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Microfluidics
by Bingcheng LinFlow Control Methods and Devices in Micrometer Scale Channels, by Shuichi Shoji and Kentaro Kawai. Micromixing Within Microfluidic Devices, by Lorenzo Capretto, Wei Cheng, Martyn Hill and Xunli Zhang. Basic Technologies for Droplet Microfluidics, by Shaojiang Zeng, Xin Liu, Hua Xie and Bingcheng Lin. Electrorheological Fluid and Its Applications in Microfluidics, by Limu Wang, Xiuqing Gong and Weijia Wen. Biosensors in Microfluidic Chips, by Jongmin Noh, Hee Chan Kim and Taek Dong Chung. A Nanomembrane-Based Nucleic Acid Sensing Platform for Portable Diagnostics, by Satyajyoti Senapati, Sagnik Basuray, Zdenek Slouka, Li-Jing Cheng and Hsueh-Chia Chang. Optical Detection Systems on Microfluidic Chips, by Hongwei Gai, Yongjun Li and Edward S. Yeung. Integrated Microfluidic Systems for DNA Analysis, by Samuel K. Njoroge, Hui-Wen Chen, Małgorzata A. Witek and Steven A. Soper. Integrated Multifunctional Microfluidics for Automated Proteome Analyses, by John K. Osiri, Hamed Shadpour, Małgorzata A. Witek and Steven A. Soper. Cells in Microfluidics, by Chi Zhang and Danny van Noort. Microfluidic Platform for the Study of Caenorhabditis elegans,by Weiwei Shi, Hui Wen, Bingcheng Lin and Jianhua Qin.
Microfluidics
by Stéphane ColinThe goal of this book is to provide engineers and researchers the tools necessary for modelling, experimenting, and simulating these microflows as a preliminary step for designing and optimizing fluidic microsystems. The various consequences of miniaturization on the hydrodynamics of gas, liquid or two-phase flows, as well as associated heat transfer are analysed. The book is illustrated with examples showing the diversity and the originality of fluidic microsystems.
Microfluidics Based Microsystems
by A. Pramuanjaroenkij B. Kosoy D. Li S. KakaçThis volume provides a comprehensive state-of-the art review of the fundamentals and applications of the microfluidics based microsystems. As the world becomes increasingly concerned with terrorism, early on-spot detection of terrorist's weapons, particularly bio-weapons agents such as bacteria and viruses are extremely important. Microfluidics are great tools for security and anti-terrorism with many applications. New and better diagnostic technology must be developed in order to be prepared for an act of bio-terrorism. Basics of Electrokinetic Microfluidics, Lab-on-a-Chip Devices for Biomedical Applications, Microfluidic Biological Application Specific Integrated Circuits, Integrated Optofluidics and Nanofluidic, Cell Culture Revolution via Dynamical Microfluidic Controls, Fundamentals of droplet flow in microfluidics, Implementation of fluidic functions in digital microfluidics, Chip architecture and applications for digital microfluidics, Mixing in microfluidic systems are presented and discussed in detail. In addition more presentations such as Optofluidics - Fusing Nanofluidics and Nanophotonics, Programmable Matter - Micro and milliscale fluid dynamics of reconfigurable assembly for control of living systems, An Overview on Microfluidic Platforms for Lab-on-a-Chip Applications, Centrifugal Microfluidics for Lab-on-a-Chip Applications are also given. Transport of droplets and bubbles in microfluidic systems - from flow through a simple pipe to logic gates and automated chips for chemical processing, Analytical, Synthesis and Bio-Medical Applications of Microchip Technology, Hydroporetic separation method for blood sample analysis, Magnetophoretic multiplexed immunoassays in a microchannel, programmable particle manipulation using lab-on-a-display, etc. are discussed in details with fundamentals and applications.
Microfluidics Diagnostics: Methods and Protocols (Methods in Molecular Biology #2804)
by Valérie Taly Stéphanie Descroix Karla Perez-TorallaThis detailed volume explores a wide range of microfluidic-based approaches that exploit the unique features of microfluidic devices, which hold significant potential in the field of diagnosis. Beginning with a section on microchips for sample preparation, including cell-free DNA, exosomes, and cells, the book continues by covering protein marker analysis and detection, single-cell analysis, analysis of bacteria and viruses, as well as human cell-based culture and analysis. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Microfluidics Diagnostics: Methods and Protocols serves as an ideal guide for researchers investigating how microfluidics can shape the future of diagnosis.
Microfluidics and Biosensors in Cancer Research: Applications in Cancer Modeling and Theranostics (Advances in Experimental Medicine and Biology #1379)
by Rui L. Reis David Caballero Subhas C. KunduThis book offers a comprehensive overview of the development and application of microfluidics and biosensors in cancer research, in particular, their applications in cancer modeling and theranostics.Over the last decades, considerable effort has been made to develop new technologies to improve the diagnosis and treatment of cancer. Microfluidics has proven to be a powerful tool for manipulating biological fluids with high precision and efficiency and has already been adopted by the pharmaceutical and biotechnology industries. With recent technological advances, particularly biosensors, microfluidic devices have increased their usefulness and importance in oncology and cancer research.The aim of this book is to bring together in a single volume all the knowledge and expertise required for the development and application of microfluidic systems and biosensors in cancer modeling and theranostics. It begins with a detailed introduction to the fundamental aspects of tumor biology, cancer biomarkers, biosensors and microfluidics. With this knowledge in mind, the following sections highlight important advances in developing and applying biosensors and microfluidic devices in cancer research at universities and in the industry. Strategies for identifying and evaluating potent disease biomarkers and developing biosensors and microfluidic devices for their detection are discussed in detail. Finally, the transfer of these technologies into the clinical environment for the diagnosis and treatment of cancer patients will be highlighted. By combining the recent advances made in the development and application of microfluidics and biosensors in cancer research in academia and clinics, this book will be useful literature for readers from a variety of backgrounds. It offers new visions of how this technology can influence daily life in hospitals and companies, improving research methodologies and the prognosis of cancer patients.
Microfluidics and Microfabrication
by Suman ChakrabortyMicrofluidics and Microfabrication discusses the interconnect between microfluidics, microfabrication and the life sciences. Specifically, this includes fundamental aspects of fluid mechanics in micro-scale and nano-scale confinements and microfabrication. Material is also presented discussing micro-textured engineered surfaces, high-performance AFM probe-based, micro-grooving processes, fabrication with metals and polymers in bio-micromanipulation and microfluidic applications. Editor Suman Chakraborty brings together leading minds in both fields who also: Cover the fundamentals of microfluidics in a manner accessible to multi-disciplinary researchers, with a balance of mathematical details and physical principles Discuss the explicit interconnection between microfluiodics and microfabrication from an application perspective Detail the amalgamation of microfluidics with logic circuits and applications in micro-electronics Microfluidics and Microfabrication is an ideal book for researchers, engineers and senior-level graduate students interested in learning more about the two fields.
Microfluidics and Microscale Transport Processes (IIT Kharagpur Research Monograph Series)
by Suman ChakrabortyThe advancements in micro- and nano-fabrication techniques, especially in the last couple of decades, have led research communities, over the world, to invest unprecedented levels of attention on the science and technology of micro- and nano-scale devices and the concerned applications. With an intense focus on micro- and nanotechnology from a flui
Microfluidics and Multi Organs on Chip
by P. V. MohananThis book highlights the application of microfluidics in cell biology research, chemical biology, and drug discovery. It covers the recent breakthroughs and prospects of organ-on-a-chip, human-on-a-chip, multi-organ-on-a-chip for personalized medicine. The book presents the preclinical studies of organs-on-a-chip, concepts of multiple vascularized organ-on-chips, application of organ-on-a-chip in blood-brain barrier model, culture and co-culture of cells on multi-organ-on-chip and parameter measurements in microfluidic devices. It underscores the advantage of microfluidic devices for developing efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening. Further, it entails human-on-a-chip for measuring the systemic response as well as immediate effects of an organ reaction on other organs. In summary, this book reviews the development of a microfluidic-based organ-on-a-chip device for the preclinical evaluation, ADME studies of drugs, chemicals, and medical devices. This book is a valuable source for pharma companies, product developers, students, researchers, academicians, and practitioners.
Microfluidics and Nanofluidics Handbook: Chemistry, Physics, and Life Science Principles
by Suman Chakraborty Sushanta K. MitraThe Microfluidics and Nanofluidics Handbook: Two-Volume Set comprehensively captures the cross-disciplinary breadth of the fields of micro- and nanofluidics, which encompass the biological sciences, chemistry, physics and engineering applications. To fill the knowledge gap between engineering and the basic sciences, the editors pulled together key
Microfluidics and Nanofluidics Handbook: Fabrication, Implementation, and Applications
by Sushanta K. Mitra and Suman ChakrabortyThis comprehensive handbook presents fundamental aspects, fabrication techniques, introductory materials on microbiology and chemistry, measurement techniques, and applications of microfluidics and nanofluidics. The second volume focuses on topics related to experimental and numerical methods. It also covers fabrication and applications in a variety of areas, from aerospace to biological systems. Reflecting the inherent nature of microfluidics and nanofluidics, the book includes as much interdisciplinary knowledge as possible. It provides the fundamental science background for newcomers and advanced techniques and concepts for experienced researchers and professionals.
Microfluidics and Nanotechnology: Biosensing to the Single Molecule Limit (Devices, Circuits, and Systems #27)
by Krzysztof Iniewski Eric LagallyAn increasing number of technologies are being used to detect minute quantities of biomolecules and cells. However, it can be difficult to determine which technologies show the most promise for high-sensitivity and low-limit detection in different applications. Microfluidics and Nanotechnology: Biosensing to the Single Molecule Limit details proven approaches for the detection of single cells and even single molecules—approaches employed by the world’s foremost microfluidics and nanotechnology laboratories. While similar books concentrate only on microfluidics or nanotechnology, this book focuses on the combination of soft materials (elastomers and other polymers) with hard materials (semiconductors, metals, and glass) to form integrated detection systems for biological and chemical targets. It explores physical and chemical—as well as contact and noncontact—detection methods, using case studies to demonstrate system capabilities. Presenting a snapshot of the current state of the art, the text: Explains the theory behind different detection techniques, from mechanical resonators for detecting cell density to fiber-optic methods for detecting DNA hybridization, and beyond Examines microfluidic advances, including droplet microfluidics, digital microfluidics for manipulating droplets on the microscale, and more Highlights an array of technologies to allow for a comparison of the fundamental advantages and challenges of each, as well as an appreciation of the power of leveraging scalability and integration to achieve sensitivity at low cost Microfluidics and Nanotechnology: Biosensing to the Single Molecule Limit not only serves as a quick reference for the latest achievements in biochemical detection at the single-cell and single-molecule levels, but also provides researchers with inspiration for further innovation and expansion of the field.
Microfluidics for Advanced Functional Polymeric Materials
by Wei Wang Liang-Yin ChuA comprehensive and systematic treatment of our current understanding of the microfluidic technique and its advantages in the controllable fabrication of advanced functional polymeric materials. Introducing and summarizing recent advances and achievements in the field, the authors cover the design and fabrication of microfluidic devices, the fundamentals and strategies for controllable microfluidic generation of multiphase liquid systems, and the use of these liquid systems with an elaborate combination of their structures and compositions for generating novel polymer materials, such as microcapsules, microfibers, valves, and membranes. Clear diagrams and illustrations throughout the text make the relevant theory and technologies more readily accessible. The result is a specialist reference for materials scientists, organic, polymer and physical chemists, and chemical engineers.
Microfluidics for Assisted Reproduction in Animals
by Vinod Kumar YataThis book describes the fundamentals of microfluidics and fabrication methods of microfluidic devices that can be adopted for animal-assisted reproduction. It presents microfluidic methods for sorting highly fertile spermatozoa. This book also describes the application of microfluidics in vitro fertilization and embryo culture. It discusses the use of microfluidics in sperm sexing and the cryopreservation of animal gametes and embryos. Lastly, the book examines the potential opportunities of microfluidics in infertility diagnosis, sperm selection and guidance, oocyte selection, insemination, and embryo monitoring.
Microfluidics for Single-Cell Analysis (Integrated Analytical Systems)
by Jin-Ming LinThis book summarizes the various microfluidic-based approaches for single-cell capture, isolation, manipulation, culture and observation, lysis, and analysis. Single-cell analysis reveals the heterogeneities in morphology, functions, composition, and genetic performance of seemingly identical cells, and advances in single-cell analysis can overcome the difficulties arising due to cell heterogeneity in the diagnostics for a targeted model of disease. This book provides a detailed review of the state-of-the-art techniques presenting the pros and cons of each of these methods. It also offers lessons learned and tips from front-line investigators to help researchers overcome bottlenecks in their own studies. Highlighting a number of techniques, such as microfluidic droplet techniques, combined microfluidics-mass-spectrometry systems, and nanochannel sampling, it describes in detail a new microfluidic chip-based live single-cell extractor (LSCE) developed in the editor’s laboratory, which opens up new avenues to use open microfluidics in single-cell extraction, single-cell mass spectrometric analysis, single-cell adhesion analysis and subcellular operations. Serving as both an elementary introduction and advanced guidebook, this book interests and inspires scholars and students who are currently studying or wish to study microfluidics-based cell analysis methods.
Microfluidics in Biotechnology (Advances in Biochemical Engineering/Biotechnology #179)
by Janina Bahnemann Alexander GrünbergerThis new volume introduces the applications of microfluidic systems to facilitate biotechnological and biomedical processes. It provides an overview on cutting-edge technologies, summarizes traditional and modern fabrication methods and highlights recent advances regarding the application of lab-on-a-chip (LoC) systems for bioanalytical purposes. This book is ideal for research scientists and students interested at the cross-section between biotechnology, chemistry and chemical engineering.
Microfluidics in Food Processing: Technologies and Applications (Sustainable Industrial and Environmental Bioprocesses)
by Ashok Pandey Claude-Gilles Dussap Ranjna Sirohi Ayon Tarafdar Barjinder Pal KaurThis book serves as a comprehensive introduction to the principles of microfluidization and its diverse applications in the food industry. It explores the use of microfluidics in processing various types of beverages derived from plant products, milk and milk products, cereal-based products, nut-based products, and meat and egg-based products. Additionally, it delves into the application of microfluidics in food micro- and nano-delivery systems, seed protein isolates, and food packaging materials. The initial chapter provides a thorough introduction to the concept of microfluidization, offering readers a comprehensive overview of the underlying principles and techniques involved in this transformative technology. The book highlights the role of microfluidics in the extraction of bioactive ingredients from food sources and explores the use of microfluidic systems for ensuring food safety, including the detection of molecular interactions in food samples. Furthermore, the book explores the application of microfluidics in the fabrication of nanomaterials with tailored properties. With its comprehensive coverage of microfluidization in food processing, this book serves as a valuable resource for researchers, scientists, and professionals in the food industry.
Microfluidics in Pharmaceutical Sciences: Formulation, Drug Delivery, Screening, and Diagnostics (AAPS Introductions in the Pharmaceutical Sciences #14)
by Dimitrios A. Lamprou Edward WeaverThe book covers the basics of microfluidics, current applications in areas such as formulation, drug delivery, drug screening and development, monitoring and diagnostics, and case studies from a teaching perspective to undergraduate and postgraduate students, allowing application of the content in a flipped classroom. Multiple choice questions are included at the end of each chapter. All chapter authors are pioneers and world leaders. This is an ideal book for students, researchers, and industry professionals working on microfluidics in the pharmaceutical sciences.
Microfluidics-Enabled Soft Manufacture
by Liqiu Wang Pingan ZhuThis book covers state-of-the-art development in microfluidics-enabled soft manufacturing (MESM), ranging from fundamentals to applications. The book addresses the long-standing challenge in the manufacture of simultaneously achieving both precise control over nano-/micro-scale structures and large-scale fabrication of materials for pragmatic use, with microfluidics-enabled soft manufacture to fill the gap between the widely-varied length scales involved. It offers a comprehensive insight into the microfluidic generation of fluid systems as liquid templates, such as droplets, bubbles, jets, emulsions, and foams, which are categorized into individual templates, one-dimensional arrays, and two-/three-dimensional assemblies for the modular fabrication of microparticles, microfibers, and porous materials, respectively. MESM enriches the compositional and structural diversity of engineered materials for well-tailored properties and functionalities, markedly broadening the application horizons across interdisciplinary fields, including engineering, environment, physics, chemistry, biology, and medicine. This book aims to systematize this emerging yet versatile and powerful technology, with the hope of aiding the realization of its full potential. Microfluidics-Enabled Soft Manufacture will be an invaluable reference for graduate students, postgraduates, researchers, and practitioners/professionals working in micro and nanofabrication, materials science, surface science, fluid dynamics, and engineering.
Microgravity and Vision Impairments in Astronauts
by Erik SeedhouseRecent missions on board the International Space Station have revealed previously unreported physiological consequences of long duration space flight, particularly in eyesight, and in this Brief Dr. Seedhouse reviews the existing theories on what causes this degeneration and how long it will last. Notably, 60% of long-duration crews have reported subjective degradation in vision, a clear indication that further study is necessary before astronauts embark on even longer-term space missions. Decreased near-visual acuity was reported in 46% of ISS/Mir crewmembers, resulting in a change of up to 2 dioptres in their refractive correction. It is possible that ophthalmic changes have been present since the first days of spaceflight, but had been attributed to other causes; this approach to the issue as well as other hypotheses are all presented in full to give a broad foundation of the existing knowledge on the topic. The changes have occurred at various times during a mission with varying degrees of visual degradation. Some cases resolved on return to Earth, but several crewmembers have not regained pre-flight visual acuity, indicating the damage may be permanent. One explanation of the syndrome has been attributed to hyperopic shift due to aging, but onboard analysis techniques, including visual acuity assessments, retinal imagery, and ultrasound examination of the eye, has led to the acceptance of a wider syndrome. In addition to vision changes, studies have reported flattening of the globe, swelling of the optic disc (papilledema), choroidal folds in the retina, swelling of the optic nerve sheath, and visual field defects. It is widely hypothesized that this spectrum of symptoms may be explained by an elevation of intracranial pressure (ICP). Establishing the provenance of this medical problem, monitoring its occurrence and resolving the symptoms for future long term space missions is a key challenge for space medicine. With this book, readers have an entry point for understanding the full scope of the problem and its possible origins.
Microgrid Architectures, Control and Protection Methods (Power Systems)
by Nicu Bizon Naser Mahdavi Tabatabaei Ersan KabalciThis book presents intuitive explanations of the principles of microgrids, including their structure and operation and their applications. It also discusses the latest research on microgrid control and protection technologies and the essentials of microgrids as well as enhanced communication systems.The book provides solutions to microgrid operation and planning issues using various methodologies includingplanning and modelling;AC and DC hybrid microgrids;energy storage systems in microgrids; andoptimal microgrid operational planning.Written by specialists, it is filled in innovative solutions and research related to microgrid operation, making it a valuable resource for those interested in developing updated approaches in electric power analysis, design and operational strategies. Thanks to its in-depth explanations and clear, three-part structure, it is useful for electrical engineering students, researchers and technicians.
Microgrid: Design, Optimization, and Applications (Smart Engineering Systems: Design and Applications)
by Vivek Patel Suman Lata Tripathi Sanjeevikumar Padmanaban Amit Kumar Pandey Vikas PatelThe book discusses principles of optimization techniques for microgrid applications specifically for microgrid system stability, smart charging, and storage units. It also highlights the importance of adaptive learning techniques for controlling autonomous microgrids. It further presents optimization-based computing techniques like fuzzy logic, and neural networks to enhance the computational speed.Features Discusses heuristic techniques and evolutionary algorithms in microgrids optimization problems Covers operation management, distributed control approaches, and conventional control methods for microgrids Presents intelligent control for energy management and battery charging systems Highlights a comprehensive treatment of power sharing in DC microgrids Explains control of low-voltage microgrids with master-slave architecture, where distributed energy resources interface with the grid by means of conventional current-driven inverters It is primarily written for senior undergraduates, graduate students, and academic researchers in the fields of electrical engineering, electronics, and communications engineering, computer science and engineering, and environmental engineering.
Microgrid: Operation, Control, Monitoring and Protection (Lecture Notes in Electrical Engineering #625)
by Papia Ray Monalisa BiswalThis book discusses various challenges and solutions in the fields of operation, control, design, monitoring and protection of microgrids, and facilitates the integration of renewable energy and distribution systems through localization of generation, storage and consumption.It covers five major topics relating to microgrid i.e., operation, control, design, monitoring and protection. The book is primarily intended for electric power and control engineering researchers who are seeking factual information, but also appeals to professionals from other engineering disciplines wanting an overview of the entire field or specific information on one aspect of it. Featuring practical case studies and demonstrating different root causes of large power failures, it helps readers develop new concepts for mitigating blackout issues.This book is a comprehensive reference resource for graduate and postgraduate students, academic researchers, and practicing engineers working in the fields of power system and microgrid.
Microgrids
by Jens Bo Holm-Nielsen Sanjeevikumar Padmanaban K. Nithiyananthan S. Prabhakar KarthikeyanMicrogrids offers a complete discussion and details about microgrids and their applications, including modeling of AC/DC and hybrid grids in a tied mode with simulation for the solar systems, wind turbines, biomass and fuel cells, and deployment issues. The data communications and control mechanism implementations are analyzed for proper coordination of the AC/DC microgrid. The various real-time applications and future development of the microgrid are also discussed in this book, with MATLAB®-based simulations and results. This book: Discusses the fundamentals of microgrids, the components of microgrids, the modeling of renewable energy sources, and the implementation of microgrids. Explores AC and DC microgrid modeling with real-time examples. Examines the effective extraction of energy from renewable energy sources. Covers analysis of data communications and control-mechanism implementations. Includes HOMER/MATLAB®-based simulations and results on microgrids. This book would be a welcome addition to the libraries of researchers, senior undergraduate students, and graduate students in power and electrical engineering, especially those working with smart and microgrids.
Microgrids
by Nikos HatziargyriouMicrogrids are the most innovative area in the electric power industry today. Future microgrids could exist as energy-balanced cells within existing power distribution grids or stand-alone power networks within small communities.A definitive presentation on all aspects of microgrids, this text examines the operation of microgrids - their control concepts and advanced architectures including multi-microgrids. It takes a logical approach to overview the purpose and the technical aspects of microgrids, discussing the social, economic and environmental benefits to power system operation. The book also presents microgrid design and control issues, including protection and explaining how to implement centralized and decentralized control strategies.Key features:original, state-of-the-art research material written by internationally respected contributors unique case studies demonstrating success stories from real-world pilot sites from Europe, the Americas, Japan and Chinaexamines market and regulatory settings for microgrids, and provides evaluation results under standard test conditionsa look to the future - technical solutions to maximize the value of distributed energy along with the principles and criteria for developing commercial and regulatory frameworks for microgridsOffering broad yet balanced coverage, this volume is an entry point to this very topical area of power delivery for electric power engineers familiar with medium and low voltage distribution systems, utility operators in microgrids, power systems researchers and academics. It is also a useful reference for system planners and operators, manufacturers and network operators, government regulators, and postgraduate power systems students.CONTRIBUTORSThomas DegnerAris DimeasAlfred EnglerNuno GilAsier Gil de MuroGuillermo Jiménez-EstévezGeorge KariniotakisGeorge KorresAndré MadureiraMeiqin MaoChris MarnayJose Miguel YarzaSatoshi MorozumiAlexander OudalovFrank van OverbeekeRodrigo Palma BehnkeJoao Abel Pecas LopesFernanda ResendeJohn RomankiewiczChristine SchwaegerlNikos SoultanisLiang TaoAntonis Tsikalakis
Microgrids Design and Implementation
by Antonio Carlos Zambroni de Souza Miguel CastillaThis book addresses the emerging trend of smart grids in power systems. It discusses the advent of smart grids and selected technical implications; further, by combining the perspectives of researchers from Europe and South America, the book captures the status quo of and approaches to smart grids in a wide range of countries. It describes the basic concepts, enabling readers to understand the theoretical aspects behind smart grid formation, while also examining current challenges and philosophical discussions. Like the industrial revolution and the birth of the Internet, smart grids are certain to change the way people use electricity. In this regard, a new term – the “prosumer” – is used to describe consumers who may sometimes also be energy producers. This is particularly appealing if we bear in mind that most of the distributed power generation in smart grids does not involve carbon emissions. At first glance, the option of generating their own power could move consumers to leave their current energy provider. Yet the authors argue that doing so is not a wise choice: utilities will play a central role in this new scenario and should not be ignored.