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Uncertainty in Biology
by Liesbet Geris David Gomez-CabreroComputational modeling allows to reduce, refine and replace animal experimentation as well as to translate findings obtained in these experiments to the human background. However these biomedical problems are inherently complex with a myriad of influencing factors, which strongly complicates the model building and validation process. This book wants to address four main issues related to the building and validation of computational models of biomedical processes: 1. Modeling establishment under uncertainty 2. Model selection and parameter fitting 3. Sensitivity analysis and model adaptation 4. Model predictions under uncertainty In each of the abovementioned areas, the book discusses a number of key-techniques by means of a general theoretical description followed by one or more practical examples. This book is intended for graduate students and researchers active in the field of computational modeling of biomedical processes who seek to acquaint themselves with the different ways in which to study the parameter space of their model as well as its overall behavior.
Uncertainty in Complex Networked Systems: In Honor of Roberto Tempo (Systems & Control: Foundations & Applications)
by Tamer BaşarThe chapters in this volume, and the volume itself, celebrate the life and research of Roberto Tempo, a leader in the study of complex networked systems, their analysis and control under uncertainty, and robust designs. Contributors include authorities on uncertainty in systems, robustness, networked and network systems, social networks, distributed and randomized algorithms, and multi-agent systems—all fields that Roberto Tempo made vital contributions to. Additionally, at least one author of each chapter was a research collaborator of Roberto Tempo’s.This volume is structured in three parts. The first covers robustness and includes topics like time-invariant uncertainties, robust static output feedback design, and the uncertainty quartet. The second part is focused on randomization and probabilistic methods, which covers topics such as compressive sensing, and stochastic optimization. Finally, the third part deals with distributed systems and algorithms, and explores matters involving mathematical sociology, fault diagnoses, and PageRank computation.Each chapter presents exposition, provides new results, and identifies fruitful future directions in research. This book will serve as a valuable reference volume to researchers interested in uncertainty, complexity, robustness, optimization, algorithms, and networked systems.
Uncertainty in Mechanical Engineering: Proceedings of the 4th International Conference on Uncertainty in Mechanical Engineering (ICUME 2021), June 7–8, 2021 (Lecture Notes in Mechanical Engineering)
by Peter F. Pelz Peter GrocheThis open access book reports on methods and technologies to describe, evaluate and control uncertainty in mechanical engineering applications. It brings together contributions by engineers, mathematicians and legal experts, offering a multidisciplinary perspective on the main issues affecting uncertainty throughout the complete system lifetime, which includes process and product planning, development, production and usage. The book is based on the proceedings of the 4th International Conference on Uncertainty in Mechanical Engineering (ICUME 2021), organized by the Collaborative Research Center (CRC) 805 of the TU Darmstadt, and held online on June 7–8, 2021. All in all, it offers a timely resource for researchers, graduate students and practitioners in the field of mechanical engineering, production engineering and engineering optimization.
Uncertainty Management for Robust Industrial Design in Aeronautics: Findings and Best Practice Collected During UMRIDA, a Collaborative Research Project (2013–2016) Funded by the European Union (Notes on Numerical Fluid Mechanics and Multidisciplinary Design #140)
by Charles Hirsch Dirk Wunsch Jacek Szumbarski Łukasz Łaniewski-Wołłk Jordi Pons-PratsThis book covers cutting-edge findings related to uncertainty quantification and optimization under uncertainties (i.e. robust and reliable optimization), with a special emphasis on aeronautics and turbomachinery, although not limited to these fields. It describes new methods for uncertainty quantification, such as non-intrusive polynomial chaos, collocation methods, perturbation methods, as well as adjoint based and multi-level Monte Carlo methods. It includes methods for characterization of most influential uncertainties, as well as formulations for robust and reliable design optimization. A distinctive element of the book is the unique collection of test cases with prescribed uncertainties, which are representative of the current engineering practice of the industrial consortium partners involved in UMRIDA, a level 1 collaborative project within the European Commission's Seventh Framework Programme (FP7). All developed methods are benchmarked against these industrial challenges. Moreover, the book includes a section dedicated to Best Practice Guidelines for uncertainty quantification and robust design optimization, summarizing the findings obtained by the consortium members within the UMRIDA project. All in all, the book offers a authoritative guide to cutting-edge methodologies for uncertainty management in engineering design, covers a wide range of applications and discusses new ideas for future research and interdisciplinary collaborations.
Uncertainty Quantification
by Christian SoizeAdvanced Computational Vibroacoustics presents an advanced computational method for the prediction of sound and structural vibrations, in low- and medium-frequency ranges - complex structural acoustics and fluid-structure interaction systems encountered in aerospace, automotive, railway, naval, and energy-production industries. The formulations are presented within a unified computational strategy and are adapted for the present and future generation of massively parallel computers. A reduced-order computational model is constructed using the finite element method for the damped structure and the dissipative internal acoustic fluid (gas or liquid with or without free surface) and using an appropriate symmetric boundary-element method for the external acoustic fluid (gas or liquid). This book allows direct access to computational methods that have been adapted for the future evolution of general commercial software. Written for the global market, it is an invaluable resource for academic researchers, graduate students, and practising engineers.
Uncertainty Quantification in Computational Fluid Dynamics
by Hester Bijl Didier Lucor Siddhartha Mishra Christoph SchwabFluid flows are characterized by uncertain inputs such as random initial data, material and flux coefficients, and boundary conditions. The current volume addresses the pertinent issue of efficiently computing the flow uncertainty, given this initial randomness. It collects seven original review articles that cover improved versions of the Monte Carlo method (the so-called multi-level Monte Carlo method (MLMC)), moment-based stochastic Galerkin methods and modified versions of the stochastic collocation methods that use adaptive stencil selection of the ENO-WENO type in both physical and stochastic space. The methods are also complemented by concrete applications such as flows around aerofoils and rockets, problems of aeroelasticity (fluid-structure interactions), and shallow water flows for propagating water waves. The wealth of numerical examples provide evidence on the suitability of each proposed method as well as comparisons of different approaches.
Uncertainty Quantification in Computational Fluid Dynamics and Aircraft Engines (SpringerBriefs in Applied Sciences and Technology)
by Francesco MontomoliThis book introduces design techniques developed to increase the safety of aircraft engines, and demonstrates how the application of stochastic methods can overcome problems in the accurate prediction of engine lift caused by manufacturing error. This in turn addresses the issue of achieving required safety margins when hampered by limits in current design and manufacturing methods. The authors show that avoiding the potential catastrophe generated by the failure of an aircraft engine relies on the prediction of the correct behaviour of microscopic imperfections. This book shows how to quantify the possibility of such failure, and that it is possible to design components that are inherently less risky and more reliable.This new, updated and significantly expanded edition gives an introduction to engine reliability and safety to contextualise this important issue, evaluates newly-proposed methods for uncertainty quantification as applied to jet engines.Uncertainty Quantification in Computational Fluid Dynamics and Aircraft Engines will be of use to gas turbine manufacturers and designers as well as CFD practitioners, specialists and researchers. Graduate and final year undergraduate students in aerospace or mathematical engineering may also find it of interest.
Uncertainty Quantification in Computational Fluid Dynamics and Aircraft Engines
by Francesco Montomoli Mauro Carnevale Antonio D'Ammaro Michela Massini Simone SalvadoriThis book introduces novel design techniques developed to increase the safety of aircraft engines. The authors demonstrate how the application of uncertainty methods can overcome problems in the accurate prediction of engine lift, caused by manufacturing error. This in turn ameliorates the difficulty of achieving required safety margins imposed by limits in current design and manufacturing methods. This text shows that even state-of-the-art computational fluid dynamics (CFD) are not able to predict the same performance measured in experiments; CFD methods assume idealised geometries but ideal geometries do not exist, cannot be manufactured and their performance differs from real-world ones. By applying geometrical variations of a few microns, the agreement with experiments improves dramatically, but unfortunately the manufacturing errors in engines or in experiments are unknown. In order to overcome this limitation, uncertainty quantification considers the probability density functions of manufacturing errors. It is then possible to predict the overall variation of the jet engine performance using stochastic techniques. Uncertainty Quantification in Computational Fluid Dynamics and Aircraft Engines demonstrates that some geometries are not affected by manufacturing errors, meaning that it is possible to design safer engines. Instead of trying to improve the manufacturing accuracy, uncertainty quantification when applied to CFD is able to indicate an improved design direction. This book will be of interest to gas turbine manufacturers and designers as well as CFD practitioners, specialists and researchers. Graduate and final year undergraduate students may also find it of use.
Uncertainty Quantification in Laminated Composites: A Meta-model Based Approach
by Sudip Dey Tanmoy Mukhopadhyay Sondipon AdhikariOver the last few decades, uncertainty quantification in composite materials and structures has gained a lot of attention from the research community as a result of industrial requirements. This book presents computationally efficient uncertainty quantification schemes following meta-model-based approaches for stochasticity in material and geometric parameters of laminated composite structures. Several metamodels have been studied and comparative results have been presented for different static and dynamic responses. Results for sensitivity analyses are provided for a comprehensive coverage of the relative importance of different material and geometric parameters in the global structural responses.
Uncertainty Quantification of Stochastic Defects in Materials (Emerging Materials and Technologies)
by Liu ChuUncertainty Quantification of Stochastic Defects in Materials investigates the uncertainty quantification methods for stochastic defects in material microstructures. It provides effective supplementary approaches for conventional experimental observation with the consideration of stochastic factors and uncertainty propagation. Pursuing a comprehensive numerical analytical system, this book establishes a fundamental framework for this topic, while emphasizing the importance of stochastic and uncertainty quantification analysis and the significant influence of microstructure defects on the material macro properties. Key Features Consists of two parts: one exploring methods and theories and the other detailing related examples Defines stochastic defects in materials and presents the uncertainty quantification for defect location, size, geometrical configuration, and instability Introduces general Monte Carlo methods, polynomial chaos expansion, stochastic finite element methods, and machine learning methods Provides a variety of examples to support the introduced methods and theories Applicable to MATLAB and ANSYS software This book is intended for advanced students interested in material defect quantification methods and material reliability assessment, researchers investigating artificial material microstructure optimization, and engineers working on defect influence analysis and nondestructive defect testing.
Uncharted
by Erez AidenBreaking open Big Data, two Harvard scientists reveal a ground-breaking way of looking at history and culture. One of the greatest untapped resources of today isn’t offshore oil or natural gas-it’s data. Gigabytes, exabytes (that’s one quintillion bytes) of data are sitting on servers across the world. So how can we start to access this explosion of information, this "big data,” and what can it tell us? Erez Aiden and Jean-Baptiste Michel are two young scientists at Harvard who started to ask those questions. They teamed up with Google to create the Ngram Viewer, a Web-based tool that can chart words throughout the massive Google Books archive, sifting through billions of words to find fascinating cultural trends. On the day that the Ngram Viewer debuted in 2010, more than one million queries were run through it. On the front lines of Big Data, Aiden and Michel realized that this big dataset-the Google Books archive that contains remarkable information on the human experience-had huge implications for looking at our shared human history. The tool they developed to delve into the data has enabled researchers to track how our language has evolved over time, how art has been censored, how fame can grow and fade, how nations trend toward war. How we remember and how we forget. And ultimately, how Big Data is changing the game for the sciences, humanities, politics, business, and our culture. .
Uncharted: How Scientists Navigate Their Own Health, Research, and Experiences of Bias
by Skylar Bayer Gabriela Serrato MarksPeople with disabilities are underrepresented in STEM fields, and all too often, they face isolation and ableism in academia. Uncharted is a collection of powerful first-person stories by current and former scientists with disabilities or chronic conditions who have faced changes in their careers, including both successes and challenges, because of their health. It gives voice to common experiences that are frequently overlooked or left unspoken. These deeply personal accounts describe not only health challenges but also the joys, sorrows, humor, and wonder of science and scientists.With a breadth of perspectives on being disabled or chronically ill, these stories highlight the intersectionality of minoritized identities with the disability community. Uncharted features essays by contributors who are d/Deaf, blind, neurodivergent, wheelchair users, have experienced traumatic brain injuries, have blood sugar disorders, have rare medical diagnoses, or have received psychiatric diagnoses, among many others. In many cases, the scientific field is not fully accessible to them, and they frankly describe struggling as well as thriving alongside their conditions.This book serves as representation for scientists who have never felt comfortable disclosing their disability or who have never felt fully understood. The stories shared in this book seek to normalize medical conditions and disabilities in scientific culture, offering recommendations for how and why to improve access. Uncharted is vital and compelling reading for current and aspiring scientists who want to make their fields more inclusive and supportive for everyone.
Uncle John's Facts to Go: Mad Science (Facts to Go #3)
by Bathroom Readers' InstituteA collection of crazy science facts on everything from rocket ships and death rays to atoms, experiments, and bizarre scientists. From the amazing to the amusing, this byte-sized collection will bring you the inside stories behind earth-shattering discoveries, accidental inventions, and outlandish studies. Featuring Uncle John&’s most mind-bending science articles—along with a few all-new &“experiments&”—this book will make you think, make you laugh, and make you ask yourself, &“What the heck were they thinking?&” Get ready to cackle like a mad scientist as you uncover the truth about . . . · The mystery of Tesla&’s death ray machine · How to reanimate the dead · The next space race: Interstellar travel · Serendipity: The origins of the microwave oven and Silly Putty · The eccentric Dr. Einstein · The simple science behind nuclear fission · &“Pigeons&’ Ability to Discriminate Between Monet and Picasso&” and other strange-but-true studies · Toilets in Spaaaaace! And much, much more
Uncle Tungsten: Memories of a Chemical Boyhood
by Oliver SacksLong before Oliver Sacks became a distinguished neurologist and bestselling writer, he was a small English boy fascinated by metals–also by chemical reactions (the louder and smellier the better), photography, squids and cuttlefish, H.G. Wells, and the periodic table. In this endlessly charming and eloquent memoir, the author of The Man Who Mistook His Wife for a Hat and Awakenings chronicles his love affair with science and the magnificently odd and sometimes harrowing childhood in which that love affair unfolded.In Uncle Tungsten we meet Sacks’ extraordinary family, from his surgeon mother (who introduces the fourteen-year-old Oliver to the art of human dissection) and his father, a family doctor who imbues in his son an early enthusiasm for housecalls, to his “Uncle Tungsten,” whose factory produces tungsten-filament lightbulbs. We follow the young Oliver as he is exiled at the age of six to a grim, sadistic boarding school to escape the London Blitz, and later watch as he sets about passionately reliving the exploits of his chemical heroes–in his own home laboratory. Uncle Tungsten is a crystalline view of a brilliant young mind springing to life, a story of growing up which is by turns elegiac, comic, and wistful, full of the electrifying joy of discovery.
Uncommon Dissent: Intellectuals Who Find Darwinism Unconvincing
by William DembskiRecent years have seen the rise to prominence of ever more sophisticated philosophical and scientific critiques of the ideas marketed under the name of Darwinism. In Uncommon Dissent, mathematician and philosopher William A. Dembski brings together essays by leading intellectuals who find one or more aspects of Darwinism unpersuasive. As Dembski explains, Darwinism has gathered around itself an aura of invincibility that is inhospitable to rational discussion--to say the least: "Darwinism, its proponents assure us, has been overwhelmingly vindicated. Any resistance to it is futile and indicates bad faith or worse." Indeed, those who question the Darwinian synthesis are supposed, in the famous formulation of Richard Dawkins, to be ignorant, stupid, insane, or wicked.The hostility of dogmatic Darwinians like Dawkins has not, however, prevented the advent of a growing cadre of scholarly critics of metaphysical Darwinism. The measured, thought-provoking essays in Uncommon Dissent make it increasingly obvious that these critics are not the brainwashed fundamentalist buffoons that Darwinism's defenders suggest they are, but rather serious, skeptical, open-minded inquirers whose challenges pose serious questions about the viability of Darwinist ideology. The intellectual power of their contributions to Uncommon Dissent is bracing.
Uncommon Sense Teaching: Practical Insights in Brain Science to Help Students Learn
by Terrence J. Sejnowski Barbara Oakley Beth RogowskyA groundbreaking guide to improve teaching based on the latest research in neuroscience, from the bestselling author of A Mind for Numbers.Neuroscientists and cognitive scientists have made enormous strides in understanding the brain and how we learn, but little of that insight has filtered down to the way teachers teach. Uncommon Sense Teaching applies this research to the classroom for teachers, parents, and anyone interested in improving education. Topics include: • keeping students motivated and engaged, especially with online learning • helping students remember information long-term, so it isn't immediately forgotten after a test • how to teach inclusively in a diverse classroom where students have a wide range of abilitiesDrawing on research findings as well as the authors' combined decades of experience in the classroom, Uncommon Sense Teaching equips readers with the tools to enhance their teaching, whether they're seasoned professionals or parents trying to offer extra support for their children's education.
Uncommon Ulcers of the Extremities
by Ajay K. Khanna Satyendra Kumar TiwaryThe book covers all uncommon ulcers of the extremities which remain a difficult diagnosis for clinicians most of the times. A variety of causes like metabolic, infective, rheumatoid, drug induced or inflammation may lead to ulcerations. Diagnosis of these ulceration is difficult as these diseases are systemic, and treatment is carried out by physicians but ulcers are managed by the surgeons. Any lacunae or gap in assessment or work-up may lead to failure in diagnosis and increased morbidity. This book provides a systematic and step wise approach to the differential diagnosis of every possible uncommon ulcers in the extremities with detailed work-up, flow chart and summary. The book is systematically designed to serve the purpose of covering every possible uncommon ulcer with elaborate clinical presentation in the background of etiology and pathogenesis with risk factors included investigations and treatment with medical, surgical options well discussed as per the requirement. The book includes illustrations, flow diagrams, images, charts and tables. The book provides every information clinically relevant and useful about the uncommon ulcers and serves as a complete resource for general surgeons, vascular surgeons, plastic surgeons, orthopedic surgeons, surgical trainees, family physicians. It may also be useful for podiatrists, phlebologists, radiologists, cardiologists, nephrologists, neurologists, wound care nurses, physicians and primary care workers.
Uncommon Understanding: Development and disorders of language comprehension in children (Psychology Press & Routledge Classic Editions)
by Dorothy V. BishopThis is a Classic Edition of Dorothy Bishop's award-winning textbook on the development of language comprehension, which has been in print since 1997, and now includes a new introduction from the author. The book won the British Psychological Society book award in 1999, and is now widely seen as a classic in the field of developmental language disorders. Uncommon Understanding provides a comprehensive account of the process of comprehension, from the reception of an acoustic signal, to the interpretation of communicative intentions, and integrates a vast field of research on language acquisition, psycholinguistics and neuropsychology. In the new introduction Dorothy Bishop reflects on the organization of the book, and developments in the field since the book was first published. A major theme in the book is that comprehension should not be viewed as a unitary skill – to understand spoken language one needs the ability to classify incoming speech sounds, to relate them to a "mental lexicon," to interpret the propositions encoded by word order and grammatical inflections, and to use information from the environmental and social context to grasp an intended meaning. Another important theme is that although neuropsychological and experimental research on adult comprehension provides useful concepts and methods for assessing comprehension, it should be applied with caution, because a sequential, bottom-up information processing model of comprehension is ill-suited to the developmental context. Although the main focus of the book is on research and theory, rather than practical matters of assessment and intervention, the theoretical framework presented in the book will continue to help clinicians develop a clearer understanding of what comprehension involves, and how different types of difficulty may be pin-pointed.
Uncomputable: Play and Politics In the Long Digital Age
by Alexander GallowayA journey through the uncomputable remains of computer historyNarrating some lesser known episodes from the deep history of digital machines, Alexander R. Galloway explains the technology that drives the world today, and the fascinating people who brought these machines to life. With an eye to both the computable and the uncomputable, Galloway shows how computation emerges or fails to emerge, how the digital thrives but also atrophies, how networks interconnect while also fray and fall apart. By re-building obsolete technology using today's software, the past comes to light in new ways, from intricate algebraic patterns woven on a hand loom, to striking artificial-life simulations, to war games and back boxes. A description of the past, this book is also an assessment of all that remains uncomputable as we continue to live in the aftermath of the long digital age.
Unconscious Branding: How Neuroscience Can Empower (and Inspire) Marketing
by Douglas Van PraetFor too long marketers have been asking the wrong question. If consumers make decisions unconsciously, why do we persist in asking them directly through traditional marketing research why they do what they do? They simply can't tell us because they don't really know. Before marketers develop strategies, they need to recognize that consumers have strategies too . . .human strategies, not consumer strategies. We need to go beyond asking why, and begin to ask how,behavior change occurs. Here, author DouglasVan Praet takes the most brilliant and revolutionary concepts from cognitive science and applies them to how we market, advertise, and consume in the modern digital age. Van Praet simplifies the most complex object in the known universe - the human brain - into seven codified actionable steps to behavior change. These steps are illustrated using real world examples from advertising, marketing, media and business to consciously unravel what brilliant marketers and ad practitioners have long done intuitively, deconstructing the real story behind some of the greatest marketing and business successes in recent history, such as Nike's "Just Do It" campaign; "Got Milk?"; Wendy's "Where's the Beef?" ;and the infamous Volkswagen "Punch Buggy" launch as well as their beloved "The Force" (Mini Darth Vader) Super Bowl commercial.
The Unconscious in Neuroscience and Psychoanalysis: On Lacan and Freud (The Routledge Neuropsychoanalysis Series)
by Marco Máximo BalzariniThe Unconscious in Neuroscience and Psychoanalysis presents a unique and provocative approach to the assimilation of these two disciplines while offering a thorough assessment of the unconscious from a neuropsychoanalytic and Lacanian perspective.Marco Máximo Balzarini offers a comprehensive overview of Freud’s theory of the unconscious and its importance within psychoanalysis, before looking to how it has been integrated into contemporary neuropsychoanalytic work. Paying close attention to the field-defining work of neuropsychoanalysts such as Mark Solms, Francois Ansermet, and Pierre Magistretti, Balzarini considers the dichotomy between neuroscience and psychoanalysis, and the omnipresent debate on if and how they should be integrated when working with the unconscious. Throughout, he provides a fascinating Lacanian interpretation, showing how the work of Lacan can offer a new way of developing the dialogue and understanding around this vital topic.Part of the Routledge Neuropsychoanalysis Series, this book will be of interest to any psychoanalyst seeking to explore the foundations of the relationship between neuropsychoanalytic and Lacanian ideas in their clinical and theoretical work.
The Unconstructable Earth: An Ecology of Separation (Meaning Systems)
by Frédéric NeyratWinner, French Voices Award for excellence in publication and translation.The Anthropocene announces a post-natural planet that can be remade at will through the process of geoengineering. With it, a new kind of power, geopower, takes the entire Earth, in its social, biological, and geophysical dimensions, as an object of knowledge, intervention, and governmentality. This shift has been aided, wittingly or not, by theorists of the constructivist turn who have likewise called into question the divide between nature and culture and have thus found themselves helpless against the project to replace Earth with Earth 2.0.Against both camps, this book confronts the unconstructable Earth, proposing an “ecology of separation” that acknowledges the wild, subtractive capacity of nature. Against technocratic delusion, but equally against a racially tinged organicism, Neyrat shows what it means to appreciate Earth as an unsubstitutable becoming that cannot be replicated in a laboratory and that always escapes the hubris of those who would remake and master it.
Uncontrolled Spread: Why COVID-19 Crushed Us and How We Can Defeat the Next Pandemic
by Scott GottliebNEW YORK TIMES BESTSELLER“Uncontrolled Spread is everything you’d hope: a smart and insightful account of what happened and, currently, the best guide to what needs to be done to avoid a future pandemic." —Wall Street Journal“Informative and well paced.”—The Guardian“An intense ride through the pandemic with chilling details of what really happened. It is also sprinkled with notes of true wisdom that may help all of us better prepare for the future.”—Sanjay Gupta, MD, chief medical correspondent, CNNPhysician and former FDA commissioner Scott Gottlieb asks: Has America’s COVID-19 catastrophe taught us anything?In Uncontrolled Spread, he shows how the coronavirus and its variants were able to trounce America’s pandemic preparations, and he outlines the steps that must be taken to protect against the next outbreak. As the pandemic unfolded, Gottlieb was in regular contact with all the key players in Congress, the Trump administration, and the drug and diagnostic industries. He provides an inside account of how level after level of American government crumbled as the COVID-19 crisis advanced.A system-wide failure across government institutions left the nation blind to the threat, and unable to mount an effective response. We’d prepared for the wrong virus. We failed to identify the contagion early enough and became overly reliant on costly and sometimes divisive tactics that couldn’t fully slow the spread. We never considered asymptomatic transmission and we assumed people would follow public health guidance. Key bureaucracies like the CDC were hidebound and outmatched. Weak political leadership aggravated these woes. We didn’t view a public health disaster as a threat to our national security.Many of the woes sprung from the CDC, which has very little real-time reporting capability to inform us of Covid’s twists and turns or assess our defenses. The agency lacked an operational capacity and mindset to mobilize the kind of national response that was needed. To guard against future pandemic risks, we must remake the CDC and properly equip it to better confront crises. We must also get our intelligence services more engaged in the global public health mission, to gather information and uncover emerging risks before they hit our shores so we can head them off. For this role, our clandestine agencies have tools and capabilities that the CDC lacks.Uncontrolled Spread argues we must fix our systems and prepare for a deadlier coronavirus variant, a flu pandemic, or whatever else nature -- or those wishing us harm -- may threaten us with. Gottlieb outlines policies and investments that are essential to prepare the United States and the world for future threats.
Unconventional Computing: A Volume in the Encyclopedia of Complexity and Systems Science, Second Edition (Encyclopedia of Complexity and Systems Science Series #22)
by Andrew AdamatzkyThis volume of the Encyclopedia of Complexity and Systems Science, Second Edition, is a unique collection of concise overviews of state-of-art, theoretical and experimental findings, prepared by the world leaders in unconventional computing. Topics covered include bacterial computing, artificial chemistry, amorphous computing, computing with Solitons, evolution in materio, immune computing, mechanical computing, molecular automata, membrane computing, bio-inspired metaheuristics, reversible computing, sound and music computing, enzyme-based computing, structural machines, reservoir computing, infinity computing, biomolecular data structures, slime mold computing, nanocomputers, analog computers, DNA computing, novel hardware, thermodynamics of computation, and quantum and optical computing. Topics added to the second edition include: social algorithms, unconventional computational problems, enzyme-based computing, inductive Turing machines, reservoir computing, Grossone Infinity computing, slime mould computing, biomolecular data structures, parallelization of bio-inspired unconventional computing, and photonic computing.Unconventional computing is a cross-breed of computer science, physics, mathematics, chemistry, electronic engineering, biology, materials science and nanotechnology. The aims are to uncover and exploit principles and mechanisms of information processing in, and functional properties of, physical, chemical and living systems, with the goal to develop efficient algorithms, design optimal architectures and manufacture working prototypes of future and emergent computing devices.
Unconventional Conflict: A Modeling Perspective (Understanding Complex Systems)
by Dean S. Hartley IIIThis book describes issues in modeling unconventional conflict and suggests a new way to do the modeling. It presents an ontology that describes the unconventional conflict domain, which allows for greater ease in modeling unconventional conflict. Supporting holistic modeling, which means that we can see the entire picture of what needs to be modeled, the ontology allows us to make informed decisions about what to model and what to omit. The unconventional conflict ontology also separates the things we understand best from the things we understand least. This separation means that we can perform verification, validation and accreditation (VV&A) more efficiently and can describe the competence of the model more accurately.However, before this message can be presented in its entirety the supporting body of knowledge has to be explored. For this reason, the book offers chapters that focus on the description of unconventional conflict and the analyses that have been performed, modeling, with a concentration on past efforts at modeling unconventional conflict, the precursors to the ontology, and VV&A. Unconventional conflict is a complex, messy thing. It normally involves multiple actors, with their own conflicting agendas and differing concepts of legitimate actions. This book will present a useful introduction for researchers and professionals within the field.