- Table View
- List View
Systems Biology Volume 1: Integrative Biology and Simulation Tools
by Aleš Prokop Bela CsukasGrowth in the pharmaceutical market has slowed down - almost to a standstill. One reason is that governments and other payers are cutting costs in a faltering world economy. But a more fundamental problem is the failure of major companies to discover, develop and market new drugs. Major drugs losing patent protection or being withdrawn from the market are simply not being replaced by new therapies - the pharmaceutical market model is no longer functioning effectively and most pharmaceutical companies are failing to produce the innovation needed for success. This multi-authored new book looks at a vital strategy which can bring innovation to a market in need of new ideas and new products: Systems Biology (SB). Modeling is a significant task of systems biology. SB aims to develop and use efficient algorithms, data structures, visualization and communication tools to orchestrate the integration of large quantities of biological data with the goal of computer modeling. It involves the use of computer simulations of biological systems, such as the networks of metabolites comprise signal transduction pathways and gene regulatory networks to both analyze and visualize the complex connections of these cellular processes. SB involves a series of operational protocols used for performing research, namely a cycle composed of theoretical, analytic or computational modeling to propose specific testable hypotheses about a biological system, experimental validation, and then using the newly acquired quantitative description of cells or cell processes to refine the computational model or theory.
Systems Biology and Bioinformatics: A Computational Approach
by Kayvan Najarian Siamak Najarian Shahriar Gharibzadeh Christopher N. EichelbergerThe availability of molecular imaging and measurement systems enables today's biologists to swiftly monitor thousands of genes involved in a host of diseases, a critical factor in specialized drug development. Systems Biology and Bioinformatics: A Computational Approach provides students with a comprehensive collection of the computational methods
Systems Biomechanics of the Cell
by Ivan V. MalySystems Biomechanics of the Cell attempts to outline systems biomechanics of the cell as an emergent and promising discipline. The new field owes conceptually to cell mechanics, organism-level systems biomechanics, and biology of biochemical systems. Its distinct methodology is to elucidate the structure and behavior of the cell by analyzing the unintuitive collective effects of elementary physical forces that interact within the heritable cellular framework. The problematics amenable to this approach includes the variety of cellular activities that involve the form and movement of the cell body and boundary (nucleus, centrosome, microtubules, cortex, and membrane). Among the elementary system effects in the biomechanics of the cell, instability of symmetry, emergent irreversibility, and multiperiodic dissipative motion can be noted. Research results from recent journal articles are placed in this unifying framework. It is suggested that the emergent discipline has the potential to expand the spectrum of questions asked about the cell, and to further clarify the physical nature of animate matter and motion.
Systems Collaboration and Integration: See Past and Future Research through the PRISM Center (Automation, Collaboration, & E-Services #14)
by Chin-Yin Huang Sang Won YoonThis book is a groundbreaking exploration of the historical and contemporary challenges in systems collaboration and integration. This exceptional book delves into engineering design, planning, control, and management, offering invaluable insights into the evolving nature of systems and networks. In an era defined by the ongoing cyber and digital transformation, coupled with artificial intelligence and machine learning, this book offers insights into the future of systems collaboration and integration. Over the past three decades, the PRISM Center and its affiliated PRISM Global Research Network (PGRN) have spearheaded pioneering theories, technologies, and applications in the realm of systems collaboration and integration. Their research, driven by the motto “Knowledge through information; Wisdom through collaboration,” has yielded remarkable advancements. Those achievements and papers presented and updated by the PGRN scholars in the 26th ICPR are included in this book.
Systems Design Based on the Benefits of Inconvenience (Translational Systems Sciences #31)
by Hiroshi KawakamiThis book is about the "benefits of inconvenience (BoI)", providing a new approach to designing innovative systems and opening an alternative viewpoint to readers for looking at the world. BoI says that convenient living has “black boxed” the processes we used to rely on, while BoI is about looking at the benefits that were originally provided by these actions that have been black-boxed. Consider the relationship between humans and artificial objects, or things, newly created by engineering technology. In the past, things were “extensions” of people, but before we knew it, things began to substitute for people. BoI can be a keyword for thinking about the relationship that should come after “substitution”. It is a principle of systems design, one that requires time and effort rather than being convenient without any bother. Leading system scientists, technology creators, service producers, and product designers have contributed to this volume. In the first half of the book, many researchers describe their theory of BoI from the perspectives of systems engineers, value engineers, designers, and innovators. In the second half of the book, examples of implementing BoI are introduced in various fields, such as product design, service design, social robotics, tourism engineering, and human activity support systems. They will support innovations in systems or services. It is generally said that necessity is the mother of invention. In that belief, inconveniences should be eliminated, which can be a motive force for new technological development. On the other hand, this book shows that inconveniences are not something to be eliminated, but, on the contrary, are essential to obtain some benefit, and shows us how to create beneficial inconveniences.
Systems Design and Engineering: Facilitating Multidisciplinary Development Projects
by G. Maarten Bonnema Karel T. Veenvliet Jan F. BroeninkSystems Engineering is gaining importance in the high-tech industry with systems like digital single-lens reflex cameras, medical imaging scanners, and industrial production systems. Such systems require new methods that can handle uncertainty in the early phases of development, that systems engineering can provide. This book offers a toolbox approach by presenting the tools and illustrating their application with examples. This results in an emphasis on the design of systems, more than on analysis and classical systems engineering. The book is useful for those who need an introduction to system design and engineering, and those who work with system engineers, designers and architects.
Systems Engineering & Management: Ein generischer Ansatz zur Gestaltung und Lenkung sozio-technischer Systeme
by Volker AhrensDieses Buch zeigt Schritt für Schritt, wie man technische Systeme effizient und effektiv entwickelt, realisiert (Engineering) und betreibt (Administration). Dazu wird zunächst erklärt, wie komplexe reale Systeme vereinfacht, also modelliert werden, um ihre relevanten Eigenschaften sichtbar zu machen. Dies erfolgt interdisziplinär, indem neben technologischen auch soziologische und psychologische Aspekte berücksichtigt werden. Anschließend werden fünf allgemeingültige Vorgehensmodelle erläutert, die ausreichen, um Systeme in allen ihren Lebensphasen zu gestalten und zu lenken. Schließlich wird der Problemlösungszyklus im Detail erläutert. Für jede Phase einer Entwicklung wird erklärt, was wann, warum und wie getan werden sollte, um das Vorhaben erfolgreich abzuschließen. Ergänzend werden Bezüge zum Projektmanagement hergestellt. Alle erläuterten Modelle, Methoden, Verfahren und Werkzeuge haben sich in der Praxis schon vielfach bewährt. Daher eignet sich das Buch als Leitfaden für Praktiker*innen und für die akademische Lehre. Vor allem diejenigen, die nicht nur wissen wollen, was sie tun sollen, sondern auch verstehen wollen, warum das eine besser funktioniert als das andere, werden nicht nur entsprechende Erklärungen finden, sondern darüber hinaus auch zahlreiche Anregungen, die zum konstruktiv-kritischen Weiterdenken verleiten und Innovation ermöglichen.
Systems Engineering Agile Design Methodologies
by James A. Crowder Shelli FriessThis book examines the paradigm of the engineering design process. The author discusses agile systems and engineering design. The book captures the entire design process (function bases), context, and requirements to affect real reuse. It provides a methodology for an engineering design process foundation for modern and future systems design. Captures design patterns with context for actual Systems Engineering Design Reuse and contains a new paradigm in Design Knowledge Management.
Systems Engineering Competency Assessment Guide
by INCOSESystems Engineering Compilation of 37 competencies needed for systems engineering, with information for individuals and organizations on how to identify and assess competence This book provides guidance on how to evaluate proficiency in the competencies defined in the systems engineering competency framework and how to differentiate between proficiency at each of the five levels of proficiency defined within that document. Readers will learn how to create a benchmark standard for each level of proficiency within each competence area, define a set of standardized terminology for competency indicators to promote like-for-like comparison, and provide typical non-domain-specific indicators of evidence which may be used to confirm experience in each competency area. Sample topics covered by the three highly qualified authors include: The five proficiency levels: awareness, supervised practitioner, practitioner, lead practitioner, and expert The numerous knowledge, skills, abilities, and behavior indicators of each proficiency level What an individual needs to know and be able to do in order to behave as an effective systems engineer How to develop training courses, education curricula, job advertisements, job descriptions, and job performance evaluation criteria for system engineering positions For organizations, companies, and individual practitioners of systems engineering, this book is a one-stop resource for considering the competencies defined in the systems engineering competency framework and judging individuals based off them.
Systems Engineering Guidebook: A Process for Developing Systems and Products (Systems Engineering Ser. #10)
by James N. MartinSystems Engineering Guidebook: A Process for Developing Systems and Products is intended to provide readers with a guide to understanding and becoming familiar with the systems engineering process, its application, and its value to the successful implementation of systems development projects. The book describes the systems engineering process as a multidisciplinary effort. The process is defined in terms of specific tasks to be accomplished, with great emphasis placed on defining the problem that is being addressed prior to designing the solution.
Systems Engineering Models: Theory, Methods, and Applications (Systems Innovation Book Series)
by Adedeji B. BadiruThis book presents a comprehensive compilation of practical systems engineering models. The application and recognition of systems engineering is spreading rapidly, however there is no book that addresses the availability and usability of systems engineering models. Notable among the models to be included are the V-Model, DEJI Model, and Waterfall Model. There are other models developed for specific organizational needs, which will be identified and presented in a practical template so that other organizations can learn and use them. A better understanding of the models, through a comprehensive book, will make these models more visible, embraced, and applied across the spectrum. Visit www.DEJImodel.com for model details. Features Covers applications to both small and large problems Displays decomposition of complex problems into smaller manageable chunks Discusses direct considerations of the pertinent constraints that exist in the problem domain Presents systematic linking of inputs to goals and outputs
Systems Engineering Neural Networks
by Alessandro Migliaccio Giovanni IannoneSYSTEMS ENGINEERING NEURAL NETWORKS A complete and authoritative discussion of systems engineering and neural networks In Systems Engineering Neural Networks, a team of distinguished researchers deliver a thorough exploration of the fundamental concepts underpinning the creation and improvement of neural networks with a systems engineering mindset. In the book, you’ll find a general theoretical discussion of both systems engineering and neural networks accompanied by coverage of relevant and specific topics, from deep learning fundamentals to sport business applications. Readers will discover in-depth examples derived from many years of engineering experience, a comprehensive glossary with links to further reading, and supplementary online content. The authors have also included a variety of applications programmed in both Python 3 and Microsoft Excel. The book provides: A thorough introduction to neural networks, introduced as key element of complex systems Practical discussions of systems engineering and forecasting, complexity theory and optimization and how these techniques can be used to support applications outside of the traditional AI domains Comprehensive explorations of input and output, hidden layers, and bias in neural networks, as well as activation functions, cost functions, and back-propagation Guidelines for software development incorporating neural networks with a systems engineering methodology Perfect for students and professionals eager to incorporate machine learning techniques into their products and processes, Systems Engineering Neural Networks will also earn a place in the libraries of managers and researchers working in areas involving neural networks.
Systems Engineering Principles and Practice
by Sam Seymour William N. Sweet Steven M. Biemer Alexander KossiakoffSystems Engineering Principles and Practice is a national standard textbook for the study of traditional systems engineering for advanced undergraduate and graduate students. It addresses the need for an introductory overview, first-text for the development and acquisition of complex technical systems. The material is well organized, readable and fundamental to learning how to think like a systems engineer and carry out best practices in the field. Since systems engineering is still developing as a discipline, there have been new concepts and practices that have entered the field since the text was published in 2003. As an increasing number of students have used the text, topics have been discovered that would benefit from expansion, integration and clarification.The proposed second edition will be developed by colleagues of the original authors to upgrade this unique interdisciplinary guide to systems engineering to maintain relevance and currency in this rapidly changing and demanding field.
Systems Engineering Principles and Practice: Principles And Practice (Wiley Series in Systems Engineering and Management #67)
by Steven M. Biemer Alexander Kossiakoff Samuel J. Seymour David A. FlaniganA comprehensive and interdisciplinary guide to systems engineering Systems Engineering: Principles and Practice, 3rd Edition is the leading interdisciplinary reference for systems engineers. The up-to-date third edition provides readers with discussions of model-based systems engineering, requirements analysis, engineering design, and software design. Freshly updated governmental and commercial standards, architectures, and processes are covered in-depth. The book includes newly updated topics on: Risk Prototyping Modeling and simulation Software/computer systems engineering Examples and exercises appear throughout the text, allowing the reader to gauge their level of retention and learning. Systems Engineering: Principles and Practice was and remains the standard textbook used worldwide for the study of traditional systems engineering. The material is organized in a manner that allows for quick absorption of industry best practices and methods. Throughout the book, best practices and relevant alternatives are discussed and compared, encouraging the reader to think through various methods like a practicing systems engineer.
Systems Engineering Simplified
by Robert Cloutier Clifton Baldwin Mary Alice BoneDesigned to give non-engineers an understanding of systems engineering, Systems Engineering Simplified presents a gentle introduction to the subject and its importance in any profession. The book shows you how to look at any system as a whole and use this knowledge to gain a better understanding of where a system might break down, how to troublesho
Systems Engineering Tools and Methods (Engineering and Management Innovation)
by Ali K. Kamrani Maryam AzimiWaste, inadequate system performance, cost overruns, and schedule problems often result from failure to apply advanced systems engineering early in project development. Systems engineering is a systematic method to manage the formulation, analysis, and interpretation of what a system will produce and whether the outcome is the one that is desired. This book provides detailed discussions on engineering design and management processes within system lifecycles. The text addresses various issues of systems engineering fundamentals, emphasizing an integrated approach. The author presents methods, frameworks, techniques and tools for designing, implementing, and managing large-scale systems.
Systems Engineering Using the DEJI Systems Model®: Evaluation, Justification, and Integration with Case Studies and Applications (Systems Innovation Book Series)
by Adedeji B. BadiruWhile we need to work more with a systems approach, there are few books that provide systems engineering theory and applications. This book presents a comprehensive collection of systems engineering models. Each of the models is fully covered with guidelines of how and why to use them, along with case studies. Systems Engineering Using the DEJI Systems Model®: Evaluation, Justification, and Integration with Case Studies and Applications provides systems integration as a unifying platform for systems of systems and presents a structured model for systems applications and explicit treatment of human-in-the-loop systems. It discusses systems design in detail and covers the justification methodologies along with examples. Systems evaluation tools and techniques are also included with a discussion on how engineering education is playing a major role for systems advancement. Practicing professionals, as well as educational institutions, governments, businesses, and industries, will find this book of interest.
Systems Engineering and Analysis (Prentice Hall International Series in Industrial and Systems Engineering)
by Benjamin S. Blanchard Wolter J. Fabrycky<p>For senior-level undergraduate and first and second year graduate systems engineering and related courses. Systems Engineering and Analysis, 5/e, provides a total life-cycle approach to systems and their analysis. <p>This practical introduction to systems engineering and analysis provides the concepts, methodologies, models, and tools needed to understand and implement a total life-cycle approach to systems and their analysis. The authors focus first on the process of bringing systems into being—beginning with the identification of a need and extending that need through requirements determination, functional analysis and allocation, design synthesis, evaluation, and validation, operation and support, phase-out, and disposal. Next, the authors discuss the improvement of systems currently in being, showing that by employing the iterative process of analysis, evaluation, feedback, and modification, most systems in existence can be improved in their affordability, effectiveness, and stakeholder satisfaction.</p>
Systems Engineering and Analysis of Electro-Optical and Infrared Systems
by William Wolfgang ArrasmithElectro-optical and infrared systems are fundamental in the military, medical, commercial, industrial, and private sectors. Systems Engineering and Analysis of Electro-Optical and Infrared Systems integrates solid fundamental systems engineering principles, methods, and techniques with the technical focus of contemporary electro-optical and infrared optics, imaging, and detection methodologies and systems. The book provides a running case study throughout that illustrates concepts and applies topics learned. It explores the benefits of a solid systems engineering-oriented approach focused on electro-optical and infrared systems.This book covers fundamental systems engineering principles as applied to optical systems, demonstrating how modern-day systems engineering methods, tools, and techniques can help you to optimally develop, support, and dispose of complex, optical systems. It introduces contemporary systems development paradigms such as model-based systems engineering, agile development, enterprise architecture methods, systems of systems, family of systems, rapid prototyping, and more. It focuses on the connection between the high-level systems engineering methodologies and detailed optical analytical methods to analyze, and understand optical systems performance capabilities.Organized into three distinct sections, the book covers modern, fundamental, and general systems engineering principles, methods, and techniques needed throughout an optical system’s development lifecycle (SDLC); optical systems building blocks that provide necessary optical systems analysis methods, techniques, and technical fundamentals; and an integrated case study that unites these two areas. It provides enough theory, analytical content, and technical depth that you will be able to analyze optical systems from both a systems and technical perspective.
Systems Engineering and Architecting: Creating Formal Requirements
by Laurence BellagambaSystems Engineering and Architecting: Creating Formal Requirements presents formal requirements to help you accomplish key systems engineering and architecting activities more efficiently. The formal requirements-explicit, executable, verifiable instructions-explain how to model systems behavior, make decisions, establish natural language requirements, and improve your systems engineering and architecting processes.Each chapter opens with case studies and lessons learned, which supply the real-world context for the formal requirements. Topics covered include how to use fuzzy logic and agents to model uncertainty and how to make decisions when confronted with ambiguity. The book also clarifies the differences between architecting and systems engineering.Mathematical Tools for Systems Engineering and ArchitectingWritten in Mathematica (R), each formal requirement provides a tool or serves as the algorithm for a more efficient implementation in another form. All of the requirements are available as an open source library for anyone to use, improve upon, or add to. Worked examples, illustrations, and example surveys help you apply the requirements to your own systems. The book also lists heuristics to guide you in those systems engineering or architecting activities that cannot yet be formally stipulated.Bring More Consistency to Your Systems Development and ManagementAcknowledging that much of the practice remains an art, this book brings as much scientific rigor as possible to the tasks performed by systems engineers and architects. Written by a director of engineering who led systems engineering or architecting efforts for the Space Shuttle Program, Space Control Architecture Development, and others, this book shows you how to develop more consistent processes for large-scale systems.
Systems Engineering and Safety: Building the Bridge
by Peter J. GlismannSystems engineering principles are currently being applied to system safety best practices in several industries, as well as state and local governments. This book covers the payoff in both dollars and goodwill to the investment made in merging those two important and often neglected disciplines. It can be read, understood, and acted upon by the Chief Executive Officer of a multinational corporation, right down to the line manager of systems engineering or the technical professional in the safety department. The value in terms of cost savings, be it in the form of financial, human, or social capital, is clearly illustrated with real world examples.
Systems Engineering for Commercial Aircraft: A Domain-Specific Adaptation
by Scott JacksonThe key principle of systems engineering is that an aircraft should be considered as a whole and not as a collection of parts. Another principle is that the requirements for the aircraft and its subsystems emanate from a logical set of organized functions and from economic or customer-oriented requirements as well as the regulatory requirements for certification. The resulting process promises to synthesize and validate the design of aircraft which are higher in quality, better meet customer requirements and are most economical to operate. This book is more of a how to and a why to rather than a what to guide. It stresses systems engineering is an integrated technical-managerial process that can be adapted without sacrificing quality in which risk handling and management is a major part. It explains that the systems view applies to both the aircraft and the entire air transport system. The book emphasizes that system engineering is not an added layer of processes on top of the existing design processes; it is the glue that holds all the other processes together. The readership includes the aircraft industry, suppliers and regulatory communities, especially technical, program and procurement managers; systems, design and specialty engineers (human factors, reliability, safety, etc.); students of aeronautical and systems engineering and technical management; and government agencies such as FAA and JAA.
Systems Engineering for Commercial Aircraft: A Domain-Specific Adaptation
by Scott JacksonThe key principle of systems engineering is that an aircraft should be considered as a whole and not as a collection of parts. Another principle is that the requirements for the aircraft and its subsystems emanate from a logical set of organized functions and from economic or customer-oriented requirements as well as the regulatory requirements for certification. The resulting process promises to synthesize and validate the design of aircraft which are higher in quality, better meet customer requirements and are most economical to operate. This book is more of a how to and a why to rather than a what to guide. It stresses systems engineering is an integrated technical-managerial process that can be adapted without sacrificing quality in which risk handling and management is a major part. It explains that the systems view applies to both the aircraft and the entire air transport system. The book emphasizes that system engineering is not an added layer of processes on top of the existing design processes; it is the glue that holds all the other processes together. The readership includes the aircraft industry, suppliers and regulatory communities, especially technical, program and procurement managers; systems, design and specialty engineers (human factors, reliability, safety, etc.); students of aeronautical and systems engineering and technical management; and government agencies such as FAA and JAA.
Systems Engineering for Commercial Aircraft: A Domain-Specific Adaptation
by Scott JacksonSystems-engineered aircraft are designed to transport passengers safely, ensuring all components work together seamlessly. This book explores the concept of aircraft as a complex system, including humans, with safety as a crucial aspect. By prioritizing safety and quality, fewer fatalities can be achieved, leading to efficient, reliable, and safe aircraft for passengers and crew.Systems Engineering for Commercial Aircraft: A Domain-Specific Adaptation, Third Edition focuses on Deming's definition of quality, its methods, and the benefits it brings, which were not covered in the previous edition. The Risk chapter will also be expanded to include discussions on Risk Denial, its consequences, and strategies to avoid it. A detailed examination of resilience will be provided, highlighting how it enables an aircraft to prevent, endure, and recover from disruptions such as bird strikes. The book will explore the proactive and reactive aspects of resilience, how a system, like an aircraft, can be defined by its functions, and how an aircraft's design should prioritize the needs of various stakeholders, including passengers, regulatory agencies, and other relevant parties.The primary audience for this book consists of major aircraft companies engaged in advanced design, aeronautical engineers, and systems engineers.
Systems Engineering for Microscale and Nanoscale Technologies
by M. Ann Garrison Darrin Janet L. BarthTo realize the full potential of micro- and nanoscale devices in system building, it is critical to develop systems engineering methodologies that successfully integrate stand-alone, small-scale technologies that can effectively interface with the macro world. So how do we accomplish this?Systems Engineering for Microscale and Nanoscale Technologie