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Stochastic Process Variation in Deep-Submicron CMOS
by Amir ZjajoOne of the most notable features of nanometer scale CMOS technology is the increasing magnitude of variability of the key device parameters affecting performance of integrated circuits. The growth of variability can be attributed to multiple factors, including the difficulty of manufacturing control, the emergence of new systematic variation-generating mechanisms, and most importantly, the increase in atomic-scale randomness, where device operation must be described as a stochastic process. In addition to wide-sense stationary stochastic device variability and temperature variation, existence of non-stationary stochastic electrical noise associated with fundamental processes in integrated-circuit devices represents an elementary limit on the performance of electronic circuits. In an attempt to address these issues, Stochastic Process Variation in Deep-Submicron CMOS: Circuits and Algorithms offers unique combination of mathematical treatment of random process variation, electrical noise and temperature and necessary circuit realizations for on-chip monitoring and performance calibration. The associated problems are addressed at various abstraction levels, i. e. circuit level, architecture level and system level. It therefore provides a broad view on the various solutions that have to be used and their possible combination in very effective complementary techniques for both analog/mixed-signal and digital circuits. The feasibility of the described algorithms and built-in circuitry has been verified by measurements from the silicon prototypes fabricated in standard 90 nm and 65 nm CMOS technology.
Stochastic Processes
by Toshio NakagawaReliability theory is of fundamental importance for engineers and managers involved in the manufacture of high-quality products and the design of reliable systems. In order to make sense of the theory, however, and to apply it to real systems, an understanding of the basic stochastic processes is indispensable. As well as providing readers with useful reliability studies and applications, Stochastic Processes also gives a basic treatment of such stochastic processes as: the Poisson process,the renewal process,the Markov chain,the Markov process, andthe Markov renewal process.Many examples are cited from reliability models to show the reader how to apply stochastic processes. Furthermore, Stochastic Processes gives a simple introduction to other stochastic processes such as the cumulative process, the Wiener process, the Brownian motion and reliability applications. Stochastic Processes is suitable for use as a reliability textbook by advanced undergraduate and graduate students. It is also of interest to researchers, engineers and managers who study or practise reliability and maintenance.
Stochastic Reachability Analysis of Hybrid Systems
by Luminita Manuela BujorianuStochastic reachability analysis (SRA) is a method of analyzing the behavior of control systems which mix discrete and continuous dynamics. For probabilistic discrete systems it has been shown to be a practical verification method but for stochastic hybrid systems it can be rather more. As a verification technique SRA can assess the safety and performance of, for example, autonomous systems, robot and aircraft path planning and multi-agent coordination but it can also be used for the adaptive control of such systems. Stochastic Reachability Analysis of Hybrid Systems is a self-contained and accessible introduction to this novel topic in the analysis and development of stochastic hybrid systems. Beginning with the relevant aspects of Markov models and introducing stochastic hybrid systems, the book then moves on to coverage of reachability analysis for stochastic hybrid systems. Following this build up, the core of the text first formally defines the concept of reachability in the stochastic framework and then treats issues representing the different faces of SRA: * stochastic reachability based on Markov process theory; * martingale methods; * stochastic reachability as an optimal stopping problem; and * dynamic programming. The book is rounded off by an appendix providing mathematical underpinning on subjects such as ordinary differential equations, probabilistic measure theory and stochastic modeling, which will help the non-expert-mathematician to appreciate the text. Stochastic Reachability Analysis of Hybrid Systems characterizes a highly interdisciplinary area of research and is consequently of significant interest to academic researchers and graduate students from a variety of backgrounds in control engineering, applied mathematics and computer science. The Communications and Control Engineering series reports major technological advances which have potential for great impact in the fields of communication and control. It reflects research in industrial and academic institutions around the world so that the readership can exploit new possibilities as they become available.
Stochastic Reliability and Maintenance Modeling
by Toshio Nakagawa Tadashi DohiIn honor of the work of Professor Shunji Osaki, Stochastic Reliability and Maintenance Modeling provides a comprehensive study of the legacy of and ongoing research in stochastic reliability and maintenance modeling. Including associated application areas such as dependable computing, performance evaluation, software engineering, communication engineering, distinguished researchers review and build on the contributions over the last four decades by Professor Shunji Osaki. Fundamental yet significant research results are presented and discussed clearly alongside new ideas and topics on stochastic reliability and maintenance modeling to inspire future research. Across 15 chapters readers gain the knowledge and understanding to apply reliability and maintenance theory to computer and communication systems. Stochastic Reliability and Maintenance Modeling is ideal for graduate students and researchers in reliability engineering, and workers, managers and engineers engaged in computer, maintenance and management works.
Stochastic Structural Optimization
by Makoto Yamakawa Makoto OhsakiStochastic Structural Optimization presents a comprehensive picture of robust design optimization of structures, focused on nonparametric stochastic-based methodologies. Good practical structural design accounts for uncertainty, for which reliability-based design offers a standard approach, usually incorporating assumptions on probability functions which are often unknown. By comparison, a worst-case approach with bounded support used as a robust design offers simplicity and a lower level of sensitivity. Linking structural optimization with these two approaches by a unified framework of non-parametric stochastic methodologies provides a rigorous theoretical background and high level of practicality. This text shows how to use this theoretical framework in civil and mechanical engineering practice to design a safe structure which accounts for uncertainty. Connects theory with practice in the robust design optimization of structures Advanced enough to support sound practical designs This book provides comprehensive coverage for engineers and graduate students in civil and mechanical engineering.Makoto Yamakawa is a Professor at Tokyo University of Science, and a member of the Advisory Board of the 2020 Asian Congress of Structural and Multidisciplinary Optimization. Makoto Ohsaki is a Professor at Kyoto University, Japan, treasurer of the International Association for Shell & Spatial Structures and former President of the Asian Society for Structural and Multidisciplinary Optimization.
Stochastic Systems
by Mircea GrigoriuUncertainty is an inherent feature of both properties of physical systems and the inputs to these systems that needs to be quantified for cost effective and reliable designs. The states of these systems satisfy equations with random entries, referred to as stochastic equations, so that they are random functions of time and/or space. The solution of stochastic equations poses notable technical difficulties that are frequently circumvented by heuristic assumptions at the expense of accuracy and rigor. The main objective of Stochastic Systems is to promoting the development of accurate and efficient methods for solving stochastic equations and to foster interactions between engineers, scientists, and mathematicians. To achieve these objectives Stochastic Systems presents: A clear and brief review of essential concepts on probability theory, random functions, stochastic calculus, Monte Carlo simulation, and functional analysis Probabilistic models for random variables and functions needed to formulate stochastic equations describing realistic problems in engineering and applied sciences Practical methods for quantifying the uncertain parameters in the definition of stochastic equations, solving approximately these equations, and assessing the accuracy of approximate solutions Stochastic Systems provides key information for researchers, graduate students, and engineers who are interested in the formulation and solution of stochastic problems encountered in a broad range of disciplines. Numerous examples are used to clarify and illustrate theoretical concepts and methods for solving stochastic equations. The extensive bibliography and index at the end of the book constitute an ideal resource for both theoreticians and practitioners.
Stochastic Teams, Games, and Control under Information Constraints (Systems & Control: Foundations & Applications)
by Tamer Başar Serdar YükselThis monograph presents a mathematically rigorous and accessible treatment of the interaction between information, decision, control, and probability in single-agent and multi-agent systems. The book provides a comprehensive and unified theory of information structures for stochastic control, stochastic teams, stochastic games, and networked control systems.Part I of the text is concerned with a general mathematical theory of information structures for stochastic teams, leading to systematic characterizations and classifications, geometric and topological properties, implications on existence, approximations and relaxations, their comparison, and regularity of optimal solutions in information. Information structures in stochastic games are then considered in Part II, and the dependence of equilibrium solutions and behavior on information is demonstrated. Part III studies information design through information theory in networked control systems – both linear and nonlinear – and discusses optimality and stability criteria. Finally, Part IV introduces information and signaling games under several solution concepts, with applications to prior mismatch, cost mismatch and privacy, reputation games and jamming. This text will be a valuable resource for researchers and graduate students interested in control theory, information theory, statistics, game theory, and applied mathematics. Readers should be familiar with the basics of linear systems theory, stochastic processes, and Markov chains.
Stochastic Tools in Mathematics and Science
by Alexandre J. Chorin Ole H Hald"Stochastic Tools in Mathematics and Science" covers basic stochastic tools used in physics, chemistry, engineering and the life sciences. The topics covered include conditional expectations, stochastic processes, Brownian motion and its relation to partial differential equations, Langevin equations, the Liouville and Fokker-Planck equations, as well as Markov chain Monte Carlo algorithms, renormalization, basic statistical mechanics, and generalized Langevin equations and the Mori-Zwanzig formalism. The applications include sampling algorithms, data assimilation, prediction from partial data, spectral analysis, and turbulence. The book is based on lecture notes from a class that has attracted graduate and advanced undergraduate students from mathematics and from many other science departments at the University of California, Berkeley. Each chapter is followed by exercises. The book will be useful for scientists and engineers working in a wide range of fields and applications. For this new edition the material has been thoroughly reorganized and updated, and new sections on scaling, sampling, filtering and data assimilation, based on recent research, have been added. There are additional figures and exercises. Review of earlier edition: "This is an excellent concise textbook which can be used for self-study by graduate and advanced undergraduate students and as a recommended textbook for an introductory course on probabilistic tools in science." Mathematical Reviews, 2006
Stochastic Transport in Upper Ocean Dynamics II: STUOD 2022 Workshop, London, UK, September 26–29 (Mathematics of Planet Earth #11)
by Bertrand Chapron Dan Crisan Darryl Holm Etienne Mémin Anna RadomskaThis open access proceedings volume brings selected, peer-reviewed contributions presented at the Third Stochastic Transport in Upper Ocean Dynamics (STUOD) 2022 Workshop, held virtually and in person at the Imperial College London, UK, September 26–29, 2022. The STUOD project is supported by an ERC Synergy Grant, and led by Imperial College London, the National Institute for Research in Computer Science and Automatic Control (INRIA) and the French Research Institute for Exploitation of the Sea (IFREMER). The project aims to deliver new capabilities for assessing variability and uncertainty in upper ocean dynamics. It will provide decision makers a means of quantifying the effects of local patterns of sea level rise, heat uptake, carbon storage and change of oxygen content and pH in the ocean. Its multimodal monitoring will enhance the scientific understanding of marine debris transport, tracking of oil spills and accumulation of plastic in the sea.All topics of these proceedings are essential to the scientific foundations of oceanography which has a vital role in climate science. Studies convened in this volume focus on a range of fundamental areas, including:Observations at a high resolution of upper ocean properties such as temperature, salinity, topography, wind, waves and velocity;Large scale numerical simulations;Data-based stochastic equations for upper ocean dynamics that quantify simulation error;Stochastic data assimilation to reduce uncertainty.These fundamental subjects in modern science and technology are urgently required in order to meet the challenges of climate change faced today by human society. This proceedings volume represents a lasting legacy of crucial scientific expertise to help meet this ongoing challenge, for the benefit of academics and professionals in pure and applied mathematics, computational science, data analysis, data assimilation and oceanography.
Stochastic Transport in Upper Ocean Dynamics III: STUOD 2023 Workshop, Plouzané, France, September 25–28 (Mathematics of Planet Earth #13)
by Bertrand Chapron Dan Crisan Darryl D. Holm Etienne Mémin Jane-Lisa CoughlanThis open-access proceedings volume brings selected, peer-reviewed contributions presented at the Fourth Stochastic Transport in Upper Ocean Dynamics (STUOD) 2023 Workshop, held at IFREMER in Plouzané, France, September 25–28, 2023. The STUOD project is supported by an ERC Synergy Grant, and led by Imperial College London, the National Institute for Research in Computer Science and Automatic Control (INRIA), and the French Research Institute for Exploitation of the Sea (IFREMER). The project aims to deliver new capabilities for assessing variability and uncertainty in upper ocean dynamics. It will provide decision makers a means of quantifying the effects of local patterns of sea level rise, heat uptake, carbon storage, and change of oxygen content and pH in the ocean. Its multimodal monitoring will enhance the scientific understanding of marine debris transport, tracking of oil spills, and accumulation of plastic in the sea. All topics of these proceedings are essential to the scientific foundations of oceanography which has a vital role in climate science. Studies convened in this volume focus on a range of fundamental areas, including: Observations at a high resolution of upper ocean properties such as temperature, salinity, topography, wind, waves and velocity; Large-scale numerical simulations; Data-based stochastic equations for upper ocean dynamics that quantify simulation error; Stochastic data assimilation to reduce uncertainty. These fundamental subjects in modern science and technology are urgently required in order to meet the challenges of climate change faced today by human society. This proceedings volume represents a lasting legacy of crucial scientific expertise to help meet this ongoing challenge, for the benefit of academics and professionals in pure and applied mathematics, computational science, data analysis, data assimilation, and oceanography.
Stochastic Two-Dimensional Microscopic Traffic Model: Theory and Applications (Lecture Notes in Intelligent Transportation and Infrastructure)
by HongSheng QiMicroscopic traffic model serves as the foundation of traffic flow theory and is the basis for applications such as traffic simulation, autonomous vehicle simulation, and digital twin technology. Conventional traffic models have primarily focused on the longitudinal dimension and have been deterministic in nature. However, vehicles' movements involve both longitudinal and lateral dimensions, and their dynamics are inherently stochastic. Therefore, a two-dimensional treatment is essential.This book explores the theory and application of stochastic two-dimensional microscopic traffic models, including the development of theory, establishment of methods, and applications to autonomous vehicles. The book is organized into three sections: data, theory, and application. In the data section, various open-source trajectory data are analyzed and noise reduction techniques are discussed. In the theory section, various two-dimensional traffic models are developed. In the application section, the potential applications of these models are discussed, including behavioral inferences and lateral wandering. This book will be a useful reference for students, researchers and engineers in the fields of vehicle engineering and traffic technology.
Stochastik in den Ingenieurwissenschaften: Eine Einführung mit R
by Christine Müller Liesa DeneckeDas Buch bietet eine ausführliche Einführung in die Wahrscheinlichkeitsrechnung und Statistik für Ingenieur- und Naturwissenschaftler. Es behandelt die wesentlichen grundlegenden Methoden, die insbesondere im ingenieurwissenschaftlichen Bereich ihre Anwendung finden. Anhand von Beispielen und realen Datensätzen werden die Anwendungen der Methoden verdeutlicht und mit der freien Statistik Software R auch die Gelegenheit gegeben, alle Beispiele direkt nachzuvollziehen und die erlernten Methoden auf andere Datensätze anzuwenden. Dazu wird ebenfalls eine kurze Einführung in R gegeben. Am Ende jedes Abschnitts finden sich Übungsaufgaben mit deren Hilfe die Verfahren geübt werden können. Lösungen zu den Aufgaben werden elektronisch bereitgestellt.
Stock Exchange Trading Using Grid Pattern Optimized by A Genetic Algorithm with Speciation: The Case of S&P 500 (SpringerBriefs in Applied Sciences and Technology)
by Tiago Martins Rui NevesThis book presents a genetic algorithm that optimizes a grid template pattern detector to find the best point to trade in the SP 500. The pattern detector is based on a template using a grid of weights with a fixed size. The template takes in consideration not only the closing price but also the open, high, and low values of the price during the period under testing in contrast to the traditional methods of analysing only the closing price. Each cell of the grid encompasses a score, and these are optimized by an evolutionary genetic algorithm that takes genetic diversity into consideration through a speciation routine, giving time for each individual of the population to be optimized within its own niche. With this method, the system is able to present better results and improves the results compared with other template approaches. The tests considered real data from the stock market and against state-of-the-art solutions, namely the ones using a grid of weights which does not have a fixed size and non-speciated approaches. During the testing period, the presented solution had a return of 21.3% compared to 10.9% of the existing approaches. The use of speciation was able to increase the returns of some results as genetic diversity was taken into consideration.
Stoff- und Formleichtbau: Leichter Einstieg mit eindimensionalen Strukturen
by Andreas ÖchsnerDieses Lehrbuch stellt die unterschiedlichen Leichtbaukonzepte anhand einfacher eindimensionaler Strukturen in sehr verständlicher Weise dar und ermöglicht einen leichten Einstieg in das Thema. Es werden nachvollziehbare Informationen und Hinweise zur Werkstoffauswahl und geometrischen Gestaltung von Bauteilen gegeben.
Stone Cladding Engineering
by Rui de Sousa CamposinhosThis volume presents new methodologies for the design of dimension stone based on the concepts of structural design while preserving the excellence of stonemasonry practice in façade engineering. Straightforward formulae are provided for computing action on cladding, with special emphasis on the effect of seismic forces, including an extensive general methodology applied to non-structural elements. Based on the Load and Resistance Factor Design Format (LRDF), minimum slab thickness formulae are presented that take into consideration stress concentrations analysis based on the Finite Element Method (FEM) for the most commonly used modern anchorage systems. Calculation examples allow designers to solve several anchorage engineering problems in a detailed and objective manner, underlining the key parameters. The design of the anchorage metal parts, either in stainless steel or aluminum, is also presented.
Stone in Architecture
by Siegfried Siegesmund Rolf SnethlageThe weathering of historical buildings and, indeed, of monuments and sculptures of natural stone is a problem that has been encountered for hundreds of years. However, a dramatic increase in deterioration in the structure of our built heritage has been observed during the past century. To understand the complex interaction that the stone in a building suffers with its near environment (the building) and the macro environment (the local climate and atmospheric conditions) requires an interdisciplinary approach and the application of many disciplines. Climate change over the next 100 years is likely to have a range of direct and indirect impacts on many natural and physical environments, including the built environment. The protection of our architectural heritage has both cultural and historical importance, as well as substantial economic and ecological value. Large sums of money are being spent world-wide on measures for the preservation of monuments and historical buildings. The past few decades has seen an unprecedented level of research activity in this area, the results of which are often difficult to access and are summarized in the new edition of STONE IN ARCHITECTURE.
Stone Matrix Asphalt: Theory and Practice
by Krzysztof BlazejowskiIn the years since the development and subsequent success of Stone Matrix Asphalt (SMA), a plethora of articles have emerged, scattered throughout various publications. The time is right for a comprehensive resource that collects, examines, and organizes this information and makes it easily accessible. A compilation and distillation of the latest k
The Stone of Archimedes
by Trevor ScottJake Adams finds himself in a Tunisian prison, being held for murdering an international terrorist who happens to be well connected in that country. When a mysterious man suddenly shows up to offer him a get out of jail free card, Jake is a bit suspicious. But what choice does he have? To secure his release all he has to do is one favor for a wealthy Texas senator--find his sister who is missing somewhere in Europe. No problem. When Jake picks up a tail almost immediately after leaving Tunisia, he quickly discovers that this case might not be as easy as it seems. The case takes Jake across Italy, from Rome to the catacombs of Sicily, and finally to a harrowing rescue that could get him killed.
Stone Will Answer: A Journey Guided by Craft, Myth and Geology
by Beatrice SearleA beautiful memoir, travelogue and meditation on stone by artist and stone mason Beatrice Searle.'Extraordinary' Guardian‘A magnificent book’ Alex Woodcock‘Exceptional’ Kerri Andrews‘Luminous’ SpectatorAt the age of twenty-six, artist and Cathedral stonemason Beatrice Searle crossed the North Sea and walked 500 miles along a medieval pilgrim path through Southern Norway, taking with her a 40-kilogram Orcadian stone.Fascinated with the mysterious footprint stones of Northern Europe and the ancient Greco-Roman world, stones closely associated with travellers, saints and the inauguration of Kings, she follows in their footsteps as her stone becomes a talisman, a bedrock and an offering to those she meets along the way.Stone Will Answer is an unusual adventure story of journeys practical, spiritual and geological, of weight and motion, and an insight into a beguiling craft.
Stop-Motion-Trickfilme selber machen für Dummies Junior (Für Dummies)
by Vera Borngässer Michaela WeißYouTube-Videos schauen kann jeder, aber einen Stop-Motion-Trickfilm selbst produzieren? Das ist ganz einfach: Denke dir eine Geschichte aus und bastle aus einfachen Materialien Figuren. Lass die Puppen tanzen und vermische Wirklichkeit und Fantasie. Hintergründe und Ton-Dateien bieten wir dir zum Download an. Im Buch findest du außerdem jede Menge Tipps zu Beleuchtung, Geräuschen, Anordnung der Figuren und Spezialeffekten. Sei kreativ, bearbeite die Filme am Computer weiter und verblüffe Freunde und Familie mit deinem Video. Wir zeigen dir Schritt für Schritt, wie es geht. Bestens geeignet für Kinder und Jugendliche ab 8 Jahre.
Storage Networks Explained
by Wolfgang Mueller-Friedt Ulf Troppens Rainer Erkens Rainer Wolafka Nils HausteinAll you need to know about Storage Area NetworksThe amount of data of an average company doubles every year. Thus, companies who own 1TB of data today will own 32TB in five years. Storage networks help to tame such data quantities and to manage this data growth efficiently. Since stored data and information are the biggest asset of any company, anyone who is involved in the planning or the operation of IT systems requires a basic knowledge of the principle and the use of storage networks.Storage Networks Explained covers the fundaments, techniques and functions of storage networks such as disk subsystems, Fibre Channel SAN, Internet SCSI (iSCSI), Fibre Channel over Ethernet (FCoE), Network Attached Storage (NAS), file systems, and storage virtualization. Furthermore the authors describe the use of these techniques and how they are designed to achieve high-availability, flexibility, and scalability of data and applications. Additional attention is given to network backup and the management of storage networks. Written by leading experts in the field, this book on storage area networks is updated and fully revised.Key features:Presents the basic concepts of storage networks, such as I/O techniques, disk subsystems, virtualization, NAS and SAN file systemsCovers the design of storage networks which provide flexible, highly-available, and scaleable IT systemsExplains the use of storage networks for data sharing, data protection, and digital archivingDiscusses management of storage networks using SNMP, SMI-S, and IEEE 1244This book provides system administrators and system architects, as well as students and decision makers, with the tools needed for optimal selection and cost-effective use of storage networks.The Linux Journal awarded the first edition with the "Editor's Choice Award 2005" in the category "System Administration Book."
Storage of Gases in Rock Caverns: Proceedings of the International Conference on Storage of Gases in Rock Caverns/Trondheim/26-28 June 1989
by BJØRN NILSEN; JØRN OLSENContains papers of a conference on [title] held in Trondheim, Norway, June 1989. The following storage concepts are considered: pressurized, compressed air energy, air cushion surge chambers, amonia products storage.
Storage of LPG in Large Rock Caverns (ISRM Book Series)
by Kenji AokiThis book uses actual construction projects as examples to elaborate the various technologies regarding groundwater control and air-tightness guarantees for the construction of large storage rock caverns in complicated geological conditions. It introduces the latest technologies to give hands-on experience of what to do in unexpected geological conditions, and provides insight into the design, construction and operation of underground facilities. The book is hence useful in feasibility studies, developments and other research into these underground facilities. Drawing on the experience gained from building Japan's largest LPG storage caves, Storage of LPG in Large Rock Caverns is a must-read for engineers, academics and students in the fields of rock mechanics, geotechnical engineering and related disciplines.
Storage Ring-Based Inverse Compton X-ray Sources: Cavity Design, Beamline Development and X-ray Applications (Springer Theses)
by Benedikt Sebastian GüntherThis thesis presents research on novel laboratory-scale synchrotron X-ray sources based on inverse Compton scattering and applications of their X-ray radiation using the Munich Compact Light Source (MuCLS) as an example. It provides an introduction to the theory of this laser-electron interaction, laser resonators and X-ray interactions with matter. On this basis, upgrades to the laser system including the development of a new laser optic, X-ray beam stabilisation and two techniques for fast X-ray energy switching of inverse Compton sources are presented. On the application side, the beamline, designed and developed for the inverse Compton X-ray source at the MuCLS, is described before various techniques and applications are demonstrated at this laboratory-scale synchrotron X-ray facility. Among them are K-edge subtraction imaging, X-ray phase contrast imaging and X-ray absorption spectroscopy. Additionally, a new X-ray microscopy technique, called full-field structured-illumination super-resolution X-ray transmission microscopy, is presented.Apart from research conducted at the MuCLS, this thesis contains an in-depth overview on the state of the art of the various types of inverse Compton X-ray sources that have been realised so far. Accordingly, this thesis may serve as a guide and reference work for researchers working with inverse Compton X-ray sources as well as future users of such devices.
Store-Operated Ca²⁺ Entry (SOCE) Pathways
by Klaus Groschner Wolfgang F. Graier Christoph RomaninStore-operated Ca2+ entry (SOCE) serves to control essential functions throughout the human body and represents a novel and attractive target for therapeutic intervention. This book provides an extensive overview of the role of SOCE pathways in Molecular Physiology and Cell Biology, as well as their clinical significance. (Patho)physiological principles and emerging therapeutic strategies are delineated in a way that is valuable both for the education of graduate students in advanced Cell Biology/Molecular Physiology and for the promotion of innovative research and developments in the clinical/therapeutic fields. A comprehensive, clear and elaborate representation of current concepts is provided, including a pathophysiological section arranged in a tissue/organ/system-oriented manner. The book is intended for basic researchers specializing in cell signaling, ion transport, or pharmacology, as well as biomedical scientists and clinicians with a focus on immunology, neurology or cardiology.