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Mycorrhiza - Eco-Physiology, Secondary Metabolites, Nanomaterials
by Ajit Varma Ram Prasad Narendra TutejaThis is the fourth updated and revised edition of a well-received book that emphasises on fungal diversity, plant productivity and sustainability. It contains new chapters written by leading experts in the field. This book is an up-to-date overview of current progress in mycorrhiza and association with plant productivity and environmental sustainability. The result is a must hands-on guide, ideally suited for agri-biotechnology, soil biology, fungal biology including mycorrhiza and stress management, academia and researchers. The topic of this book is particularly relevant to researchers involved in mycorrhiza, especially to food security and environmental protection. Mycorrhizas are symbioses between fungi and the roots of higher plants. As more than 90% of all known species of plants have the potential to form mycorrhizal associations, the productivity and species composition and the diversity of natural ecosystems are frequently dependent upon the presence and activity of mycorrhizas. The biotechnological application of mycorrhizas is expected to promote the production of food while maintaining ecologically and economically sustainable production systems.
Mycorrhiza - Nutrient Uptake, Biocontrol, Ecorestoration
by Narendra Tuteja Ajit Varma Ram PrasadThis is the fourth updated and revised edition of a well-received book that emphasises on fungal diversity, plant productivity and sustainability. It contains new chapters written by leading experts in the field. This book is an up-to-date overview of current progress in mycorrhiza and association with plant productivity and environmental sustainability. The result is a must hands-on guide, ideally suited for agri-biotechnology, soil biology, fungal biology including mycorrrhiza and stress management, academia and researchers. The topic of this book is particularly relevant to researchers involved in mycorrhiza, especially to food security, plant microbe interaction and environmental protection. Mycorrhizas are symbioses between fungi and the roots of higher plants. As more than 90% of all known species of plants have the potential to form mycorrhizal associations, the productivity and species composition and the diversity of natural ecosystems are frequently dependent upon the presence and activity of mycorrhizas. The biotechnological application of mycorrhizas is expected to promote the production of food while maintaining ecologically and economically sustainable production systems.
Mycorrhiza Optimization Algorithm (SpringerBriefs in Applied Sciences and Technology)
by Fevrier Valdez Hector Carreon-Ortiz Oscar CastilloThis book provides two new optimization algorithms to address real optimization problems. Optimization is a fundamental concept in engineering and science, and its applications are needed in many fields. From designing products and systems to developing algorithms and models, optimization plays a critical role in achieving efficient and effective solutions to complex problems. Optimization algorithms inspired by nature have proven effective in solving a wide range of problems, including those in engineering, finance, and machine learning. These algorithms are often used when traditional optimization techniques are impractical due to the size or complexity of the problem. In this book, we are presenting two new optimization algorithms inspired by plant roots and the Mycorrhiza Network. The first algorithm is called the Continuous Mycorrhiza Optimization Algorithm (CMOA), which was proposed based on the model of the Continuous Lotka-Volterra System Equations. The second algorithm is called the Discrete Mycorrhiza Optimization Algorithm (DMOA), which design based on the model of Discrete Lotka-Volterra System Equations. By mastering the proposed algorithms, the readers able to develop innovative solutions that improve efficiency, reduce costs, and improve performance in the corresponding field of work.
Mycorrhizal Fungi: Use in Sustainable Agriculture and Land Restoration
by Zakaria M. Solaiman Lynette K. Abbott Ajit VarmaThis volume explores the various functions and potential applications of mycorrhizas, including topics such as the dynamics of root colonization, soil carbon sequestration and the function of mycorrhizas in extreme environments. Some contributions focus on the use of arbuscular mycorrhizal fungi in various crop production processes, including soil management practices, their use as biofertilizers and in relation to medicinal plants. Other chapters elucidate the role of arbuscular mycorrhizal fungi in the alleviation of plant water stress and of heavy metal toxicity, in the remediation of saline soils, in mining-site rehabilitation and in the reforestation of degraded tropical forests. In addition to their impact in ecosystems, the economic benefits of applying arbuscular mycorrhizal fungi are discussed. A final chapter describes recent advances in the cultivation of edible mycorrhizal mushrooms.
Mycorrhizas - Functional Processes and Ecological Impact
by Silvio Gianinazzi Jose Miguel Barea Vivienne Gianinazzi-Pearson Concepción Azcón-AguilarMycorrhizal symbioses are central to the multitrophic interactions that impact plant productivity, competitiveness and survival. This book integrates present-day knowledge from well-known research groups on some of the topics which are at the forefront of mycorrhizal research. Topics include the cell programmes that drive mycorrhiza formation and function, the processes sustaining symbiotic mutualism, stress response mechanisms in mycorrhizal symbionts, and the diversity and ecological impacts of mycorrhizal systems. The efficient management of mycorrhizal systems has the potential to support the sustainable production of quality foods while ensuring environmental quality for future generations.
Mycorrhizosphere and Pedogenesis
by Ajit Varma Devendra K. ChoudharyThe present book highlights importance of mycorrhiza in soil genesis wherein it reflects mycorrhizal occurrence and diversity, various tools to characterize them and its impact on soil formation/health together with crop productivity. The edited compendium provides glimpses on the mycorrhizal fungi and their prominent role in nutrient transfer into host plants, and presenting view on application of mycorrhiza for crop biofortification. It focuses on the mechanisms involve in weathering process employed by mycorrhiza with highlighting the current and advanced molecular approaches for studying mycorrhizal diversity. Further, book emphasizes following aspects in details: significance of AMF in phytoremediation of hydrocarbon contaminated sites, the role of mycorrhiza in soil genesis using scientometric approach, the concept of mycorrhizosphere, xenobiotic metabolism, molecular approaches for detoxifying the organic xenobiotics and the role of mycorrhizosphere in stabilizing the environment in an eco-friendly way. In addition, the book will be benign to researchers that involved in mycorrhiza characterization especially by deploying metagenomics/PCR based and non PCR based molecular techniques that may be utilized to study the microbial diversity and structure within the mycorrhizosphere.
Mycosynthesis of Nanomaterials: Perspectives and Challenges
by Mahendra Rai Patrycja GolińskaMycosynthesis of Nanomaterials: Perspectives and challenges focus on the use of diverse groups of fungi for the synthesis of inorganic (metal and metalloid) and organic nanoparticles. Such synthesis is eco-friendly, economically viable, and can be carried out at ambient temperature without the use of high temperature, pressure or toxic chemicals. It also describes different techniques used for the characterization of the nanoparticles and various hypotheses put forward to elucidate the mechanistic aspect of the synthesis by fungi. There is a worldwide representation of eminent contributors including the US, Europe, Canada, Russia, India, Korea, Egypt, Brazil, Mexico, Colombia, Iran, and Sri Lanka. The book is interdisciplinary and essential reading for academicians.
Mycotoxins: Detection Methods, Management, Public Health and Agricultural Trade
by J. Leslie Ramananda Bandyopadhyay A. ViscontiMycotoxins are produced worldwide by several fungi on a wide range of agricultural commodities and are closely related to human and animal food chains. Examining mycotoxins and their impact from a public health viewpoint, this book provides an overview and introduction to the subject and examines the health, trade and legislation issues involved. Management of mycotoxins is discussed in detail as well as the global problems caused by mycotoxins.
Mycotoxins and Mycotoxicoses
by Karuna Singh Ankita KumariThis book presents a comprehensive view on mycotoxins of agricultural as well as non-agricultural environments and their health effects in humans and animals. Mycotoxins have immunosuppressive effects; but some of them can cause cancers, mutagenicity, neurotoxicity, liver and kidney damage, birth defects, DNA damage and respiratory disorders. The problem of mycotoxins is long-lasting and their direct or indirect exposures to humans and animals must be further discussed. The first chapter will cover the historical perspective of mycotoxins along with timeline while the second one will provide overview including classification of mycotoxins and mycotoxicoses. The comprehensive information/ literature on traditional, emerging and mushroom mycotoxins will be given in chapters 3, 4 and 5 respectively. Chapter 6 will deal with mycotoxins co-occurrence poisoning whereas new and masked mycotoxins will be described in chapter 7. The important aspects of mycotoxin studies like extraction, characterization and analysis and management strategies will be summarized in 8 and 9 chapters. The last chapter of the book will cover the recent developments in toxicokinetic studies of mycotoxins. The book will have the most up-to-date information and recent discoveries to deliver accurate data and to illustrate essential points to a wide range of readers including mycologists, clinicians, agricultural scientists, chemists, veterinarians, environmentalists and food scientists.
Mycotoxins and Their Metabolites in Humans and Animals
by Martin WeidenbörnerA mycotoxin is a toxin produced by a fungus under special conditions of moisture and temperature. These fungi are aerobic and microscopic and, moreover, may colonize many kinds of food from the field to the table. Mycotoxins are not only a spoilage issue for food, but in high doses can be a serious health threat for humans. The book will be similar to Weidenborner's previous two books - "Mycotoxins in Feedstuffs" and "Mycotoxins in Foodstuffs" - in that it will be a review of the literature to create a comprehensive reference for mycotoxin levels. It will be his third (and last) book on the topic, this time focusing on the incidence of a mycotoxin in humans and/or animals (natural or artificial incidence). Each entry will include contamination, concentration rate, mean concentration of organs (humans and animals) with a mycotoxin, as well as sample constitution (where possible) and country of origin of the sample.
Mycotoxins in Animal Products: Milk and Milk Products, and Meat
by Martin WeidenbörnerThis book is one of three volumes expanding upon content found in Mycotoxins in Foodstuffs, Second Edition, and focuses on milk and milk products, and meat. Foodstuffs of plant origin that play only a minor role in mycotoxin contamination, such as asparagus, are also covered.Mycotoxins in Animal Products - Milk and Milk Products, and Meat comprises:More than 100 new publications and 300 publications in allSingle chapter overview with all mycotoxins and each foodstuff that is contaminatedCoverage of "co-contamination," showing the co-occurrence of mycotoxins in a foodstuff, where possibleCoverage of "further contamination,“ describing further foodstuffs with their mycotoxins documented, where possibleList of articles dealing with conventionally and organically produced foodstuffs and their mycotoxin contamination
Mycotoxins in Feedstuffs,. 2nd Edition
by Martin WeidenbörnerMycotoxins are substances produced from fungal secondary metabolic processes. They impair animal health, thereby causing great economic losses of livestock through disease. Livestock come into contact with mycotoxins through contaminated feedstuff. Feedstuff is any of the constituent nutrients of an animal ration. The plants used in feed, such as grains, oil seeds, nuts, and root crops, are susceptible to mycotoxin contamination. Mycotoxins in Feedstuffs lists (in the style of a dictionary) feeds which have been reported to have been contaminated with mycotoxins, including data on the degree of contamination, the concentration of the toxins, and the country of origin and/or detection of the contaminated feed. This second edition will feature: - More than 180 new publications concerning mycotoxins in feedstuffs. - A more efficient organization of the content, making the book easier to use in daily practice. - A single-chapter overview of mycotoxins in the corresponding feedstuffs.
Mycotoxins in Feedstuffs, 2nd Edition
by Martin WeidenbörnerMycotoxins are substances produced from fungal secondary metabolic processes. They impair animal health, thereby causing great economic losses of livestock through disease. Livestock come into contact with mycotoxins through contaminated feedstuff. Feedstuff is any of the constituent nutrients of an animal ration. The plants used in feed, such as grains, oil seeds, nuts, and root crops, are susceptible to mycotoxin contamination. Mycotoxins in Feedstuffs lists (in the style of a dictionary) feeds which have been reported to have been contaminated with mycotoxins, including data on the degree of contamination, the concentration of the toxins, and the country of origin and/or detection of the contaminated feed. This second edition will feature: - More than 180 new publications concerning mycotoxins in feedstuffs. - A more efficient organization of the content, making the book easier to use in daily practice. - A single-chapter overview of mycotoxins in the corresponding feedstuffs.
Mycotoxins in Food and Beverages: Innovations and Advances Part I (Food Biology Series)
by Didier Montet, Catherine Brabet, Sabine Schorr-Galindo and Ramesh C. RayMycotoxins are secondary metabolites produced by fungi in a wide range of foods (cereals, peanut, tree nuts, dried fruits, coffee, cocoa, grapes, spices…) both in the field and after harvest, particularly during storage. They can also be found in processed foods of plant origin, or by transfer, in food products of animal (milk, eggs, meat and offal). Mycotoxins are of major concern since they can cause acute or chronic intoxications in both humans and animals which are sometimes fatal. Many countries, particularly in Europe, have set maximum acceptable levels for mycotoxins in food and feed. The book reviews the latest literature and innovations on important aspects of mycotoxins, e.g. mycotoxin producing fungi and the related ecosystems, mycotoxin occurrence, toxicity, analysis and management. Quantitative estimations of impacts of climate change on mycotoxin occurrence have been made recently, using predictive modelling. There is also a growing interest in the occurrence and toxicity of multiple mycotoxins in food and feed, including emerging or modified forms of mycotoxins. Innovative tools were also developed to detect and quantify toxinogenic fungi and their toxins. In order to reduce the use of chemicals that are harmful to the environment and health of consumers, alternative methods of prevention and decontamination of mycotoxins were tested in pre- and post-harvest, using microorganisms, natural substances or radiation treatments.
Mycotoxins in Food and Beverages: Innovations and Advances, Part II (Food Biology Series)
by Didier Montet; Catherine Brabet; Sabine Schorr-Galindo; Ramesh C. RayMycotoxins are secondary metabolites produced by fungi in a wide range of foods (cereals, peanut, tree nuts, dried fruits, coffee, cocoa, grapes, spices…) both in the field and after harvest, particularly during storage. They can also be found in processed foods of plant origin, or by transfer, in food products of animal (milk, eggs, meat and offal). Mycotoxins are of major concern since they can cause acute or chronic intoxications in both humans and animals which are sometimes fatal. Many countries, particularly in Europe, have set maximum acceptable levels for mycotoxins in food and feed. The book reviews the latest literature and innovations on important aspects of mycotoxins, e.g. mycotoxin producing fungi and the related ecosystems, mycotoxin occurrence, toxicity, analysis and management. Quantitative estimation of impacts of climate change on mycotoxin occurrence have been made recently, using predictive modelling. There is also a growing interest in studying the occurrence and toxicity of multiple mycotoxins in food and feed, including emerging or modified forms of mycotoxins. Innovative tools have also developed to detect and quantify toxinogenic fungi and their toxins. In order to reduce the use of chemicals that are harmful to the environment and health of consumers, alternative methods of prevention and decontamination of mycotoxins were tested in pre- and post-harvest, using microorganisms, natural substances or radiation treatments.
Mycotoxins in Food and Feed: Detection and Management Strategies
by Pradeep Kumar Madhu Kamle Dipendra Kumar MahatoMycotoxins represent an assorted range of secondary fungal metabolites that extensively occur in numerous food and feed ingredients at any stage during pre- and post-harvest conditions. Mycotoxin contamination in food and feed cause acute and chronic mycotoxicosis, including teratogenic, carcinogenic, oestrogenic, neurotoxic, and immunosuppressive effects and several others health issues. Mycotoxins in Food and Feed presents an overview of all the major mycotoxins, sources of production, chemistry and biosynthesis, occurrence in food and feed, effect on agriculture, effect on human health, detection technique, masked mycotoxins, and management and control strategies. Key Features Provides broad coverage of mycotoxins and their effects on food and feed Includes comprehensive information of occurrence, chemistry, detections methods and management strategies for each toxin Discusses the recent development in detection technologies for major mycotoxins Explores agricultural practices and post-harvest management strategies for managing mycotoxin infestations
Mycotoxins in Food, Feed and Bioweapons
by Ajit Varma Mahendra RaiMycotoxins are made by different biosynthetic pathways, and they have an extremely wide range of pharmacological effects. This book will update readers on several cutting-edge aspects of mycotoxin research, including topics such as: new analytical methods for detection; the adoption of an ancient Mexican process for detoxification of aflatoxins; mycotoxin management in Ireland, Lithuania and South America; mycotoxin reduction through plant breeding and integrated management practices; and natural aflatoxin inhibitors from medicinal plants. Further contributions examine ochratoxins, selected trichothecenes, zearalenone, and aflatoxin-like gene clusters, as well as sclerotial development in Aspergillus flavus and A. parasiticus. Of particular interest are the chapters on the potential use of mycotoxins as bioweapons. This book will stimulate new thinking on the need to develop therapeutic as well as preventative interventions to reduce the toxicological threat of mycotoxins.
Mycotoxins in Plants and Plant Products: Cocoa, Coffee, Fruits and Fruit Products, Medicinal Plants, Nuts, Spices, Wine
by Martin WeidenbörnerThis book is one of three volumes that are an expansion of Mycotoxins in Foodstuffs, Second Edition, and it focuses on cocoa, coffee, fruits and fruit products, medicinal plants, nuts, spices, and wine. In addition all foodstuffs of plant origin except cereals and cereal products are covered.Mycotoxins in Plants and Plant Products – Cocoa, Coffee, Fruits and Fruit Products, Medicinal Plants, Nuts, Spices, Wine comprises: More than 280 new publications and 900 publications in all Each item includes "Co-contamination", showing the co-occurrence of mycotoxins in a foodstuff, where possible Each item includes "Further contamination", describing the same or further foodstuff/s with its/their mycotoxins documented, where possible Single chapter overview with all mycotoxins and their foodstuff-spectrum Single chapter overview with each single foodstuff and its mycotoxin-spectrum Separate list of the articles dealing with conventionally and organically produced foodstuffs and their mycotoxin contamination Numerical and Alphabetical Bibliography
Myocardial Tissue Engineering
by Sian Harding Aldo R. BoccacciniMyocardial tissue engineering (MTE), a concept that intends to prolong patients' life after cardiac damage by supporting or restoring heart function, is continuously improving. Common MTE strategies include an engineered 'vehicle', which may be a porous scaffold or a dense substrate or patch, made of either natural or synthetic polymeric materials. The function of the substrate is to aid transportation of cells into the diseased region of the heart and support their integration. This book, which contains chapters written by leading experts in MTE, gives a complete analysis of the area and presents the latest advances in the field. The chapters cover all relevant aspects of MTE strategies, including cell sources, specific TE techniques and biomaterials used. Many different cell types have been suggested for cell therapy in the framework of MTE, including autologous bone marrow-derived or cardiac progenitors, as well as embryonic or induced pluripotent stem cells, each having their particular advantages and disadvantages. The book covers a complete range of biomaterials, examining different aspects of their application in MTE, such as biocompatibility with cardiac cells, mechanical capability and compatibility with the mechanical properties of the native myocardium as well as degradation behaviour in vivo and in vitro. Although a great deal of research is being carried out in the field, this book also addresses many questions that still remain unanswered and highlights those areas in which further research efforts are required. The book will also give an insight into clinical trials and possible novel cell sources for cell therapy in MTE.
Myrmidon
by David WellingtonAn e-book original action thriller by acclaimed author David Wellington. Wounded Special Forces veteran Jim Chapel now specializes in missions improbable (and sometimes impossible). After confronting a Russian triple agent, Chapel must infiltrate a separatist militia group to track and seize contraband Russian weaponry. But the militia leader has his own agenda . . . and an ace up his sleeve.
Mysteries of the Deep: How Seafloor Drilling Expeditions Revolutionized Our Understanding of Earth History
by James Lawrence PowellA groundbreaking chronicle of scientific ocean drilling—a crowning achievement of the twentieth century—and how it shaped our knowledge of Earth's past.Under the radar—or, rather, sonar—of most people and many scientists, for the last six decades ships have plied the world&’s oceans, mining the seafloor for its secrets—and quietly resolving confounding geological mysteries. Continental drift and plate tectonics. The origin of the Hawaiʻian Islands. The erstwhile disappearance of the Mediterranean. The mystery of the ice ages. All are part of the story told by deep-sea drilling—and chapters in the history that unfolds in Mysteries of the Deep. In a series of vignettes ranging from the voyage of the HMS Challenger in the 1870s to the adventures of research ship Chikyū in the 2020s, James Powell recounts the surprises the seafloor has yielded to the probing of scientists.With a global, sometimes even extraterrestrial scope and a scientific reach that extends to every corner of geology and astrobiology, Powell&’s work recounts how cores extracted from the ocean floor have:· produced insights into microbial life on Mars and the end of dinosaurs&’ tenure on Earth· demonstrated that astronomical cycles control many geological events, and even human evolution· used a past episode of global warming to reveal the peril of high temperatures today· shown that global warming could melt enough Antarctic ice to drown the seacoastsThe mysteries uncovered by deep-sea drilling, and covered by Powell in this eye-opening book, are many and various, often surprising and sometimes alarming—consequential not just for the science of the seafloor, but for how we learn about our planet's past and what we can do about its future.
The Mysteries of the Marco Polo Maps
by Benjamin B. OlshinIn the thirteenth century, Italian merchant and explorer Marco Polo traveled from Venice to the far reaches of Asia, a journey he chronicled in a narrative titled "Il Milione," later known as "The Travels of Marco Polo. " While PoloOCOs writings would go on to inspire the likes of Christopher Columbus, scholars have long debated their veracity. Some have argued that Polo never even reached China, while others believe that he came as far as the Americas. Now, thereOCOs new evidence for this historical puzzle: a very curious collection of fourteen little-known maps and related documents said to have belonged to the family of Marco Polo himself. In "The Mysteries of the Marco Polo Maps," historian of cartography Benjamin B. Olshin offers the first credible book-length analysis of these artifacts, charting their course from obscure origins in the private collection of Italian-American immigrant Marcian Rossi in the 1930s; to investigations of their authenticity by the Library of Congress, J. Edgar Hoover, and the FBI; to the work of the late cartographic scholar Leo Bagrow; to OlshinOCOs own efforts to track down and study the Rossi maps, all but one of which are in the possession of RossiOCOs great-grandson Jeffrey Pendergraft. Are the maps forgeries, facsimiles, or modernized copies? Did Marco PoloOCOs daughtersOCowhose names appear on several of the artifactsOCopreserve in them geographic information about Asia first recorded by their father? Or did they inherit maps created by him? Did Marco Polo entrust the maps to Admiral Ruggero Sanseverino, who has links to RossiOCOs family line? Or, if the maps have no connection to Marco Polo, who made them, when, and why? Regardless of the mapsOCO provenance, OlshinOCOs taleOCostretching from the remote reaches of the northern Pacific to early Chinese legendsOCotakes readers on a journey confounding yet fascinating, offering insights into Italian history, the age of exploration, and the wonders of cartography. "
The Mysterious Affair at Olivetti: IBM, the CIA, and the Cold War Conspiracy to Shut Down Production of the World's First Desktop Computer
by Meryle SecrestThe never-before-told true account of the design and development of the first desktop computer by the world's most famous high-styled typewriter company, more than a decade before the arrival of the Osborne 1, the Apple 1, the first Intel microprocessor, and IBM's PC5150.The human, business, design, engineering, cold war, and tech story of how the Olivetti company came to be, how it survived two world wars and brought a ravaged Italy back to life, how after it mastered the typewriter business with the famous "Olivetti touch," it entered the new, fierce electronics race; how its first desktop compter, the P101, came to be; how, within eighteen months, it had caught up with, and surpassed, IBM, the American giant that by then had become an arm of the American government, developing advanced weapon systems; Olivetti putting its own mainframe computer on the market with its desktop prototype, selling 40,000 units, including to NASA for its lunar landings. How Olivetti made inroads into the US market by taking control of Underwood of Hartford CT as an assembly plant for Olivetti's own typewriters and future miniaturized personal computers; how a week after Olivetti purchased Underwood, the US government filed an antitrust suit to try to stop it; how Adriano Olivetti, the legendary idealist, socialist, visionary, heir to the company founded by his father, built the company into a fantastical dynasty--factories, offices, satellite buildings spread over more than fifty acres--while on a train headed for Switzerland in 1960 for supposed meetings and then to Hartford, never arrived, dying suddenly of a heart attack at fifty-eight . . . how eighteen months later, his brilliant young engineer, who had assembled Olivetti's superb team of electronic engineers, was killed, as well, in a suspicious car crash, and how the Olivetti company and the P101 came to its insidious and shocking end.
Mysterious Messages: A History of Codes and Ciphers
by Gary BlackwoodHistory?s amazing secrets and codes?and how to crack them yourself. This fascinating look at history?s most mysterious messages is packed with puzzles to decode and ciphers that kids can use themselves. Here are the encrypted notes of Spartan warriors, the brilliant code-crackers of Elizabeth I, secret messages of the American Revolution, spy books of the Civil War, the famous Enigma Machine, and the Navajo code talkers. As computers change the way we communicate, codes today are more intriguing than ever. From invisible ink to the CIA, this exciting trip through history is a hands-on, interactive experience? so get cracking!
Mystery Disease: Problem-Based Learning (Grades 5-8)
by Mark A. BohlandA serious illness is sweeping through town. Why are people getting sick? What is the source of this disease? With this problem-based learning unit, students become public health workers as they track down the source of a mysterious illness. Working in teams to solve the real-world problem and present their findings, they experience genuine, higher order learning. Decisions they make affect the outcome of the simulation.The activities combine science, social studies, math, research, thinking, cooperation, and speech skills in one great unit. This guide includes everything you need—teacher's directions and student information in the form of memos and medical reports.This open-ended scenario will draw students into a real-life drama.Allow your students to solve more real-life problems in Crime Scene Detective, Detective Club, Mystery Science, and The Great Chocolate Caper.Grades 5-8