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Development of In-Tether Carbon Chiral Center-Induced Helical Peptide: Methodology and Applications (Springer Theses)
by Kuan HuThis book focuses on the development of stapled peptides, a novel molecular modality used to regulate aberrant intracellular protein–protein interactions (PPIs). The author designs and presents a novel helical peptide stabilization methodology by constructing a chiral cross-linker moiety, namely “chiral center induced peptide helicity (CIH)”. The book demonstrates that a precisely positioned carbon chiral center on tether can decisively determine the secondary structure of a peptide, and that the R-configured peptide is helical, while the S-configured peptide is non-helical. Further, it reports that helicity-enhanced R isomer peptides displayed significantly enhanced cell permeability and target binding affinity, as well as tumor inhibition efficiency, in comparison to S isomer peptides. The book will not only advance readers’ understanding of the basic principle of stapled peptides, but also accelerate the clinical transformation of stapled peptide drugs.
Development of Infrared Techniques for Practical Defect Identification in Bonded Joints
by Rachael C. WaughMaximizing reader insights into the use of thermography, specifically pulsed and pulse phase thermography (PT and PPT), for the identification of kissing defects in adhesive bonds, this thesis focuses on the application of PT and PPT for the identification of a range of defect types in a variety of materials to establish the effect of material properties on identification of defects. Featuring analysis of a numerical model developed to simulate the thermal evolution created during a PT or PPT experiment, after validation through a series of case studies, this model is then used as a predictive tool to relate defect detectability to the thermal property contrast between defect and bulk materials. Demonstrating a means of producing realistic kissing defects in bonded joints where insufficient thermal property contrast exists defects have a limited effect on heat propagation through a component and therefore are not detected using PT or PPT, this thesis discusses the addition of a small load to bonds containing kissing defects which was found to open the defects sufficiently to enable their detection. A low cost infrared detector, Flir Tau320, is compared to the research based photon detector, Flir SC5000, and is shown to be suitable for application in PT, thus enabling a significantly lower cost tool to be developed.
Development of Medical Garments and Apparel for the Elderly and the Disabled (Textile Progress Ser.)
by Ng Sau-FunAlthough the main theme of this book is products for the elderly and the disabled, it also contains major sections on medical garments, which include personal protective equipment (PPE), hip protectors (HP), pressure garments (PG), compression stockings (CS), wet dressings, products for wound dressing, adult incontinence products, sanitary napkins, disposable diapers, vital signs monitoring garments, motion aware clothing, wearable sensors and smart diapers and so on. The development of apparel for the elderly and the disabled is a challenge for the healthcare and clothing industries. The developed apparel products are not only based on various design, fashion and comfort concepts but also considered in terms of particular medical problems, restorative care functions, and appropriate solutions for healthcare purposes.
Development of Medications for the Treatment of Opiate and Cocaine Addictions: Issues for the Government and Private Sector
by Committee to Study Medication Development Research at the National Institute on Drug AbusePharmacotherapy, as a means of treating drug addiction in combination with other treatment modalities, has received too little attention from the research community, the pharmaceutical industry, public health officials, and the federal government. Medications to combat drug addiction could have an enormous impact on the medical consequences and socioeconomic problems associated with drug abuse, both for drug-dependent individuals and for American society as a whole. This book examines the current environment for and obstacles to the development of anti-addiction medications, specifically those for treating opiate and cocaine addictions, and proposes incentives for the pharmaceutical industry that would help overcome those obstacles and accelerate the development of anti-addiction medications.
Development of Navigation Technology for Flight Safety (Springer Aerospace Technology)
by Sauta O.I. Shatrakov Y.G. Bestugin A.R. Baburov S.V. Galyamov A.M.This book highlights practical solutions for flight safety improvement techniques, which are currently the focus of the International Civil Aviation Organization (ICAO). It has become clear that, in order to rapidly and significantly improve flight safety, the integrated use of new aeronautical technologies is called for. Considering the size of the aviation fleet, its constant growth and the long service lives of aircraft, new technologies should be adapted both to cutting-edge air navigation systems and to those that have been used for over a decade. Concretely, the book discusses methodological approaches to the construction of ground and on-board avionics that make it possible to achieve improved flight safety using innovative new methods. The proposed approaches are illustrated with real-world examples of e.g. satellite-based navigation systems and enhanced ground proximity warning systems. The book is written for professionals involved in the development of avionics systems, as well as students, researchers and experts in the field of radiolocation, radio navigation and air traffic control, the book will support the development and modeling of radio technical complexes, as well as the analysis of complex radio technical systems.
Development of New Catalytic Performance of Nanoporous Metals for Organic Reactions
by Mei YanIn this thesis, the focus is on the study of new catalytic properties of unsupported nanoporous metals in heterogeneous organic reactions under liquid-phase conditions. The author was the first to fabricate nanoporous copper with tunable nanoporosity and apply it for organic reactions. The catalyst can be reused up to ten times without loss of catalytic activity. In addition, the author developed the highly selective semihydrogenation of alkynes using nanoporous gold as a catalyst for the first time, affording Z-alkenes in 100% selectivity, which cannot be realized by traditional catalysts. All of the results described here will help readers to develop new catalytic performance of nanoporous metals for organic reactions.
Development of Novel Bioelectrochemical Membrane Separation Technologies for Wastewater Treatment and Resource Recovery (Springer Theses)
by Yunkun WangThe most commonly used biological wastewater treatment technologies still have serious technical-economical and sustainability-related limitations, due to their high energy requirements, poor effluent quality, and lack of energy and resource recovery processes. In this thesis, novel electrochemical membrane bioreactors (EMBRs), which take advantage of membrane separation and bioelectrochemical techniques, are developed for wastewater treatment and the simultaneous recovery of energy and resources. Above all, this innovative system holds great promise for the efficient wastewater treatment and energy recovery. It can potentially recover net energy from wastewater while at the same time harvesting high-quality effluent. The book also provides a proof-of-concept study showing that electrochemical control might offer a promising in-situ means of suppressing membrane fouling. Lastly, by integrating electrodialysis into EMBRs, phosphate separation and recovery are achieved. Hence, these new EMBR techniques provide viable alternatives for sustainable wastewater treatment and resource recovery.
The Development of Nuclear Propulsion in the Royal Navy, 1946-1975 (Security, Conflict and Cooperation in the Contemporary World)
by Gareth Michael JonesThis book examines the development of nuclear propulsion in the Royal Navy from the first proposal in 1946 to the start-up of the last core improvement for the first submarine reactor power plant PWR 1 in December 1974. Drawing from unreleased records and archives, the book answers questions around three main themes. Political: what problems were encountered in transferring nuclear knowledge from the USA to the UK in the post-war period, and how much support was there for the development of nuclear propulsion? Military: why was there a requirement to develop nuclear propulsion, and in particular, why submarines? Technical: were the problems associated with nuclear energy fully appreciated, and did the UK have the technical and engineering capability to develop nuclear propulsion? Aside from the political considerations and military motives for developing nuclear propulsion in the Royal Navy, the author focuses on the technical problems that had to be overcome by all participants in the Royal Navy’s development of nuclear propulsion, adding significantly to naval historiography. Providing a critical analysis of the political, technological, operational and industrial issues of introducing nuclear propulsion into the Royal Navy, the author situates his research in the context of the evolving Cold War, changing Anglo-American relations, the end of Empire and the relative decline of British power.
The Development of Personal Learning Environments in Higher Education: Promoting Culturally Responsive Teaching and Learner Autonomy
by Yilin Sun Xiaoshu XuThe Development of Personal Learning Environments in Higher Education explores how today’s knowledge-based, learner-centered virtual platforms, which often limit teaching to a complimentary facilitation role, can compromise with the requirements and regulations of colleges and universities. Personal Learning Environments (PLEs) driven by culturally responsive teaching and learner autonomy represent a shift in the higher education paradigm, but how can scholars, designers, administrators, and faculty ensure effective, institutionally compatible construction and management of these systems? This book offers forward-thinking insights into the variety of student-centered learning interactions, particularly culturally and linguistically responsive pedagogies, that can be integrated into PLEs. Attending to quality assessment rubrics, the nuances of stakeholders’ needs, and theoretically sound frameworks, these cross-cultural, interdisciplinary chapters explore how leaders, instructors, technologists, and learners can form a precise yet flexible ecosystem to fully realize PLEs in which co-created, intercultural narratives yield rich, relevant digital learning experiences.
Development of Procedures and Technical Manuals for the Marine and Offshore Industries (Synthesis Lectures on Ocean Systems Engineering)
by Alexander Arnfinn Olsen Fidaa KarkoriThis book is devoted to the development of procedures and technical manuals for the marine and offshore industries, providing a comprehensive guide to creating clear, effective instructional materials. At the heart of this book is the matter of safety and environmental considerations, ensuring that all documentation aligns with current practices, policies, and regulatory requirements. The chapters cover topics such as the role of instructional materials, writing techniques, the use of graphics, and the processes for verifying, validating, approving, certifying, and implementing these materials. The authors present an expert analysis of how well-written administrative, regulatory, operating, emergency, maintenance, and routine duty procedures can enhance productivity and reduce accidents. Readers will also discover practical insights into managing instructional materials within safety programs. This book is essential for engineers and professionals tasked with developing technical manuals and texts in safety-critical industries. It serves as a valuable reference for academics and students in industrial design and engineering, as well as a textbook for students of marine architecture. Offshore installation managers and senior safety management professionals will find this guide indispensable for ensuring consistency and quality control in their operations.
Development of Redox Mediators for High-Energy-Density and High-Efficiency Lithium-Oxygen Batteries (Springer Theses)
by Youngmin KoThis thesis addresses the introduction of redox mediator into lithium-oxygen batteries to improve their electrochemical performance especially in terms of practical energy density and round-trip efficiency. In chapter 1, basic electrochemistry regarding lithium-oxygen batteries and redox mediators are introduced. In chapter 2 to 4, comprehensive researches including the discovery of a new redox mediator inspired by biological system, the investigation on kinetic property of redox mediator, and the prevention of shuttle phenomenon are introduced, followed by chapter 5 summarizing the contents. This thesis is targeted to students and researchers interested in electrochemistry and energy storage systems.
The Development of Renewable Energy Sources and its Significance for the Environment
by Almas Heshmati Shahrouz Abolhosseini Jörn AltmannThis book analyzes the effects of power generated by renewable energy sources, renewable energy production technologies, energy efficiency, and market regulation of carbon emissions. It elaborates on how these parameters have direct and indirect effects on carbon emission reduction, such as the results of an environmental tax that could directly reduce carbon emissions by decreasing fossil fuel consumption or by stimulating energy savings through technological innovation, as well as how renewable energy sources can affect both economic growth and the environment. In addition to a detailed analysis of the interrelationships between renewable energy consumption, production technology, and market regulation, The Development of Renewable Energy Sources and its Significance for the Environment proposes a model for measuring the effectiveness and results of the interaction between these links. Furthermore, a structure for a marketplace of renewable energy sources is put forward, as well as an outline of the requirements that must be met in order for this market to function. Suitable policy recommendations to enhance the market for renewable energies are also provided.
The Development of Science and Technology in Iran
by Abdol S. Soofi Mehdi GoodarziThis book examines the policies, conducts, and performances of organizations tasked with developing medium and high technologies in Iran. This collection assists readers in understanding the interaction between different players involve in the process of Iran's science, technology, and innovation development in specific technology areas over the last two decades. Chapters from expert contributors are organized into three themed parts: science and technology policy formulation and implementation, outcomes, and evaluation, including recommendations for further development of technological learning in Iran.
Development of Smart Context-Aware Services for Cargo Transportation: An Operational Management Approach (International Series in Operations Research & Management Science #330)
by Dalė Dzemydienė Aurelija Burinskienė Kristina Čižiūnienė Arūnas MiliauskasWith a focus on cargo transportation, this book addresses the development of approaches intended to secure an infrastructure of smart services to support the adaptive implementation of online multi-modal freight transport management processes. It discusses the development of multi-criteria decision-making components and their integration into the multi-layered computer-based information management of intelligent systems. Through detailed descriptions of various components of intelligent transport management systems, the book demonstrates how to develop the services needed in the right place and at the right time, and how to properly adapt to user needs, making necessary interventions to ensure the safety of the transportation process. Further, it describes the main ways to increase the autonomy and efficiency of user-vehicle interaction and shows how Information and Communications Technology (ICT) structural support for current and past situations in AI-based systems can help to anticipate future developments in freight transportation.
Development of Solar Cells: Theory and Experiment (Challenges and Advances in Computational Chemistry and Physics #32)
by Jerzy Leszczynski Supratik Kar Juganta K. RoyThis book presents a comprehensive overview of the fundamental concept, design, working protocols, and diverse photo-chemicals aspects of different solar cell systems with promising prospects, using computational and experimental techniques. It presents and demonstrates the art of designing and developing various solar cell systems through practical examples. Compared to most existing books in the market, which usually analyze existing solar cell approaches this volume provides a more comprehensive view on the field. Thus, it offers an in-depth discussion of the basic concepts of solar cell design and their development, leading to higher power conversion efficiencies. The book will appeal to readers who are interested in both fundamental and application-oriented research while it will also be an excellent tool for graduates, researchers, and professionals working in the field of photovoltaics and solar cell systems.
Development of Sustainable Thermal Insulators from Waste Materials: A Circular Economy Approach (Materials Horizons: From Nature to Nanomaterials)
by Sarika Verma Mohd. Akram Khan A. K. SrivastavaThis book focuses on the major global waste management issues and development of thermal insulating materials by utilizing these wastes. It helps address various global issues like sustainable environment, waste to wealth, waste to resource material, advanced multifunctional material, skill development and employment generation. The book highlights the potentiality and the applicability of various wastes, such as municipal solid waste, agricultural waste, industrial waste, construction waste, textile waste, waste polystyrene, geopolymer, leather rubber waste, other miscellaneous waste to be considered as a resource and its availability and conversion technologies from waste to wealth as thermal insulating materials. It also discusses recent trends, for processing the waste to wealth as a thermally insulating material. This book is a useful guide to researchers and professionals working in the areas of energy storage, sustainable civil engineering, material science and others allied fields.
Development of Transport by Telematics: 19th International Conference on Transport System Telematics, TST 2019, Jaworze, Poland, February 27 – March 2, 2019, Selected Papers (Communications in Computer and Information Science #1049)
by Jerzy MikulskiThis book constitutes selected papers from the 19th International Conference on Transport Systems Telematics, TST 2019, held in Jaworze, near Bielsko-Biala, Poland, in March 2019. The 31 full papers presented in this volume were carefully reviewed and selected from 104 submissions. They were organized in topical sections named: telematics in rail transport; telematics in road transport; telematics in marine transport; telematics in air transport; and general about telematics.
The Development of Transportation in Modern England (Routledge Revivals)
by William T. JackmanPublished in 1962: In offering this work as a modest contribution to our knowledge of the economic development of England from the standpoint of transportation, the author must say, in the first place that he has endeavoured to adhere rigidly to the subject in hand, withour making deviations into collateral fields
The Development of Women and Young Professionals in STEM Careers: Tips and Tricks (CRC Press Focus Shortform Book Program)
by Michele Kruger Hannelie NelThis book is fluent and systematic. The authors work through the fears and ambitions of young people new to STEM careers in the professional environment. Often, there is a lack of mentors, which leaves a young STEM practitioner exposed and doubting their own abilities. This book encourages young professionals and women in STEM careers to know that they are not alone and provides insight into their ability to deal with the stress of developing into a successful professional. Features Presents a method or vehicle to fast track young professionals and women in STEM Includes key issues that they should be aware of as they grow and develop in their education and field Describes how STEM career women are owners of their own path and provides an understanding of engineering and the business of consulting Conveys how young professionals and women in STEM can be aware of their own productivity and enjoy what they do and the career path they have selected This book is ideal for those new to the engineering, science, and consulting fields, including students in science and engineering education, administrators, libraries, those involved in leadership, organization behavior, human resources, STEM, and other areas as well.
Development Planning: A Strategic Approach to Future Air Force Capabilities
by Committee on Improving the Effectiveness Efficiency of U.S. Air Force Pre-Acquisition Development PlanningThe development and application of technology has been an essential part of U. S. airpower, leading to a century of air supremacy. But that developmental path has rarely been straight, and it has never been smooth. Only the extraordinary efforts of exceptional leadership - in the Air Forces and the wider Department of Defense, in science and in industry - have made the triumphs of military airpower possible. "Development Planning" provides recommendations to improve development planning for near-term acquisition projects, concepts not quite ready for acquisition, corporate strategic plans, and training of acquisition personnel. This report reviews past uses of development planning by the Air Force, and offers an organizational construct that will help the Air Force across its core functions. Developmental planning, used properly by experienced practitioners, can provide the Air Force leadership with a tool to answer the critical question, Over the next 20 years in 5-year increments, what capability gaps will the Air Force have that must be filled? Development planning will also provide for development of the workforce skills needed to think strategically and to defectively define and close the capability gap. This report describes what development planning could be and should be for the Air Force.
Development Practice in Eastern and Southern Africa: Lived Experiences from the Trenches
by Tshilidzi Madzivhandila Sepo Hachigonta Joseph Francis Joseph Kamuzhanje Oluwatoyin Dare Kolawole Shirley DeWolfThis book is a rare collection of reflective and reflexive stories that reveal how seasoned academics, agents of grassroots social change, leaders and journalists transformed and shaped the development landscape in eastern and southern Africa. Whereas practical experiences are crucial assets and resources for shaping the academic environment and development practice landscape, most of the existing literature recommended as key learning materials in tertiary institutions is rarely in synch with the practical realities of development practice. The shared individual lived experiences from academic endeavours and fieldwork provide hands-on tools for students and emerging practitioners who might be involved in or are currently facilitating development work. The thrust of the book, therefore, is to demystify the day-to-day experiences of development practitioners while contributing to learning pathways or strategies for achieving viable solutions to the myriad of challenges, which grassroots communities face. The relevance of the book as a crucial resource for students pursuing development-oriented degree programmes in colleges and universities is obvious. Without any doubt, the compilation will be handy in the implementation of diverse development-oriented transformation agenda at academic, programming and policy levels.
Development, Social Change and Environmental Sustainability: Proceedings of the International Conference on Contemporary Sociology and Educational Transformation (ICCSET 2020), Malang, Indonesia, 23 September 2020
by SumarmiNowadays, the concept of SDGs (Sustainable Development Goals) is starting to replace the concept of MDGs (Millennium Developmental Goals). It is a global goal adopted by all United Nations member states. It emphasizes the idea that the development of every country can only be achieved by balancing other factors such as social, economic, and environmental sustainability. It is already clear how sustainable development works with environmental ethics and management. However, there are still issues regarding the sustainable development and human well-being. Sustainable development should focus on finding a way for society to meet their present needs for the long term without sacrificing the ability of future generations to meet their needs. This international seminar provides research results and literature regarding the topic of sustainable development concept, the dynamics of sustainable development and social change, and environmental sustainability. The international seminar, entitled 1st International Conference on Contemporary Sociology and Educational Transformation, listed speakers from several countries providing an overview on human and environmental resilience. This book contains a selection of papers presented at the conference.
A Development Strategy for Hybrid Products: The Case of the Japanese Animation Industry
by Takeyasu IchikohjiThis is the first book that deals with technological innovation in Japanese animation industry from a management perspective. In reviewing prior research and explaining the history of the technology, the author raises the difficulty of dealing with new technologies. In particular, the focus is on systems that combine analog technology (drawing by hand) and digital technology (3D computer graphics or 3DCG) to create a product. This combined technology is referred to as "hybrid technology" in this book, and the development and management of "hybrid products" using this technology are studied. The study was conducted in two stages. The first stage was to determine the engineers’ (animators’) perception of hybrid technology. The results showed that in terms of potential, the hybrid technology of hand-drawn animation combined with 3DCG was rated more highly by engineers than hand-drawn alone. However, in terms of the assessment at that time, hybrid technology was rated higher than 3DCG alone but lower than hand-drawn. Therefore, it was assumed that hybrid technology, while useful, would pose challenges with respect to systematic implementation. The second stage was the development management of hybrid products. The results showed that the "adaptive engineer," who openly accepts other new technologies in the early stages of their emergence contributed to the integration of new and existing technologies.
Development with Identity: Community, Culture, and Sustainability in the Andes
by Robert E. RhoadesThroughout Latin America, indigenous peoples are demanding that development must address local priorities, including ethnic identity. Simultaneously, sustainability scientists need to conduct place-based research on the interaction between environment and society that will have global relevance. This book reports on a 6 year interdisciplinary research project on natural resource management in Cotacachi, Ecuador, where scientists and indigenous groups learned to seek common ground. The book discusses how local people and the environment have engaged each other over time to create contemporary Andean landscapes. It also explores human-environment interaction in relation to biodiversity, soils and water, and equitable development. This book will be of significant interest to sociologists, anthropologists, economists and sustainability scientists researching environment and agriculture in rural communities.
Developmental Genetics and Plant Evolution (Systematics Association Special Volumes)
by Quentin C. B. Cronk Richard M. Bateman Julie A. HawkinsA benchmark text, Developmental Genetics and Plant Evolution integrates the recent revolution in the molecular-developmental genetics of plants with mainstream evolutionary thought. It reflects the increasing cooperation between strongly genomics-influenced researchers, with their strong grasp of technology, and evolutionary morphogenetists and sys