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A Guide to Outcome Modeling In Radiotherapy and Oncology: Listening to the Data (Series in Medical Physics and Biomedical Engineering)
by Issam El NaqaThis book explores outcome modeling in cancer from a data-centric perspective to enable a better understanding of complex treatment response, to guide the design of advanced clinical trials, and to aid personalized patient care and improve their quality of life. It contains coverage of the relevant data sources available for model construction (panomics), ranging from clinical or preclinical resources to basic patient and treatment characteristics, medical imaging (radiomics), and molecular biological markers such as those involved in genomics, proteomics and metabolomics. It also includes discussions on the varying methodologies for predictive model building with analytical and data-driven approaches. This book is primarily intended to act as a tutorial for newcomers to the field of outcome modeling, as it includes in-depth how-to recipes on modeling artistry while providing sufficient instruction on how such models can approximate the physical and biological realities of clinical treatment. The book will also be of value to seasoned practitioners as a reference on the varying aspects of outcome modeling and their current applications. Features: Covers top-down approaches applying statistical, machine learning, and big data analytics and bottom-up approaches using first principles and multi-scale techniques, including numerical simulations based on Monte Carlo and automata techniques Provides an overview of the available software tools and resources for outcome model development and evaluation, and includes hands-on detailed examples throughout Presents a diverse selection of the common applications of outcome modeling in a wide variety of areas: treatment planning in radiotherapy, chemotherapy and immunotherapy, utility-based and biomarker applications, particle therapy modeling, oncological surgery, and the design of adaptive and SMART clinical trials
A Guide to Pharmacovigilance Audits in the USA
by Heather MurphyPharmacovigilance Audits are an important and growing requirement for Pharmaceutical/BioTech companies. A niche skillset combined with an understanding of audit principles and pharmacovigilance operational and regulatory knowledge are required to effectively conduct these audits This book provides practical guidance to auditors as to what questions to ask, what information to look for, and what documents to request to ensure the auditee Pharmacovigilance System is compliant with regulations, contractual requirements, and industry best practice. The scope is limited to the requirements based on the US Food and Drug Administration (FDA) Regulations. This is an ideal book for auditors and auditees who want to obtain practical PV auditing skills to use within the BioTechnology/Pharmaceutical Industry in the USA.
A Guide to Practical Toxicology: Evaluation, Prediction and Risk
by Adam WoolleyAn experienced toxicologist researcher and consultant provides an overview of toxicology for practicing toxicologists and students in the field, with 15 chapters addressing topics from the necessity of measurement and definitions and maintenance of normality to larger issues of risk assessment and management in the workplace and environment and the future of toxicity testing. Pedagogical tools include text boxes with necessary background information; tables and case studies; and study design and interpretation. Annotation ©2004 Book News, Inc., Portland, OR (booknews.com)
A Guide to Qualitative Field Research
by Carol A. BaileyThoroughly revised, the Second Edition of A Guide to Qualitative Field Research provides novice researchers with comprehensive and accessible instructions for conducting qualitative field research. Using rich examples from classic ethnographies to help bring abstract principles alive, author Carol A. Bailey thoroughly explains the entire research process from selecting a topic to writing the final manuscript, and all of the steps in between!
A Guide to SQL (Eighth Edition)
by Mary Z. Last Philip J. PrattA GUIDE TO SQL, 8E, continues to be the essential SQL reference. It builds on the success of previous editions by presenting basic SQL commands in the context of a running case in which a business uses SQL to manage orders, parts, customers, and sales reps. The book covers the fundamentals of SQL programming using straightforward instruction and extensive hands-on exercises. Continuing with its focus on learning the basics regardless of the database environment chosen, this edition features examples from the latest databases: Oracle 11g, Access 2007, and MySQL. The eighth edition expands on the use of running case studies by adding a third running case to the extensive hands-on pedagogy at the end of every chapter.
A Guide to Sample Size for Animal-based Studies
by Penny S. ReynoldsA Guide to Sample Size for Animal-based Studies Understand a foundational area of experimental design with this innovative reference Animal-based research is an essential part of basic and preclinical research, but poses a unique set of experimental design challenges. The most important of these are the 3Rs − Replacement, Reduction and Refinement − the principles comprising the ethical framework for humane animal-based studies. However, many researchers have difficulty navigating the design trade-offs necessary to simultaneously minimize animal use, and produce scientific information that is both rigorous and reliable. A Guide to Sample Size for Animal-based Studies meets this need with a thorough, accessible reference work to the subject. This book provides a straightforward systematic approach to “rightsizing” animal-based experiments, with sample size estimates based on the fundamentals of statistical thinking: structured research questions, variation control and appropriate design of experiments. The result is a much-needed guide to planning animal-based experiments to ensure scientifically valid and reliable results. This book offers: Step-by-step guidance in diverse methods for approximating and refining sample size Detailed treatment of research topics specific to animal-based research, including pilot, feasibility and proof-of-concept studies Sample size approximation methods for different types of data − binary, continuous, ordinal, time to event − and different study types − description, comparison, nested designs, reference interval construction and dose-response studies Numerous worked examples, using real data from published papers, together with SAS and R code A Guide to Sample Size for Animal-based Studies is a must-have reference for preclinical and veterinary researchers, as well as ethical oversight committees and policymakers.
A Guide to Signals and Systems in Continuous Time
by Stéphane LafortuneThis textbook is a concise yet precise supplement to traditional books on Signals and Systems, focusing exclusively on the continuous-time case. Students can use this guide to review material, reinforce their understanding, and see how all the parts connect together in a uniform treatment focused on mathematical clarity. Readers learn the “what”, “why” and “how” about the ubiquitous Fourier and Laplace transforms encountered in the study of linear time-invariant systems in engineering: what are these transforms, why do we need them, and how do we use them? Readers will come away with an understanding of the gradual progression from time-domain analysis to frequency-domain and s-domain techniques for continuous-time linear time-invariant systems. This book reflects the author’s experience in teaching this material for over 25 years in sophomore- and junior-level required engineering courses and is ideal for undergraduate classes in electrical engineering.
A Guide to Writing in the Sciences
by Patricia Patchet-Golubev Andrea A. GilpinWhile teaching writing to undergraduate science students, Gilpin and Patchet-Golubev discovered that although many relatively sophisticated manuals for scientific writing exist, most are aimed at mainly professionals or specialists and are of little practical use to the majority of students. This introductory guide fills that large gap.Direct and friendly in tone the book provides clear and concise explanations of the basic elements of scientific writing required of students. The various genres are detailed -- in particular lab reports and research essays - as well as scientific articles, poster presentations, proposals, and even essay exams. Similarities and differences among these genres are underlined in order to illustrate structural principles and to provide practical writing tips. A detailed chapter covers the elements of grammar and punctuation that are fundamental to all good writing; it also outlines some key points about scientific style in particular.Using accessible language throughout, the authors organize their material with helpful lists, copious examples, and boxed writing and research tips. There are several useful appendices (including a classification chart of organisms and an international units conversion chart), an index, and selected bibliography on science and technical writing. Unique in its field, this guide offers a practical and valuable guide to the basic principles and conventions of science writing.
A Guide to Zona Pellucida Domain Proteins
by Eveline S. Litscher Paul M. WassarmanThis book provides a coherent, clear, and uniform presentation of structural, genetic, molecular, and biochemical information available for the zona pellucida domain protein family, which impact pathologies such as infertility, deafness, and cancer. Furthermore it: Details information about the structure and function of the ZP domain in ZPDC-proteins Provides illustrations of the organization of ZPDC-proteins, the genes that encode the proteins, and examples of mutations in the ZP domain that cause diseases Speculates as to the evolution of the ZP domain and potential therapeutics for diseases stemming from ZP domain mutations Addresses mammalian and non-mammalian systems
A Guide to a Healthier Planet, Volume 2: Scientific Insights and Actionable Steps to Help Resolve Climate, Pollution and Biodiversity Issues
by Erlijn van GenuchtenThis successor volume builds upon the first book with additional chapters meant to inspire readers to take action towards a healthier planet. It focuses on closing the gap between scientific insights on pressing environmental issues that do not often reach the general public, and putting that scientific knowledge in the hands of everyday people who can use these insights to take action against climate change, pollution, and biodiversity loss. The goal of this work is to share fascinating facts about nature and sustainability to inspire taking action toward a healthier planet, and to provide ideas on how we can take action to solve environmental issues in an informed and easy-to-understand way. The chapters are sourced from the author's work published on medium.com/@ErlijnG with added content not available on medium.com.All chapters are based on open-access research articles covering various environmental issues and solutions that are not often disseminated in popular discourse but are nonetheless important for non-scientific audiences to understand and become familiar with. They allow readers to explore the broad range of concepts and issues and recognize the far-reaching consequences, and trigger the desire to take action. Also, each chapter provides concrete ideas of how we as individuals can take action in daily life to make a positive difference related to the issues described. The book is a multimodal work, as it includes images and videos that accompany the text.
A Guide to a Healthier Planet: Scientific Insights and Actionable Steps to Help Resolve Climate, Pollution and Biodiversity Issues
by Erlijn van GenuchtenThis book focuses on closing the gap between scientific insights on pressing environmental issues that do not often reach the general public, and putting that scientific knowledge in the hands of everyday people who can use these insights to take action against climate change, pollution, and biodiversity loss. The goal of this work is to share fascinating facts about nature and sustainability to inspire taking action toward a healthier planet, and to provide ideas on how we can take action to solve environmental issues in an informed and easy-to-understand way. The chapters are sourced from the author's work published on medium.com/@ErlijnG with added content not available on medium.com.All chapters are based on open-access research articles covering various environmental issues and solutions that are not often disseminated in popular discourse but are nonetheless important for non-scientific audiences to understand and become familiar with. They allow readers to explore the broad range of concepts and issues and recognize the far-reaching consequences, and trigger the desire to take action. Also, each chapter provides concrete ideas of how we as individuals can take action in daily life to make a positive difference related to the issues described. The book is a multimodal work, as it includes images and videos that accompany the text.
A Guide to the Economic Removal of Metals from Aqueous Solutions
by Yogesh C. SharmaWater pollution is topic of immense and common concern throughout the world. This book presents the results and data from research and adsorption experiments carried out on the removal of nickel and chromium (as well as other metals) from aqueous solutions using modified silica sand.
A Guide to the Scientific Career: Virtues, Communication, Research, and Academic Writing
by Marios Loukas R. Shane Tubbs Mohammadali M. Shoja Marion Karl Anastasia Arynchyna Anthony V. D'antoni Sandra M. BuergerA concise, easy-to-read source of essential tips and skills for writing research papers and career management In order to be truly successful in the biomedical professions, one must have excellent communication skills and networking abilities. Of equal importance is the possession of sufficient clinical knowledge, as well as a proficiency in conducting research and writing scientific papers. This unique and important book provides medical students and residents with the most commonly encountered topics in the academic and professional lifestyle, teaching them all of the practical nuances that are often only learned through experience. Written by a team of experienced professionals to help guide younger researchers, A Guide to the Scientific Career: Virtues, Communication, Research and Academic Writing features ten sections composed of seventy-four chapters that cover: qualities of research scientists; career satisfaction and its determinants; publishing in academic medicine; assessing a researcher’s scientific productivity and scholarly impact; manners in academics; communication skills; essence of collaborative research; dealing with manipulative people; writing and scientific misconduct: ethical and legal aspects; plagiarism; research regulations, proposals, grants, and practice; publication and resources; tips on writing every type of paper and report; and much more. An easy-to-read source of essential tips and skills for scientific research Emphasizes good communication skills, sound clinical judgment, knowledge of research methodology, and good writing skills Offers comprehensive guidelines that address every aspect of the medical student/resident academic and professional lifestyle Combines elements of a career-management guide and publication guide in one comprehensive reference source Includes selected personal stories by great researchers, fascinating writers, inspiring mentors, and extraordinary clinicians/scientists A Guide to the Scientific Career: Virtues, Communication, Research and Academic Writing is an excellent interdisciplinary text that will appeal to all medical students and scientists who seek to improve their writing and communication skills in order to make the most of their chosen career.
A Guide to the Systems of Provision Approach: Who Gets What, How and Why
by Ben Fine Kate BaylissUnderstanding consumption requires looking at the systems by which goods and services are provided – not just how they are produced but the historically evolved structures, power relations and cultures within which they are located. The Systems of Provision approach provides an interdisciplinary framework for unpacking these complex issues. This book provides a comprehensive account of the Systems of Provision approach, setting out core concepts and theoretical origins alongside numerous case studies. The book combines fresh understandings of everyday consumption using examples from food, housing, and water, with implications for society’s major challenges, including inequality, climate change, and prospects for capitalism. Readers do not require prior knowledge across the subject matter covered but the text remains significant for accomplished researchers and policymakers, especially those interested in the messy real world realities underpinning who gets what, how, and why across public and private provision in global, national, and historical contexts.
A Guided Tour of Mathematical Methods for the Physical Sciences, Third Edition
by Roel Snieder Kasper Van WijkMathematical methods are essential tools for all physical scientists. This book provides a comprehensive tour of the mathematical knowledge and techniques that are needed by students across the physical sciences. In contrast to more traditional textbooks, all the material is presented in the form of exercises. Within these exercises, basic mathematical theory and its applications in the physical sciences are well integrated. In this way, the mathematical insights that readers acquire are driven by their physical-science insight. This third edition has been completely revised: new material has been added to most chapters, and two completely new chapters on probability and statistics and on inverse problems have been added. This guided tour of mathematical techniques is instructive, applied, and fun. This book is targeted for all students of the physical sciences. It can serve as a stand-alone text, or as a source of exercises and examples to complement other textbooks.
A Handbook for DNA-Encoded Chemistry
by Robert A. Goodnow Jr.This book comprehensively describes the development and practice of DNA-encoded library synthesis technology. Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening. The book:Provides a valuable guide for understanding and applying DNA-encoded combinatorial chemistry Helps chemists generate and screen novel chemical libraries of large size and quality Bridges interdisciplinary areas of DNA-encoded combinatorial chemistry - synthetic and analytical chemistry, molecular biology, informatics, and biochemistry Shows medicinal and pharmaceutical chemists how to efficiently broaden available "chemical space" for drug discovery Provides expert and up-to-date summary of reported literature for DNA-encoded and DNA-directed chemistry technology and methods
A Handbook of Bioanalysis and Drug Metabolism
by Gary EvansRecent years have seen a greater industrial emphasis in undergraduate and postgraduate courses in the pharmaceutical and chemical sciences. However, textbooks have been slow to adapt, leaving the field without a text/reference that is both instructional and practical in the industrial setting – until now. A Handbook of Bioanalysis and Drug Metabolismis a stimulating new text that examines the techniques, methodology, and theory of bioanalysis, pharmacokinetics, and metabolism from the perspective of scientists with extensive professional experience in drug discovery and development. These three areas of research help drug developers to optimize the active component within potential drugs thereby increasing their effectiveness, and to provide safety and efficacy information required by regulators when granting a drug license. Professionals with extensive experience in drug discovery and development as well as specialized knowledge of the individual topics contributed to each chapter to create a current and well-credentialed text. It covers topics such as high performance liquid chromatography, protein binding, pharmacokinetics and drug–drug interactions. The unique industrial perspective helps to reinforce theory and develop valuable analytical and interpreting skills. This text is an invaluable guide to students in courses such as pharmaceutical science, pharmacology, chemistry, physiology and toxicology, as well as professionals in the biotechnology industry.
A Handbook of Biological Investigation (Seventh Edition)
by Harrison W. Ambrose Katharine Peckham Ambrose Douglas J. Emlen Kerry L. BrightThis book is written as a reference aid to be used by biology students at any time they are first exposed to the scientific method and to original research. It guides the beginner through elementary experimental design, data collection and analysis, and the subsequent writing of a scientific report. In addition, it provides an introduction to the literature of biology and a basic search strategy for finding relevant, published information in a library.
A Handbook of Environmental Toxicology: Human Disorders and Ecotoxicology
by Nikki Jones Aftab Ahmad Marina Santana Alberto Gomez Arturo Aburto-Medina L. Agullo-Chazarra Shama Ahmad A. Ahmad Agneta Akesson Sandra Arismendez Andy S. Ball E. Barrajon-Catalan William M. Caudle L. M. Crosby P. D. Darbre R Del Kollerud Miguel Dopico C. J. Everett N. Fuentes N. Hachiya N. Haleyur V. Harrison S. Haycox G. Z. He M. Herranz-Lopez Y.C.T. Huang H. Jiang A. L. Katner Maria Kippler N. Kovats P. J. Lein Chan Juan Liang Johan Lundqvist S. J. Ross A. A. Mansur Boris Melloni James S. Metcalf V. Micol H. W. Mielke Paul A. Montagna C. Noubactep W. H. Orem J. M. Otaki Daniela M. Pampanin Almudena Perez-Sanchez David A. Purser L. Rivera D. Schlenk S. Seneff S. Sethi Esmaeil Shahsavari P. Silveyra X. F. Sima Nara R. Souza Jan A. Staessen Horst Thiermann K. C. Thompson Jesse L. Tucker Jouko Tuomisto A. Turra Matti Viluksela Timo Wille M. J. Wilson Franz Worek Wenyi YangA Handbook of Environmental Toxicology focuses on two key aspects: human disorders and ecotoxicology as affected by major toxins originating from biological sources and pollutants, as well as radiation generated spontaneously or as a result of anthropogenic activity. A diverse array of these potentially harmful agents regularly appear in the atmosphere, soil, water and food, compromising both human health and biodiversity in natural and managed ecosystems. This book: - provides authoritative reviews together with specialist short communications to complement the main chapters and address contemporary issues with important case studies; - explores the cutting edge of research and also indicates the likely direction of future developments; - contains extensive coverage of toxicants that are of significant current interest and will be of increasing concern for many years to come; and - encourages international cooperation in future research on pollution and other environmental agents causing harm to human health and degradation of natural habitats in the ecosystem. Written by an international team of authors from a range of educational, medical and research establishments, this book is an essential reference for advanced students and researchers in the areas of environmental sciences, ecology, agriculture, environmental health and medicine, in addition to industry and government personnel responsible for environmental regulations and directives.
A Handbook of Gene and Cell Therapy
by Clévio Nóbrega Liliana Mendonça Carlos A. MatosThis is a reference handbook for young researchers exploring gene and cell therapy. Gene therapy could be defined as a set of strategies modifying gene expression or correcting mutant/defective genes through the administration of DNA (or RNA) to cells, in order to treat disease. Important advances like the discovery of RNA interference, the completion of the Human Genome project or the development of induced pluripotent stem cells (iPSc) and the basics of gene therapy are covered. This is a great book for students, teachers, biomedical researchers delving into gene/cell therapy or researchers borrowing skills from this scientific field.
A Handbook of Geriatric Neuropsychology: Practice Essentials (Studies on Neuropsychology, Neurology and Cognition)
by Shane S. Bush Brian P. YochimA Handbook of Geriatric Neuropsychology: Practice Essentials (Second Edition) brings together experts in the field to integrate the knowledge and skills needed to understand and treat older adults who are experiencing problems with memory and other thinking skills. With three new sections, including coverage of other conditions beyond neuropsychological disorders, special assessment contexts, and more on interventions and ethics, as well as multiple new chapters, and significant updates from the first edition, this book provides a strong foundation for clinicians, educators, and researchers invested in the wellbeing of older adults. The impact and experience of aging, like the practice of neuropsychology, evolves over time. Similarly, through advances in science and professional techniques, neuropsychological practice has continued to evolve. Neuropsychological evaluation remains the most effective method of diagnosing age-related cognitive decline, cognitive difficulties that result from psychological factors, and other related disorders, as well as determining how the various disorders impact functioning and quality of life. This book explores these areas and offers state-of-the-art assessment techniques to assess changes in cognition and behavior and to distinguish normal changes from neuropathology. This book is a go-to resource and key reference for psychologists who serve older adults with known or suspected cognitive problems, as well as those who are invested in promoting brain wellness. It provides much of the information needed to establish and improve foundational and functional competencies in geriatric neuropsychology and establish practices that are personally and professionally rewarding, all aimed at promoting the understanding and wellbeing of older adults.
A Handbook of Global Freshwater Invasive Species
by Robert A. FrancisInvasive non-native species are a major threat to global biodiversity. Often introduced accidentally through international travel or trade, they invade and colonize new habitats, often with devastating consequences for the local flora and fauna. Their environmental impacts can range from damage to resource production (e.g. agriculture and forestry) and infrastructure (e.g. buildings, road and water supply), to human health. They consequently can have major economic impacts. It is a priority to prevent their introduction and spread, as well as to control them. Freshwater ecosystems are particularly at risk from invasions and are landscape corridors that facilitate the spread of invasives. This book reviews the current state of knowledge of the most notable global invasive freshwater species or groups, based on their severity of economic impact, geographic distribution outside of their native range, extent of research, and recognition of the ecological severity of the impact of the species by the IUCN. As well as some of the very well-known species, the book also covers some invasives that are emerging as serious threats. Examples covered include a range of aquatic and riparian plants, insects, molluscs, crustacea, fish, amphibians, reptiles and mammals, as well as some major pathogens of aquatic organisms. The book also includes overview chapters synthesizing the ecological impact of invasive species in fresh water and summarizing practical implications for the management of rivers and other freshwater habitats.
A Handbook of Neuropsychological Assessment (Psychology Library Editions: Neuropsychology #3)
by John R. Crawford Denis M. Parker William W. MckinlayOriginally published in 1992, this is a wide-ranging text concerned with the principles and practice of neuropsychological assessment in adults. It combines a flexible hypothesis testing approach to assessment with information on specialised test batteries. The book covers the major areas of memory, language, perception, attention, and executive dysfunctions, and includes chapters on dementia, alcohol, drug and toxic conditions, stroke and closed head injury. Assessment of dysfunction in cases involving claims for compensation and chapters on specialised assessment techniques, including automated test procedures, are provided. The book presents a sound introduction to this complex area and gives guidelines for the clinician who may need concise information on a specialised topic.
A Handbook of Public Speaking for Scientists and Engineers
by Peter KennyA Handbook of Public Speaking for Scientists and Engineers helps scientists and engineers improve their skills at speaking in public in the course of their professional activities. The book shows how best to prepare papers for presentation at a technical conference and how to put cases to committee meetings. Not only does the book deal with specific events, but it also provides the techniques of more effective speaking, whether presenting papers, answering questions, or speaking "off-the-cuff." The book is written in a highly entertaining manner and should put all complacent lecturers on their guard.
A Handbook of Transcription Factors: Handbook Of Transcription Factors (Subcellular Biochemistry #52)
by Timothy R. HughesTranscription factors are the molecules that the cell uses to interpret the genome: they possess sequence-specific DNA-binding activity, and either directly or indirectly influence the transcription of genes. In aggregate, transcription factors control gene expression and genome organization, and play a pivotal role in many aspects of physiology and evolution. This book provides a reference for major aspects of transcription factor function, encompassing a general catalogue of known transcription factor classes, origins and evolution of specific transcription factor types, methods for studying transcription factor binding sites in vitro, in vivo, and in silico, and mechanisms of interaction with chromatin and RNA polymerase.