real-time analysis of transmembrane receptor signaling in live cells, and bioluminescence energy transfer to monitor protein-protein interaction. Additional chapters use state-of-the-art methods to analyze gene expression and proteomic profiles related to transmembrane signaling events, as well as to genetically reconstitute bone marrow for the study of signal transduction ex vivo. The protocols follow the successful Methods in Molecular BiologyTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
Transmembrane Signaling Protocols
by Dafna Bar-SagiThis collection of practical, cutting-edge techniques for the study of cell signaling provides detailed, step-by-step instructions, helpful notes, and troubleshooting tips that make even the most powerful of the newest techniques readily reproducible. The protocols presented include the use of peptide libraries to study transmembrane signaling; the use of single-cell assays to analyze signal transduction pathways; the reconstitution of signaling complexes; methods for analyzing protein-protein interactions, and more. Introductory reviews explain the basic theory and enable researchers new to the area to rapidly gain understanding, as well as command of the practical knowledge and expertise afforded by the protocols. Transmembrane Signaling Protocols makes available to all researchers the many state-of-the-art techniques that have recently led to landmark discoveries in transmembrane signaling.
Transmission, Distribution, and Renewable Energy Generation Power Equipment: Aging and Life Extension Techniques, Second Edition
by Bella H. ChudnovskyThe revised edition presents, extends, and updates a thorough analysis of the factors that cause and accelerate the aging of conductive and insulating materials of which transmission and distribution electrical apparatus is made. New sections in the second edition summarize the issues of the aging, reliability, and safety of electrical apparatus, as well as supporting equipment in the field of generating renewable energy (solar, wind, tide, and wave power). When exposed to atmospheric corrosive gases and fluids, contaminants, high and low temperatures, vibrations, and other internal and external impacts, these systems deteriorate; eventually the ability of the apparatus to function properly is destroyed. In the modern world of "green energy", the equipment providing clean, electrical energy needs to be properly maintained in order to prevent premature failure. The book’s purpose is to help find the proper ways to slow down the aging of electrical apparatus, improve its performance, and extend the life of power generation, transmission, and distribution equipment.
Transmission Electron Microscopy
by David B. Williams C. Barry CarterThis text is a companion volume to Transmission Electron Microscopy: A Textbook for Materials Science by Williams and Carter. The aim is to extend the discussion of certain topics that are either rapidly changing at this time or that would benefit from more detailed discussion than space allowed in the primary text. World-renowned researchers have contributed chapters in their area of expertise, and the editors have carefully prepared these chapters to provide a uniform tone and treatment for this exciting material. The book features an unparalleled collection of color figures showcasing the quality and variety of chemical data that can be obtained from today's instruments, as well as key pitfalls to avoid. As with the previous TEM text, each chapter contains two sets of questions, one for self assessment and a second more suitable for homework assignments. Throughout the book, the style follows that of Williams & Carter even when the subject matter becomes challenging--the aim is always to make the topic understandable by first-year graduate students and others who are working in the field of Materials Science Topics covered include sources, in-situ experiments, electron diffraction, Digital Micrograph, waves and holography, focal-series reconstruction and direct methods, STEM and tomography, energy-filtered TEM (EFTEM) imaging, and spectrum imaging. The range and depth of material makes this companion volume essential reading for the budding microscopist and a key reference for practicing researchers using these and related techniques.
Transmission Electron Microscopy Methods for Understanding the Brain
by Elisabeth J. Van BockstaeleThis volume is directed at individuals interested in the field of neuroscience who are novices or experts in the use of transmission electron microscopy. The goal of is to provide a comprehensive series of chapters on how this tool can be used to study the brain with a strong emphasis on successful hands on application of the electron microscopy technique. Written in the popular Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your own laboratory. Concise and easy-to-use, Transmission Electron Microscopy Methods for Understanding the Brain aims to ensure successful results in the further study of this vital field. "
Transmission Electron Microscopy Sample Preparation: From Specimen to Micrograph
by Rajender SinghThis book is a thorough guide tailored for researchers, academics, and practitioners immersed in the intricate world of Transmission Electron Microscopy (TEM). It offers a seamless blend of theoretical understanding and practical insights, providing readers with the essential skills to navigate the complexities of TEM sample preparation for optimal imaging. The book begins by introducing the basics of TEM operation, progressing to advanced modes, and dedicating significant attention to the nuances of sample preparation. Each chapter serves as a stepping stone, guiding readers from specimen selection to the acquisition of high-resolution micrographs. The motivation behind this book lies in addressing the practical challenges of TEM operation and sample preparation. The book bridges the gap between theory and application, offering a simplified yet scientific repository of dos and don’ts for achieving successful results in TEM sample preparation. Within these pages, readers will explore various thinning techniques, delve into the preparation of nanomaterials and biological samples, and grasp the intricacies of cryo-TEM and in-situ TEM. Along with troubleshooting guidance to common pitfalls, the book also provides practical tips for overcoming challenges in the sample preparation process. The book also addresses the importance of properly prepared TEM samples, emphasizing the often-underestimated role they play in unlocking the full potential of TEM imaging. Real-world case studies showcase the impact of high-quality sample preparation across diverse research fields. This book is not just an informative guide; it is a journey of transformation and enlightenment, empowering the reader with the confidence and expertise needed for precise sample preparation and quality imaging.
Transmission Line Matrix (TLM) in Computational Mechanics
by Donard de Cogan William J. O'Connor Susan PulkoThe finite element method reigns as the dominant technique for modeling mechanical systems. Originally developed to model electromagnetic systems, the Transmission Line Matrix (TLM) method proves to match, and in some cases exceed, the effectiveness of finite elements for modeling several types of physical systems. Transmission Line Matrix in Compu
Transmission Lines
by Richard CollierThis rigorous treatment of transmission lines presents all the essential concepts in a clear and straightforward manner. Key principles are demonstrated by numerous practical worked examples and illustrations, and complex mathematics is avoided throughout. Early chapters cover pulse propagation, sinusoidal waves and coupled lines, all set within the context of a simple lossless equivalent circuit. Later chapters then develop this basic model by demonstrating the derivation of circuit parameters, and the use of Maxwell's equations to extend this theory to major transmission lines. Finally, a discussion of photonic concepts and properties provides valuable insights into the fundamental physics underpinning transmission lines. Covering DC to optical frequencies, this accessible text is an invaluable resource for students, researchers and professionals in electrical, RF and microwave engineering.
Transmission Lines in Digital and Analog Electronic Systems
by Clayton R. PaulIn the last 30 years there have been dramatic changes in electrical technology--yet the length of the undergraduate curriculum has remained four years. Until some ten years ago, the analysis of transmission lines was a standard topic in the EE and CpE undergraduate curricula. Today most of the undergraduate curricula contain a rather brief study of the analysis of transmission lines in a one-semester junior-level course on electromagnetics. In some schools, this study of transmission lines is relegated to a senior technical elective or has disappeared from the curriculum altogether. This raises a serious problem in the preparation of EE and CpE undergraduates to be competent in the modern industrial world. For the reasons mentioned above, today's undergraduates lack the basic skills to design high-speed digital and high-frequency analog systems. It does little good to write sophisticated software if the hardware is unable to process the instructions. This problem will increase as the speeds and frequencies of these systems continue to increase seemingly without bound. This book is meant to repair that basic deficiency.
Transmission Lines in Digital Systems for EMC Practitioners
by Clayton R. PaulThis is a brief but comprehensive book covering the set of EMC skills that EMC practitioners today require in order to be successful in high-speed, digital electronics. The basic skills in the book are new and weren't studied in most curricula some ten years ago. The rapidly changing digital technology has created this demand for a discussion of new analysis skills particularly for the analysis of transmission lines where the conductors that interconnect the electronic modules have become "electrically large," longer than a tenth of a wavelength, which are increasingly becoming important. Crosstalk between the lines is also rapidly becoming a significant problem in getting modern electronic systems to work satisfactorily. Hence this text concentrates on the modeling of "electrically large" connection conductors where previously-used Kirchhoff's voltage and current laws and lumped-circuit modeling have become obsolete because of the increasing speeds of modern digital systems. This has caused an increased emphasis on Signal Integrity. Until as recently as some ten years ago, digital system clock speeds and data rates were in the hundreds of megahertz (MHz) range. Prior to that time, the "lands" on printed circuit boards (PCBs) that interconnect the electronic modules had little or no impact on the proper functioning of those electronic circuits. Today, the clock and data speeds have moved into the low gigahertz (GHz) range.
Transmissions: Critical Tactics for Making and Communicating Research
by Kat JungnickelResearchers rethink tactics for inventing and disseminating research, examining the use of such unconventional forms as poetry, performance, catalogs, interactive machines, costume, and digital platforms.Transmission is the research moment when invention meets dissemination—the tactical combination of making (how theory, methods, and data shape research) and communicating (how research is shown and shared). In this book, researchers from a range of disciplines examine tactics for the transmission of research, exploring such unconventional forms as poetry, performance, catalogs, interactive machines, costume, and digital platforms. Focusing on transmissions draws attention to a critical part of the research process commonly overlooked and undervalued. Too often, the results of radically experimental research methodologies are pressed into conventional formats. The contributors to Transmissions rethink tactics for making and communicating research as integral to the kind of projects they do, pushing against disciplinary edges with unexpected and creative combinations and collaborations.Each chapter focuses on a different tactic of transmission. One contributor merges literary styles of the empirical and poetic; another uses an angle grinder to construct machines of enquiry. One project invites readers to participate in an exchange about value; another provides a series of catalog cards to materialize ordering systems of knowledge. All the contributors share a commitment to uniting the what with the how, firmly situating their transmissions in their research and in each unique chapter of this book.ContributorsNerea Calvillo, Rebecca Coleman, Larissa Hjorth, Janis Jefferies, Kat Jungnickel, Sarah Kember, Max Liboiron, Kristina Lindström, Alexandra Lippman, Bonnie Mak, Julien McHardy, Julia Pollack, Ingrid Richardson, Åsa Ståhl, Laura Watts
Transmitted Light Microscopy of Rock-Forming Minerals: An Introduction to Optical Mineralogy (Springer Textbooks in Earth Sciences, Geography and Environment)
by Susanne Theodora SchmidtThis book presents a guide of optical mineralogy for beginners and microscopists who need to brush up their knowledge. It allows the fast identification of common rock-forming minerals in a thin section using a polarized light microscope and transmitted plane and cross polarized light. The book summarizes essential principles of optical mineralogy in numerous schemes. It explains, with the aid of more than 1000 microscopic images, how to determine the diagnostic optical characteristics of a mineral in a thin section. Seventy-two mineral plates of sixty-five common rock-forming minerals comprising typical microscopic images in plane and cross polarized light illustrate the most important optical and crystallographic parameters and their diagnostic characteristics and typical appearance in various geological settings. The original approach of the book is to facilitate mineral identification by mineral plates organized according to color in transmitted plane polarized light and, in each color category, according to decreasing maximum birefringence in cross polarized light. In addition, two chapters are devoted to the classification of magmatic and metamorphic rocks and their common mineral parageneses and textures.The book reflects the author’s experience of teaching optical mineralogy in the most efficient way possible to generations of students at the Universities of Heidelberg (Germany), Basel (Switzerland), and Geneva (Switzerland).
Transmittierender Faraday-Effekt-Stromsensor (essentials)
by Reiner ThieleReiner Thiele zeigt die Lösung auf, wie die Messung von hohen elektrischen Strömen ohne Eingriff in den Messgrößenkreis gelingt - ein grundsätzliches Problem der elektrischen Energietechnik. Er schlägt dies durch die Applikation des Faraday-Effektes zur Polarisations-Ebenen-Drehung linear polarisierten Lichts in Lichtwellenleitern vor, induziert durch das den stromführenden elektrischen Leiter umgebende Magnetfeld. Eine in Transmission arbeitende erfindungsgemäße Schaltungsanordnung aus optischen und elektronischen Komponenten stellt dabei den gewünschten linearen Zusammenhang zwischen Messgröße und Messwert bei Elimination der störenden Doppelbrechung der Lichtwellenleiter her, die sich ansonsten vermindernd auf die Effizienz des Faraday-Effektes auswirkt.
The Transmutations of Chymistry: Wilhelm Homberg and the Académie Royale des Sciences (Synthesis Ser.)
by Lawrence M. DeMartinoThis book reevaluates the changes to chymistry that took place from 1660 to 1730 through a close study of the chymist Wilhelm Homberg (1653–1715) and the changing fortunes of his discipline at the Académie Royale des Sciences, France’s official scientific body. By charting Homberg’s remarkable life from Java to France’s royal court, and his endeavor to create a comprehensive theory of chymistry (including alchemical transmutation), Lawrence M. Principe reveals the period’s significance and reassesses its place in the broader sweep of the history of science. Principe, the leading authority on the subject, recounts how Homberg’s radical vision promoted chymistry as the most powerful and reliable means of understanding the natural world. Homberg’s work at the Académie and in collaboration with the future regent, Philippe II d’Orléans, as revealed by a wealth of newly uncovered documents, provides surprising new insights into the broader changes chymistry underwent during, and immediately after, Homberg. A human, disciplinary, and institutional biography, The Transmutations of Chymistry significantly revises what was previously known about the contours of chymistry and scientific institutions in the early eighteenth century.