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Biomaterials and Nanotechnology for Tissue Engineering
by Swaminathan Sethuraman, Uma Maheswari Krishnan and Anuradha SubramanianNanotechnology and high-end characterization techniques have highlighted the importance of the material choice for the success of tissue engineering. A paradigm shift has been seen from conventional passive materials as scaffolds to smart multi-functional materials that can mimic the complex intracellular milieu more effectively. This book presents a detailed overview of the rationale involved in the choice of materials for regeneration of different tissues and the future directions in this fascinating area of materials science with specific chapters on regulatory challenges & ethics; tissue engineered medical products.
Biomaterials and Neurodegenerative Disorders
by Gaurav Kumar Sumedha Mukherjee Santosh KumarThe book covers the fundamental aspects of biomaterials, including their introduction, types, synthesis, and characterization. It delves into the field of neuro-compatible biomaterials, examining nervous tissue response and the role of biomaterials in neuroprotection. It discusses clinical trials and applications along with intellectual property rights in neuroprotective biomaterials. The book also explores the innovative neuro-targeted drug delivery system and its potential in improving treatment outcomes. Lastly, it explores biomaterials' impact on neurodegeneration and neuro diagnosis, providing valuable insights for researchers, academicians and doctoral students working in the field of Neuroscience, Neuroprotection, Biomaterial based Neurotherapeutics, Biomaterial based Neuro diagnosis and Biomaterial mediated drug delivery.
Biomaterials and Stem Cells in Regenerative Medicine
by Murugan Ramalingam Seeram Ramakrishna Serena BestWork in the area of biomaterials and stem cell therapy has revealed great potential for many applications, from the treatment of localized defects and diseases to the repair and replacement of whole organs. Researchers have also begun to develop a better understanding of the cellular environment needed for optimal tissue repair and regeneration. Bi
Biomaterials and Tissue Engineering (Stem Cell Biology and Regenerative Medicine #74)
by Oguzhan Gunduz Christophe Egles Román A. Pérez Denisa Ficai Cem Bulent UstundagThis contributed volume covers all fundamental principles for researchers and professionals interested in the field of Biomaterials and Tissue Engineering, an interdisciplinary field of research with contributions from biomedical scientists, engineers, and physicians. With a strong focus on biomaterials and scaffolds, the book also covers testing and evaluation pathways for in vitro and in vivo studies. This book also presents a broad range of topics including fundamentals of 3D printing and bioprinting, followed by contemporary technology used in tissue engineering applications as well as currently available biomaterials suitable for tissue repair and regeneration. This volume provides information on: (i) why humans need biomaterials, especially in medical applications, (ii) different types of tissue engineering strategies, and (iii) modeling, characterization, and evaluation of outputs of those strategies. This book is a reference material in the field of tissue engineering, and it is very useful for bachelor, M.Sc., and Ph.D. students, researchers, academics, medical, industry, and healthcare professionals from diverse backgrounds.
Biomaterials as Green Flame Retardants (Engineering Materials)
by Teboho Clement Mokhena Mokgaotsa Jonas Mochane Emmanuel Rotimi Sadiku Suprakas Sinha RayThis book highlights the utilization of biomaterials as emerging suitable and effective flame retardants (FRs) to replace most of the conventional FRs (e.g., halogenated FRs). Biomaterials are considered to be sustainable, biodegradable, and renewable resources. They are abundantly available, which makes them affordable. Information and findings on the characteristics of biomaterials and their use as FRs have been explored. Herein, the tremendous scientific progress made in using biomaterials as flame retardants for a wide range of products is elucidated. The major goal is to draw attention to the opportunities and challenges of switching to biomaterial-based FRs in place of conventional FRs in order to create a sustainable society.
Biomaterials as Stem Cell Niche (Studies in Mechanobiology, Tissue Engineering and Biomaterials #2)
by Krishnendu RoyRecent developments in stem cell biology have opened new directions in cell therapy. This book provides the state-of-the-art developments in using biomaterials as artificial niches for engineering stem cells, both for the purpose of better understanding their biology under 3D biomimetic conditions as well as for developing new strategies for efficient long term maintenance and directed differentiation of stem cells into various therapeutic lineages. Animal and human stem cells of both embryonic and adult origin are discussed with applications ranging from nerve regeneration, orthopedics, cardiovascular therapy, blood cell generation and cancer therapy. Both synthetic and natural biomaterials are reviewed with emphasis on how material-stem cell interactions direct specific signaling pathways and ultimately modulate the cell fate. This book is valuable for biomaterial scientists, tissue engineers, clinicians as well as stem cell biologists involved in basic research and applications of adult and embryonic stem cells.
Biomaterials Associated Infection: Immunological Aspects and Antimicrobial Strategies
by Henk J. Busscher Sebastian A.J. Zaat Fintan MoriartyBiomaterials associated infection (BAI) is one of the most common complications associated with implantation of any biomaterial regardless of form or function. These infections usually involve bacterial colonization and biofilm formation on the biomaterial itself, rendering the infection impervious to antimicrobials and host defenses. In addition, it is becoming increasingly clear that infection of the surrounding tissues also plays an important role in BAI, and that the infection may be influenced by the composition and design of the implanted biomaterial. In this book, worldwide leaders in the field address this critical problem in the translation of biomaterials research into clinical practice. The book begins with an emphasis on the latest research in the pathogenesis of BAI from microbiological, immunological, and materials science perspectives. The current state of the art in antimicrobial activation of biomaterials through surface modification and the incorporation of antimicrobial agents is then discussed. In the concluding chapters, successful translation of a selection of antimicrobial technologies from preclinical research into clinical use is described alongside a discussion of the utility of these devices and perspectives for future development. This book is essential reading for researchers and clinicians who are interested in understanding the fundamentals of BAI, the latest in antimicrobial materials research, and the state of the art in clinically available antimicrobial containing medical devices.
Biomaterials-Based Sensors: Recent Advances and Applications
by Prasun Kumar Sandip Kumar Dash Subhasree Ray Shahila ParweenWith the recent technological advancement usage of unique nanomaterials and bio-based composite materials as sensors has been greatly improved. Biopolymers and bio-based composite materials have especially been exploited due to their unique physical, optical, electrochemical, and biocompatible properties. In this book, experts and researchers in various sensor technology areas discuss the basics of biosensors, the methods used to synthesize different biomaterials, and the characterization and functionalization of these biomaterials. Processes for the self-assembly of biomaterials and the fabrication of biomaterials onto transducers are clearly explained. It also outlines the current status in the field and the utility of such bio-based sensors for medical diagnostics, food safety, industrial, and environmental monitoring. Besides pressure and temperature sensing applications, other applications include detecting gases, chemicals, biomolecules, body fluids, bacteria, and viruses. The book is well illustrated, and the presentation is concise and systematic throughout. Biomaterials-Based Sensors will be an ideal source of up-to-date information for all engaged in their research, design, and use.
Biomaterials Effect on the Bone Microenvironment: Fabrication, Regeneration, and Clinical Applications
by Jiacan Su Xiao Chen Yingying JingBiomaterials Effect on the Bone Microenvironment Practical resource on clinical bone regeneration from a variety of related interdisciplinary researchers Biomaterials Effect on the Bone Microenvironment focuses on the structure-activity relationship between bone biomaterials and microenvironment regulation, presenting a systematic exposition from all aspects of biomaterials regulated microenvironment in bone regeneration and covering design strategies, applications, and mechanisms of biomaterials that regulate bone microenvironment, along with the methods for manufacturing biomaterials and their clinical translation. The subject’s potential challenges and future development direction are discussed, and the design and initiative principle of tailored biomaterials with various features, including bioactive components and physicochemical property, are elucidated in depth. Numerous biomaterials, including natural and synthetic, are summarized and compared. Their advantages and features are also evaluated, particularly in bone microenvironmental regulation and bone generation. Moreover, the stimulation mechanism of the microenvironment to bone generation is discussed in detail, including mechanical-support effect, redox effect, pro-angiogenesis effect, inflammatory immune effect, and anti-aging effect. Biomaterials Effect on the Bone Microenvironment provides further coverage of sample topics such as: Role of bone microenvironment and its associated biomaterials in modulation bone diseases, reviewing the biomaterials used to regulate bone microenvironment Relationship between biological factors of various materials and physiological functions in bone microenvironment Application of the third generation of biomaterials, which would regenerate the bone to regulate bone microenvironment Emerging biological material manufacturing technology and mechanisms of novel biomaterial modulating microenvironment for bone regeneration Future outlook of bone tissue engineering along with the general process of bone remodeling and regeneration With comprehensive coverage of one of the most promising and valuable candidates for clinical bone regeneration, Biomaterials Effect on the Bone Microenvironment is an ideal resource for materials scientists, biotechnologists, biochemists, bioengineers, orthopedists, and clinical chemists who want to stay on the cutting edge of this rapidly evolving field.
Biomaterials Fabrication and Processing Handbook
by Paul K. Chu Xuanyong LiuFocusing on a lucrative and increasingly important area of biomedicine, the Biomaterials Fabrication and Processing Handbook brings together various biomaterials production and processing aspects, including tissue engineering scaffold materials, drug delivery systems, nanobiomaterials, and biosensors. With contributions from renowned interna
Biomaterials for Cell Delivery: Vehicles in Regenerative Medicine (Gene and Cell Therapy)
by Aaron S. GoldsteinThe purpose of this book is to summarize key strategies and recent accomplishments in the area of developing cell/biomaterial constructs for regenerative medicine. The first section is a review of the state-of-the-art of biomaterial carriers and is divided into synthetic and natural materials. A subset of the latter are decellularized organs which retain the structure and some of the biological activities of the target organ. The bulk of the book is devoted to unique problems associated with key tissue and organ targets. Key selling features: Describes developing cell/biomaterial constructs for regenerative medicine Reviews state-of-the-art of biomaterial carriers Summarizes the unique problems associated with key tissue and organ targets Discusses issues associated with clinical translation including quality control, manufacturing practices, nondestructive imaging, and animal models
Biomaterials for Clinical Applications: Novel Technologies For Clinical Applications
by Sujata K. BhatiaBiomaterials for Clinical Applications is organized according to the World Health Organization's report of the top 11 causes of death worldwide, and lays out opportunities for both biomaterials scientists and physicians to tackle each of these leading contributors to mortality. The introductory chapter discusses the global burden of disease. Each of the subsequent eleven chapters focuses on a specific disease process, beginning with the leading cause of death worldwide, cardiovascular disease. The chapters start with describing diseases where clinical needs are most pressing, and then envisions how biomaterials can be designed to address these needs, instead of the more technologically centered approached favored by most books in the field. This book, then, should appeal to chemical engineers and bioengineers who are designing new biomaterials for drug delivery and vaccine delivery, as well as tissue engineering.
Biomaterials for Surgical Operation
by Yoshito Ikada Shuko SuzukiBiomaterials for Surgical Operation offers a review of the latest advances made in developing bioabsorbable devices for surgical operations which include surgical adhesives (sealants), barriers for the prevention of tissue adhesion, polymers for fractured bone fixation, growth factors for the promotion of wound healing, and sutures. Over the years, many descriptions of biomaterials have appeared in academic journals and books, but most of them have been devoted to limited clinical areas. This is in marked contrast with this volume which covers a wide range of bioabsorbable devices used in surgery from a practical point of view. The currently applied polymeric devices are critical in surgery, but all involve serious problems due to their poor performance. For instance, fibrin glue, the most widely used surgical sealant, can produce only a weak gel with low adhesive strength to tissues, accentuating the limited effectiveness of current treatment options. Likewise, the currently available barrier membranes cannot fully prevent tissue adhesion at the acceptable level and are, moreover, not easy to handle with endoscopes due to their poor mechanical properties. Biomaterials for Surgical Operation is aimed at those who are interested in expanding their knowledge of how the problems associated with the currently used devices for surgical operation can be solved. It primarily focuses on the absorbable biomaterials which are the main components of these medical devices.
Biomaterials for Tissue Engineering Applications: A Review of the Past and Future Trends
by Robert L. Mauck Jason A. BurdickA concise overview of tissue engineering technologies and materials towards specific applications, both past and potential growth areas in this unique discipline is provided to the reader. The specific area of the biomaterial component used within the paradigm of tissue engineering is examined in detail. This is the first work to specifically covers topics of interest with regards to the biomaterial component. The book is divided into 2 sections: (i) general materials technology (e.g., fibrous tissue scaffolds) and (ii) applications in the engineering of specific tissues (e.g., materials for cartilage tissue engineering). Each chapter covers the fundamentals and reflects not only a review of the literature, but also addresses the future of the topic. The book is intended for an audience of researchers in both industry and academia that are interested in a concise overview regarding the biomaterials component of tissue engineering, a topic that is timely and only growing as a field.
Biomaterials for Tissue Regeneration: Advances and Challenges for Fabrication and Clinical Translation (SpringerBriefs in Materials)
by Mohammad M. Farag Zainab M. Al-RashidyThis book comprehensively reviews the essential characteristics of biomaterials and their designs important for applications in tissue regeneration. It delves into both past research milestones in tissue engineering and emerging trends poised for future integration. The primary focus lies on the evolution of biomaterial generations and the burgeoning domain of tissue engineering discovery. Furthermore, it examines various biomaterial categories, including bioceramics, bioactive glasses, synthetic and natural polymers, alongside their composite derivatives, all pivotal in scaffold fabrication, a cornerstone of tissue engineering. The book also looks at diverse scaffold fabrication methodologies, providing readers with a thorough understanding of the technical intricacies involved. The book showcases recent breakthroughs in tissue engineering across multiple fronts such as bone, skin, cartilage, neural, and cardiac regeneration, highlighting their potential as pre-clinical interventions for rehabilitating injured or diseased tissues and organs. Finally, it reviews the contemporary landscape of biomaterials for tissue regeneration, shedding light on emerging trends and confronting the challenges that lie ahead.
Biomaterials from Nature for Advanced Devices and Therapies
by Nuno M. Neves Rui L. ReisIn-depth information on natural biomaterials and their applications for translational medicine! Undiluted expertise: edited by world-leading experts with contributions from top-notch international scientists, collating experience and cutting-edge knowledge on natural biomaterials from all over the world A must-have on the shelf in every biomaterials lab: graduate and PhD students beginning their career in biomaterials science and experienced researchers and practitioners alike will turn to this comprehensive reference in their daily work Link to clinical practice: chapters on translational research make readers aware of what needs to be considered when a biomaterial leaves the lab to be routinely used
Biomaterials in Orthopaedics and Bone Regeneration: Design and Synthesis (Materials Horizons: From Nature to Nanomaterials)
by Preetkanwal Singh Bains Sarabjeet Singh Sidhu Marjan Bahraminasab Chander PrakashThis book focuses on the recent advances in the field of orthopaedic biomaterials, with a particular emphasis on their design and fabrication. Biomimetic materials, having similar properties and functions to that of the natural tissue, are becoming a popular choice for making customized orthopaedic implants and bone scaffolds. The acceptability of these materials in the human body depends on the right balance between their mechanical and biological properties. This book provides a comprehensive overview of the state-of-the-art research in this rapidly evolving field. The chapters cover different aspects of multi-functional biomaterials design, and cutting-edge methods for the synthesis and processing of these materials. Advanced manufacturing techniques, like additive manufacturing, used for developing new biomimetic materials are highlighted in the book. This book is a valuable reference for students and researchers interested in biomaterials for orthopaedic applications.
Biomaterials in Orthopaedics & Trauma: Current Status and Future Trends in Revolutionizing Patient Care
by Raju Vaishya Sourabh GhoshThe landscape of orthopaedics and trauma is rapidly evolving, driven by groundbreaking advancements in biomaterials. This book offers an in-depth exploration of the current state-of-the-art, highlighting the latest innovations and their clinical applications. The intersection of materials science and medicine has given rise to a revolutionary field: biomaterials. These engineered substances, designed to interact with biological systems, have become indispensable in orthopaedics and trauma surgery. From repairing broken bones to replacing worn-out joints, biomaterials have significantly advanced patient care and quality of life. In recent years, the focus has shifted towards bioactive and biodegradable materials. Bioactive materials, such as calcium phosphate ceramics, actively interact with bone tissue, promoting bone growth and integration. This characteristic is particularly valuable in bone grafts and tissue engineering applications. On the other hand, biodegradable materials, like polylactic acid (PLA) and polyglycolic acid (PGA), offer the advantage of being gradually absorbed by the body as the surrounding tissue regenerates. These materials are employed in various forms, including screws, plates, and bone scaffolds. This book offers a holistic view of biomaterials in orthopaedics and trauma by presenting an understanding of the fundamental properties of biomaterials and exploring their role in tissue regeneration and implant design. This comprehensive resource also delves into the future, examining emerging trends and technologies that are revolutionizing patient care and paving the way for new treatment modalities. This book is an essential guide to the exciting world of biomaterials for orthopaedic surgeons, trauma surgeons and biomedical researchers.
Biomaterials in Tissue Engineering and Regenerative Medicine: From Basic Concepts to State of the Art Approaches
by Birru Bhaskar Parcha Sreenivasa Rao Naresh Kasoju Vasagiri Nagarjuna Rama Raju BaadheThis book comprehensively explores the basic concepts and applications of biomaterials in tissue engineering and regenerative medicine. The book is divided into four sections; the first section deals with the basic concepts and different types of biomaterials used in tissue engineering. The second section discusses the functional requirements and types of materials that are used in developing state-of-the-art of scaffolds for tissue engineering applications. The third section presents the applications of biomaterials for hard and soft tissue engineering, as well as for specialized tissue engineering. The last section addresses the future prospects of nanobiomaterials, intelligent biomaterials, and 3D bioprinting biomaterials in tissue engineering and regenerative medicine. It also discusses various in vitro disease models for tissue bioengineering and regenerative medicine. As such, it offers a valuable resource for students, researchers, scientists, entrepreneurs, and medical/healthcare professionals.
Biomaterials, Medical Devices, and Combination Products: Biocompatibility Testing and Safety Assessment
by Shayne Cox Gad Samantha Gad-McDonaldBiomaterials, Medical Devices, and Combination Products is a single-volume guide for those responsible for-or concerned with-developing and ensuring patient safety in the use and manufacture of medical devices.The book provides a clear presentation of the global regulatory requirements and challenges in evaluating the biocompatibility and clinical
Biomaterials Science
by Amit Bandyopadhyay Roger Narayan Susmita BoseTaking place at the David L. Lawrence Convention Center, Pittsburgh, Pennsylvania, this CT Volume contains 17 papers from the following 2014 Materials Science and Technology (MS&T'14) symposia: Next Generation Biomaterials Surface Properties of Biomaterials
Biomaterials Science: Ceramic Transactions, Volume 251
by Roger Narayan Susmita Bose Amit BandyopadhyayCeramic Transactions, Volume 242; Biomaterials Science - Processing, Properties and Applications IIISusmita Bose, Roger Narayan, and Amit Bandyopadhyay, EditorsThis CT Volume contains14 contributed papers from the following 2012 Materials Science and Technology (MS&T'12) symposia: Next Generation BiomaterialsSurface Properties of Biomaterials
Biomaterials Science: An Integrated Clinical and Engineering Approach
by Yitzhak Rosen"This book is essential when designing, developing and studying biomedical materials.� provides an excellent review-from a patient, disease, and even genetic point of view-of materials engineering for the biomedical field. � This well presented book strongly insists on how the materials can influence patients' needs, the ultimate drive for biomedic
Biomaterials Science and Implants: Status, Challenges and Recommendations
by Bikramjit BasuBiomaterials as a research theme is highly socially relevant with impactful applications inhuman healthcare. In this context, this book provides a state-of-the-art perspective onbiomaterials research in India and globally. It presents a sketch of the Indian landscapeagainst the backdrop of the international developments in biomaterials research.Furthermore, this book presents highlights from major global institutes of importance,and challenges and recommendations for bringing inventions from the bench to thebedside. It also presents valuable information to those interested in existing issuespertaining to developing the biomaterials research ecosystem in developing countries.The contents also serve to inspire and educate young researchers and students to take upresearch challenges in the areas of biomaterials, biomedical implants, and regenerativemedicine. With key recommendations for developing frontier research and policy, italso speaks to science administrators, policymakers, industry experts, and entrepreneurs onhelping shape the future of biomaterials research and development.
Biomaterials Science and Technology: Fundamentals and Developments
by Yaser DahmanBiomaterials Science and Technology: Fundamentals and Developments presents a broad scope of the field of biomaterials science and technology, focusing on theory, advances, and applications. It reviews the fabrication and properties of different classes of biomaterials such as bioinert, bioactive, and bioresorbable, in addition to biocompatibility. It further details traditional and recent techniques and methods that are utilized to characterize major properties of biomaterials. The book also discusses modifications of biomaterials in order to tailor properties and thus accommodate different applications in the biomedical engineering fields and summarizes nanotechnology approaches to biomaterials. This book targets students in advanced undergraduate and graduate levels in majors related to fields of Chemical Engineering, Materials Engineering and Science, Biomedical Engineering, Bioengineering, and Life Sciences. It assists in understanding major concepts of fabrication, modification, and possible applications of different classes of biomaterials. It is also intended for professionals who are interested in recent advances in the emerging field of biomaterials.