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CPP, Cell-Penetrating Peptides
by Ülo LangelIn this book, a summary and update of the most important areas of cell-penetrating peptides (CPP) research are presented, while raising relevant questions for further development. The CPP sequences are presented and discussed throughout the book. The methods for testing CPP mechanisms are discussed in detail. Various approaches for the testing of endocytotic pathways of CPP uptake are also described. Different CPP uptake experiments are compared since it is becoming clear that it is often best to apply several methods in a complementary manner in order to most comprehensively evaluate CPP uptake mechanisms due to the complexity of these processes. A brief summary of functionality issues of CPPs, both in vitro and in vivo, is discussed. Therapeutic potential of CPPs and commercial developments are discussed. The present, second edition of this book is the updated and expanded version of the first edition, published in 2019. The development of the field of cell-penetrating peptides in these five years has been obvious and exciting. This second edition of the book has been partly reorganized and comprehensively expanded with the exciting research in 2019-2023. Around 2500 novel scientific articles have become available, most of them are reviewed in the second edition. Additional rapidly growing areas of high impact presented in this second edition are therapeutic developments (Chapter 16) and delivery of oligonucleotides and proteins/peptides (Chapters 5 and 6) including novel reports on genome editing with CPP assistance. Also, several additional examples are available now on clinical trials using CPPs (Chapter 15). The book is written for researchers and students in the field.
A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution
by Jennifer A. Doudna Samuel H. SternbergA trailblazing biologist grapples with her role in the biggest scientific discovery of our era: a cheap, easy way of rewriting genetic code, with nearly limitless promise and peril. Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR—a revolutionary new technology that she helped create—to make heritable changes in human embryos. The cheapest, simplest, most effective way of manipulating DNA ever known, CRISPR may well give us the cure to HIV, genetic diseases, and some cancers, and will help address the world’s hunger crisis. Yet even the tiniest changes to DNA could have myriad, unforeseeable consequences—to say nothing of the ethical and societal repercussions of intentionally mutating embryos to create “better” humans. Writing with fellow researcher Samuel Sternberg, Doudna shares the thrilling story of her discovery, and passionately argues that enormous responsibility comes with the ability to rewrite the code of life. With CRISPR, she shows, we have effectively taken control of evolution. What will we do with this unfathomable power?
Cracked: Life on the Edge in a Rehab Clinic, A Doctor's Story
by Drew Pinsky Todd GoldDr. Drew Pinsky is best known as the cohost of the long-running radio advice program Loveline. But his workday is spent at a major Southern California clinic, treating the severest cases of drug dependency and psychiatric breakdown. In this riveting book, Pinsky reveals the intimate and often shocking stories of his patients as they struggle with emotional trauma, sexual abuse, and a host of chemical nemeses: alcohol, marijuana, Ecstasy, heroin, speed, cocaine, and prescription drugs. At the center of these stories is Pinsky himself, who immerses himself passionately, almost obsessively, in his work. From the sexually compulsive model to the BMW-driving soccer mom, Cracked exposes, in fast-moving, powerful vignettes, the true scope and severity of addiction, a nationwide epidemic.
Cracking Control on Early-Age Concrete Through Internal Curing
by Dejian ShenThis monograph is written based on the author's research on the assessment, control, and repair of cracking of early-age concrete in the recent decade. The technique of internal curing for increasing cracking resistance of early-age concrete is further developed through experimental and theoretical research. It establishes models for predicting the internal relative humidity and autogenous shrinkage of internally cured concrete at early age; reveals the variation law and mechanism of early-age tensile creep of internally cured concrete; and explores the variation law and mechanism of early-age cracking resistance of internally cured concrete under continuous restrained condition or uniaxial restrained condition. It is designed as a reference work for professionals or practitioners and a textbook for undergraduates or postgraduates. As such, this book provides valuable knowledge, useful methods, and practical experience that can be considered in the field of concrete cracking control.
Cracking Hitler's Atlantic Wall: The 1st Assault Brigade Royal Engineers on D-Day
by Richard C AndersonA military historian analyzes the ingenious WWII tanks known as Hobart&’s Funnies, detailing their development and their role in the D-Day campaign. When the British and Canadians landed in Normandy on June 6, 1944, they were accompanied by specialized armored vehicles designed to remove German obstacles and mines. Developed by the Royal Engineers, these tanks known as Hobart's Funnies featured a range of ingenious innovations, from carpet-laying and bridge-laying devices to a giant 290-millimeter mortar. Examining these vehicles from technical development to combat deployment, military historian Richard C. Anderson Jr. gives a minute-by-minute account of D-Day's early hours on Sword, Juno, and Gold Beaches—the critical moments when success hinged on the assault engineers&’ ability to clear a path or breach the seawall. Anderson also describes the events on Omaha and Utah Beaches, where U.S. troops, despite being offered these vehicles, stormed ashore without them. Through careful comparison of conditions and outcomes, Anderson assesses the vehicles&’ performance and impact on D-Day's successes and failures.
Cracking Key Concepts in Secondary Science (Corwin Ltd)
by Adam Boxer Heena Dave Gethyn JonesThe perfect companion to help you crack some of secondary science’s most challenging concepts in your teaching. Secondary science teaching is a heroic task, taking some of humanity’s greatest discoveries and explaining them to the next generation of students. Cracking some of the trickiest concepts in biology, chemistry and physics, with walkthrough explanations and examples inspired by direct instruction, this book will bring a fresh perspective to your teaching. · 30 key concepts explored in depth · Understand what students should know before and after the lesson · Tips and tricks offer detailed advice on each topic · Checks for understanding so you can test your students’ knowledge Adam Boxer is Head of Science at The Totteridge Academy in North London. Heena Dave was Head of Science at Bedford Free School. Gethyn Jones is a teacher of physics at an independent school in London
Cracking Key Concepts in Secondary Science (Corwin Ltd)
by Adam Boxer Heena Dave Gethyn JonesThe perfect companion to help you crack some of secondary science’s most challenging concepts in your teaching. Secondary science teaching is a heroic task, taking some of humanity’s greatest discoveries and explaining them to the next generation of students. Cracking some of the trickiest concepts in biology, chemistry and physics, with walkthrough explanations and examples inspired by direct instruction, this book will bring a fresh perspective to your teaching. · 30 key concepts explored in depth · Understand what students should know before and after the lesson · Tips and tricks offer detailed advice on each topic · Checks for understanding so you can test your students’ knowledge Adam Boxer is Head of Science at The Totteridge Academy in North London. Heena Dave was Head of Science at Bedford Free School. Gethyn Jones is a teacher of physics at an independent school in London
Cracking Phenomena in Welds IV
by John C. Lippold Thomas Boellinghaus Carl Edward CrossThis is the fourth volume inthe well-established series of compendiums devoted to the subject of weld hotcracking. It contains the papers presented at the 4th InternationalCracking Workshop held in Berlin in April 2014. In the context of thisworkshop, the term "cracking" refers to hot cracking in the classical andprevious sense, but also to cold cracking, stress-corrosion cracking andelevated temp. solid-state cracking. A variety of different crackingsubjects are discussed, including test standards, crack prediction, weldabilitydetermination, crack mitigation, stress states, numerical modelling, andcracking mechanisms. Likewise, many different alloys were investigatedsuch as aluminum alloys, copper-aluminum dissimilar metal, austenitic stainlesssteel, nickel base alloys, duplex stainless steel, creep resistant steel, andhigh strength steel.
Cracking the Elements (Cracking Series)
by Rebecca MilehamFrom the earliest-known elements to those named in 2016, this book takes a comprehensive look at the development of the periodic table - and reveals untold stories, unsung pioneers and plenty of fascinating science along the way. In twelve illustrated chapters, the book makes sense of the patterns and groups within the periodic table, introducing each of the 118 known elements individually and exploring questions including:- Why did the history of fizzy water give early chemistry a sparkle?- How did hydrogen reveal the structure of the atom?- What was the Bunsen burner's role in discovering new elements?- Which of the alkaline earth metals accounts for a kilogramme of your weight?- Why is Marie Curie such a scientific star?- How do tungsten and vanadium explain the secret of super-sharp Syrian swords?- Who discovered the most elements in the periodic table?- What made nihonium, element 113, such a wonderful new year's gift for Japan?- Is glass a liquid or a solid?- How did nitrogen fulfill the alchemists' dream?- Would you have smeared antimony on your face if you'd lived in ancient Egypt?- Why might naked mole rats have clues for surviving a heart attack?- How did the Haya people of Tanzania make steel 1500 years ago?- What makes xenon a great anaesthetic - and why can't all patients use it?- Might there be a pattern in yet undiscovered elements beyond number 118?
Cracking the Elements (Cracking Ser.)
by Rebecca MilehamFrom the earliest-known elements to those named in 2016, this book takes a comprehensive look at the development of the periodic table - and reveals untold stories, unsung pioneers and plenty of fascinating science along the way. In twelve illustrated chapters, the book makes sense of the patterns and groups within the periodic table, introducing each of the 118 known elements individually and exploring questions including:- Why did the history of fizzy water give early chemistry a sparkle?- How did hydrogen reveal the structure of the atom?- What was the Bunsen burner's role in discovering new elements?- Which of the alkaline earth metals accounts for a kilogramme of your weight?- Why is Marie Curie such a scientific star?- How do tungsten and vanadium explain the secret of super-sharp Syrian swords?- Who discovered the most elements in the periodic table?- What made nihonium, element 113, such a wonderful new year's gift for Japan?- Is glass a liquid or a solid?- How did nitrogen fulfill the alchemists' dream?- Would you have smeared antimony on your face if you'd lived in ancient Egypt?- Why might naked mole rats have clues for surviving a heart attack?- How did the Haya people of Tanzania make steel 1500 years ago?- What makes xenon a great anaesthetic - and why can't all patients use it?- Might there be a pattern in yet undiscovered elements beyond number 118?
Cracking the Machine Learning Code: Technicality or Innovation? (Studies in Computational Intelligence #1155)
by KC Santosh Rodrigue Rizk Siddhi K. BajracharyaEmploying off-the-shelf machine learning models is not an innovation. The journey through technicalities and innovation in the machine learning field is ongoing, and we hope this book serves as a compass, guiding the readers through the evolving landscape of artificial intelligence. It typically includes model selection, parameter tuning and optimization, use of pre-trained models and transfer learning, right use of limited data, model interpretability and explainability, feature engineering and autoML robustness and security, and computational cost – efficiency and scalability. Innovation in building machine learning models involves a continuous cycle of exploration, experimentation, and improvement, with a focus on pushing the boundaries of what is achievable while considering ethical implications and real-world applicability. The book is aimed at providing a clear guidance that one should not be limited to building pre-trained models to solve problems using the off-the-self basic building blocks. With primarily three different data types: numerical, textual, and image data, we offer practical applications such as predictive analysis for finance and housing, text mining from media/news, and abnormality screening for medical imaging informatics. To facilitate comprehension and reproducibility, authors offer GitHub source code encompassing fundamental components and advanced machine learning tools.
Cracking the PM Interview: How to Land a Project Manager Job in Technology
by Gayle McDowell Jackie BavaroHow many pizzas are delivered in Manhattan? How do you design an alarm clock for the blind? What is your favorite piece of software and why? How would you launch a video rental service in India? This book offers proven tips on how to answer questions like these and more. Cracking the PM Interview is a comprehensive book about landing a product management role in a startup or bigger tech company. Learn how the ambiguously-named "PM" (product manager / program manager) role varies across companies, what experience you need, how to make your existing experience translate, what a great PM resume and cover letter look like, and finally, how to master the PM interview questions (estimation questions, behavioral questions, case questions, product questions, technical questions, and the super important "pitch").
Craft and the Creative Economy
by Susan LuckmanCraft and the Creative Economy examines the place of craft and making in the contemporary cultural economy, with a distinctive focus on the ways in which this creative sector is growing exponentially as a result of online shopfronts and home-based micro-enterprise, 'mumpreneurialism' and downshifting, and renewed demand for the handmade.
The Craft of Model-Based Testing
by Paul C. JorgensenIn his latest work, author Paul C Jorgensen takes his well-honed craftsman’s approach to mastering model-based testing (MBT). To be expert at MBT, a software tester has to understand it as a craft rather than an art. This means a tester should have deep knowledge of the underlying subject and be well practiced in carrying out modeling and testing techniques. Judgment is needed, as well as an understanding of MBT the tools. <P><P>The first part of the book helps testers in developing that judgment. It starts with an overview of MBT and follows with an in-depth treatment of nine different testing models with a chapter dedicated to each model. These chapters are tied together by a pair of examples: a simple insurance premium calculation and an event-driven system that describes a garage door controller. The book shows how simpler models—flowcharts, decision tables, and UML Activity charts—express the important aspects of the insurance premium problem. It also shows how transition-based models—finite state machines, Petri nets, and statecharts—are necessary for the garage door controller but are overkill for the insurance premium problem. Each chapter describes the extent to which a model can support MBT. <P><P>The second part of the book gives testers a greater understanding of MBT tools. It examines six commercial MBT products, presents the salient features of each product, and demonstrates using the product on the insurance premium and the garage door controller problems. These chapters each conclude with advice on implementing MBT in an organization. The last chapter describes six Open Source tools to round out a tester’s knowledge of MBT. In addition, the book supports the International Software Testing Qualifications Board’s (ISTQB®) MBT syllabus for certification.
The Craft Of Research
by Wayne Booth Gregory G. Colomb Joseph M. WilliamsSince 1995, more than 150,000 students and researchers have turned to The Craft of Research for clear and helpful guidance on how to conduct research and report it effectively . Now, master teachers Wayne C. Booth, Gregory G. Colomb, and Joseph M. Williams present a completely revised and updated version of their classic handbook. <p><p> Like its predecessor, this new edition reflects the way researchers actually work: in a complex circuit of thinking, writing, revising, and rethinking. It shows how each part of this process influences the others and how a successful research report is an orchestrated conversation between a researcher and a reader. Along with many other topics, The Craft of Research explains how to build an argument that motivates readers to accept a claim; how to anticipate the reservations of thoughtful yet critical readers and to respond to them appropriately; and how to create introductions and conclusions that answer that most demanding question, "So what?" <p> Celebrated by reviewers for its logic and clarity, this popular book retains its five-part structure. Part 1 provides an orientation to the research process and begins the discussion of what motivates researchers and their readers. Part 2 focuses on finding a topic, planning the project, and locating appropriate sources. This section is brought up to date with new information on the role of the Internet in research, including how to find and evaluate sources, avoid their misuse, and test their reliability. <p> Part 3 explains the art of making an argument and supporting it. The authors have extensively revised this section to present the structure of an argument in clearer and more accessible terms than in the first edition. New distinctions are made among reasons, evidence, and reports of evidence. The concepts of qualifications and rebuttals are recast as acknowledgment and response. Part 4 covers drafting and revising, and offers new information on the visual representation of data. Part 5 concludes the book with an updated discussion of the ethics of research, as well as an expanded bibliography that includes many electronic sources. <p> The new edition retains the accessibility, insights, and directness that have made The Craft of Research an indispensable guide for anyone doing research, from students in high school through advanced graduate study to businesspeople and government employees. The authors demonstrate convincingly that researching and reporting skills can be learned and used by all who undertake research projects. <p> New to this edition: <p> Extensive coverage of how to do research on the internet, including how to evaluate and test the reliability of sources <p> New information on the visual representation of data <p> Expanded bibliography with many electronic sources
The Craft of Research (3rd edition)
by Wayne C. Booth Gregory G. Colomb Joseph M. WilliamsWith more than 200,000 copies in print, The Craft of Research is the unrivaled resource for researchers at every level, from first-year undergraduates to research reporters at corporations and government offices. Now, seasoned researchers and educators Gregory G. Colomb and Joseph M. Williams present an updated third edition of their classic handbook, whose first and second editions were written in collaboration with the late Wayne C. Booth. The Craft of Research explains how to build an argument that motivates readers to accept a claim; how to anticipate the reservations of readers and to respond to them appropriately; and how to create introductions and conclusions that answer that most demanding question, "So what?"
The Craft of Scientific Films: How to Make Videos of Your Laboratory, Research, or Technical Projects
by Lauren Murphy Michael AlleyThis book, the first of its kind, helps scientists and engineers of all stages and disciplines share their work in a new way—with movies. Today, much of scientific communication is embedded in papers and presentations, but these documents don’t often extend outside of a specific academic field. By adding movies as a medium of communication, scientists and engineers can better communicate with their colleagues while also increasing their reach to students, professors, peers, potential collaborators, and the public. Scientific films help translate complex technical topics into more accessible and consumable messages. By following Lauren Murphy’s filmmaking formula – planning, shooting, and editing – readers will create their very own scientific films that look professional and polished. Using tools as simple as a smartphone, readers can develop short, personal stories with no cost or experience needed. This book will guide readers through all steps of the movie making process to a finished product. Readers will evolve their creative thinking skills and use their movies to improve classroom presentations, network across student organizations, present at conferences, recruit students for their labs, secure grant money, and more. Adding a movie to your body of work can be the tool that sparks interest in audiences to learn more—driving traffic to your publications, research projects, and websites. This book will help you develop new skills to become a better communicator while spreading your ideas and research to new audiences.
The Craft of Scientific Presentations: Critical Steps to Succeed and Critical Errors to Avoid
by Michael AlleyThe Craft of Scientific Presentations, 2nd edition aims to strengthen you as a presenter of science and engineering. The book does so by identifying what makes excellent presenters such as Brian Cox, Jane Goodall, Richard Feynman, and Jill Bolte Taylor so strong. In addition, the book explains what causes so many scientific presentations to flounder. One of the most valuable contributions of this text is that it teaches the assertion-evidence approach to scientific presentations. Instead of building presentations, as most engineers and scientists do, on the weak foundation of topic phrases and bulleted lists, this assertion-evidence approach calls for building presentations on succinct message assertions supported by visual evidence. Unlike the commonly followed topic-subtopic approach that PowerPoint leads presenters to use, the assertion-evidence approach is solidly grounded in research. By showing the differences between strong and weak presentations, by identifying the errors that scientific presenters typically make, and by teaching a much more powerful approach for scientific presentations than what is commonly practiced, this book places you in a position to elevate your presentations to a high level. In essence, this book aims to have you not just succeed in your scientific presentations, but excel. About the Author Michael Alley has taught workshops on presentations to engineers and scientists on five continents, and has recently been invited to speak at the European Space Organization, Harvard Medical School, MIT, Sandia National Labs, Shanghai Jiao Tong University, Simula Research Laboratory, and United Technologies. An Associate Professor of engineering communication at Pennsylvania State University, Alley is a leading researcher on the effectiveness of different designs for presentation slides.
Craft Weed, with a new preface by the author: Family Farming and the Future of the Marijuana Industry
by Ryan StoaHow the future of post-legalization marijuana farming can be sustainable, local, and artisanal.What will the marijuana industry look like as legalization spreads? Will corporations sweep in and create Big Marijuana, flooding the market with mass-produced weed? Or will marijuana agriculture stay true to its roots in family farming, and reflect a sustainable, local, and artisanal ethic? In Craft Weed, Ryan Stoa argues that the future of the marijuana industry should be powered by small farms—that its model should be more craft beer than Anheuser-Busch.To make his case for craft weed, Stoa interviews veteran and novice marijuana growers, politicians, activists, and investors. He provides a history of marijuana farming and its post-hippie resurgence in the United States. He reports on the amazing adaptability of the cannabis plant and its genetic gifts, the legalization movement, regulatory efforts, the tradeoffs of indoor versus outdoor farms, and the environmental impacts of marijuana agriculture. To protect and promote small farmers and their communities, Stoa proposes a Marijuana Appellation system, modeled after the wine industry, which would provide a certified designation of origin to local crops. A sustainable, local, and artisanal farming model is not an inevitable future for the marijuana industry, but Craft Weed makes clear that marijuana legalization has the potential to revitalize rural communities and the American family farm.As the era of marijuana prohibition comes to an end, now is the time to think about what kind of marijuana industry and marijuana agriculture we want. Craft Weed will help us plan for a future that is almost here.
Crafting Innovative Places for Australia’s Knowledge Economy
by Edward J. Blakely Richard HuThis book integrates planning, policy, economics, and urban design into an approach to crafting innovative places. Exploring new paradigms of innovative places under the framework of globalisation, urbanisation, and new technology, it argues against state-centric policies to innovation and focuses on how a globalized approach can shape innovative capacity and competitiveness. It notably situates the innovative place making paradigm in a broader context of globalisation, urbanisation, the knowledge economy and technological advancement, and employs an international perspective that includes a wide range of case studies from America, Europe, Asia, and Australia. Developing a co-design and co-creation paradigm that integrates governments, the private sector and the community into shared understanding and collaborative action in crafting innovative places, it discusses place-based innovation in Australian context to inform policy making and planning, and to contribute to policy debates on programs of smart cities and communities.
The Crafting of the 10,000 Things: Knowledge and Technology in Seventeenth-Century China
by Dagmar SchäferThe last decades of the Ming dynasty, though plagued by chaos and destruction, saw a significant increase of publications that examined advances in knowledge and technology. Among the numerous guides and reference books that appeared during this period was a series of texts by Song Yingxing (1587–1666?), a minor local official living in southern China. His Tiangong kaiwu, the longest and most prominent of these works, documents the extraction and processing of raw materials and the manufacture of goods essential to everyday life, from yeast and wine to paper and ink to boats, carts, and firearms. In The Crafting of the 10,000 Things, Dagmar Schäfer probes this fascinating text and the legacy of its author to shed new light on the development of scientific thinking in China, the purpose of technical writing, and its role in and effects on Chinese history. Meticulously unfolding the layers of Song’s personal and cultural life, Schäfer chronicles the factors that motivated Song to transform practical knowledge into written culture. She then examines how Song gained, assessed, and ultimately presented knowledge, and in doing so articulates this era’s approaches to rationality, truth, and belief in the study of nature and culture alike. Finally, Schäfer places Song’s efforts in conjunction with the work of other Chinese philosophers and writers, before, during, and after his time, and argues that these writings demonstrate collectively a uniquely Chinese way of authorizing technology as a legitimate field of scholarly concern and philosophical knowledge. Offering an overview of a thousand years of scholarship, The Crafting of the 10,000 Things explains the role of technology and crafts in a culture that had an outstandingly successful tradition in this field and was a crucial influence on the technical development of Europe on the eve of the Industrial Revolution.
Craig's Soil Mechanics
by Jonathan Knappett R.F. CraigCraig’s Soil Mechanics continues to evolve and remain the definitive text for civil engineering students worldwide. It covers fundamental soil mechanics and its application in applied geotechnical engineering from A to Z and at the right depth for an undergraduate civil engineer, with sufficient extension material for supporting MSc level courses, and with practical examples and digital tools to make it a useful reference work for practising engineers. This new edition now includes: Restructured chapters on foundations and earthworks, the latter including new material on working platforms and collapse of underground cavities (sinkhole formation). New mobilised-stress-based deformation methods that can straightforwardly be used with both linear and non-linear soil stiffness models and field measurements of shear wave velocity, for serviceability limit state design. Extended sets of correlations for making sensible first estimates of soil parameters, adding deformation-based parameters for broader coverage than the Eighth Edition. Extended section on robust statistical selection of characteristic soil parameters. Greater use of consolidation theory throughout in determining whether actions, processes and laboratory/in-situ tests are drained or undrained. Extended chapter on in-situ testing, adding the Flat Dilatometer Test (DMT), and interpretation of consolidation parameters from CPTU and DMT testing. An updated section on pile load testing. Additional worked examples and end-of-chapter problems covering new material, with fully worked solutions for lecturers. The electronic resources on the book’s companion website are developed further, with the addition of two new spreadsheet numerical analysis tools and improvement of existing tools from the Eighth Edition. Using these, readers can take real soil test data, interpret its mechanical properties and apply these to a range of common geotechnical design problems at ultimate and serviceability limiting states.
Craniofacial 3D Imaging: Current Concepts In Orthodontics And Oral And Maxillofacial Surgery
by Onur Kadioglu G. Fräns CurrierThis book is designed to serve as an up-to-date reference on the use of cone-beam computed tomography for the purpose of 3D imaging of the craniofacial complex. The focus is in particular on the ways in which craniofacial 3D imaging changes how we think about conventional diagnosis and treatment planning and on its clinical applications within orthodontics and oral and maxillofacial surgery. Emphasis is placed on the value of 3D imaging in visualizing the limits of the alveolar bone, the airways, and the temporomandibular joints and the consequences for treatment planning and execution. The book will equip readers with the knowledge required in order to apply and interpret 3D imaging to the benefit of patients. All of the authors have been carefully selected on the basis of their expertise in the field. In describing current thinking on the merits of 3D craniofacial imaging, they draw both on the available scientific literature and on their own translational research findings.
Crash
by David Hagberg Lawrence LightThe second Great Depression is coming. The world’s economies are groaning under too much debt. If one thing goes wrong, the entire rickety system collapses. Now, acclaimed award-winning New York Times bestselling novelist David Hagberg and renowned financial reporter Lawrence Light have combined forces to dramatize—hour by hour—how this all-too-real catastrophe could go down in Crash.With debt-burdened governments and businesses worldwide about to go bust, a cabal of Wall Street big shots plot to destroy the globe’s stock exchanges. To provide that one thing that goes wrong. In 24 hours, a powerful computer worm will smash the exchanges and spark an international panic, pushing a debt-laden world into the abyss. The Wall Street gang’s investment bank will be the last one standing, able to make a killing amid the ruins.But one person, who works for their bank as a computer expert, spots the worm embedded deep in its network. Cassy Levin invents a program to destroy the cyber-intruder. Angered by Cassy’s discovery, her bosses order her kidnapping.Her boyfriend, a former Navy SEAL, is alarmed at Cassy’s disappearance and unravels the plot. Ben Whalen only has until the next morning to save the woman he loves and prevent the economic apocalypse.This story is based on the genuine threat posed by towering debt, which will make the 2008 financial crisis look puny.At the Publisher's request, this title is being sold without Digital Rights Management Software (DRM) applied.
Crash Course #1
by Landry Q. Walker Keith ZooGuardians of the Galaxy meets Minecraft in this hilarious sci-fi series for middle grade readers. TERRAFORMING 101 - Learn the basics of FARMING IN SPACE!! Open to first year students. For eleven-year-old Elara, life at the Academy of Terraforming Arts is a lot tougher—and stranger—than she expected. Her latest experiment accidentally blew up the moon. Her roommate, Clare, is a mute intergalactic sponge. And no one at her new school knows what it's like to grow up on a planet called "Nowhere." But if the greatest Planetary Designers in the galaxy made it through their first year, then so can she.Based on the real science behind terraforming, this action-packed story mixes world-building adventures with side-splitting humor, plus a dash of intergalactic madness.