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The ID CaseBook: Case Studies in Instructional Design
by Peggy A. Ertmer Krista D. Glazewski Jill E. Stefaniak Adrie A. KoehlerThe ID CaseBook provides instructional design students with 25 realistic, open-ended case studies that encourage adept problem-solving across a variety of client types and through all stages of the process. After an introduction to the technique of case-based reasoning, the book offers four sections dedicated to K–12, informal learning, post-secondary, and industry clients, respectively, each comprising varied, detailed cases created by instructional design experts. All cases, alongside their accompanying discussion questions, encourage students to analyze the available information, develop action plans, and consider alternative possibilities in resolving problems. This revised and updated sixth edition attends to the profound impacts that public health crises; urgent access, equity, and inclusion needs among diverse learners; and a rapidly expanded reliance on digital learning formats have had on the design of learning today.
Ideas de Internet: ¡Formas de convertirse en parte de la comunidad en línea! (Cómo... #124)
by Owen JonesBienvenido a "Ideas de Internet " – un manual de principiantes, tu guía para dominar el ámbito digital con confianza y comprensión. . Internet se ha convertido en una herramienta esencial para comunicación, aprendizaje y entretenimiento. Como experto en todo lo relacionado con Internet, estoy encantado de ser tu guía en este aleccionador viaje. Este manual se creó meticulosamente elaborado para proveer a los principiantes con bases sólidas para recorrer el vasto entorno de Internet. Bien sea que te estás conectando por primera vez, o buscas profundizar tu conocimiento, esta guía te fortalecerá para navegar con facilidad y tomar decisiones con fundamento. Ten la seguridad de que toda la información que aquí se presenta es exacta y está basada en los conocimientos más recientes. El Internet, aunque increíblemente poderoso, puede ser complejo, pero al embarcarse juntos en esta aventura, te estás preparando para el éxito. Adquiere las habilidades y la sabiduría que necesitas para sacar el máximo partido de la era digital, manteniendo los valores de la verdad y la integridad. ¡Comencemos a explorar las infinitas posibilidades de Internet! Espero que la información te resulte útil, provechosa y redituable.
Ideias Para a Internet: Formas de fazer parte da comunidade online! (Como faz... #124)
by Owen JonesFormas de fazer parte da comunidade online e se atualizar com o século 21! Ideias para a Internet Bem-vindo ao "Ideias para a Internet" - um manual para iniciantes, seu guia para dominar o mundo digital com confiança e compreensão. No mundo interconectado de hoje, a Internet tornou-se uma ferramenta essencial para comunicação, aprendizado e entretenimento. Como especialista experiente em tudo o que envolve a internet, estou empolgado por ser seu guia nesta jornada esclarecedora. Este manual foi meticulosamente elaborado para fornecer aos iniciantes uma base sólida para atravessar a vasta paisagem da Internet. Esteja você se conectando pela primeira vez ou buscando aprofundar seus conhecimentos, este guia permitirá que você navegue com facilidade e tome decisões informadas. Tenha a certeza de que cada pedaço de informação apresentado aqui está enraizado na precisão e nas últimas perspectivas. A Internet, embora incrivelmente poderosa, pode ser complexa, mas ao embarcar nesta aventura juntos, você está se preparando para o sucesso. Equipe-se com as habilidades e sabedoria necessárias para aproveitar ao máximo a era digital, mantendo os valores da verdade e da integridade. Vamos começar nossa exploração das possibilidades ilimitadas da Internet! Espero que você ache as informações úteis, proveitosas e lucrativas.
Identity: Murder, Fraud and the Making of a Garda Forensic Expert
by John SweetmanWhen a violent incident in his stationed town led John Sweetman into the Garda Technical Bureau with incriminating evidence, the course of his life changed dramatically. As a young garda struggling with personal demons, he went from being on verge of leaving the force to finding his true calling. John spent the next 25 years as a detective garda working on the frontline of crime scene investigations - as both a fingerprint expert and, in later years, a forensic handwriting and document expert. His natural eye for detail and tenacity led him to becoming involved in many criminal investigations and high-profile cases.From the brutal murder of Marie Dillon in Finglas in 1998 to the gangland killing of Raymond Salinger in 2003, John was involved in the search for forensic evidence at these, and numerous other, crime scenes. He later employed his handwriting expertise in the investigation of fraudulence, threatening letters and counterfeit documents, as well as the investigations into the callous murders of Jasmine McGonagle and student Jastine Valdez and the horrific Hawe familicide in Cavan in 2016.Identity is both a fascinating insight into specialist forensic fields - that peeks behind the curtain of how crimes are solved - and a bravely told story of a misfit detective in a remarkable career.
Identity: Murder, Fraud and the Making of a Garda Forensic Expert
by John SweetmanWhen a violent incident in his stationed town led John Sweetman into the Garda Technical Bureau with incriminating evidence, the course of his life changed dramatically. As a young garda struggling with personal demons, he went from being on verge of leaving the force to finding his true calling. John spent the next 25 years as a detective garda working on the frontline of crime scene investigations - as both a fingerprint expert and, in later years, a forensic handwriting and document expert. His natural eye for detail and tenacity led him to becoming involved in many criminal investigations and high-profile cases.From the brutal murder of Marie Dillon in Finglas in 1998 to the gangland killing of Raymond Salinger in 2003, John was involved in the search for forensic evidence at these, and numerous other, crime scenes. He later employed his handwriting expertise in the investigation of fraudulence, threatening letters and counterfeit documents, as well as the investigations into the callous murders of Jasmine McGonagle and student Jastine Valdez and the horrific Hawe familicide in Cavan in 2016.Identity is both a fascinating insight into specialist forensic fields - that peeks behind the curtain of how crimes are solved - and a bravely told story of a misfit detective in a remarkable career.
Identity: Murder, Fraud and the Making of a Garda Forensic Expert
by John SweetmanWhen a violent incident in his stationed town led John Sweetman into the Garda Technical Bureau with incriminating evidence, the course of his life changed dramatically. As a young garda struggling with personal demons, he went from being on verge of leaving the force to finding his true calling. John spent the next 25 years as a detective garda working on the frontline of crime scene investigations - as both a fingerprint expert and, in later years, a forensic handwriting and document expert. His natural eye for detail and tenacity led him to becoming involved in many criminal investigations and high-profile cases.From the brutal murder of Marie Dillon in Finglas in 1998 to the gangland killing of Raymond Salinger in 2003, John was involved in the search for forensic evidence at these, and numerous other, crime scenes. He later employed his handwriting expertise in the investigation of fraudulence, threatening letters and counterfeit documents, as well as the investigations into the callous murders of Jasmine McGonagle and student Jastine Valdez and the horrific Hawe familicide in Cavan in 2016.Identity is both a fascinating insight into specialist forensic fields - that peeks behind the curtain of how crimes are solved - and a bravely told story of a misfit detective in a remarkable career.
Identity Construction as a Spatiotemporal Phenomenon within Doctoral Students' Intellectual and Academic Identities: Contradictions, Contestations and Convergences (Routledge Research in Higher Education)
by Rudo F. HwamiInvestigating the interplay between space, time and identity construction, this book brings to focus how spatiality and temporality have been largely overlooked in the study and theorisation of identity construction.Offering Gloria Anzaldúa concept of ‘conocimento’ as a theoretical tool for analysing identity construction, the book investigates how doctoral students hold varying assumptions about their intellectual identity, where the doctoral process enables them to deconstruct and reconstruct these identities. Chapters examine the implications for scholars who find themselves in the in-between space of transitional identities, advocating the need for innovative identity theorisation to strike a balance in the shifting dynamics between different presentations of identity and belief systems. Bringing together Lefebvre’s theorisation of the relationship between space and the body in rhythmanalysis and Anzaldua’s theorisation of the relationship between the body and identity construction, the book offers a transdisciplinary reading of space, body, and identity.Providing a space to continue and progress the foregrounding of narratives from marginalised voices and groups in higher education, the book will be of interest to scholars, researchers and academics in the fields of sociology of education, multicultural education, higher education, and philosophy of education.
If Something Happens to Me: A Novel
by Alex FinlayFrom “one of the genre’s most exciting voices” (E! News) comes one of the year’s most-anticipated thrillers.For the past five years, Ryan Richardson has relived that terrible night. The car door ripping open. The crushing blow to the head. The hands yanking him from the vehicle. His girlfriend Ali’s piercing scream as she is taken.With no trace of Ali or the car, a cloud of suspicion hangs over Ryan. But with no proof and a good lawyer, he’s never charged, though that doesn’t matter to the podcasters and internet trolls. Now, Ryan has changed his last name, and entered law school. He's put his past behind him.Until, on a summer trip abroad to Italy with his law-school classmates, Ryan gets a call from his father: Ali's car has finally been found, submerged in a lake in his hometown. Inside are two dead men and a cryptic note with five words written on the envelope in Ali’s handwriting: If something happens to me… Then, halfway around the world, the unthinkable happens: Ryan sees the man who has haunted his dreams since that night.As Ryan races from the rolling hills of Tuscany, to a rural village in the UK, to the glittering streets of Paris in search of the truth, he has no idea that his salvation may lie with a young sheriff’s deputy in Kansas working her first case, and a mobster in Philadelphia who’s experienced tragedy of his own.In classic Alex Finlay form, If Something Happens to Me is told by several distinct, compelling characters whose paths intersect, detonating into a story of twist after pulse-pounding twist. The novel cements Finlay as one of the leading thriller writers today.
If You Can't Take the Heat: Tales of Food, Feminism, and Fury
by Geraldine DeRuiterNATIONAL BESTSELLER • From the James Beard Award–winning blogger behind The Everywhereist come hilarious, searing essays on how food and cooking stoke the flames of her feminism.&“With charm and humor, Geraldine DeRuiter welcomes us into her personal history and thus reconnects us with ourselves.&”—Mikki Kendall, New York Times bestselling author of Hood FeminismWhen celebrity chef Mario Batali sent out an apology letter for the sexual harassment allegations made against him, he had the gall to include a recipe—for cinnamon rolls, of all things. Geraldine DeRuiter decided to make the recipe, and she happened to make food journalism history along with it. Her subsequent essay, with its scathing commentary about the pervasiveness of misogyny in the food world, would be read millions of times, lauded by industry luminaries from Martha Stewart to New York Times restaurant critic Pete Wells, and would land DeRuiter in the middle of a media firestorm. She found herself on the receiving end of dozens of threats when all she wanted to do was make something to eat (and, okay fine, maybe take down the patriarchy).In If You Can&’t Take the Heat, DeRuiter shares stories about her shockingly true, painfully funny (and sometimes just painful) adventures in gastronomy. We&’ll learn how she finally got a grip on her debilitating anxiety by emergency meal–planning for the apocalypse. (&“You are probably deeply worried that in times of desperation I would eat your pets. And yes, I absolutely would.&”) Or how she learned to embrace her hanger. (&“Because women can be a lot of things, but we can&’t be angry. Or president, apparently.&”) And how she inadvertently caused another international incident with a negative restaurant review. (She made it on to the homepage of The New York Times&’s website! And she got more death threats!)Deliciously insightful and bitingly clever, If You Can&’t Take the Heat is a fresh look at food and feminism from one of the culinary world&’s sharpest voices.
If You Can't Take the Heat
by Michael RuhlmanFrom James Beard Award–winning author Michael Ruhlman, a coming-of-age story about finding a new life and love in the kitchen…and trying not to get burned along the way.When high school football star Theo Claverback breaks his leg just weeks after a devastating break-up, he&’s forced to call an audible on his summer plans and put his college ones on hold. He soon finds himself in the most unlikely of places for a jock on crutches: the kitchen of an upscale French restaurant, where he&’ll work as a prep cook while his heart and leg heal.But it&’s in the kitchen where Theo finds new purpose and a new romance. As he becomes a trusted employee to Chef and is welcomed into his inner circle, Theo begins to discover the true costs of running a restaurant—and what happens when you get into hot water with the wrong people.Set in Cleveland, Ohio, in 1980, If You Can't Take the Heat is a gritty look inside the belly of an upscale kitchen where love and danger boil behind closed doors.
If You Knew My Name: A Novel in Verse
by Lisa Roberts CarterLisa Roberts Carter&’s debut, If You Knew My Name, is a novel-in-verse telling the story of 17-year-old Mason Tyndall— an aspiring rap artist whose mother is a BLM activist. She saw fatal officer-involved shootings as senseless tragedies. He viewed them as trending hashtags — that is, until he almost became one.Mason Zy&’Aire Tyndall has big dreams. Dreams of sick beats, epic mic-drops, sold out stadiums. Mason&’s going to be a rap star—and you don&’t become a rap star by hitting up BLM protests with your mom or sitting at a desk. Mason wants to get out there and make a name for himself, but he&’ll have to graduate high school first. And he can&’t do that if he fails his senior year. Convinced his poetry class is a waste of time, Mason&’s teacher helps him see just how valuable a couplet and a rhyme can be. But when an unarmed Black man is killed by the police in his city, tensions start to rise—among the cops, the community, and even Mason&’s peers. Caught in the middle of increasingly violent conflicts, Mason will have to find a way to use his voice for change…and fast.
Il cuore di Lachlan: Secondo libro della Saga dei MacCullough (Saga dei MacCullough #2)
by Suzan TisdaleLa saga dei MacCullough continua... Lachlan MacCullough non vuole essere un laird. Non lo ha mai fatto. Ma quando suo cugino, Black Richard, gli chiede di governare i possedimenti di Randall Chisolm, conquistati di recente, fino a quando il primogenito di Black Richard non sarà abbastanza grande per farlo, non può rifiutare la richiesta. Anche se questo lo allontanerà dall'unica donna che desidera... Keevah. Keevah non può sfuggire al suo passato. Conosciuta come la vecchia prostituta, nemmeno la sua amicizia con la moglie di Black Richard, Aeschene, le risparmierà le dicerie e gli insulti che la perseguitano da anni. Ma ci sono cose peggiori dell'essere evitati. Quando Keevah riceve la notizia che una vecchia e cara amica sta morendo, deve tornare a Inverness per darle addio e mantenere una vecchia promessa. Questo scherzo del destino la fa incontrare ancora una volta con Lachlan, l’uomo che ama ma di cui si sente disperatamente indegna. La mette anche sulla strada di un assassino squilibrato intenzionato a liberare il mondo dalle prostitute. Troverà la sicurezza e la felicità tra le braccia di Lachlan, o pagherà con il prezzo più alto i peccati del suo passato?
Il Dolce Far Niente: The Italian Way of Summer
by Lucy LauchtThis book is a gorgeous, photographic ode to the magic of southern coastal Italy in the summer by renowned travel, fashion, and lifestyle photographer Lucy Laucht. A languorous August afternoon. That brilliant light and those impossible Mediterranean blues. The touch of sun on hot skin. And everywhere, the sounds of laughter and lighthearted conversation. Captured by photographer Lucy Laucht, these lyrical scenes of Naples, Ischia, the Amalfi Coast, Capri, Puglia, Sicily, and the Aeolian and Egadi Islands are an ode to the Italian way of summer and that distinctly Italian art of sweet idleness.
Il Treno
by Anna GregoPrendi il treno? Non sai esattamente dove sta andando finché non raggiunge il suo destino... In Il Treno non è diverso. Quando la velocità del treno aumenta, i passeggeri sanno che c’è qualcosa che non va. Qualcosa di molto sbagliato... e inevitabile. La destinazione inaspettata riserva l’inimmaginabile ai passeggeri.
Il Visconte Scomparso: Contrattempi magici
by Jane CharlesLady Clara Westcott si innamora di Pierce Drakos, visconte Harcourt, all’età di quindici anni. Da quel momento in poi tutto va storto, dal punto di vista magico. Quando lo incontra di nuovo a Londra, Clara capisce subito che potrebbe essere un pericolo per Harcourt e giura di mantenere le distanze. Pierce considerava lady Clara dolce e carina a quindici anni, ma a diciotto è maturata in modo delizioso. Tuttavia, ogni volta che lui desidera avvicinarsi, lei sparisce. Ora che è in programma una visita alla tenuta della sua famiglia e la partecipazione al Ballo delle Streghe di sua madre, si ripromette di scoprire perché lei lo evita. Quello che non ha previsto è che sarà lui stesso a sparire.
The Illiberal Public Sphere: Media in Polarized Societies
by Sabina Mihelj Václav ŠtětkaThis open access book provides the first systematic analysis of the role of the media in the rise of illiberalism, based on an original theoretical framework and extensive empirical research in Eastern Europe – a region that serves as a key battleground in the global advance of illiberalism. Liberal democracies across the world are facing a range of challenges, from the growing influence of illiberal leaders and parties to deepening polarization and declining trust in political elites and mainstream media. Although these developments attracted significant scholarly attention, the factors that contribute to the spreading of illiberalism remain poorly understood, and the communication perspective on illiberalism is particularly underdeveloped.Štětka and Mihelj address this gap by introducing the concept of the illiberal public sphere, identifying the key stages in its development, and explaining what makes illiberalism distinct from related phenomena such as populism. Their analysis reveals how and why the changing communication environment facilitates selective exposure to ideologically and politically homogeneous sources, fosters changes in normative assumptions that guide media trust, increases vulnerability to disinformation, and goes hand in hand with growing hostility to immigration and LGBTQ+ rights. The findings challenge widespread assumptions about digital platforms as key channels of illiberalism and suggest that their role shifts as the illiberal sphere progresses.The arguments presented in this book have important implications for future research on challenges to liberal democracy, as well as for journalists, media regulators and other professionals committed to rebuilding media trust and containing the forces of polarization.
Illuminating Our True Nature: Yogic Practices for Personal and Collective Healing
by Michelle Cassandra JohnsonDissolve hurtful patterns and emotional hardship through the five yogic points of suffering, or kleshas.Includes powerful and practical meditations, mantras, asanas, reflection questions, and more, to reduce our suffering—and the suffering of others.We all get stuck in hurtful patterns that continue to create more suffering in our lives. In yoga philosophy, these patterns are known as the five kleshas. In this wise, practical guide, Michelle Cassandra Johnson offers us a path toward developing a deeper understanding of them and how they hijack us emotionally.The five kleshas are: ignorance (avidya); overidentification with ego (asmita); attachment to desire or pleasure (raga); aversion or avoidance (dvesha); and fear of death or letting go (abhinivesha). Each one leads us to create tendencies and karma that move us away from realizing and remembering our true nature and seeing ourselves as separate from one another and the planet. In yogic terms, this perpetuates a constant cycle of pain for us all.Readers will learn to: • deepen their connection with self and others; • look at their relationship and attachment to pleasure and aversion to discomfort; • notice more fully how their actions affect others; • meet each moment as it arises and ride the waves of life as they come; • and much moreJohnson offers us a way to find a sense of clarity, groundedness, and equanimity within ourselves by working through the kleshas one-by-one using asana, pranayama, mudra, mantra, reflection questions, and meditation.
The Illustrated & Complete Brigadier Gerard
by Sir Arthur Conan Doyle“At the head of the Grande Armee march the Hussars of Conflans—and leading them is Brigadier Gerard!These are the adventures of Conan Doyle's incomparable French hero—the finest swordsman in the Light Cavalry—Etienne Gerard. Arranged for the first time in historical chronological order, his many enthusiasts can now properly appreciate his colourful career as he fights, loves and blunders his way through the Napoleonic epoch—from his earliest adventure as a young blade determined to reach his lady love despite the unwelcome attention of her father’s bull—through many campaigns and special missions—to the bloody field of Waterloo, the downfall of his beloved Emperor and beyond. This is the complete collection of these classic stories. What makes this edition exceptional is the inclusion of nearly 140 illustrations—mostly by the famed military artist William Barnes Wollen—which accurately portray the spirit of the stories and the uniforms and scenes of the events they portray. At last the modern reader can fully appreciate the Brigadier as he originally appeared in The Strand magazine. This unique volume will be a delight for fans of Conan Doyle and the Brigadier-and will be a perfect addition to the libraries of enthusiasts of the age of Napoleon in fiction and in history alike.—Print ed.
Im Brennpunkt der Wirtschaftspolitik: Innovation, Globalisierung und Klimawandel
by Christian KeuschniggDieser Open-Access-Sammelband zeigt, wie innovative Forschung und Lehre in der Volkswirtschaftslehre zu einer besseren Gesellschaft beitragen können. Eine Wirtschaftspolitik mit Ziel und Plan sollte auf rigorosem theoretischem Fundament stehen und sich auf verlässliche empirische Evidenz stützen. Damit die Forschung Wirkung entfalten kann, müssen die Forscher die neuesten Erkenntnisse in eine populäre Sprache übersetzen, damit sie einer breiten und nicht spezialisierten Öffentlichkeit zugänglich werden. Wähler und Entscheidungsträger der Politik können von den Ergebnissen der Forschung nur profitieren, wenn diese in nicht-technischer Sprache zugänglich sind. Die Aufgaben der Universitäten sind Forschung, Lehre und Information der Öffentlichkeit. Im Projekt "Next Generation" fassen die besten Masterstudierenden der Universität St. Gallen politikrelevante Ergebnisse der volkswirtschaftlichen Forschung populär zusammen. Mit diesem "Readers Digest" der Ökonomie leisten sie einen wichtigenBeitrag zur dritten Mission der Universität.
I'm Mostly Here to Enjoy Myself: One Woman's Pursuit of Pleasure in Paris
by Glynnis MacNicolWhen you&’re a woman of a certain age, you are only promised that everything will get worse. But what if everything you&’ve been told is a lie?Come to Paris, August 2021, when the City of Lights was still empty of tourists and a thirst for long-overdue pleasure gripped those who wandered its streets.After New York City emptied out in March 2020, Glynnis MacNicol, aged forty-six, unmarried with no children, spent sixteen months alone in her tiny Manhattan apartment. The isolation was punishing. A year without touch. Women are warned of invisibility as they age, but this was an extreme loneliness no one can prepare you for. When the opportunity to sublet a friend&’s apartment in Paris arose, MacNicol jumped on it. Leaving felt less like a risk than a necessity.What follows is a decadent, joyful, unexpected journey into one woman&’s pursuit of radical enjoyment.The weeks in Paris are filled with friendship and food and sex. There is dancing on the Seine; a plethora of gooey cheese; midnight bike rides through empty Paris; handsome men; afternoons wandering through the empty Louvre; nighttime swimming in the ocean off a French island. And yes, plenty of nudity.In the spirit of Nora Ephron and Deborah Levy (think Colette . . . if she&’d had access to dating apps), I&’m Mostly Here to Enjoy Myself is an intimate, insightful, powerful, and endlessly pleasurable memoir of an intensely lived experience whose meaning and insight expand far beyond the personal narrative. MacNicol is determined to document the beauty, excess, and triumph of a life that does not require permission.The pursuit of enjoyment is a political act, both a right and a responsibility. Enjoying yourself—as you are—is not something the world tells you is possible, but it is.Here&’s the proof.
I'm Never Drinking Again: How to Stop Drinking So Much and Change Your Relationship with Alcohol
by Dominic McGregor'Dom opens people's eyes to show them that what's holding their life back might be hiding at the bottom of their glass...'- Chris Williamson - Modern Wisdom ‘I saw firsthand how Dominic transformed his relationship with alcohol. This enabled him to become the best version of himself and inspired him to achieve his personal and business goals.’- Steven Bartlett, Entrepreneur, Speaker, Investor, Author and the host of the UK’s No.1 Podcast ‘The Diary of a CEO’ ‘Like any drug, if not taken in moderation, alcohol is a poison and impacts every part of your system. Dominic McGregor saw this clearly on his own journey to change his relationship with alcohol, and interweaves his own personal challenges with practical advice and wisdom.’- Professor Steve Peters, Consultant Psychiatrist and Bestselling Author of The Chimp Paradox An insightful account into how changing your relationship with alcohol can change your life In I'm Never Drinking Again: How to stop drinking so much and change your relationship with alcohol, successful entrepreneur, investor, and mental health advocate Dominic McGregor, now seven years sober, explains how changing your relationship with alcohol can transform every aspect of your life. In the book, you'll explore the role alcohol plays in our society and how dangerous it can be when mixed with poor emotional wellbeing and challenges in life. You'll also discover the advantages of questioning your relationship with alcohol, whether sobriety or moderating alcohol can lead to success, and how, if unmanaged, alcohol can take over your life. The author explains: How to manage mental health problems, addictions to alcohol and other drugs, burnout, and other harmful phenomena associated with success How exploring a “sober-curious” lifestyle can aid success How your life can be positively impacted by questioning your relationship with alcohol I'm Never Drinking Again will prove invaluable for anyone who is "sober-curious" and wishes to understand the affect alcohol may play in their lives. Whether you are battling addiction, questioning your relationship with alcohol, or just intrigued by the prospect of challenging yourself to go alcohol free, I'm Never Drinking Again will empower you to strive for a better lifestyle.
Imaging Cell Signaling (Methods in Molecular Biology #2800)
by Robert F. Murphy Christoph WülfingThis volume explores recent innovations across the entire pipeline of imaging signal transduction, cell preparation, cellular manipulation, image acquisition, and computational analysis. The chapters in this book cover topics such as rapid preparation of living Drosophila pupal macrophages for ex vivo imaging; controlling the potency of T cell activation using an optically tuneable chimeric antigen receptor; in situ imaging of proteins using DNA-PAINT super-resolution microscopy; reconstructing signaling networks using biosensor barcoding; and morphological, spatial, and dynamic models for cellular components. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and authoritative, Imaging Cell Signaling is a valuable resource that provides guidance to researchers looking to learn how to effectively tailor design projects to image, manipulate, and model signal transduction.
Imagining the American Polity, Second Edition: Political Science and the Discourse of Democracy
by John G. GunnellAmericans have long prided themselves on living in a country that serves as a beacon of democracy to the world, but from the time of the founding they have also engaged in debates over what the criteria for democracy are as they seek to validate their faith in the United States as a democratic regime. In this book John G. Gunnell shows how the academic discipline of political science has contributed in a major way to this ongoing dialogue, thereby playing a significant role in political education and the formulation of popular conceptions of American democracy. Gunnell traces the dynamics of conceptual change and continuity as American political science evolved from a focus in the nineteenth century on the idea of the state, through the emergence of a pluralist theory of democracy in the 1920s and its transfiguration into liberalism in the mid- 1930s, up to the rearticulation of pluralist theory in the 1950s and its resurgence, yet again, in the 1990s. Along the way he explores how political scientists have grappled with a fundamental question about popular sovereignty: Does democracy require a people and a national democratic community, or can the requisites of democracy be achieved through fortuitous social configurations coupled with the design of certain institutional mechanisms?
The Immeasurable Power of Prayer (The Buddhism of the Sun)
by Daisaku IkedaDoes prayer work? What does it mean to pray in Buddhism? In a world where problems, both personal and global, seem out of our control, Buddhist philosopher Daisaku Ikeda explains the power of chanting Nam-myoho-renge-kyo: “ Daimoku is so powerful that there is nowhere in the universe it does not reach.” The Immeasurable Power of Prayer is a collection of essays where Daisaku Ikeda outlines the limitless power of prayer in Nichiren Buddhism. We learn that no matter how difficult our circumstances, through chanting, we develop the ability to take bold action, create value, and make positive changes.
Immune Homeostasis: Methods and Protocols (Methods in Molecular Biology #2782)
by Vijay KumarThis volume discusses different aspects of immune homeostasis regulation and its dysregulation during various diseases, including infections, cancers, neurodegenerative diseases, autoinflammation, autoimmune diseases, and immunodeficiency, along with immunological, genetic, cell biology, and molecular biology techniques designed to understand immune homeostasis at different stages. The chapters in this book cover topics such as T cell subsets; monocyte-myofibroblast immunomodulation in a 3D co-culture system; human peripheral blood mononuclear cells in patients with neurodegenerative diseases; and CRISPR-Cas9 induced gene-editing in primary human monocytes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and comprehensive, Immune Homeostasis: Methods and Protocols is a valuable resource for both novice and experts researchers interested in learning more about this important and developing field.