- Table View
- List View
VEGF Signaling: Methods and Protocols (Methods in Molecular Biology #2475)
by Lorna R. Fiedler Caroline Pellet-ManyThis volume provides an updated collection of protocols for manipulating and studying VEGF signaling pathways in vitro and in vivo and aims to present a range of both firmly established and newly emerging technologies. Covering multiple model species, from mouse to zebrafish to human, the book explores the role of VEGF and VEGFR isoforms in exosomes, cultured cells, or in tissues, as well as robust cell assays for the investigation of basic angiogenic mechanisms and VEGF signaling in more complex cellular systems, amongst other subjects. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, VEGF Signaling: Methods and Protocols, Second Edition provides a useful tool for researchers in the vascular biology community and beyond in understanding the basic biology of VEGF signaling and in translating this research into the clinic.
Vehicle Crash Mechanics
by Matthew HuangGoverned by strict regulations and the intricate balance of complex interactions among variables, the application of mechanics to vehicle crashworthiness is not a simple task. It demands a solid understanding of the fundamentals, careful analysis, and practical knowledge of the tools and techniques of that analysis.Vehicle Crash Mechanics s
Vehicle Dynamics: Theory and Application
by Reza N. JazarVehicle Dynamics: Theory and Application offers comprehensive coverage of fundamental and advanced topics in vehicle dynamics. This class-tested guide is designed for senior undergraduate and first-year graduate students pursuing mechanical and automotive engineering degrees. It covers a wide range of concepts in detail, concentrating on practical applications that enable students to understand, analyze, and optimize vehicle handling and ride dynamics. Related theorems, formal proofs, and real-world case examples are included. The textbook is divided into four parts, covering all the essential aspects of vehicle dynamics: Vehicle Motion: covers tire dynamics, forward vehicle dynamics, and driveline dynamics Vehicle Kinematics: covers applied kinematics, applied mechanisms, steering dynamics, and suspension mechanisms Vehicle Dynamics: covers applied dynamics, vehicle planar dynamics, and vehicle roll dynamics Vehicle Vibration: covers applied vibrations, vehicle vibrations, and suspension optimization. This revised edition adds an engineering perspective to each example, highlighting the practical relevance of mathematical models and helping you understand when experimental results may differ from analytical ones. New coverage includes vehicle vibrations in transient responses and the control concept in ride optimization. Students, researchers, and practicing engineers alike will appreciate the user-friendly presentation of the science and engineering of the mechanical aspects of vehicles, emphasizing steering, handling, ride, and related components.
Vehicle Dynamics
by Dieter Schramm Manfred Hiller Roberto BardiniThe authors examine in detail the fundamentals and mathematical descriptions of the dynamics of automobiles. In this context different levels of complexity will be presented, starting with basic single-track models up to complex three-dimensional multi-body models. A particular focus is on the process of establishing mathematical models on the basis of real cars and the validation of simulation results. The methods presented are explained in detail by means of selected application scenarios.
Vehicle-to-Grid: A Sociotechnical Transition Beyond Electric Mobility (Energy, Climate and the Environment)
by Lance Noel Gerardo Zarazua de Rubens Johannes Kester Benjamin K. SovacoolThis book defines and charts the barriers and future of vehicle-to-grid technology: a technology that could dramatically reduce emissions, create revenue, and accelerate the adoption of battery electric cars. This technology connects the electric power grid and the transportation system in ways that will enable electric vehicles to store renewable energy and offer valuable services to the electricity grid and its markets. To understand the complex features of this emergent technology, the authors explore the current status and prospect of vehicle-to-grid, and detail the sociotechnical barriers that may impede its fruitful deployment. The book concludes with a policy roadmap to advise decision-makers on how to optimally implement vehicle-to-grid and capture its benefits to society while attempting to avoid the impediments discussed earlier in the book.
Vehicular Accident Investigation and Reconstruction
by Donald J Van KirkAccident investigation/reconstruction is more than just a job or even a profession; it is more art than science and requires a dedication greater than a commitment of time. It takes constant reading, study, and analysis of accident information and case reconstructions to keep improving your performance, both in the field and in the courtroom.
Veiled Reality: An Analysis Of Present- Day Quantum Mechanical Concepts
by Bernard D'EspagnatBy questioning the validity of some of our basic concepts, such as space, object, and causality, quantum physics contributes quite decisively to the dramatic changes now taking place in our world picture.This book is addressed not only to physicists at an early stage in their careers (the first or second year graduate student) but also to philosophers, as well as to all the senior physicists interested in the interpretation problem. Beginning with a chapter that could be described as ?philosophy for physicists,? it presents an in-depth analysis of present-day quantum mechanical concepts, an analysis of physicists and philosophers alike. Specifically, it first offers an extensive critical analysis of such topics as the Einstein, Podolsky, Rosen reality criterion, nonseparatability, the quantum measurement riddle, decoherence theory, consistent histories approaches and ontologically interpretable theories. All this then naturally leads to philosophical questions concerning, in particular, intersubjective agreement and the limit of realism. And a thorough examination of this whole material finally leads to the view that distinguishing between empirical reality and a veiled man-independent reality yields an acceptable answer to the perplexing question of how to interpret quantum physics. Veiled Reality offers nonspecialists, including students in physics, philosophy and the history of science, an accessible perspective on basic problems in the foundations of physics.
Veins of the Desert: A Review on Qanat / Falaj / Karez
by Ali Asghar Yazdi Majid Labbaf KhaneikiQanat is a gently sloping subterranean canal, which taps a water-bearing zone at a higher elevation than cultivated lands. A qanat consist of a series of vertical shafts in sloping ground, interconnected at the bottom by a tunnel with a gradient flatter than that of the ground. From the air, this system looks like a line of anthills leading from the foothills across the desert to the greenery of an irrigated settlement. Qanat engages a variety of knowledge and its studying entails an interdisciplinary approach. In a traditional realm, qanats are embraced by a socio-economic system which guarantees their sustainability. The facets of this socio-economic system operate closely together and make it possible for the qanats to remain into future.Veins of the Desert shows that digging a qanat requires a variety of sciences and technologies, though at a glance qanat is just a horizontal tunnel which drains out groundwater. Qanat is a feat of technology left from our ancestors; hidden underground, but its technical importance is apparent, not less valuable than such surface structures as bridges, castles, towers, etc. Qanat enjoys extended structures and sometimes its length reaches tens of kilometers. It passes through geological formations and faces different conditions and obstacles, so the qanat masters' efforts to solve these problems led to the accumulation of knowledge in terms of qanat construction over time, which has been handed down from generation to generation. Qanat is one of the most complicated traditional technologies, which require knowledge on nature ranging from groundwater to management. This indigenous technology used to bring water efficiently from tens of kilometers away to the thirsty lands.This book also gives insight into cultural and social heritages, which have crystalized around this technique.
Velocity-Free Localization Methodology for Acoustic and Microseismic Sources
by Longjun Dong Xibing LiIn this book, we proposed velocity-free localization methods for acoustic and microseismic sources. This method does not require predetermination of wave velocity, which is a dynamically adjusted free real-time parameter. These methods solve the problem of large localization error caused by the difference between measured wave velocity and actual wave velocity in the source area and greatly improve the positioning accuracy. They are suitable for complex structures where the wave velocity changes dynamically in time and space, such as mines, bridges, buildings, pavements, loaded mechanical structures, dams, geothermal mining, oil extraction, and other engineering fields. This book includes progress in the development of localization methods, factors affecting the accuracy of source localization, analytical methods without the pre-measured wave velocity, velocity-free numerical methods for localizing acoustic sources, combined optimal velocity-free localization methods, velocity-free source localization considering complex paths of spatial structures, and theories as well as some cases of engineering applications of these methods.
The Velocity of Honey
by Jay IngramAlways witty and stimulating and to the point, Jay Ingram's essays are modelsf their kind, revealing again and again the fascination that can be foundeneath the surface of everyday life if we just pause to consider theignificance of objects and phenomena that we normally take completely forranted.
Venerable Trees: History, Biology, and Conservation in the Bluegrass
by Tom Kimmerer“Will likely become a classic among books about Kentucky’s natural history and environment, because it covers so much new information.” —Lexington Herald-LeaderWhen the first settlers arrived in the Bluegrass region of Kentucky, they found an astonishing landscape of open woodland grazed by vast herds of bison. Farmers quickly replaced the bison with cattle, sheep, and horses, but left many of the trees to shade their pastures. Today, central Kentucky and central Tennessee still boast one of the largest populations of presettlement trees in the nation, found in both rural and urban areas.In Venerable Trees: History, Biology, and Conservation in the Bluegrass, Tom Kimmerer showcases the beauty, age, size, and splendor of these ancient trees and the remaining woodland pastures. Documenting the distinctive settlement history that allowed for their preservation, Kimmerer explains the biology of Bluegrass trees and explores the reasons why they are now in danger. He also reveals the dedication and creativity of those fighting to conserve these remarkable three-hundred- to five-hundred-year-old plants—from innovative, conscientious developers who build around them rather than clearing the land to farmers who use lightning rods to protect them from natural disasters.Featuring more than one hundred color photographs, this beautifully illustrated book offers guidelines for conserving ancient trees worldwide while educating readers about their life cycle. Venerable Trees is an informative call to understand the challenges faced by the companions so deeply rooted in the region’s heritage and a passionate plea for their preservation.“A fascinating book about a unique landscape in the Bluegrass Region of Kentucky.” —Frans Vera, author of Grazing Ecology and Forest History
Venom: The Secrets Of Nature's Deadliest Weapon
by Ronald Jenner Eivind UndheimVenom brings readers face to face with some of the most dangerous creatures on the planet, including jellyfish, snakes, and wasps, as it uncovers the story of venom. The book explores how venom is used for predation, defense, competition, and communication by an incredible diversity of species. It examines the unique methods that these species have evolved to create and deliver their deadly toxins. The book traces venom back to its origin in early jellyfish and sea anemones, and reveals how venoms have evolved dozens of times independently all across the animal kingdom since that time. And finally, it examines the relationships between these dangerous creatures and humans. Humans have not only learned to live with them, but also to benefit from them: scientists increasingly are harnessing the power of venom to create new drugs, treatments, and anti-venoms.
Venom Doc: The Edgiest, Darkest, Strangest Natural History Memoir Ever
by Bryan Grieg FrySteve Irwin meets David Attenborough in this jaw-dropping account of studying the world’s most venomous creatures. Venomologist Bryan Grieg Fry has one of the most dangerous jobs on Earth: he works with its deadliest creatures. He’s been bitten by twenty-six venomous snakes, been stung by three stingrays, and survived a near-fatal scorpion sting while deep in the Amazon jungle. He’s received more than four hundred stitches and broken twenty-three bones, including breaking his back in three places, and had to learn how to walk again. But when you research only the venom you yourself have collected, the adventures—and danger—never stop. Bryan’s discoveries have radically reshaped views on venom evolution and contributed to the creation of venom-based life-saving medications. In pursuit of venom, he has traveled the world collecting samples from Indonesia to Mexico, Germany, and Brazil. He’s encountered venomous creatures of all kinds, including the Malaysian king cobra, the Komodo dragon, and the brush-footed trapdoor spider. Bryan recounts his lifelong passion for studying the world’s most venomous creatures in this outlandish, captivating memoir, where he and danger are never far apart.
Venomous
by Christie WilcoxIn Venomous, molecular biologist Christie Wilcox investigates venoms and the animals that use them, revealing how they work, what they do to the human body, and how they can revolutionize biochemistry and medicine today. <p><p> Wilcox takes us from the coast of Indonesia to the rainforests of Peru in search of the secrets of these mysterious animals. We encounter jellyfish that release microscopic venom-packed darts known to kill humans in just two minutes, a two-inch caterpillar with toxic bristles that trigger hemorrhaging throughout the body, and a stunning blue-ringed octopus with saliva capable of inducing total paralysis. How could an animal as simple as a jellyfish evolve such an intricate, deadly poison? And how can a snake possess enzymes that tear through tissue yet leave its own body unscathed? <p><p> Wilcox meets the fearless scientists who often risk their lives studying these lethal beasts to find out and puts her own life on the line to examine these species up close. Drawing on her own research on venom chemistry and evolution, she also shows how venom is helping us untangle the complex mechanisms of some of our most devastating diseases. <p><p> Venomous reveals that the animals we fear the most actually hold the keys to a deeper understanding of evolution, adaptation, and immunity. Thrilling and surprising at every turn, Venomous will change the way you think about our natural world.
Venomous: How Earth's Deadliest Creatures Mastered Biochemistry
by Christie WilcoxA thrilling tale of encounters with nature’s masters of biochemistryFrom the coasts of Indonesia to the rainforests of Peru, venomous animals are everywhere—and often lurking out of sight. Humans have feared them for centuries, long considering them the assassins and pariahs of the natural world.Now, in Venomous, the biologist Christie Wilcox investigates and illuminates the animals of our nightmares, arguing that they hold the keys to a deeper understanding of evolution, adaptation, and immunity. She reveals just how venoms function and what they do to the human body. With Wilcox as our guide, we encounter a jellyfish with tentacles covered in stinging cells that can kill humans in minutes; a two-inch caterpillar with toxic bristles that trigger hemorrhaging; and a stunning blue-ringed octopus capable of inducing total paralysis. How do these animals go about their deadly work? How did they develop such intricate, potent toxins? Wilcox takes us around the world and down to the cellular level to find out. Throughout her journey, Wilcox meets the intrepid scientists who risk their lives studying these lethal beasts, as well as “self-immunizers” who deliberately expose themselves to snakebites. Along the way, she puts her own life on the line, narrowly avoiding being envenomated herself. Drawing on her own research, Wilcox explains how venom scientists are untangling the mechanisms of some of our most devastating diseases, and reports on pharmacologists who are already exploiting venoms to produce lifesaving drugs. We discover that venomous creatures are in fact keystone species that play crucial roles in their ecosystems and ours—and for this alone, they ought to be protected and appreciated.Thrilling and surprising at every turn, Venomous will change everything you thought you knew about the planet’s most dangerous animals.
Venomous Snakes of Texas
by Andrew H. PriceTexas has about one hundred twenty native species and subspecies of snakes, fifteen of which are venomous. Since 1950, Texans have turned to the Poisonous Snakes of Texas pamphlet series published by the Texas Parks and Wildlife Department for help in identifying these snakes and for expert advice on preventing and treating snakebite. Venomous Snakes of Texas, a thoroughly revised and updated edition of Poisonous Snakes, carries on this tradition as a one-stop, all-you-need-to-know guide to Texas's rattlesnakes, copperheads, cottonmouths, and coral snakes. In this authoritative field guide, you'll find:- Full-color photographs and a county-by-county distribution map for each species. - Each species' common and scientific name, description, look-alikes, and a summary sketch of its habitat, behavior, reproduction, venom characteristics, predator-prey relationships, and fossil record. - Up-to-date advice on recognizing venomous snakes and preventing and treating snakebite, both at home and in the field. - A glossary of terms and an extensive bibliography. A special feature of this guide is an expanded treatment of the ecological and evolutionary context in which venomous snakes live, which supports Price's goal "to lessen the hatred and fear and to increase the understanding, the respect, and even the appreciation with which venomous snakes should be regarded. "
Venous Embolization of the Liver
by David C. Madoff Jean-Nicolas Vauthey Masato Nagino Masatoshi MakuuchiVenous Embolization of the Liver: Radiologic and Surgical Practice explores the theoretical advantages and clinical implications for utilizing Venous Embolization techniques, including portal vein and hepatic vein embolization. The practice of venous embolization of the liver was originally developed in Japan by Dr. Makuuchi (one of the co-editors of this book) in 1990 and since then, the techniques reviewed in this book are practiced throughout the world and are now considered the "standard of care" at many hepatobiliary centres worldwide. Venous Embolization of the Liver: Radiologic and Surgical Practice covers a multitude of topics, including: pertinent vascular (microscopic and macroscopic) and surgical anatomy, liver regeneration (including the atrophy-hypertrophy complex), historical perspectives of major hepatic resection, various hepatobiliary surgical procedures , factors affecting hypertrophy, pathophysiology of embolization and resection, embolization techniques (including approaches and embolic agents), the indications for embolization and resection (including pre-operative volumetric and functional assessment and post-embolization followup), potential complications, outcomes data for different diseases, recently advocated strategies (including "definitive" treatment of hepatocellular carcinoma using portal vein embolization after transcatheter arterial chemoembolization) and future perspectives. This book is a valuable resource for interventional radiologists and hepatobiliary surgeons who perform the embolization procedures and liver resections. Venous Embolization of the Liver: Radiologic and Surgical Practice can also be used secondarily by diagnostic radiologists, medical oncologists specializing in gastrointestinal malignancies, hepatologists, gastroenterologists, liver transplant surgeons and basic scientists interested in liver regeneration physiology research.
Venous Thrombosis: From Genes to Clinical Medicine
by D.N. Cooper M. KrawczakThrombotic disease is a major cause of death and disablement in Western society. The most common causes is an inherited defect in one of the many genes encoding a protein which is involved in clotting, It's regulation or the process of clot dissolution, Fibrinolysis.Venous Thrombosis: from genes to clinical medicine, presents our current knowledge of potentially prothrombotic protein at modalities, together with the clear and concise views of the roles these proteins play in haemostasis, and the use of molecular techniques in the analysis and diagnosis of inherited defects. Each chapter describes a specific protein deficiency, with information on protein structure, function and biochemistry, gene structure and expression, as well as epidemiological and molecular genetic aspects of the deficiency state.This multifaceted approach aims to examine the possible causes of venous thrombosis, to explain the underlying molecular defects, and to explore the genotype-phenotype relationship in this complex multi gene disorder. The potential roles of both aesthetic interactions and environmental risk factors are also discussed. This book will be of value to haematologists, genetic counsellors and clinical geneticists.
The Vent and Seep Biota
by Steffen KielOases of life around black smokers and hydrocarbon seeps in the deep-sea were among the most surprising scientific discoveries of the past three decades. These ecosystems are dominated by animals having symbiotic relationships with chemoautotrophic bacteria. Their study developed into an international, interdisciplinary venture where scientists develop new technologies to work in some of the most extreme places on Earth. This book highlights discoveries, developments, and advances made during the past 10 years, including remarkable cases of host-symbiont coevolution, worms living on frozen methane, and a fossil record providing insights into the dynamic history of these ecosystems since the Paleozoic.
Ventilation and Energy Efficiency in Welding Shops: A Practical Guide (SpringerBriefs in Applied Sciences and Technology)
by Alexander ZhivovThis Guide is based on several decades of author’s research and practical experience in the areas of process optimization, ventilation and energy conservation in welding shops of auto manufacturing and maintenance facilities. The Guide will describe principles of Weld Fume Control, advanced ventilation systems for facilities with welding and allied processes and with energy conservation opportunities that result from the process related measures to reduce emission of fumes and gases and the building envelope improvements. The objectives of the Guide are to improve the health and safety in the industrial environment and offer strategies for energy conservation. The Guide is designed for engineers, production operators and energy managers.
Ventilation of Normobaric and Hyperbaric Objects
by Ryszard KłosConsidering the increased need to test and develop ventilation both for normobaric and hyperbaric use in underwater technology industries (diving equipment, submarines and other underwater facilities), mining, and other relevant industries, this book presents a complete study in the field of normobaric and hyperbaric ventilation. It focuses on development and verification of the research-based mathematical modeling approach for deterministic modeling of ventilation processes, both for objects with semi-closed and closed circulation of breathing gas. It also proposes validated analytical models of ventilation processes, and a new type of carbon dioxide emission simulator that was also developed. Features Describes ventilation processes by replacing semi-empirical models with more accurate analytical models. Includes concepts based on deterministic models (cause-and-effect models). Focuses on analytical mathematical model of the ventilation process. Covers both the objects with semi-closed and closed circulation of breathing gas, for hyperbaric and normobaric conditions. Summarizes relevant research results and their validation in real conditions and implemented into operational practice. This book is aimed at researchers, professionals, and graduate students in hyperbaric facility processing, building ventilation processing, life support system design, shipbuilding, marine engineering, and diving submarine safety.
Venture Capital and the Corporate Governance of Chinese Listed Companies
by Lin ZhangState-controlled listed companies have always dominated Chinese stock markets. As a result of the rampant scandals related to them, there have been voluminous academic efforts to explore their corporate governance, underpinned by agency costs. However, these studies have yet to examine the phenomenon from the perspective of venture capital and adaptive efficiency. During the last ten years, despite China's remarkable progress in the development of its venture capital market, its domestic venture capital has been marginalized by American competitors. Given the different performance between them, the author contends that the corporate governance system of Chinese state-controlled listed companies has hampered the performance of the institutional factors which are responsible for the prosperity of American venture capital in Chinese venture capital markets. With the practice of American venture capital as the mirror, he empirically demonstrates that Chinese domestic venture capital lacks the four factors related to the success of their American counterparts: large and independent funding, application of incentive mechanisms, efficient exit channels, and a high risk tolerance level. More importantly, these defects as a whole are closely linked to the corporate governance of state-controlled listed companies. Considering the potential negative consequences on economic and social development, the author identifies policy reforms underway to harmonize agency costs and adaptive efficiency.
Venture into the Stratosphere: Flying the First Jetliners
by Dominic ColvertA fascinating, one-of-a-kind memoir that takes readers on a journey to the dawn of the jet age—and reveals how technology will shape the world to come. Drawing on engineering breakthroughs achieved during World War II, aviation in the 1950s was an exciting and uplifting sequel to the most destructive conflict in history. It gave birth to the jet age and fostered remarkable social changes. Venture into the Stratosphere is a memoir about the exhilaration and challenges of flying the first jetliners—the de Havilland Comets. Former Irish Air Corpsman and aviation engineer Dominic Colvert explains technical matters in layman&’s terms, tells a fascinating love story, examines the post-war ethos, and reveals intimate details of the flight deck in both routine and emergency situations. By opening a window onto cultural developments after the turn of the century, Colvert offers key insights into how new technologies shape behavior and values. Passenger jets have become a routine part of life for most people, but have you ever wondered—how did we get here? Read Venture into the Stratosphere to find out!
Venture Investing in Science (Columbia Business School Publishing)
by Douglas Jamison Stephen WaiteOver the past decade, software companies have increasingly monopolized the flow of venture capital, starving support for scientific research and its transformative discoveries. New medicines, cheaper and faster personal computers, and other life-changing developments all stem from investment in science. In the past, these funds led to steam engines, light bulbs, microprocessors, 3D printers, and even the Internet. In Venture Investing in Science, the venture capitalist Douglas W. Jamison and the investment author Stephen R. Waite directly link financial support to revolutionary advancements in physics, computers, chemistry, and biology and make a passionate case for continued investing in science to meet the global challenges of our time.Clean air and water, cures for intractable diseases, greener public transportation, cheaper and faster communication technologies—these are some of the rich opportunities awaiting venture capital investment today. Jamison and Waite focus on how early-stage companies specializing in commercializing transformative technologies based on deep science have been shunned by venture capitalists, and how the development of such companies have been hampered by structural changes in capital markets and government regulation over the past decade. The authors argue that reinvigorating science-based technological innovation is crucial to reactivating the economic dynamism that lifts living standards and fuels prosperity over time.
Venture Philanthropy Strategies to Support Translational Research: Workshop Summary
by Institute of MedicineMany voluntary health organizations fund translational research. An increasing number of these organizations are looking at venture philanthropy as a critical way to advance their missions of helping patients and working to cure disease. A wide range of participants gathered on October 3, 2008 at the Beckman Center of the National Academies of Science for a workshop titled "Venture Philanthropy Strategies Used by Patient Organizations to Support Translational Research." Participants with experience in venture philanthropy shared their experiences and lessons learned in order to improve efficiency and effectiveness in translational research.