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Addressing Unhealthy Alcohol Use in Primary Care

by Richard Saitz

While there is a wealth of published information on addiction medicine, the psychological aspects of alcohol abuse, and behavioral medicine with regard to addiction, virtually none of these resources were written with the primary care provider in mind. Addressing Unhealthy Alcohol Use in Primary Care is a resource for primary care clinicians who are confronted by patients with these problems daily, and who wish to successfully address these issues in their practice. It would focus on the literature and science relevant to primary care practice and cover the range of interventions appropriate for this setting. Topics include assessment, brief counseling interventions, pharmacotherapy, referrals to both specialty care and Alcoholics Anonymous (and other self-help programs), psychiatric co-morbidity and other drug use, and other information specific to the needs of the primary care provider.

Addressing Wicked Problems through Science Education: The Role of Out-of-School Experiences (Contributions from Science Education Research #8)

by Marianne Achiam Justin Dillon Melissa Glackin

This book discusses a number of ways in which out-of-school science education can uniquely engage learners with ‘wicked’ global problems such as biodiversity loss and climate change. The idea for the volume originated in discussions among members of the ESERA special interest group on "Science Education in Out-of-School contexts". It emerged from these discussions that out-of-school institutions and experiences offer opportunities for critical engagement in wicked problems that go far beyond what is possible solely in the science classroom.The book opens with a principled discussion of the nature of wicked problems and what addressing them involves. This introduction clarifies key terms and ideas to create a coherent backdrop for the rest of the book. Subsequent chapters discuss the challenges of designing educational experiences to address wicked problems, as well as the teaching and learning that takes place. The authors offer perspectives across a range of out-of-school environments such as science centres, natural history museums, botanical gardens, geological sites, and local communities. The book concludes with a chapter that synthesises the findings from the various contributions and points to the messages for educators. Finally, the editors outline an exciting research agenda to build knowledge of education addressing wicked problems. The intended audience of the book includes teachers, educators/facilitators, teacher educators, curriculum developers, and early career researchers as well as established researchers.

Addysgu Bioleg yn yr Uwchradd (Teaching Secondary Biology 3rd Edition Welsh Language edition)

by The Association Education

Enhance your teaching with expert advice and support for Key Stages 3 and 4 Biology from the Teaching Secondary series - the trusted teacher's guide for NQTs, non-specialists and experienced teachers.Written in association with ASE, this updated edition provides best practice teaching strategies from academic experts and practising teachers.- Refresh your subject knowledge, whatever your level of expertise- Gain strategies for delivering the big ideas of science using suggested teaching sequences- Engage students and develop their understanding with practical activities for each topic- Enrich your lessons and extend knowledge beyond the curriculum with enhancement ideas- Improve key skills with opportunities to introduce mathematics and scientific literacy highlighted throughout- Support the use of technology with ideas for online tasks, video suggestions and guidance on using cutting-edge software- Place science in context; this book highlights where you can apply science theory to real-life scenarios, as well as how the content can be used to introduce different STEM careersAlso available: Teaching Secondary Chemistry, Teaching Secondary Physics

Addysgu Bioleg yn yr Uwchradd (Teaching Secondary Biology 3rd Edition Welsh Language edition)

by The Association Education

Enhance your teaching with expert advice and support for Key Stages 3 and 4 Biology from the Teaching Secondary series - the trusted teacher's guide for NQTs, non-specialists and experienced teachers.Written in association with ASE, this updated edition provides best practice teaching strategies from academic experts and practising teachers.- Refresh your subject knowledge, whatever your level of expertise- Gain strategies for delivering the big ideas of science using suggested teaching sequences- Engage students and develop their understanding with practical activities for each topic- Enrich your lessons and extend knowledge beyond the curriculum with enhancement ideas- Improve key skills with opportunities to introduce mathematics and scientific literacy highlighted throughout- Support the use of technology with ideas for online tasks, video suggestions and guidance on using cutting-edge software- Place science in context; this book highlights where you can apply science theory to real-life scenarios, as well as how the content can be used to introduce different STEM careersAlso available: Teaching Secondary Chemistry, Teaching Secondary Physics

Addysgu Cemeg yn yr Uwchradd (Teaching Secondary Chemistry 3rd Edition Welsh Language edition)

by The Association Education

Enhance your teaching with expert advice and support for Key Stages 3 and 4 Chemistry from the Teaching Secondary series - the trusted teacher's guide for NQTs, non-specialists and experienced teachers.Written in association with ASE, this updated edition provides best practice teaching strategies from academic experts and practising teachers.- Refresh your subject knowledge, whatever your level of expertise- Gain strategies for delivering the big ideas of science using suggested teaching sequences- Engage students and develop their understanding with practical activities for each topic- Enrich your lessons and extend knowledge beyond the curriculum with enhancement ideas- Improve key skills with opportunities to introduce mathematics and scientific literacy highlighted throughout- Support the use of technology with ideas for online tasks, video suggestions and guidance on using cutting-edge software- Place science in context; this book highlights where you can apply science theory to real-life scenarios, as well as how the content can be used to introduce different STEM careersAlso available: Teaching Secondary Biology, Teaching Secondary Physics

Addysgu Cemeg yn yr Uwchradd (Teaching Secondary Chemistry 3rd Edition Welsh Language edition)

by The Association Education

Enhance your teaching with expert advice and support for Key Stages 3 and 4 Chemistry from the Teaching Secondary series - the trusted teacher's guide for NQTs, non-specialists and experienced teachers.Written in association with ASE, this updated edition provides best practice teaching strategies from academic experts and practising teachers.- Refresh your subject knowledge, whatever your level of expertise- Gain strategies for delivering the big ideas of science using suggested teaching sequences- Engage students and develop their understanding with practical activities for each topic- Enrich your lessons and extend knowledge beyond the curriculum with enhancement ideas- Improve key skills with opportunities to introduce mathematics and scientific literacy highlighted throughout- Support the use of technology with ideas for online tasks, video suggestions and guidance on using cutting-edge software- Place science in context; this book highlights where you can apply science theory to real-life scenarios, as well as how the content can be used to introduce different STEM careersAlso available: Teaching Secondary Biology, Teaching Secondary Physics

Addysgu Ffiseg yn yr Uwchradd (Teaching Secondary Physics 3rd Edition Welsh Language edition)

by The Association Education

Enhance your teaching with expert advice and support for Key Stages 3 and 4 Physics from the Teaching Secondary series - the trusted teacher's guide for NQTs, non-specialists and experienced teachers.Written in association with ASE, this updated edition provides best practice teaching strategies from academic experts and practising teachers.- Refresh your subject knowledge, whatever your level of expertise- Gain strategies for delivering the big ideas of science using suggested teaching sequences- Engage students and develop their understanding with practical activities for each topic- Enrich your lessons and extend knowledge beyond the curriculum with enhancement ideas- Improve key skills with opportunities to introduce mathematics and scientific literacy highlighted throughout- Support the use of technology with ideas for online tasks, video suggestions and guidance on using cutting-edge software- Place science in context; this book highlights where you can apply science theory to real-life scenarios, as well as how the content can be used to introduce different STEM careersAlso available: Teaching Secondary Chemistry, Teaching Secondary Biology

Addysgu Ffiseg yn yr Uwchradd (Teaching Secondary Physics 3rd Edition Welsh Language edition)

by The Association Education

Enhance your teaching with expert advice and support for Key Stages 3 and 4 Physics from the Teaching Secondary series - the trusted teacher's guide for NQTs, non-specialists and experienced teachers.Written in association with ASE, this updated edition provides best practice teaching strategies from academic experts and practising teachers.- Refresh your subject knowledge, whatever your level of expertise- Gain strategies for delivering the big ideas of science using suggested teaching sequences- Engage students and develop their understanding with practical activities for each topic- Enrich your lessons and extend knowledge beyond the curriculum with enhancement ideas- Improve key skills with opportunities to introduce mathematics and scientific literacy highlighted throughout- Support the use of technology with ideas for online tasks, video suggestions and guidance on using cutting-edge software- Place science in context; this book highlights where you can apply science theory to real-life scenarios, as well as how the content can be used to introduce different STEM careersAlso available: Teaching Secondary Chemistry, Teaching Secondary Biology

The Adélie Penguin: Bellwether of Climate Change

by David Ainley

The Adélie penguin is one of the best-studied birds in the world and is the subject of research programs from a dozen nations interested in monitoring changes in the environment and the food webs of the Southern Ocean. This species' population has been changing dramatically over the past few decades coincident with a general warming of the maritime portion of Antarctica. When the sea-ice is seen to decline so does the population of Adélie penguins. Further south, however, the population is increasing. This book summarizes our present ecological knowledge of this polar seabird. In so doing, David Ainley describes the ecological factors important to its life history and details the mechanisms by which it is responding to climate change. The author also chronicles the history of research on Adélie penguins, beginning with the heroic expeditions at the beginning of the twentieth century. Weaving together history, ecology, natural history, and written accounts from the earliest Antarctic naturalists into a fascinating account of this charismatic bird, The Adélie Penguin provides a foundation upon which future ornithological research and environmental monitoring can be based. It is a model for investigations into the effect of climate change on a particular species. The book also contains many fine illustrations from the accomplished illustrator Lucia deLeiris and photographs by the author.

Adelita's Amazing Journey

by Elizabeth Armstrong Hall

Adelita, a loggerhead sea turtle, was the first ocean-going animal to be tracked with a satellite transmitter. How would she find her way?

Adeno-Associated Virus: Methods and Protocols (Methods in Molecular Biology #807)

by Richard O. Snyder Philippe Moullier

Today, progress in rAAV-mediated gene transfer is so robust that long-term, efficient, and regulatable transgene expression is reproducibly achieved in large animal models. The complexity of gene transfer agents in the context of their clinical use requires investigators from a wide variety of backgrounds to have an understanding -- or at least an appreciation of -- the regulatory environment and constraints that affect vector design, manufacturing, pre-clinical testing, and clinical use, with an emphasis on patient protection. In Adeno-Associated Virus: Methods and Protocols, experts from the United States and Europe have contributed current knowledge of this multi-dimensional field relating to the biology of AAV, rAAV vector design, vector manufacturing and product testing, performance of rAAV vectors in major organs, rAAV-related immunological issues, design of animal and clinical studies, and clinical experience. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Adeno-Associated Virus: Methods and Protocols provides a complete and comprehensive understanding of this multi-disciplinary and rapidly progressing field.

Adenosine: A Key Link between Metabolism and Brain Activity

by Susan Masino Detlev Boison

Homeostasis of key metabolites and metabolic health affects all bodily systems. Not surprisingly, altered metabolic function is associated with a wide spectrum of dysfunctions in the central nervous system - including developmental disorders, acute nervous system injury, and neurodegenerative disorders. Accordingly, metabolism-based therapies offer significant promise as new category of treatment options designed to limit, delay or reverse the disease process by reconstructing homeostatic functions. Increasingly it is appreciated that restoring metabolic health could promote normal nervous system activity, and improve behavior and cognition. Adenosine: A Key Link Between Metabolism and Central Nervous System Activity focusses on diverse aspects of adenosine, an evolutionarily conserved homeostatic bioenergetic regulator in the central nervous system. Because of its interrelationship with ATP (adenosine triphosphate), adenosine is integral to cell metabolism. At the same time, adenosine influences neuronal activity directly via receptors, and is involved in biochemical processes related to gene expression. Thus, adenosine is uniquely placed as a reciprocal and rapid link between changes in metabolism and changes in neuronal activity, and, on a longer time scale, to changes in gene expression and long term changes in cell function. Leaders in the field feature basic research on adenosine at the cellular level in the central nervous system, and relate these findings to its recognized potential in diverse acute and chronic disorders. This comprehensive overview of adenosine also highlights emerging adenosine-based treatments and associated opportunities for central nervous system disorders.

Adenosine Deaminases Acting on RNA (Current Topics in Microbiology and Immunology #353)

by Charles E. Samuel

"The objective of this CTMI volume is to provide readers with a foundation for understanding what ADARs are and how they act to affect gene expression and function. It is becoming increasingly apparent that ADARs may possess roles not only as enzymes that deaminate adenosine to produce inosine in RNA substrates with double-stranded character, but also as proteins independent of their catalytic property. Because A-to-I editing may affect base-pairing and RNA structure, processes including translation, splicing, RNA replication, and miR and siRNA silencing may be affected. Future studies of ADARs no doubt will provide us with additional surprises and new insights into the modulation of biological processes by the ADAR family of proteins."

Adenosine Receptors in Health and Disease (Handbook of Experimental Pharmacology #193)

by Constance N. Wilson S. Jamal Mustafa

Since their discovery approximately 25 years ago, adenosine receptors have now emerged as important novel molecular targets in disease and drug discovery. These proteins play important roles in the entire spectrum of disease from inflammation to immune suppression. Because of their expression on a number of different cell types and in a number of different organ systems they play important roles in specific diseases, including asthma, rheumatoid arthritis, Parkinson's disease, multiple sclerosis, Alzheimer's disease, heart disease, stroke, cancer, sepsis, and obesity. As a result of intense investigations into understanding the molecular structures and pharmacology of these proteins, new molecules have been synthesized that have high specificity for these proteins and are now entering clinical trials. These molecules will define the next new classes of drugs for a number of diseases with unmet medical needs.

Adenovirus: Methods and Protocols (Methods in Molecular Biology #1089)

by Miguel Chillón Assumpció Bosch

Reflecting the development of powerful new tools and high-throughput methods to analyze adenoviral particles and their interactions with host cells, the third edition of "Adenovirus Methods and Protocols" calls upon experts in the field to convey advances in molecular biology, genomics and proteomics, imaging, and bioinformatics. Beginning with cryo-electron microscopy, atomic force microscopy, and mass spectrometry for a high resolution image and characterization of the virion, this detailed book then continues with capsid modifications and viral-like particles as promising alternatives to classical adenovirus vectors, and the study of adenovirus in host interactions in vitro at the cellular level as well as in vivo in animal models. Finally, the volume concludes with an extensive update of the most efficient protocols to generate, amplify, and/or purify, at small and large scale, standard human Ad5 as well as non-human, chimeric, and helper-dependent adenovirus vectors. Written in the greatly successful "Methods in Molecular Biology" series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, "Adenovirus Methods and Protocols, Third Edition" serves as an ideal guide for scientists continuing to research this highly valuable viral tool.

Adenovirus Methods and Protocols: Volume 2: Ad Proteins And Rna, Lifecycle And Host Interactions, And Phyologenetics (Methods in Molecular Medicine #21)

by William S. Wold

In Adenovirus Methods and Protocols, William S.M. Wold has organized a collection of readily reproducible methods for conducting research with adenoviruses, the premier and most widely used model in cell and molecular biology. The methods range from how to grow and titer adenoviruses and how to construct specific alterations in the adenovirus genome, to how to measure apoptosis induced by cells of the immune system, cytokines, and intrinsic apoptosis effectors. In addition, there are methods to study transcription and splicing with in vitro systems and for the adenovirus-mediated transformation of cells to a malignant state. Each method is written by a prominent investigator well-versed in the technique and includes a brief background discussion, as well as tried and true step-by-step instructions.<P><P> Adenovirus Methods and Protocols will be useful to both entry-level and senior scientists seeking to enter the adenovirus field, to researchers from other areas wishing to construct adenovirus vectors for their own research, and to adenovirologists wanting to enter new sectors of research. Its cutting-edge techniques are certain to make it today's reference of choice, one from which even expert researchers will learn many productive and time-saving techniques.

Adenovirus Methods and Protocols, Second Edition, Volume 1: Volume 1: Adenoviruses, Ad Vectors, Quantitation, and Animal Models (Methods in Molecular Medicine #130)

by William S. Wold Ann E. Tollefson

Adenovirus Methods and Protocols, Second Edition, now in two volumes, is an essential resource for adenovirus (Ad) researchers beginning in the field, and an inspirational starting point for researchers looking to branch into new areas of Ad study. In addition to updating and expanding the first edition, the authors have added new chapters that address innovative areas of emphasis in Ad research, including Ad vector construction and use, real-time PCR, use of new animal models, and methods for quantification of Ad virus or virus expression/interactions. Each of the protocols presented in these volumes is written by trendsetting researchers.

Adenovirus Methods and Protocols, Second Edition, Volume 2: Volume 2: Ad Proteins and RNA, Lifecycle and Host Interactions, and Phyologenetics (Methods in Molecular Medicine #131)

by William S. Wold Ann E. Tollefson

Adenovirus Methods and Protocols, Second Edition, now in two volumes, is an essential resource for adenovirus (Ad) researchers beginning in the field, and an inspirational starting point for researchers looking to branch into new areas of Ad study. In addition to updating and expanding the first edition, the authors have added new chapters that address innovative areas of emphasis in Ad research, including Ad vector construction and use, real-time PCR, use of new animal models, and methods for quantification of Ad virus or virus expression/interactions. Each of the protocols presented in these volumes is written by trendsetting researchers.

ADHD as a Model of Brain-Behavior Relationships (SpringerBriefs in Neuroscience)

by Leonard F. Koziol Deborah Ely Budding Dana Chidekel

ADHD as a Model of Brain-Behavior Relationships Leonard F. Koziol, Deborah Ely Budding, and Dana Chidekel Series Title: Springer Briefs in Neuroscience Subseries: The Vertically Organized Brain in Theory and Practice It's been a basic neurological given: the brain does our thinking, and has evolved to do the thinking, as controlled by the neocortex. In this schema, all dysfunction can be traced to problems in the brain's lateral interactions. But in scientific reality, is this really true? Challenging this traditional cortico-centric view is a body of research emphasizing the role of the structures that control movement-the brain's vertical organization-in behavioral symptoms. Using a well-known, widely studied disorder as a test case, ADHD as a Model of Brain-Behavior Relationships offers an innovative framework for integrating neuroscience and behavioral research to refine diagnostic process and advance the understanding of disorders. Identifying a profound disconnect between current neuropsychological testing and the way the brain actually functions, this revision of the paradigm critiques the DSM and ICD in terms of the connectedness of brain structures regarding cognition and behavior. The authors argue for a large-scale brain network approach to pathology instead of the localizing that is so common historically, and for an alternate set of diagnostic criteria proposed by the NIMH. Included in the coverage: The diagnosis of ADHD: history and context. ADHD and neuropsychological nomenclature Research Domain Criteria: a dimensional approach to evaluating disorder The development of motor skills, executive function, and a relation to ADHD The role of the cerebellum in cognition, emotion, motivation, and dysfunction How large-scale brain networks interact Heralding a more accurate future of assessment, diagnosis, and treatment of neurodevelopmental disorders, ADHD as a Model of Brain-Behavior Relationships represents a major step forward for neuropsychologists, child psychologists, and psychiatrists, or any related profession interested in a neuroscientific understanding of brain function. ​

ADHD in Adults: A Practical Guide to Evaluation and Management (Current Clinical Psychiatry #0)

by Craig B.H. Surman

ADHD in Adults: A Practical Guide to Evaluation and Management is the product of a unique collaboration of international specialists. This volume offers easy-to-read guidance, and includes checklists, rating scales and treatment planning tools. It was designed for a broad audience of caregivers working in diverse settings, including psychiatrists, social workers, primary care physicians, nurse specialists and psychologists. The authors are highly acclaimed clinicians, investigators and educators. They offer step-by-step guidance for implementation of best practices, drawing from clinical research and their experience treating thousands of patients. They cover diagnosis, treatment planning, and state-of-the-art application of pharmacology, psychotherapy, skill-building, family system and environmental interventions - for both simple and complex cases. The scales and worksheets in this Guide were developed to efficiently facilitate assessment and management. The Editor is an international leader in the field from the Clinical and Research Program in Adult ADHD at Massachusetts General Hospital (MGH) and Harvard Medical School, which has made pioneering and highly cited contributions to the understanding of ADHD. This Guide is a definitive, indispensable resource for all health providers who wish to optimize their approach to adult patients with ADHD.

ADHD, Stress, and Development (SpringerBriefs in Psychology)

by Petr Bob Jana Konicarova

This first-of-its-kind volume revisits current findings on ADHD in terms of classic thinking on developmental neuropsychology for a more rounded concept of brain disorganization. Insights from Freud, Janet, John Hughlings Jackson, and other pioneers help identify mechanisms (e.g., the primitive reflexes) that can cause children with ADHD to be prone to cognitive dissociation when exposed to stressful environments. The authors’ model of the developing distracted brain pinpoints effects of stress on cognitive and affective functions, most notably attention and memory, and suggests situations in which stimuli may facilitate integration between brain and mind. This expanded knowledge opens out new educational possibilities for vulnerable students as well as new opportunities for therapeutic breakthroughs for children with ADHD. Included in the coverage: · Definition, diagnosis, and epidemiology of Attention Deficit and Hyperactivity Disorder. · Historical and recent research on ADHD. · Attentional functions, executive dysfunctions, and stress, implications for ADHD. · Neural dissolution, dissociation, and stress in ADHD. · Attention, brain-mind integration and ADHD. · Implications for education and therapy of ADHD children. ADHD, Stress, and Development ably synthesizes past and current understanding into a robust framework with implications for real-world practice. It offers practitioners and researchers new perspectives and future directions in neuropsychology, psychiatry, child and school psychology, and pediatrics.

Adherens Junctions: From Molecular Mechanisms To Tissue Development And Disease (Subcellular Biochemistry #60)

by Tony Harris

Cell-cell adhesion is fundamental for the development and homeostasis of animal tissues and organs. Adherens junctions (AJs) are the best understood cell-cell adhesion complexes. In this volume, a group of internationally recognized experts reviews AJ biology over a wide range of organization; from atoms to molecules, to protein complexes, molecular networks, cells, tissues, and overall animal development. AJs have also been an integral part of animal evolution, and play central roles in cancer development, pathogen infection and other diseases. This book addresses major questions encompassing AJ biology. * How did AJs evolve? * How do cadherins and catenins interact to assemble AJs and mediate adhesion? * How do AJs interface with other cellular machinery to couple adhesion with the whole cell? * How do AJs affect cell behaviour and multicellular development? * How can abnormal AJ activity lead to disease?

Adhesion and Bonding in Composites

by Ryutoku Yosomiya

This book deals with the roles played by the component material interface in composites, with special emphasis on methods used to improve the adhesion and bonding between them. It is helpful for scientists and engineers in the materials field and to engineers working with adhesives or composites.

Adhesion in Layered Cement Composites

by Łukasz Sadowski

This book discusses how to identify the level of adhesion in layered systems made of cement composites using a multi-scale approach based on experimental and numerical analyses. In particular, it explains <p><p> 1. The suitability of previously used artificial intelligence tools and learning algorithms for reliable assessment of the level of adhesion of layered systems made of cement composites based on non-destructive tests <p> 2. The development of the methodology for a reliable non-destructive evaluation of the level of adhesion in newly constructed layered systems of any overlay thickness and in existing layered systems made of cement composites <p> 3. How to determine whether to assess the level of adhesion of the layered systems, and discusses the amplitude parameters, spatial, hybrid and volume parameters describing the morphology of the concrete substrate surface in the mesoscale <p> 4. How to ascertain whether the effective surface area of the existing concrete substrate and the contribution of the exposed aggregate on this substrate, determined in mesoscale, have an impact on the level of adhesion of layered systems made of cement composites <p> 5. The assessment of the structure of air pores in the microscale and the chemical composition of the cement composite on the nanoscale in the interphase zone together with the determination of their impact on the level of adhesion of layered systems made of cement composites <p> 6. The development of an effective methodology for testing the level of adhesion of layered systems made of cement composites in a multi-scale approach, including the research methods and descriptors used.

Adhesion Measurement Methods: Theory and Practice

by Robert Lacombe

Adhesion Measurement Methods: Theory and Practice provides practical information on the most important measurement techniques, their unique advantages and disadvantages, and the selection of the proper method for a given application. It includes useful information and formulae on adhesion related matters such as driving force formulae for various m

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