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Vaccine Design: Methods and Protocols, Volume 3. Resources for Vaccine Development (Methods in Molecular Biology #2412)
by Sunil ThomasThis volume provides a practical guide providing step-by-step methods and protocols on vaccine development and production. Divided into three volumes, Volume 3: Resources for Vaccine Development guides readers through chapters on vaccine adjuvants, vaccine vectors, production, vaccine delivery systems, vaccine bioinformatics, vaccine regulation, and intellectual property. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and practical, Vaccine Design: Methods and Protocols, Second Edition, Volume 3: Resources for Vaccine Development aims to be a useful practical guide to researchers to help further their study in this field.
Vaccine Design: Methods and Protocols, Volume 2. Vaccines for Veterinary Diseases (Methods in Molecular Biology #2411)
by Sunil ThomasThis volume provides a practical guide providing step-by-step protocol to explore vaccines for farm and companion animals, as well as for fish and insects. Divided into three volumes, Volume 2: Vaccines for Veterinary Diseases guides readers through veterinary vaccines, vaccines for poultry, vaccines for farm animals, and vaccines for veterinary parasites. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and practical, Vaccine Design: Methods and Protocols, Second Edition, Volume 2: Vaccines for Veterinary Diseases aims to be a useful practical guide to researchers to help further their study in this field.
Vaccine Design: Methods and Protocols, Volume 1. Vaccines for Human Diseases (Methods in Molecular Biology #2410)
by Sunil ThomasThis volume provides a practical guide providing step-by-step protocol to design and develop vaccines for human diseases. Divided into three volumes, Volume 1: Vaccines for Human Diseases guides readers through an introductory section on future challenges for vaccinologists and the immunological mechanism of vaccines. Chapters focus on design of human vaccines for viral, bacterial, fungal, and parasitic diseases as well as tumor vaccines. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and practical, Vaccine Design: Methods and Protocols, Second Edition, Volume 1: Vaccines for Human Diseases aims to be a useful practical guide to researchers to help further their study in this field.
Vaccine Development and Manufacturing
by Narahari S. Pujar Ronald Ellis Emily P. WenVaccine Manufacturing and Production is an invaluable reference on how to produce a vaccine - from beginning to end - addressing all classes of vaccines from a processing, production, and regulatory viewpoint. It will provide comprehensive information on the various fields involved in the production of vaccines, from fermentation, purification, formulation, to regulatory filing and facility designs. In recent years, there have been tremendous advances in all aspects of vaccine manufacturing. Improved technology and growth media have been developed for the production of cell culture with high cell density or fermentation. Vaccine Manufacturing and Production will serve as a reference on all aspects of vaccine production by providing an in-depth description of the available technologies for making different types of vaccines and the current thinking in facility designs and supply issues. This book will provide insight to the issues scientists face when producing a vaccine, the steps that are involved, and will serve as a reference tool regarding state-of-the-art vaccine manufacturing technologies and facility set-up.Highlights include:Comprehensive coverage of vaccine production : from a process point of view- fermentation to purification to formulation developments; from a production point of view - from facility design to manufacturing; and from a regulatory point of view - requirements from government agenciesAuthors from different major pharmaceutical and biotechnology companiesDescribes the challenges and issues involved in vaccine production and manufacturing of the different classes of vaccines, an area not covered by other books currently on the market
A Vaccine Is Like a Memory
by Rajani LaRoccaThis timely book details the importance of vaccines and how they were developed throughout history, as well as how they work to protect your body and keep it healthy.Do you remember every time you've been sick?You may not, but your body does! With many illnesses, you can't get sick more than once because your body remembers and fights it off before you get sick again. But what if your body could recognize germs that you've never had before so you don't get ill? There's where vaccines come in! This book comes complete with extensive back matter all about types of germs and vaccines.
Vaccine Technologies for Veterinary Viral Diseases: Methods and Protocols (Methods in Molecular Biology #2465)
by Alejandro BrunThis second edition includes a collection of antigen production and delivery strategies for vaccine development in veterinary species. New and updated chapters guide readers through protocols for antigen production, experimental antigen delivery and the analysis of immune responses upon vaccination. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Vaccine Technologies for Veterinary Viral Diseases: Methods and Protocols, Second Edition aims to be a useful and practical guide to researches to help further their study in this field.
Vaccines for Neglected Pathogens: Focus on Leprosy, Leishmaniasis, Melioidosis and Tuberculosis
by Myron ChristodoulidesThis book reviews successes and (remaining) challenges in vaccine development for the selected Neglected Tropical Diseases (NTD) of Leprosy, Leishmaniasis, Meliodoisis and Tuberculosis, which are a continuous burden for millions of people in affected areas worldwide. Written by frontline researchers, the volume deep-dives into different vaccine strategies, provides biotechnological background information and also tackles animal models in NTD therapeutics research. By bringing together state-of-the-art expert knowledge, the book contributes to the aim of ultimately ending the epidemics of neglected tropical diseases, complying with UN Sustainable Development Goal 3, Health and Well-Being.The volume highlights the activities of the research network VALIDATE (VAccine deveLopment for complex Intracellular neglecteD pAThogEns), funded by the Medical Research Council in the UK. The four NTDs discussed in the book were selected as these are in the focus of VALIDATE’s research.The book targets scientists and clinicians working on NTDs, as well as all readers with a background in biomedicine and interest in vaccine development.This is an open access book.
Vaccines, Medicines and COVID-19: How Can WHO Be Given a Stronger Voice? (SpringerBriefs in Public Health)
by Germán VelásquezThis open access book is a collection of research papers on COVID-19 by Germán Velásquez from 2020 and early 2021 that help to answer the question: How can an agency like the World Health Organization (WHO) be given a stronger voice to exercise authority and leadership? The considerable health, economic and social challenges that the world faced at the beginning of 2020 with COVID-19 continued and worsened in many parts of the world in the second-half of 2020 and into 2021. Many of these countries and nations wanted to explore COVID-19 on their own, sometimes without listening to the main international health bodies such as WHO, an agency of the United Nations system with long-standing experience and vast knowledge at the global level and of which all countries in the world are members. In this single volume, the chapters present the progress of thinking and debate — particularly in relation to drugs and vaccines — that would enable a response to the COVID-19 pandemic or to subsequent crises that may arise. Among the topics covered:COVID-19 Vaccines: Between Ethics, Health and EconomicsMedicines and Intellectual Property: 10 Years of the WHO Global StrategyRe-thinking Global and Local Manufacturing of Medical Products After COVID-19Rethinking R&D for Pharmaceutical Products After the Novel Coronavirus COVID-19 ShockIntellectual Property and Access to Medicines and VaccinesThe World Health Organization Reforms in the Time of COVID-19Vaccines, Medicines and COVID-19: How Can WHO Be Given a Stronger Voice? is essential reading for negotiators from the 194 member countries of the World Health Organization (WHO); World Trade Organization (WTO) and World Intellectual Property Organization (WIPO) staff participating in these negotiations; academics and students of public health, medicine, health sciences, law, sociology and political science; and intergovernmental organizations and non-governmental organizations that follow the issue of access to treatments and vaccines for COVID-19.
Vacuum and Ultravacuum: Physics and Technology
by Igor BelloVacuum technology has enormous impact on human life in many aspects and fields, such as metallurgy, material development and production, food and electronic industry, microelectronics, device fabrication, physics, materials science, space science, engineering, chemistry, technology of low temperature, pharmaceutical industry, and biology. All decorative coatings used in jewelries and various daily products—including shiny decorative papers, the surface finish of watches, and light fixtures—are made using vacuum technological processes. Vacuum analytical techniques and vacuum technologies are pillars of the technological processes, material synthesis, deposition, and material analyses—all of which are used in the development of novel materials, increasing the value of industrial products, controlling the technological processes, and ensuring the high product quality. Based on physical models and calculated examples, the book provides a deeper look inside the vacuum physics and technology.
Vacuum Bubbling: Techniques and Applications
by Yong Du JunVacuum Bubbling introduces the background and applications for generating bubbles under a vacuum condition, accomplished through depressurization without the need to heat water. It presents the advantage of utilizing vapor bubble in deaeration applications because the diffusion for degassing happens between the water body and micro vapor bubbles without the need of membrane or packing.Instead of relying on massive heating, vacuum bubbling focuses on depressurization down to the level of saturated vapor pressure or below to secure vapor bubbles with virtually zero dissolved non-condensable gases, including oxygen. The book considers prospective applications, such as extracting high-oxygen-content air from water for underwater breathing, pretreatment of aircraft fuel before being pumped into a fuel tank system, and probable desalination applications through massive bubbling combined with low-grade renewable energy.The book is intended for researchers in thermal fluids, heat and mass transfer, process engineering, and water treatment fields and industry professionals working in power generation, plant and process engineering, transportation, and energy.
Vacuum Circuit Breaker for Aviation Variable Frequency Power System: Theory and Application of Arc in Electrical Apparatus (Power Systems)
by Qing Li Yuan JiangThis book introduces the concepts of more electric aircraft and aviation electrical appliances, as well as the aviation experimental platform of vacuum switches, the interruption characteristics, frequency characteristics and post-arc breakdown characteristics of intermediate frequency vacuum switches, etc. It is the first monograph on protection electrical appliances, vacuum interrupter in aviation variable frequency power system. This book includes a lot of experimental process and chart analysis for readers to understand and provides references for practical engineering problems. This book could be used as references for engineers and technicians working on electric power systems in aircrafts.
Vacuum Drying for Extending Food Shelf-Life
by Felipe Richter ReisIn this book, suitable examples of how to increase the shelf life of food materials while preserving their desirable original features are provided.
The Vacuum Interrupter: Theory, Design, and Application
by Paul G. SladeTitle: The Vacuum Interrupter: Theory, Design, and ApplicationShelving guide: Electrical EngineeringDr. Paul Slade draws from his nearly six decades of active experience to develop this second edition of The Vacuum Interrupter: Theory, Design, and Application. This book begins by discussing the design requirements for high voltage vacuum interrupters and then the contact requirements to interrupt the vacuum arc. It then continues by describing the various applications in which the vacuum interrupter is generally utilized.Part 1 of this book begins with a detailed review of the vacuum breakdown process. It continues by covering the steps necessary for the design and the manufacture of a successful vacuum interrupter. The vacuum arc is then discussed, including how it is affected as a function of current. An overview of the development and use of practical contact materials, along with their advantages and disadvantages, follows. Contact designs that are introduced to control the high current vacuum arc are also analyzed.Part 2, on application, begins with a discussion of the arc interruption process for low current and high current vacuum arcs. It examines the voltage escalation phenomenon that can occur when interrupting inductive circuits. The occurrence of contact welding for closed contacts subjected to the passage of high currents, and for contacts when closing on high currents, is explored. The general requirements for the successful manufacture and testing of vacuum circuit breakers is then presented. The general application of vacuum interrupters to switch load currents, especially when applied to capacitor circuits, is also given. The interruption of high short circuit currents is presented along with the expected performance of the two major contact designs.Owing to the ever-increasing need for environmentally friendly circuit protection devices, the development and application of the vacuum interrupter will only increase in the future. At present the vacuum circuit breaker is the technology of choice for distribution circuits (5kV to 40.5kV). It is increasingly being applied to transmission circuits (72.5kV to 242kV). In the future, its application for protecting high voltage DC networks is assured.Audience This is a practical source book for engineers and scientists interested in studying the development and application of the vacuum interrupter Research scientists in industry and universities Graduate students beginning their study of vacuum interrupter phenomena Design engineers applying vacuum interrupters in vacuum switches, vacuum contactors, vacuum circuit breakers, and vacuum contactors It provides a unique and comprehensive review of all aspects of vacuum interrupter technology for those new to the subject and for those who wish to obtain a deeper understanding of its science and application Scientists and engineers, who are beginning their research into vacuum breakdown and aspects of the vacuum arc, will find the extensive bibliography and phenomenological descriptions to be a useful introduction
Vacuum Nanoelectronic Devices
by Hans Hartnagel Anatoliy Evtukh Dimitris Pavlidis Oktay Yilmazoglu Hidenori MimuraIntroducing up-to-date coverage of research in electron field emission from nanostructures, Vacuum Nanoelectronic Devices outlines the physics of quantum nanostructures, basic principles of electron field emission, and vacuum nanoelectronic devices operation, and offers as insight state-of-the-art and future researches and developments. This book also evaluates the results of research and development of novel quantum electron sources that will determine the future development of vacuum nanoelectronics. Further to this, the influence of quantum mechanical effects on high frequency vacuum nanoelectronic devices is also assessed. Key features: * In-depth description and analysis of the fundamentals of Quantum Electron effects in novel electron sources. * Comprehensive and up-to-date summary of the physics and technologies for THz sources for students of physical and engineering specialties and electronics engineers. * Unique coverage of quantum physical results for electron-field emission and novel electron sources with quantum effects, relevant for many applications such as electron microscopy, electron lithography, imaging and communication systems and signal processing. * New approaches for realization of electron sources with required and optimal parameters in electronic devices such as vacuum micro and nanoelectronics. This is an essential reference for researchers working in terahertz technology wanting to expand their knowledge of electron beam generation in vacuum and electron source quantum concepts. It is also valuable to advanced students in electronics engineering and physics who want to deepen their understanding of this topic. Ultimately, the progress of the quantum nanostructure theory and technology will promote the progress and development of electron sources as main part of vacuum macro-, micro- and nanoelectronics.
Vacuum Technology in the Chemical Industry
by Wolfgang JorischBased on the very successful German edition and a seminar held by the German Engineers` Association (VDI) on a regular basis for years now, this English edition has been thoroughly updated and revised to reflect the latest developments. It supplies in particular the special aspects of vacuum technology, applied vacuum pump types and vacuum engineering in the chemical, pharmaceutical and process industry application-segments. The text includes chapters dedicated to latest European regulations for operating in hazardous zones with vacuum systems, methods for process pressure control and regulation and leak detection. All of the authors work or did work at a selection of the most important German companies involved in vacuum technology, and their expertise is disseminated here for engineers working in vacuum technology, chemical process design, plant operation, and mechanical engineering.
Validating Medical Packaging
by Ronald PilchikAccording to the FDA Quality System Regulations, manufacturers must ensure that "device packaging and shipping containers are designed and constructed to protect the device from alteration or damage during the customary conditions of processing, storage, handling, and distribution." As specific as this statement is, the FDA does not provide instruc
Validating Technological Innovation
by David Coniam Peter FalveyThis book discusses Hong Kong's use of onscreen marking (OSM) in public examinations. Given that Hong Kong leads the way in OSM innovation, this book has arisen from a recognised need to provide a comprehensive, coherent account of the findings of various separate but linked validation studies of onscreen public examinations in Hong Kong. The authors discuss their experience of the validation process, demonstrating how high-stakes innovation should be fully validated by a series of research studies in order to satisfy key stakeholders.
Validation and Verification of Automated Systems: Results of the ENABLE-S3 Project
by Andrea Leitner Daniel Watzenig Javier Ibanez-GuzmanThe book summarizes the main results of the the project ENABLE-S3 covering the following aspects: validation and verification technology bricks (collection and selection of test scenarios, test executions envionments incl. respective models, assessment of test results), evaluation of technology bricks in selected use cases and standardization and related initiatives. ENABLE-S3 is an industry-driven EU-project and aspires to substitute todays' cost-intensive verification and validation efforts by more advanced and efficient methods. In addition, the book includes articles about complementary international activities in order to highlight the global importance of the topic and to cover the wide range of aspects that needs to be covered at a global scale.
Validation for Medical Device and Diagnostic Manufacturers
by Carol V. Desain Charmaine V. SuttonImplementation of FDA's Design Control requirements (21 CFR 820.30) changed an entire industry. Quality System Requirements defined the approach to medical device validation. Product design, manufacturing process, and test method validation studies must be performed before or as a product is transferred to commercial production. Validation studies
Validation of Dynamic Analyses of Dams and Their Equipment: Edited Contributions to the International Symposium on the Qualification of Dynamic Analyses of Dams and their Equipments, 31 August-2 September 2016, Saint-Malo, France (ICOLD Proceedings)
by Jean-Jacques Fry Norihisa MatsumotoValidation of Dynamic Analyses of Dams and Their Equipment is the outcome of a three year cooperation program between CFBR (Comite Francais des Barrages et Reservoirs or French Committee on Large dams) and JCOLD (Japan Commission on Large Dams), and focusses on the dynamic behavior of concrete and embankment dams analyzed based on acceleration records of the JCOLD data base. The book covers a broad range of topics, including simplified and detailed methods of dynamic analysis for the seismic response of concrete and embankment dams compared with measured behavior. The response of embankment dams subjected to a 1.0 g foundation acceleration time history is computed by several analytical methods and compared. The modelling of stress-strain behavior of compacted soils for seismic stability analysis of earth-fill dams and its application for a failed earthfill dam is described. The cracking of the face slab of four faced rockfill dams during earthquakes is analyzed. The seismic behavior of concrete arch dams is discussed by the comparison of numerical and experimental results. Displacement-based seismic assessment of concrete dams is presented. Finally the book contains a comparison between the Japanese and French design criteria of gates and a comparison of the analysis of gates and field measurements. Validation of Dynamic Analyses of Dams and Their Equipment will be useful to professional and academics involved or interested in dam engineering.
Validity and Reliability in Built Environment Research: A Selection of Case Studies
by Vian AhmedThis book aims to guide researchers who are engaged in social science and built environment research through the process of testing the reliability and validity of their research outputs following the application of different methods of data collection. The book presents case studies that emphasize reliability and validity in different examples of qualitative, quantitative and mixed method data sets, as well as covering action research and grounded theory. The reader is guided through case studies that demonstrate: An understanding of the reliability and validity approaches from social science and built environment perspectives in alignment with the relevant research philosophies, approaches and data collection strategies Real research projects that have been conducted by expert researchers on topics such as Lean, BIM, Housing and Sustainability to answer specific or evolving questions in relation to the reliability and validity of research A simple and easy method that students at Masters and PhD levels can relate to in order to adopt a sound reliability and validity approach to their research This book is the essential guide for researchers at undergraduate and postgraduate level who need to understand how to validate the quality of the empirical tests they conduct using different techniques. The book will also be a great asset to supervisors from different backgrounds who need a refresher on this key aspect of the research cycle.
Valley of Genius: The Uncensored History of Silicon Valley (As Told by the Hackers, Founders, and Freaks Who Made It Boom)
by Adam Fisher"This is the most important book on Silicon Valley I've read in two decades. It will take us all back to our roots in the counterculture, and will remind us of the true nature of the innovation process, before we tried to tame it with slogans and buzzwords." -- Po Bronson, #1 New York Times bestselling author of The Nudist on the Late Shift and Nurtureshock A candid, colorful, and comprehensive oral history that reveals the secrets of Silicon Valley -- from the origins of Apple and Atari to the present day clashes of Google and Facebook, and all the start-ups and disruptions that happened along the way.Rarely has one economy asserted itself as swiftly--and as aggressively--as the entity we now know as Silicon Valley. Built with a seemingly permanent culture of reinvention, Silicon Valley does not fight change; it embraces it, and now powers the American economy and global innovation. So how did this omnipotent and ever-morphing place come to be? It was not by planning. It was, like many an empire before it, part luck, part timing, and part ambition. And part pure, unbridled genius...Drawing on over two hundred in-depth interviews, VALLEY OF GENIUS takes readers from the dawn of the personal computer and the internet, through the heyday of the web, up to the very moment when our current technological reality was invented. It interweaves accounts of invention and betrayal, overnight success and underground exploits, to tell the story of Silicon Valley like it has never been told before. Read it to discover the stories that Valley insiders tell each other: the tall tales that are all, improbably, true.
Valorisation of Agro-industrial Residues – Volume I: Biological Approaches (Applied Environmental Science and Engineering for a Sustainable Future)
by Zainul Akmar Zakaria Ramaraj Boopathy Julian Rafael DibAgriculture and industry are the two most important economic sectors for various countries around the globe, providing millions of jobs as well as being the main source of income for these countries. Nevertheless, with the increasing demand for agricultural and industrial produce, huge amounts of waste are also being produced. Without proper management, this waste (both liquid and solid) poses a serious threat to overall environmental quality, mainly due to its toxicity and slow degradation processes. Current approaches are effective but would normally require huge capital investments, are labour intensive and generate potential hazardous by-products. As such, there is a need for alternative approaches that are cheaper, easier-to-handle and have a minimum potential impact on environmental quality. This book presents up-to-date approaches using biological techniques to manage the abundance of waste generated from agricultural and industrial activities. It discusses techniques such as bioconversion, biodegradation, biotransformation, and biomonitoring as well as the utilization of these wastes. A number of chapters also include individual case studies to enhance readers’ understanding of the topics. This comprehensive book is a useful resource for anyone involved in agricultural and industrial waste management, green chemistry or biotechnology. It is also recommended as a reference work for graduate students and all agriculture and biotechnology libraries.
Valorisation of Agro-industrial Residues – Volume II: Non-Biological Approaches (Applied Environmental Science and Engineering for a Sustainable Future)
by Zainul Akmar Zakaria Cristobal N Aguilar Ratna Dewi Kusumaningtyas Parameswaran BinodThe world’s population is expected to reach the eight billion mark very soon. As a result, there is a need for increased industrial and agricultural production to ensure human wellbeing. This in turn generates huge amounts of waste. Current waste treatment solutions are effective, but usually require huge capital investment, are labour intensive and potentially lead to hazardous by-products. This book presents the latest non-biological approaches to address issues related to the abundance of waste, offering insights into best practices in various regions around the globe. It highlights techniques such as chemical extraction, pyrolysis and ultrasonics, and a number of chapters include individual case studies to further enhance readers’ understanding. This comprehensive reference resource is intended for graduate students, researchers and scientists, and is also a valuable addition to all agriculture and biotechnology libraries.
Valorisation of Waste and Secondary Materials for Roads: State-of-the-Art Report of the RILEM TC 279-WMR (RILEM State-of-the-Art Reports #38)
by Augusto Cannone Falchetto Lily Poulikakos Emiliano Pasquini Di WangThis book presents the work of the RILEM TC 279-WMR, whose purpose was to facilitate the use of waste, marginal and secondary materials for roads by investigating the performance of road materials containing waste through round robin tests and the development of standard procedures for their selection, preparation, and use. The structure of this book includes an introduction, five technical chapters, and a conclusion. The topics addressed are: the use of asphalt binder additives such as plastic and rubber; the combined use of aggregate and filler substitute in paving mixtures (construction demolition waste, rubber, and steel slags); the environmental assessment and the potential sources of pollutants originated from the use of this recycled materials.