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Abiotic Stress Adaptation in Plants: Physiological, Molecular and Genomic Foundation
by Hans J. Bohnert Ashwani Pareek Govindjee S. K. SoporyEnvironmental insults such as extremes of temperature, extremes of water status as well as deteriorating soil conditions pose major threats to agriculture and food security. Employing contemporary tools and techniques from all branches of science, attempts are being made worldwide to understand how plants respond to abiotic stresses with the aim to help manipulate plant performance that will be better suited to withstand these stresses. This book on abiotic stress attempts to search for possible answers to several basic questions related to plant responses towards abiotic stresses. Presented in this book is a holistic view of the general principles of stress perception, signal transduction and regulation of gene expression. Further, chapters analyze not only model systems but extrapolate interpretations obtained from models to crops. Lastly, discusses how stress-tolerant crop or model plants have been or are being raised through plant breeding and genetic engineering approaches. Twenty three chapters, written by international authorities, integrate molecular details with overall plant structure and physiology, in a text-book style, including key references.
Abiotic Stress Management for Resilient Agriculture
by Paramjit Singh Minhas Jagadish Rane Ratna Kumar PasalaThis book offers a state-of-the-art overview of on abiotic stresses in terms of the challenges; scope and opportunities; copping strategies for adaptation and mitigation using novel tools for building resilience in agricultural crops and livestock; as well as for policy implementation. Divided into four major parts: advances and prospects for understanding stress environments; adaptation and mitigation options; crop-based mitigation strategies; and mitigation options in animal husbandry, the book focuses on problem-solving approaches and techniques that are essential for the medium to long-term sustainability of agricultural production systems The synthesis and integration of knowledge and experiences of specialists from different disciplines offers new perspectives in the versatile field of abiotic stress management, and as such is useful for various stakeholders, including agricultural students, scientists, environmentalists, policymakers, and social scientists.
Abiotic Stresses in Crop Plants
by Usha Chakraborty Bishwanath ChakrabortyThis book is based to a great extent on the biochemical and molecular mechanisms of tolerance of commonly encountered abiotic stresses in nature. This book will deal with increasing temperature, water, salinity, and heavy metals and ozone, and how these abiotic stresses can be managed by microbes through their alleviation mechanisms. Water stress includes both drought and flooding. 1st section outlines the relevance of abiotic stresses in present day environmental conditions. The 2nd section deals with three major stresses - temperature, water and salinity and the metabolic changes and protective adjustments in plants for withstanding these stresses. The 3rd section deals with the role of heavy metals and ozone. The final section is devoted to general abiotic stresses and their alleviation by microbes. These offer a cost-effective and eco-friendly means of combating different stresses.
Abläufe verbessern - Betriebserfolg garantieren (ifaa-Edition)
by Institut für angewandte ArbeitswissenschDer Leitfaden »Abläufe verbessern – Betriebserfolg garantieren« unterstützt Führungskräfte und Mitarbeiter, Verbesserungen betrieblicher Abläufe im Alltag erfolgreich voranzutreiben und nachhaltig zu sichern. Ziele sind, den Wertschöpfungsanteil betrieblicher Abläufe stetig zu erhöhen und Verschwendung in den Produktions- und Arbeitssystemen des gesamten Unternehmens zu erkennen und zu vermeiden. Die Grundlagen hierfür sind eine klar strukturierte Vorgehensweise und die konsequente Nutzung von Zahlen, Daten und Fakten. Die Vorgehensweise berücksichtigt erfolgsrelevante Elemente bewährter Verbesserungsmethoden – wie Six Sigma, PDCA-Zyklus, 8-D Report, REFA-Planungssystematik u. a. – in pragmatischer Form. Zu den einzelnen Arbeitsschritten sind bewährte Werkzeuge in direkt anwendbarer Form verfügbar. Anschauliche Beispiele aus der Praxis ergänzen das Angebot. Seit der ersten Auflage dieses Leitfadens im Jahre 2008 haben zahlreiche Unternehmen die im Leitfaden beschriebene Vorgehensweise erfolgreich umgesetzt. Die Anwender bestätigten den Mehrwert des Leitfadens sowie ihre positiven Erfahrungen und Ergebnisse in einer begleitenden Befragung.
Ablaufsimulation in der Automobilindustrie
by Sven Spieckermann Sigrid Wenzel Gottfried Mayer Carsten PögeDas vorliegende Buch stellt den Stand der Technik zur Ablaufsimulation in der deutschen Automobilindustrie zusammen und beschreibt Simulationsanwendungen in einzelnen Gewerken sowie auf Lieferkettenebene. Ferner werden Standards zur Simulation aus dem Verein Deutscher Ingenieure (VDI) und dem Verband der Automobilindustrie (VDA) aufgegriffen sowie aktuelle Entwicklungen rund um die Digitale Fabrik und Industrie 4.0 diskutiert. Autoren aus Forschung, Automobilindustrie und Automobilzulieferindustrie sowie aus Simulationsdienstleistungsunternehmen stellen Aktualität, Praxisrelevanz, wissenschaftliche und fachliche Breite sowie die Berücksichtigung unterschiedlicher Perspektiven sicher.Die ereignisdiskrete Simulation (auch Ablaufsimulation) wird in der Automobilindustrie fast durchgängig in allen Gewerken zur Untersuchung von Produktions- und Logistikprozessen eingesetzt. Mit ihrer Hilfe kann die Planung von Produktions- und Logistiksystemen umfassend abgesichert und nachvollzogen werden. Aufgrund der zunehmenden Komplexität, Flexibilität und Wandlungsfähigkeit dieser Systeme bei gleichzeitiger Verkürzung der Planungszeiträume hat sich in den letzten Jahren die Relevanz der Ablaufsimulation als Analysemethode kontinuierlich erhöht. Mit der Etablierung eines Simultaneous Engineering, der Einführung von Werkzeugen zur Digitalen Fabrik oder der Beherrschung neuer Herausforderungen im Zusammenhang mit den Bestrebungen von Industrie 4.0 unterliegt auch die Simulation neuen Entwicklungen. Das Buch wendet sich an Anwender, Forscher und Studierende in gleichem Maße.
Ableton Live 8 and Suite 8: Create, Produce, Perform
by Keith Robinson Huston SingletaryLearn how to create, produce and perform a whole new way; prepare to unlock the power of Live. This book and DVD combination shows, if you get it right, exactly what Ableton Live can deliver.Engineered to follow Lives non linear music environment the book looks and feels like the program, its unique format utilizes the terms and creative features of Live- tabs, keys, pointers, and labels to learn the littlest things that make the biggest difference.Packed with professional testimonials, concepts, definitions, hundred of tips and tricks and hidden features the book covers the software's nuts and bolts and creative technique to create, produce, perform and make music on the fly.The accompanying DVD contains ?Live sets? and web pointer information to sync and download as well as interviews, further hints and tips and video
Ableton Live 9: Create, Produce, Perform
by Keith RobinsonNever has there been music production software that so closely emulates the human mind and the demand for delivering music through a computer than Live. With an imaginative design and a forward-thinking mission, Ableton continues their legacy with Live 9, a software package that drives music production to the cutting edge while squarely meeting the needs of the composer, producer, perform, songwriter, DJ, and beyond. With such a progressive approach to its development, some of you may feel a bit disoriented or even intimidated at first sight of Live’s unconventional design, especially those of you coming from a traditional Digital Audio Workstation (DAW) background. If you are new to DAWs, DJ style programs, or software music production in general, then you’ll soon be right at home with the "parallel concept" of Live’s Session and Arrangement Views. For the rest of you, you’ll have to rethink your approach to composing, arranging and producing music just a bit; but it will be a worthwhile adjustment. That is why this book has been written: to help reinvent the experienced software-based music producer and to unleash the new user. The goal here is to build and cultivate a strong understanding of Live 9’s concepts and to provide material that will engage all DAW users alike. With this goal in mind, at the end of each reading you should feel that your current skills and knowledge base have been elevated to the next level. For the current Ableton Love user – yes, you - there is plenty here to unlock! After all, there is still a little "new user" inside us all. Now it is time to learn how to Create, Produce and Perform with Live 9 – all you have to do is decide what your needs are, because it’s all here. First published in 2013. Routledge is an imprint of Taylor & Francis, an informa company.
Abluft-Fibel: Reinigung lösemittelhaltiger Abgase
by Manfred NitscheDieses Fachbuch beschreibt welches Verfahren zur Abluftreinigung f#65533;r Sie das Richtige ist. Zun#65533;chst wird die indirekte und direkte Kondensation, sowie die Membrananreicherung mit Kondensation erl#65533;utert. Die weiteren Kapitel besch#65533;ftigen sich mit der Absorption der L#65533;semittel in geeigneten Waschfl#65533;ssigkeiten, der Regeneration des Waschmittels und geben Auskunft #65533;ber Adsorptionsverfahren mit Dampf,- Inertgas-, und Vakuumdesorption. Der abschlie#65533;ende Beitrag behandelt die thermische und biologische Entsorgung.
Abolish Silicon Valley: How to Liberate Technology from Capitalism
by Wendy LiuFormer insider turned critic Wendy Liu busts the myths of the tech industry, and offers a galvanising argument for why and how we must reclaim technology's potential for the public good.Former insider turned critic Wendy Liu busts the myths of the tech industry, and offers a galvanising argument for why and how we must reclaim technology's potential for the public good."Lucid, probing and urgent. Wendy Liu manages to be both optimistic about the emancipatory potential of tech and scathing about the industry that has harnessed it for bleak and self-serving ends." -- Naomi Klein, author of On Fire: The Burning Case for a Green New Deal"An inspiring memoir manifesto...Technologists all over the world are realizing that no amount of code can substitute for political engagement. Liu's memoir is a road map for that journey of realization." -- Cory Doctorow, author of Radicalized and Little BrotherInnovation. Meritocracy. The possibility of overnight success. What's not to love about Silicon Valley?These days, it's hard to be unambiguously optimistic about the growth-at-all-costs ethos of the tech industry. Public opinion is souring in the wake of revelations about Cambridge Analytica, Theranos, and the workplace conditions of Amazon workers or Uber drivers. It's becoming clear that the tech industry's promised "innovation" is neither sustainable nor always desirable.Abolish Silicon Valley is both a heartfelt personal story about the wasteful inequality of Silicon Valley, and a rallying call to engage in the radical politics needed to upend the status quo. Going beyond the idiosyncrasies of the individual founders and companies that characterise the industry today, Wendy Liu delves into the structural factors of the economy that gave rise to Silicon Valley as we know it. Ultimately, she proposes a more radical way of developing technology, where innovation is conducted for the benefit of society at large, and not just to enrich a select few.
About Designing: Analysing Design Meetings
by Janet McDonnell; Peter LloydThe twenty-one contributions to About: Designing draw on a rich variety of methodological positions, research backgrounds and design disciplines including architecture, product design, engineering, applied linguistics, communication studies, cognitive psychology, and discourse studies. Collectively these studies comprise a state-of-the-art overview
About-Face Space Race (AstroKids #5)
by Robert ElmerFun and funny, this book will make even reluctant readers eager to turn the pages. When a space scooter race becomes a battle between the boys and girls, who will step in and remind the AstroKids to work as a team?
About Star Architecture: Reflecting on Cities in Europe
by Davide Ponzini Alain Thierstein Nadia Alaily-MattarCities across the world have been resorting to star architects to brand their projects, spark urban regeneration and market the city image internationally. This book shifts the attention from star architects to star architecture, arguing that the process of deciding about and implementing relevant architectural and urban projects is not the product of any single actor. Star architecture can, in fact, be better studied and understood as assembled by multiple actors and in its relationship with urban transformation. In its 18 chapters, the book presents a multidisciplinary collection of expert contributions in the fields of urban planning, architecture, media studies, urban economics, geography, and sociology, consistently brought together for the first time to deal with this topic. Through a vast array of case studies and analytical techniques touching over 20 cities in Europe, the book shows the positive and more problematic impacts of star architecture with reference to the preservation of built heritage, tourism and media. The book will be of interest to architects, sociologists, urban planners, and public administrators.
About Time: A History Of Civilization In Twelve Clocks
by David RooneyA captivating, surprising history of timekeeping and how it has shaped our world. For thousands of years, people of all cultures have made and used clocks, from the city sundials of ancient Rome to the medieval water clocks of imperial China, hourglasses fomenting revolution in the Middle Ages, the Stock Exchange clock of Amsterdam in 1611, Enlightenment observatories in India, and the high-precision clocks circling the Earth on a fleet of GPS satellites that have been launched since 1978. Clocks have helped us navigate the world and build empires, and have even taken us to the brink of destruction. Elites have used them to wield power, make money, govern citizens, and control lives—and sometimes the people have used them to fight back. Through the stories of twelve clocks, About Time brings pivotal moments from the past vividly to life. Historian and lifelong clock enthusiast David Rooney takes us from the unveiling of al-Jazari’s castle clock in 1206, in present-day Turkey; to the Cape of Good Hope observatory at the southern tip of Africa, where nineteenth-century British government astronomers moved the gears of empire with a time ball and a gun; to the burial of a plutonium clock now sealed beneath a public park in Osaka, where it will keep time for 5,000 years. Rooney shows, through these artifacts, how time has been imagined, politicized, and weaponized over the centuries—and how it might bring peace. Ultimately, he writes, the technical history of horology is only the start of the story. A history of clocks is a history of civilization.
Above and Beyond: NASA's Journey to Tomorrow
by Discovery Olugbemisola Rhuday-PerkovichSince NASA was established in 1958, it has landed rovers on distant planets and launched telescopes deep into space—all so that we can look back to the beginning of time. <P><P> Through stunning images provided by NASA and fascinating profiles and sidebars of lesser known contributors to the NASA program, young space fans will learn how NASA started, how it faced challenges along the way, how much it has achieved, and how it will continue to move forward in the future. <P> NASA’s boundless curiosity and urge to explore lies at the heart of the human adventure. NASA rises to the urgent challenges we face, using its massive reach and expertise to find answers to vital questions like: How can we learn to live in a more extreme natural environment? <P> Inspired by Rory Kennedy’s documentary of the same name (airing 10/2018), Above and Beyond aims to leave audiences hopeful and inspired about the future of our planet—and convinced that NASA is essential to our continued survival as we mark its important anniversaries and dream of new discoveries to come.
Above Ground Storage Tanks: Practical Guide to Construction, Inspection, and Testing
by Sunil PullarcotCovers All Site Activities after DesignAbove Ground Storage Tanks: Practical Guide to Construction, Inspection, and Testing is an ideal guide for engineers involved in the mechanical construction of above ground storage tanks. This text details the construction of storage tanks in accordance with the American Petroleum Institute requirements for AP
Abraham Lincoln’s Cyphering Book and Ten other Extraordinary Cyphering Books
by M. A. Ken Clements Nerida F. EllertonThis well-illustrated book provides strong qualitative and comparative support for the main arguments developed by Nerida Ellerton and Ken Clements in their groundbreaking Rewriting this History of School Mathematics in North America 1607-1861: The Central Role of Cyphering Books. Eleven extraordinary handwritten school mathematics manuscripts are carefully analyzed--six were prepared entirely in Great Britain, four entirely in North America, and 1 partly in Great Britain and partly in North America. The earliest of the 11 cyphering books was prepared around 1630, and the latest in 1835. Seven of the manuscripts were arithmetic cyphering books; three were navigation cyphering books, and one was a mensuration/surveying manuscript. One of the cyphering books examined in this book was prepared, over the period 1819-1826, by a young Abraham Lincoln, when he was attending small one-teacher schools in remote Spencer County, Indiana. Chapter 6 in this book provides the first detailed analysis of young Abraham's cyphering book--which is easily the oldest surviving Lincoln manuscript. Another cyphering book, this one prepared by William Beattie in 1835, could have been prepared as a special gift for the King of England. The analyses make clear the extent of the control which the cyphering tradition had over school mathematics in North America and Great Britain between 1630 and 1840. In their final chapter Ellerton and Clements identify six lessons from their research into the cyphering tradition which relate to present-day circumstances surrounding school mathematics. These lessons are concerned with sharp differences between intended, implemented and attained curricula, the remarkable value that many students placed upon their cyphering books, the ethnomathematical circumstances which surrounded the preparations of the extraordinary cyphering books, and qualitative differences between British and North American school mathematics.
Abrasive Water Jet Machining of Engineering Materials (SpringerBriefs in Applied Sciences and Technology)
by Kapil Gupta JagadishThis book presents insights in green techniques used in conventional and advanced machining. It consists of various experimental case studies conducted by the authors on green machining of difficult-to-machine materials, polymer and ceramic materials. Effects of green techniques / processes on machining properties like material removal rate, surface quality, geometric accuracy, productivity, and environment while machining various materials are reported.
Abrechnung und Bezahlung von Bauleistungen: Schnelleinstieg für Architekten und Bauingenieure (essentials)
by Andreas SchmidtAndreas Schmidt gibt praktische Hilfestellung f#65533;r die zeitnahe Realisierung und Absicherung von Verg#65533;tungsanspr#65533;chen. Dies ist f#65533;r Bauunternehmen eine wesentliche Voraussetzung f#65533;r den Unternehmenserfolg, denn diese sind nach der gesetzlichen Konzeption des Werkvertragsrechts grunds#65533;tzlich vorleistungspflichtig - d. h. sie m#65533;ssen das f#65533;r die Leistungserbringung erforderliche Personal, Material und Ger#65533;t zun#65533;chst vorfinanzieren. Der Autor zeigt, wie der Bauunternehmer die Regelungen im BGB und in der VOB/B betreffend die Abrechnung seiner Leistung sachgem#65533;#65533; anwendet, um Zahlungsfl#65533;sse zu beschleunigen. Zudem erf#65533;hrt der Unternehmer, wie er reagieren kann, wenn der Auftraggeber versp#65533;tet oder gar nicht zahlt und wie er seinen Verg#65533;tungsanspruch f#65533;r den Insolvenzfall absichern kann.
Abrir en caso de apocalipsis: Guía rápida para reconstruir la civilización
by Lewis Dartnell"Una mirada fascinante a los principios básicos de las principales tecnologías que sostienen la sociedad contemporánea" Wall Street Jounal Una pandemia incontrolable, el impacto de un meteorito, o quizá una guerra nuclear; por el motivo que sea, el mundo que conocemos ha desaparecido y los escasos supervivientes deben comenzar de cero. ¿Cuáles son los conocimientos fundamentales necesarios para reconstruir nuestra civilización? Tras recoger lo poco lo poco que queda, ¿cómo se puede empezar a producir lo esencial? ¿Cómo cultivar alimentos, generar electricidad, preparar medicinas o extraer metal de las rocas? ¿Se puede evitar una nueva edad oscura y aprovechar los atajos para conseguir de nuevo el desarrollo? La vida en las sociedades contemporáneas nos han desconectado de los procesos básicos que nos sostienen, así como de las elegantes premisas científicas que permiten aprender las cosas por uno mismo. "Abrir en caso de apocalipsis" es un viaje de exploración, un libro que explica todo lo que hay que saber acerca de todo lo que nos rodea. Una guía rápida para reiniciar la civilización que transformará nuestra comprensión del mundo, y nos ayudará cuando este ya no exista.
Abriss der Bierbrauerei
by Ludwig Narziss Martin Zarnkow Martina Gastl Werner BackDas Lehrbuch zur Bierbrauerei von Ludwig Narziß ist seit vielen Jahren das Standardwerk auf diesem Gebiet. Die neue, achte Auflage wurde komplett überarbeitet und aktualisiert. Für Studenten ist das Buch ein kurz gefasster Leitfaden, der jedoch alle wesentlichen Aspekte abdeckt. Der bereits im Betrieb tätige Praktiker erhält eine Fülle von Anregungen und einen umfassenden Überblick über den heutigen Stand der Brauereitechnologie sowie der naturwissenschaftlichen Grundlagen der Bierbrauerei. Neu in dieser Auflage: * das Kapitel "Die Deutschen Biertypen" * das Kapitel "Malze aus anderen Getreidearten und deren Verarbeitung" * weiterführende Literatur ab Kapitel 3 Das Autorenteam ist um drei hervorragende Fachleute auf dem Gebiet der Bierbrauerei erweitert worden. Werner Back, Martin Zarnkow und Martina Gastl (alle Technische Universität München, Weihenstephan) stehen für die kontinuierliche Weiterentwicklung dieses Lehrbuches.
Abschlussarbeiten mit LaTeX erstellen: Eine Einführung für Ingenieure, Informatiker und Naturwissenschaftler
by Marcel Müller Elmar WingsDieses Buch vermittelt die Grundlagen und das notwendige Spezialwissen, das zum Schreiben von wissenschaftlichen Abschlussarbeiten mit LaTeX erforderlich ist. Das schließt Bachelor- und Masterarbeiten sowie Dissertationen ein. Es eignet sich aber auch für die ersten Laborberichte, Studien- und Seminararbeiten.Der Leser lernt die Funktionsweise von LaTeX und diverse Werkzeuge kennen. Zur Wissensvermittlung werden Quelltextbeispiele verwendet. Übungsaufgaben und Kontrollfragen am Ende der Kapitel helfen beim Vertiefen des Erlernten. Verweise auf weiterführende Literatur und auf die jeweiligen Paketbeschreibungen unterstützen den Leser dabei, sein Wissen über den Inhalt dieses Buches hinaus zu erweitern.Das Ziel dieses Buches ist es, den Leser dahingehend zu befähigen, dass er effizient eine wissenschaftliche Abschlussarbeit in hoher typografischer Qualität mit LaTeX anfertigen kann, wenig Zeit in das Formatieren investieren muss und fokussiert am Inhalt arbeiten kann.
An Absolute Beginner's Guide to Keeping Backyard Chickens: Watch Chicks Grow from Hatchlings to Hens
by Jenna WoginrichWith delightful photographs, Jenna Woginrich chronicles the life journey of three chickens (Amelia, Honey, and Tilda) from fluffy, newly hatched bundles to grown hens laying eggs of their own. Following their progress from day to day and week to week, you'll learn everything you need to know to be successful in raising and keeping a happy, healthy flock. Topics covered include understanding chicken behavior; housing and feeding requirements; and hygiene and basic health care. Both entertaining and educational, this highly accessible book provides just the right amount of information to get started and enjoy the pleasures of keeping backyard chickens. This publication conforms to the EPUB Accessibility specification at WCAG 2.0 Level AA.
An Absolute Beginner's Guide to Raising Backyard Ducks: Breeds, Feeding, Housing and Care, Eggs and Meat
by Gail DamerowThis inspiring introductory guide provides all the information beginners need to raise ducks successfully in the yard or on a small homestead or farm. Ducks are quickly gaining on chickens as popular animals for the backyard homestead or small farm. They are friendly, productive, good at eating pests, remarkably healthy, and easier to raise than chickens in many ways. Plus, they are exceptionally adorable! This accessible introductory guide features original photography tracking the growth and care of a small flock of backyard ducks, and addresses everything the beginner duck keeper needs to know to be successful, including breed selection, housing, feeding, health care, understanding behavior, and egg and meat production. This publication conforms to the EPUB Accessibility specification at WCAG 2.0 Level AA.
Absolute Essentials of Ethereum (Absolute Essentials of Business and Economics)
by Paul Dylan-EnnisAbsolute Essentials of Ethereum is a concise textbook which guides the reader through the fascinating world of the emerging Ethereum ecosystem, from the basics of how its blockchain works to cutting-edge applications.Written by an experienced educator, each chapter is designed to progress potential students from class to class. Technical concepts are clearly explained for those new to the topic and readers are supported with definitions and summaries in each chapter. Real-life case studies situate the overviews in a contemporary context. Topics covered include the Ethereum Execution and Consensus layers, Ethereum governance and community, Decentralised Autonomous Organisations (DAOs), Decentralised Finance (DeFi), Non-Fungible Tokens (NFTs) and Layer 2.This book is the ideal text to support undergraduate and postgraduate courses on blockchain technologies, cryptocurrencies, Web3 and fintech, as well as for those who want to know how Ethereum really works.
Absolute Risk: Methods and Applications in Clinical Management and Public Health (Chapman & Hall/CRC Monographs on Statistics and Applied Probability)
by Ruth M. Pfeiffer Mitchell H. GailAbsolute Risk: Methods and Applications in Clinical Management and Public Health provides theory and examples to demonstrate the importance of absolute risk in counseling patients, devising public health strategies, and clinical management. The book provides sufficient technical detail to allow statisticians, epidemiologists, and clinicians to build, test, and apply models of absolute risk. Features: Provides theoretical basis for modeling absolute risk, including competing risks and cause-specific and cumulative incidence regression Discusses various sampling designs for estimating absolute risk and criteria to evaluate models Provides details on statistical inference for the various sampling designs Discusses criteria for evaluating risk models and comparing risk models, including both general criteria and problem-specific expected losses in well-defined clinical and public health applications Describes many applications encompassing both disease prevention and prognosis, and ranging from counseling individual patients, to clinical decision making, to assessing the impact of risk-based public health strategies Discusses model updating, family-based designs, dynamic projections, and other topics Ruth M. Pfeiffer is a mathematical statistician and Fellow of the American Statistical Association, with interests in risk modeling, dimension reduction, and applications in epidemiology. She developed absolute risk models for breast cancer, colon cancer, melanoma, and second primary thyroid cancer following a childhood cancer diagnosis. Mitchell H. Gail developed the widely used "Gail model" for projecting the absolute risk of invasive breast cancer. He is a medical statistician with interests in statistical methods and applications in epidemiology and molecular medicine. He is a member of the National Academy of Medicine and former President of the American Statistical Association. Both are Senior Investigators in the Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health.