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U.S.-Iran Engagement in Science, Engineering, and Health (2000-2009): Opportunities, Constraints, and Impacts
by National Research Council of the National AcademiesDuring the first decade of the 21st century, the National Academies, working with a number of partner organizations in Iran, carried out a program of U.S.-Iran engagement in science, engineering, and health (herein referred to as science engagement). This book reviews important aspects of the science engagement program, including: (a) objectives of the program, (b) opportunities and constraints in developing the program, and (c) scientific and political impacts of the activities. Suggestions for future activities that draw on the conclusions and recommendations that have emerged from workshops and other types of interactions are set forth. Of course, the political turmoil within Iran and uncertainties as to the direction of U.S.-Iran government-to-government relations will undoubtedly complicate initiation and implementation of new science engagement activities in the near term. At the same time, many American and Iranian participants and important government officials in the United States and Iran have believed that science engagement can contribute to the evolution of an improved political environment for development of less adversarial relations between the two governments.
U.S.-Japanese Agricultural Trade Relations (Routledge Revivals)
by Emery N. Castle Kenzo Hemmi Sally A. SkillingsFirst published in 1982, the editors and authors of this book examine the United States’ 1973 embargo on the export of soybeans and its effects on U.S.-Japanese relations. Although eventually shipment of soybeans to Japan resumed, the embargo temporarily soured the friendly relations of the two democracies. This book, prepared by a group of Japanese and U.S. scholars, demonstrates how trade relations between the two countries are affected by their internal political situations and by the nature of their respective agricultural industries. U.S.-Japanese Agricultural Trade Relations will be valuable to scholars, policy makers, and others interested in agricultural trade. It should be particularly useful in courses on international trade and on agricultural policy.
U.S. Military Information Operations in Afghanistan: Effectiveness of Psychological Operations 2001-2010
by Arturo MunozThe U. S. Marine Corps, which has long recognized the importance of influencing the civilian population in a counterinsurgency environment, requested an evaluation of the effectiveness of thepsychological operations element of U. S. military information operations in Afghanistan from 2001 to 2010 based on how well messages and themes were tailored to target audiences. This monograph responds to that request.
UAVs and Urban Spatial Analysis: An Introduction
by Tony H. Grubesic Jake R. NelsonThis book provides an introduction to the use of unmanned aerial vehicles (UAVs) for the geographic observation and spatial analysis of urban areas. The velocity of urban change necessitates observation platforms that not only enhance situational awareness for planning and allied analytical efforts, but also provide the ability to rapidly and inexpensively collect data and monitor change. UAVs can accomplish both of these tasks, but their use in urban environments is loaded with social, operational, regulatory and technical challenges that must be addressed for successful deployments. The book provides a resource for educators and students who work with geographic information and are seeking to enhance these data with the use of unmanned aerial vehicles. Topics covered include, 1) a primer on UAVs and the many different ways they can be used for geographic observation, 2) a detailed overview on the use of aviation maps and charts for operating UAVs in complex urban airspace, 3) techniques for integrating UAV-derived data with more traditional geographic information, 4) application of spatial analytical tools for urban and environmental planning, and 5) an exploration of privacy and public safety issues associated with UAV operation.
Über die Merkwürdigkeiten der Quantenmechanik (essentials)
by Josef HonerkampDie Quantenmechanik ist eine physikalische Theorie für Objekte des Mikrokosmos, also z.B. für Atome oder Elektronen. Sie hat sich bisher bestens bewährt, führt aber dazu, dass wir diesen Objekten Eigenschaften und Relationen zubilligen müssen, die weder mit unserem gesunden Menschenverstand noch mit den Begriffen der klassischen Physik vereinbar sind. Diese Merkwürdigkeiten werden vorgestellt und ihre Bedeutung für unser Erkenntnisvermögen und für ein Weltbild wird diskutiert.
Ubiquitin Chains: Degradation and Beyond
by Arnab DeThis thesis examines the evidence for regulatory ubiquitination by focusing on A20. It provides an insightful and in-depth evaluation of the current literature by critically examining the evidence of K63-linked regulatory ubiquitination in regulating cell-signalling. It is also the first thesis to directly test the role of regulatory ubiquitination in NF-kB signaling in vivo. The case for regulatory ubiquitination has been to a large extent predicated upon the presumed deubiquitinase activity of A20, long considered a key regulator of inflammatory responses as mice lacking A20 die from multi-organ inflammation and cachexia. The theses reports the creation and characterization of a knock-in mouse that expresses a mutated form of A20 which selectively lacks the deubiquitinase activity. The knock-in mice surprisingly display completely normal NF-κB activation with no accompanying inflammatory phenotype. Given that the presumed role of A20 as a deubiquitinase has been used to support the importance of regulatory K63-linked ubiquitination in NF-kB signaling, this study will help focus future research efforts into alternative target pathways that do not depend on K63 ubiquitination. In fact, the work suggests that it might be important to revisit the role of K63-linked polyubiquitination in cell-signalling. Ubiquitin Chains: Degradation and Beyond is essential reading for anyone conducting research in cell-signalling and immunology. Dr. Arnab De received his PhD from the Department of Microbiology & Immunology at Columbia University. During his PhD, he developed transgenic mice to study the mechanism of action of a critical tumor-suppressor called A20. He is also well known for having developed peptide-based prodrugs as therapeutics for diabetes. His work has been reported by the media, and has resulted in multiple patents and publications in peer reviewed journals. He presented his findings at the American Peptide Symposium and was awarded the Young Investigator's Award. He is the author of the book entitled Application of Peptide-Based Prodrug Chemistry in Drug Development, with a foreword written by Professor Jean Martinez (Former President, European Peptide Society) and published in the series SpringerBriefs in Pharmaceutical Science & Drug Development. His research interests lie at the intersection of chemistry and medicine. Besides biomedical research, he is also generally interested in public health policy and general scientific outreach.
The Ubiquitin Code (Methods in Molecular Biology #2602)
by Manuel S. Rodriguez Rosa BarrioThis volume details novel and popular approaches to decipher the Ubiquitin Code. Chapters guide readers through ubiquitin chain complexity, methods to generate non-hydrolysable ubiquitin-NEDD8, a fully synthetic method for the linear synthesis of fluorescently labelled rhodamine LC3A and LC3B, a HECT ligase-mediated ubiquitylation in vitro, a RNAi-based screening to identify DUBs, a Yuh1 activity assay, a pull-down to isolate K48 and K63 chains using specific nanobodies, identification of NeDDylated protein based in a NEDD8R74K mutant, in vivo identification of NEDDylated proteins from liver diseases, UbL-ID method to identify ubiquitin-like modified proteins, a LC3/GABARAP capturing system, and methods to isolate peptides that are closely associated with proteasomes or trapped inside the core particle of proteasomes in eukaryotic cells, among others. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, The Ubiquitin Code aims to to be a useful practical guide to researches to help further their study in this field.
Ubiquitin Family Modifiers and the Proteasome
by Martin Scheffner R. Jürgen DohmenThe ubiquitin-proteasome system (UPS) and ubiquitin-related modifiers are not only involved in cellular protein quality control but also in the regulation of many fundamental cellular processes/pathways as well as in their disease-relevant aberrations. Ubiquitin Family Modifiers and Proteasome: Reviews and Protocols presents both novel developments in UPS research and important methods related to the main recent advances in the field of ubiquitin family modifiers. Divided into five convenient sections, this volume focuses on the enzymology and substrate identification of ubiquitin family modifiers, the recognition and chain formation of these modifiers, the analysis of proteasome biogenesis and function, protein quality control, and finally the use of small molecules and strategies to study or manipulate the function of the UPS and of ubiquitin family modifiers, respectively. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Ubiquitin Family Modifiers and Proteasome: Reviews and Protocols will be of great use to investigators and students engaged in both basic and applied research in life sciences.
Ubiquitin-Proteasome Protocols
by Cam Patterson Douglas M. CyrA collection of cutting-edge techniques for studying ubiquitin-dependent protein degradation via the proteasome. The topics covered range broadly from basic biochemistry to cellular assays to discovery techniques using mass spectrometric analysis. These biochemical and cellular methods are necessary to explore the ubiquitin-proteasome system and ubiquitin-proteasome-dependent functions. State-of-the-art and user-friendly, Ubiquitin-Proteasome Protocols offers novice and experienced bench scientists alike a thorough compendium of readily reproducible techniques that will accelerate discovery, enhance productivity, and permit manipulation of the system for varied research purposes.
The Ubiquitin Proteasome System: Methods And Protocols (Methods in Molecular Biology #1844)
by Gary Kleiger Thibault Mayor“This volume explores numerous techniques used to study the ubiquitin proteasome system. The chapters in this book are organized into five parts and cover topics such as determining the mechanisms of action for E2s, E3s, and DUB enzymes; the latest advances to study the formation of poly-ubiquitin chains as well as their linkage types; the binding partners of proteins in the UPS; methods for structure determination by x-ray crystallography, cryo electron microscopy and SAXS; screening assays to select for degrons or modulators of E3s and DUBs; proteomics approaches in the ubiquitin field and methods to study 26S proteasome function. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and authoritative, The Ubiquitin Proteasome System: Methods and Protocols is a valuable resource for both experienced and novice scientists who are interested in expanding their knowledge in this field.
The Ubiquitin System in Health and Disease
by Stefan Jentsch Bernhard HaendlerThe ubiquitin system plays an essential role in numerous cellular processes by controlling protein stability and function. A deregulation of this system has been reported in various pathologies including cancer, neurodegenerative diseases and immune disorders. Most of the enzymes involved in adding or removing ubiquitin chains have been identified, but often their direct substrate and the type of ubiquitylation remains to be clarified. A better understanding of the mechanisms governing these processes is likely to allow the identification of novel targets for pharmacological intervention and pave the way for improved therapies. The latest developments in this rapidly moving field are presented in this book.
Ubiquitination in Immune System and Immune Response (Advances in Experimental Medicine and Biology #1466)
by Hongbo Hu Xianghui FuUbiquitination is a major protein post-translational modification, which is involved in many aspects of cellular procedure. The functions of ubiquitination in immune system and immune response have been intensively studied. This book aims to introduce the latest and crucial achievements, along with the fundamental principles of ubiquitination and immune responses. It covers the proteomic aspects of ubiquitination, the function of ubiquitin in innate and adoptive immunity, the development of immune cells, and the metabolism. The active researchers in this field are invited to contribute the chapters. This book is suitable for graduate students, researchers and readers who are interested in this field. It will provide readers with comprehensive insight into how ubiquitination functions in different aspects of immune system.
Ubiquity: Why Catastrophes Happen
by Mark BuchananScientists have recently discovered a new law of nature. Its footprints are virtually everywhere - in the spread of forest fires, mass extinctions, traffic jams, earthquakes, stock-market fluctuations, the rise and fall of nations, and even trends in fashion, music and art. Wherever we look, the world is modelled on a simple template: like a steep pile of sand, it is poised on the brink of instability, with avalanches - in events, ideas or whatever - following a universal pattern of change. This remarkable discovery heralds what Mark Buchanan calls the new science of 'ubiquity', a science whose secret lies in the stuff of the everyday world. Combining literary flair with scientific rigour, this book documents the coming revolution by telling the story of the researchers' exploration of the law, their ingenious work and unexpected insights. Mark Buchanan reveals how the principle of ubiquity will help us to manage, control and predict the future. This book, the world's first on the topic, will change how we think about the world and our place in it.
Übungsaufgaben zur Strömungsmechanik 2: 112 Aufgaben mit vollständigen Musterlösungen
by Valentin SchröderDieses Buch bietet in zwei Bänden vielfältige Aufgaben aus der Strömungsmechanik mit ausführlich vorgerechneten Lösungen und ist damit auch eine wertvolle Hilfe bei der Klausurvorbereitung. Es ist als Übungsbuch konzipiert und zielt darauf ab, die Inhalte der Vorlesung Strömungsmechanik anhand zahlreicher Beispiele besser verständlich zu machen. Das Buch wendet sich vor allem an Studierende der Fachbereiche Maschinenbau, Verfahrens- und Umwelttechnik an Fachhochschulen und Universitäten.Auf der Basis der Grundlagenkenntnisse des Fachs erhält der Leser Aufgaben zur Bearbeitung in verschiedenen Schwierigkeitsgraden – von kurzen Rechenübungen bis hin zu komplexen, mehrteiligen Anwendungsaufgaben. Die Übungsbeispiele decken dabei wichtige Anwendungsfälle der Lehrveranstaltung ab. Es wird besonderer Wert auf eine klar formulierte Aufgabenstellung, die verständliche Beschreibung der Vorgehensweise und die schrittweise, vollständige Lösungsfindung gelegt. Prüfungsaufgaben verschiedener Hochschulen sind ebenfalls Bestandteil des Buchs.
Übungsbuch Anatomie und Physiologie für Dummies (Für Dummies)
by Erin Odya Pat DuPreeAnatomie und Physiologie sind zwei sehr lernintensive Fächer, und der Schlüssel zum Erfolg heißt: Erst verstehen und dann üben, üben, üben. Nur durch das häufige Wiederholen des Lernstoffs wird das Wissen gefestigt. Erin Odya und Pat Dupree haben in diesem Buch grundlegende Erklärungen und zahlreiche Übungen und Abbildungen zusammengestellt. So erfahren Sie das Wichtigste über Zellen, Muskeln, Knochen, Organe, das Nahrungs- und Nervensystem sowie die Fortpflanzungsorgane. Mit Abbildungen zum Beschriften und Ausmalen sowie über 800 Aufgaben gerüstet, können Sie dann unbesorgt in die nächste Prüfung gehen.
Übungsbuch Chemie für Dummies (Für Dummies)
by Peter J. Mikulecky Katherine Brutlag Michelle Rose Gilman Brian PetersonSich all die Formeln, Funktionen und Regeln der Chemie zu merken ist schon schwierig genug - und dann soll man sie auch noch richtig anwenden. Da hilft nur üben, üben, üben! Das "Übungsbuch Chemie für Dummies" enthält über 250 Übungen zu Einheitenumrechnung, Periodensystem, Stöchiometrie, Säuren und Basen, Thermodynamik, Redoxreaktionen, funktionelllen Gruppen und vielen anderen grundlegenden Fragestellungen der Chemie. Zudem finden Sie zu Beginn eines jeden Themas eine kurze Widerholung der Theorie, bevor es dann an die Praxis geht. Natürlich gibt es auch ausführliche Lösungen zu allen Aufgaben, so gewinnen Sie Sicherheit und können sich zielgerichtet auf die nächste Prüfung vorbereiten.
Übungsbuch Chemie für Mediziner
by Jürgen SchatzDieses Übungsbuch liefert GK-orientierte Inhalte und ist die perfekte Vorbereitung auf das Physikum. Das Konzept hat sich in der Praxis bewährt.
Übungsbuch EEG bei Kindern und Jugendlichen: Atlas mit 370 Beispielen
by Gerhard Kurlemann Hubertus KursaweDieser Übungsatlas für Neuropädiater und Neurologen beinhaltet eine didaktisch aufgearbeitete Sammlung von EEG-Beispielen mit wissenschaftlichen Definitionen und knappen Fallbeschreibungen. Das breite Spektrum an Kurvenmaterial reicht vom Neugeborenen bis zum jungen Erwachsenenalter und hilft dem EEG-Lernenden, eigene Befunde zu erheben und zu bewerten.
Übungsbuch Klinisches EEG
by Hubertus Kursawe Isolde Flemming St. Karol KubickiDieser Übungsatlas beinhaltet eine didaktisch aufgearbeitete Sammlung von EEG-Beispielen mit wissenschaftlichen Definitionen und knappen Fallbeschreibungen. Die Inhalte sind unverzichtbarer Bestandteil der Weiterbildungen für Neurologen, Psychiater und Funktionsassistenten im Bereich der klinischen Enzephalographie. Ein breites Spektrum an Kurvenmaterial und wissenschaftlichen Kriterien ermöglicht dem EEG-Lernenden, eigene Befunde zu erheben und zu bewerten. Kurven aus drei Laboren zeigen, dass jeder Interpret eine eigene EEG-Handschrift haben kann: Beispiele mit Provokationsmethoden, epilepsietypischer Aktivität sowie Herden bzw. regionalen Funktionsstörungen helfen die Flexibilität in der Auswertung zu schulen.
Übungsbuch Organische Chemie für Dummies (Für Dummies)
by Arthur WinterOrganik-Klausur? Können Sie nachts nicht mehr schlafen? Wer hätte gedacht, dass es der Kohlenstoff ist, aus dem die Träume sind. Aber Rettung naht: Mit diesem Buch können Sie noch einmal schnell die Grundlagen der Organischen Chemie wiederholen und dann üben, üben, üben. Mit Fragen und Antworten zur Lewis-Struktur, zu Alkanen über Alkene und Alkohole können Sie Ihr Können prüfen und nach und nach verbessern. Genauso können Sie auch Ihr Wissen über Stereochemie, Massenspektrometrie und Spektroskopie testen und somit der nächsten Prüfung gelassener entgegensehen.
Übungsbuch Physik für Dummies (Für Dummies)
by Steven HolznerSie wollen ein einziges Buch, das Sie trotzdem perfekt für Ihre Prüfung vorbereitet? Kraft, kinetische Energie, Thermodynamik, Elektrizität sind nach diesem Buch keine Fremdwörter mehr. Im »Übungsbuch Physik für Dummies« finden Sie über 350 Aufgaben, Lösungen und Erklärungen zu den Kerngebieten der Physik. So können Sie Ihr Wissen festigen und die nötige Sicherheit gewinnen im Umgang mit dieser manchmal recht kniffligen Naturwissenschaft.
Übungsbuch Physik für Mediziner für Dummies (Für Dummies)
by Oliver KleinSeien wir doch ehrlich: Es gibt Fächer, da lernt man stur auswendig. Andere hingegen muss man wirklich verstehen und da braucht es Übung. Physik zählt zu den letzteren. Das mag lästig sein, aber Hilfe naht: Die Übungen in diesem Buch helfen Ihnen beim Verständnis von Mechanik, Thermodynamik, Elektrizitätslehre, Schwingungen und Wellen, Optik und Atomphysik. Knappe Auffrischungsinformationen und zahlreiche Beispiele ermöglichen es Ihnen, passives Wissen wieder zu aktivieren, und so ist dieses Buch für Sie ein hilfreicher Trainer vor Ihrer Physikprüfung.
Übungsbuch Physik für Studierende der Biowissenschaften, Chemie und Medizin
by Gerhard RufaDieses Übungsbuch enthält zahlreiche Aufgaben zum Inhalt einer Einführungsvorlesung Physik. Mithilfe von ausführlichen Lösungen und Erklärungen lernen und üben Studierende die Anwendung physikalischer Rechenmethoden und die hierfür erforderliche Mathematik. Vor allem in Kombination mit dem Lehrbuch Physik für Studierende der Biowissenschaften, Chemie und Medizin bildet es eine ideale Basis für die Klausurvorbereitung und weiterführende Vorlesungen.Der erste Teil des Buches bietet Übungsserien mit Aufgaben, die entsprechend dem Inhalt typischer Physikvorlesungen strukturiert sind und dabei Themen von der klassischen Mechanik bis hin zur Atom- und Quantenphysik abdecken. Jede Übungsserie besteht aus einem Verständnisteil und einem Übungsteil, der durch anwendungsorientierte Aufgaben aus Biowissenschaften, Chemie und Medizin ergänzt wird.Das Gelernte kann dann anhand des zweiten Teils überprüft werden, der aus verschiedenen Testserien besteht: Hier sind gemischte Aufgaben aus den jeweiligen Inhalten der zwei Semester enthalten, wie sie auch in Physikklausuren zu finden sind.
Uchuva (Physalis peruviana L.) Reproductive Biology
by Fernando Ramírez Thomas Lee DavenportThis work reviews and explores various aspects of uchuva growth and development from seed germination, vegetative growth and phyllotaxy, floral development, pollination, and pollen morphology through fruit development, properties and health benefits. Other sections of the book cover uchuva genetic diversity, hybridization, chromosome number and morphological diversity. Uchuva is economically important in most South American counties, has been growing in popularity in Central America, and is marketed in North American and Europe as the golden berry. This is the first concise reference work that delves into the fascinating world of uchuva reproductive biology. It includes the latest scientific references, some of which have been contributed by the authors of the current book. The authors have observed the plant in the field and have produced a unique photographic record to help the reader see the actual morphological structures and developmental processes in action.
Udder Health and Communication
by H. Hogeveen T.J.G.M. LamIn dairy industries throughout the world there is a desire to optimize udder health. An improved udder health will lead to improved animal welfare, improved production efficiency and a reduction of the use of antibiotics. To improve udder health, first of all, technical knowledge on issues such as treatment, milking, infectious pressure and host resistance is important. However, over the years we learned that knowledge alone is not enough: knowledge has to be used. And for knowledge to be used, farmers have to be motivated. This requires knowledge about motivation and communication. In this book, recent knowledge on technical udder health issues is combined with knowledge on motivation and communication. A large number of descriptions of mastitis control programs that are being carried out worldwide is combined with more specific studies. These are aimed at effective advising, motivation and communication strategies, economics, and technical studies on mastitis control and prevention. Therefore, this book provides an applied source of information for all that are willing to improve udder health.