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Intelligent 3D Technologies and Augmented Reality: Proceedings of the Fifth International Conference on 3D Imaging Technologies—Multidimensional Signal Processing and Deep Learning, Volume 2 (Smart Innovation, Systems and Technologies #401)
by Roumen Kountchev Srikanta Patnaik Yingkai Liu Roumiana KountchevaThis book presents high-quality research in the field of 3D imaging technology. The fifth edition of International Conference on 3D Imaging Technology (3DDIT-MSP&DL) continues the good traditions already established by the first four editions of the conference to provide a wide scientific forum for researchers, academia, and practitioners to exchange newest ideas and recent achievements in all aspects of image processing and analysis, together with their contemporary applications. The conference proceedings are published in two volumes. The main topics of the papers comprise famous trends such as: 3D image representation, 3D image technology, 3D images and graphics, and computing and 3D information technology. In these proceedings, special attention is paid at the 3D tensor image representation, the 3D content generation technologies, big data analysis, and also deep learning, artificial intelligence, the 3D image analysis and video understanding, the 3D virtual and augmented reality, and many related areas. The first volume contains papers in 3D image processing, transforms, and technologies. The second volume is about computing and information technologies, computer images, and graphics and related applications. The two volumes of the book cover a wide area of the aspects of the contemporary multidimensional imaging and the related future trends from data acquisition to real-world applications based on various techniques and theoretical approaches.
Proceedings of the TEPEN International Workshop on Fault Diagnostic and Prognostic: TEPEN2024-IWFDP - Volume 1 (Mechanisms and Machine Science #170)
by Bingyan Chen Xiaoxia Liang Tian Ran Lin Fulei Chu Andrew D. BallThis book gathers the latest advances, innovations, and applications in the field of efficiency and performance engineering, as presented by leading international researchers and engineers at the TEPEN International Workshop on Fault Diagnostics and Prognostics (TEPEN-IWFDP), held in Qingdao, China on May 8–11, 2024. Topics include machine and structural health monitoring, non-destructive testing and fault detection, diagnostic and prognostic for both operational and manufacturing processes, maintenance optimization and asset management, smart metamaterials and metastructures, artificial intelligence, and machine learning. The contributions, which were selected through a rigorous international peer-review process, share exciting ideas that will spur novel research directions and foster new multidisciplinary collaborations.
Integration of Legume Crops with Cereal Crops Under Changing Climate: Sustainably Increasing Food Production
by Samiha Ouda Abd El-Hafeez ZohryThe world population is steadily increases with high rate in the past decade from 7,126 billion inhibitors in 2012 to 8,095 billion inhibitors in 2024, with 14% increase. In the meantime, the number of severely food insecure people were 604.5 million in 2014, which increased by 53% in 2020 to reach 927.6 million people. These numbers raise large concerns about the future of food production to feed these continually growing population. Lately, many developing countries rely on importing large quantities of crops, such as wheat, maize, and rice to meet their food and feed needs. The negative impact of climate change and its consequences, namely high temperature causing low crops productivity and water scarcity, which causing great disruptions in food production systems. Therefore, increasing the production of cereal crops worldwide can be achieved through increasing average yield per unit area or expanding the area devoted to cereals into more marginal lands. Moreover, breeding for more resilient cultivars, which can release its potential yield could play an important role in increasing total production under the adverse growth conditions. Inclusion of legume crops, such as soybean, peanut, and cowpea in cereal-based cropping systems is a viable strategy to increase production of cereal crops. It also helps in reducing the use of chemical fertilizer. It has been reported that intercropping legume crops with cereal crops can increase the productivity of both crops. Additionally, an increase in soil nitrogen, phosphorus and potassium has been also reported when legume crops were included in cereal-based cropping system. It has been also reported that inclusion of legume crops increases the soil water-holding capacity and water used efficiency. Thus, inclusion of legume crops in cereal-based cropping systems can increase its productivity, as well as attains the sustainable use of soil and water resources. In this book, we will thoroughly tackle the benefits of the integration of legume crops within cereal-based cropping system, namely wheat, maize and rice (paddy and upland) under the changing climate (current and future). We also reviewed the innovations and interventions that could sustainably intensify the production of cereals to reduce hunger and poverty. We will use both modeling and simulation approaches to assess the impact of climate change using CMIP6 mean projection of two future scenarios, namely SSP1-2.6 and SSP5-8.5 in two time-intervals (2060-2079 and 2080-2099) on the yield and water requirements of wheat, maize and rice (paddy and upland).
The Fatwā in the Digital Age: What Are Muslim Millennials Looking For?
by Wael FarouqThe rise of a significantly large (and young) Muslim population in the West, possessing no historical tradition of being a minority in a non-Muslim environment, has led to a recurring debate about the integration of Muslims into Western societies and the compatibility of Islam with Western values. The proliferation of Islamic sites to which thousands of Western Muslims turn to request a fatwa, i.e. a religious legal opinion on any issue, hints at the urgency felt by these Muslims to find a way out of this conflictual dialectic, since most of their questions concern precisely how to reconcile Islamic principles with some aspect of modern life in the West. The pervasiveness of these internet fatwas is a striking phenomenon worth of study that can help finding answers to the longstanding debate about the integration of Muslims in the West and in modern societies. raising interesting questions: What do Muslims in Western societies ask these virtual muftis and why? Who are they? What are their desires and concerns? In their asking, are these Muslims seeking integration or separation? Do these questions reflect common clichés about Muslims, as conveyed by some Western media narratives or not? Do they reason as individuals or as members of a religious community? This book presents a scientific study aimed at answering these questions through a statistical and discourse analysis of a large corpus of more than ten thousand fatwa questions extracted from the huge fatwa databases available on the internet.
Vegane und vegetarische Ernährung aus medizinischer Sicht: Fundiert beraten bei pflanzenbasierten Ernährungsformen
by Markus KolmPflanzenbasierte Ernährungsformen erfreuen sich immer größerer Beliebtheit. Das bedeutet, dass auch in der ärztlichen Praxis jede zehnte Person zumindest schon einmal mit dem Gedanken von Veganismus gespielt hat oder eine vegetarisch/vegane Lebensweise praktiziert. Dieses Kompendium rund um eine pflanzenbasierte Kost dient als strukturierter Leitfaden zur Beratung von vegan bzw. vegetarisch lebenden Personen im ärztlichen Setting. Es stellt evidenzbasierte Informationen rund um die Vorteile einer pflanzenbasierten Kost bereit. Neben der Auflistung aussagekräftiger Laborparameter zur Abschätzung der Versorgung potentiell kritischer Nährstoffe werden auch ausgewählte ernährungsassoziierte Erkrankungen beleuchtet. Eine abwechslungsreiche, vollwertige pflanzliche Kost weist großes, bislang zu selten genutztes Potential sowohl in Prävention als auch in Therapie von einigen chronischen Erkrankungen auf, wie z.B. Adipositas, Bluthochdruck und Diabetes mellitus Typ II. Das praktische Buch richtet sich an Ärzt:innen, Angehörige anderer Gesundheitsberufe sowie an interessierte Leser:innen, die ihr Wissen über vegane Ernährung vertiefen möchten.
Intelligent Technologies: Concepts, Applications, and Future Directions, Volume 3 (Studies in Computational Intelligence #1167)
by Himansu Das Arup Abhinna Acharya Kuan-Ching LiThis book discusses automated computing systems which are mostly powered by intelligent technologies like artificial intelligence, machine learning, image recognition, speech processing, cloud computing, etc., to perform complex automated tasks which are not possible by traditional computing systems. The chapters are extended version of research works presented at third PhD Research Symposium in various advanced technologies used in the field of computer science. This book provides an opportunity for the researchers to get ideas regarding the ongoing works that help them in formulating problems of their interest. The academicians can also be benefited to know about the current research trends that smooth the way to guide their students to carry out research work in the proper direction. The industry people will be also facilitated to know about the current advances in research work and materialize the research work into industrial applications.
Broken Silence (Karen Rose)
by Karen RoseShe needed help.She needed protection. BROKEN SILENCE is a thrilling e-novella following on from DID YOU MISS ME in the Baltimore series, by Sunday Times bestseller Karen Rose.'Intense, complex and unforgettable' JAMES PATTERSON'There's action and chills galore in this nonstop thriller' TESS GERRITSEN _________Don't say a word...Assistant State's Attorney Daphne Montgomery has been told to take time off after recent personal trauma. But she refuses to sit on the side lines when she meets a six-year-old girl the police call Angel.Angel hasn't spoken a word since she was found four days ago next to a burned-out car, frozen with shock, not far from the bodies of two adults who may or may not have been her parents.FBI Special Agent Joseph Carter knows that helping Angel is exactly what Daphne needs. But when Daphne gets Angel to talk, a mysterious and chilling crime begins to unravel - one that will drive Daphne into the darkest corners of her past as she and Joseph track a ruthless killer._________Praise for Karen Rose:***** '...a compact, concise, short story of quality. It stands alone although familiarity with characters from her last novel adds to the feel of this excellently crafted story... Excellent and enjoyable'***** 'I find I can't put Karen Rose books down, they are extremely well written... keep me enthralled to the very end. She paints an excellent picture... can't wait to start the next book'***** 'An outstanding finish to Karen's previous book! Highly recommend a read, can't get enough of them!'***** 'This book is very engrossing. I thoroughly enjoyed it. I have read all Karen Rose's books and have enjoyed every one'
The Unexpected Joy of Being Sober: THE SUNDAY TIMES BESTSELLER (The Unexpected Joy Of #1)
by Catherine GrayGoing sober will make you happier, healthier, wealthier, slimmer and sexier. Despite all of these upsides, it's easier said than done. This inspirational, aspirational and highly relatable narrative champions the benefits of sobriety; combining the author's personal experience, factual reportage, contributions from experts and self-help advice.
Sunshine Warm Sober: The unexpected joy of being sober – forever (The Unexpected Joy #5)
by Catherine GrayThe long-awaited sequel to THE UNEXPECTED JOY OF BEING SOBER 'Exquisite' - Fearne Cotton, Happy Place'A paean to the longer-term pleasures of staying booze-free' - The Guardian'The kind of book that changes lives, and very possibly saves them' - The Lancet Psychiatry'A reflective, raw and riveting read. A beautiful book on what it takes to root for yourself' - Emma Gannon, Ctrl Alt Delete'No other author writes about sober living with as much warmth or emotional range as Catherine Gray. Her deep insight into the subtle psychologies of drinking, and of life, means that everything she writes is both utterly relatable and stretches our minds. Hers is a rare wisdom.' - Dr Richard Piper, CEO, Alcohol Change UKWhat's it like to give up drinking forever?We know now that being teetotal for one, three, even twelve months brings surprising joys and a recharged body... but nothing has been written about going years deep into being alcohol-free.As Catherine Gray, author of runaway success The Unexpected Joy of Being Sober, streaks towards a decade sober, she explores this uncharted territory in her trademark funny, disruptive and warm way. This is a must-read for anyone sober-curious, whether they've put down the bottle yet or not. Praise for The Unexpected Joy of Being Sober:'Fascinating' - Bryony Gordon 'Truthful, modern and real' - Stylist'Brave, witty and brilliantly written' - Marie Claire'Gray's tale of going sober is uplifting and inspiring' - Evening Standard 'Not remotely preachy' - Sunday Times 'Jaunty, shrewd and convincing' - Sunday Telegraph 'Admirably honest, light, bubbly and remarkably rarely annoying' - Guardian 'An empathetic, warm and hilarious tale from a hugely likeable human' - The Lancet Psychiatry
The Slimming Foodie in One: 100+ one-dish recipes under 600 calories
by Pip Payne'Pip Payne is on a mission to help us eat well, without feeling we're on a diet.' - BESTThe Slimming Foodie is back with a fantastic new collection of slimming recipes. These dishes are as tasty as ever but even simpler to prepare, as they can all be made in one pot, pan, tray or dish. The Slimming Foodie is known for her simple approach to food; she's a firm believer that you don't need to spend hours in the kitchen to deliver amazing results, nor do you have to completely change your eating habits to lose weight. With Pip's clever swaps and cooking techniques, you can slim down while still enjoying all your favourite foods - it's a modern weight-loss method that puts flavour first.In her first book, the Slimming Foodie showed us how easy and enjoyable slimming recipes can be. Now she has made dinnertime even simpler by creating delicious all-in-one meals with surprisingly few calories. From flash-in-the-pan dinners to slow-cooked comforts, you will find something for the whole family to enjoy without fuss and with minimal washing up!The Slimming Foodie in One is made up of seven chapters, each one reflecting a different method of one-pot cooking:Chapter 1: In a Pot Includes Pizza mac 'n' cheese, Chicken lemon pepperpot and Jumbled cottage pieChapter 2: In a PanIncludes Black bean & mushroom dal, Special chow mein and Kofta meatballs with harissa chickpea sauceChapter 3: In a TrayIncludes Bombay burritos, Rösti-topped fish pie and Cheeseburger balls with loaded chippiesChapter 4: Soup-erIncludes Arrabbiata orzo soup, Salmon & miso broth and Chicken & prawn laksaChapter 5: In a Slow-cooker Includes White chicken chilli, Coffee-rubbed barbecue pulled pork and Fakeaway doner kebabChapter 6: All in the PrepIncludes Tex-mex macaroni, Crunchy Japanese-style rice salad and Chickpea & tuna saladChapter 7: Jazz it UpIncludes Speedy preserved lemons, Ketchup with a kick and Veggie salsa verdeThe Slimming Foodie in One was a Sunday Times bestseller in July 2022
The Numinous Tarot Guide: A new way to read the cards (The Numinous)
by The Numinous Rashunda TrambleThe Numinous Tarot Guide is an interactive, self-study guide that unlocks the meaning of the cards in an instant - and in a way that is deeply personal to every reader of every level. Designed to be used with any deck, a reading for each of the 78 cards offers a modern, evolved interpretation of the card's meaning, along with prompts and journal exercises, to help guide the reader into a space of deep reflection.The traditional way to interact with the Tarot is to ask a question and then pull a card to divine the 'answer'-this guide instead offers the invitation to choose a card first, and then use it as a portal to a deeper level of self-enquiry, using the power of story to help discover why you think the way you think, and do the things you do.The Numinous Tarot Guide offers both a complete compendium of practical Tarot knowledge, and a treasured space for personal reflection. Including insights into the symbolism, mythology and the real-life relevance of each card, it is an indispensable tool for anybody invested in forging a deeper relationship with their favourite deck, as well as an ideal gift for mystical mavens, self-help fans and Tarot readers everywhere.
Shadow of Night: The second unputdownable book in the spellbinding All Souls series (All Souls #Bk. 2)
by Deborah Harkness*THE HIGHLY ANTICIPATED FIFTH NOVEL IN THE BELOVED NUMBER ONE SUNDAY TIMES BESTSELLING ALL SOULS SERIES, THE BLACK BIRD ORACLE, IS AVAILABLE TO ORDER.*'The balance of romance, magic history and suspense is just right' Reader Review, ⭐ ⭐ ⭐ ⭐ ⭐'No words can describe how much I loved this . . . it was perfect' Reader Review, ⭐ ⭐ ⭐ ⭐ ⭐'Excellent world-building . . . meticulous and absorbing' Reader Review, ⭐ ⭐ ⭐ ⭐ ⭐Fall deeper under the spell of Diana and Matthew in the captivating second instalment in the runaway Number One Sunday Times bestselling All Souls series.---In a world of witches, daemons and vampires the fragile balance of peace is unravelling. Diana and Matthew's forbidden love has broken the laws dividing creatures. To discover the manuscript which holds their hope for the future, they must now travel back to the past.When Diana Bishop, descended from a line of powerful witches, discovered a significant alchemical manuscript in the Bodleian Library, she sparked a struggle in which she became bound to long-lived vampire Matthew Clairmont. Now the coexistence of witches, daemons, vampires and humans is dangerously threatened.Seeking safety, Diana and Matthew travel back in time to London, 1590. But they soon realise that the past may not provide a haven. Reclaiming his former identity as poet and spy for Queen Elizabeth, the vampire falls back in with a group of radicals known as the School of Night. Many are unruly daemons, the creative minds of the age, including playwright Christopher Marlowe and mathematician Thomas Harriot.Together Matthew and Diana scour Tudor London for the elusive manuscript Ashmole 782, and search for the witch who will teach Diana how to control her remarkable powers...---Five reasons to read A Discovery of Witches and the ALL SOULS series:'Haunting in every way. A story thick with family secrets, human heartache, and the kind of deep magic only Harkness can conjure. You will be enchanted'LEIGH BARDUGO'Harkness's lush prose makes a fantastical world real enough to touch'JODI PICOULT'Rich, thrilling . . . A captivating and romantic ripping yarn'E L JAMES'Intelligent and off-the-wall . . . irresistible to Twilight fans'SUNDAY TIMES'A bubbling cauldron of illicit desire . . . an assured saga that blends romance with fantasy'DAILY MAIL
The Tontine: A History (Routledge Focus on Financial History)
by Andrew McDiarmidFrom the last decades of the seventeenth century until the beginning of the twentieth, the tontine, in one form or another, was a ubiquitous financial instrument. As a revenue-raising tool of governments it supported the cost of war, and as a private capital-raising instrument it provided funding for civic improvement and urban development projects.While the tontine is known today mainly through fictional works (Robert Louis Stevenson, Agatha Christie, and The Simpsons among others), this book tells the history of how it evolved from a public revenue-raising scheme into a popular private investment and infrastructure financing tool, before it was displaced by cheaper forms of borrowing. Focusing on the early development of the tontine, and with European and North American case studies, the narrative brings to life the story of a little-understood financial innovation.This concise and engaging book is an ideal introduction to the history of the tontine for all readers interested in financial history.
Ethics of Engagement in Research Practices: Response-ability in Organization and Management (Routledge Focus on Women Writers in Organization Studies)
by Michela Cozza Anna Carreri Poggio BarbaraThis book elaborates on the concept of response-ability. Although the notion is becoming popular in organization and management studies to talk about the ethical dimension of academic practices and research work, it has been formulated outside this discipline with Joan Tronto, Donna Haraway, Vinciane Despret, and Karen Barad as key authors. This book honors the foundational contribution of these scholars and their legacy.This book adopts a feminist posthumanist definition of response-ability as an iterative and emergent process that unfolds within embodied relations and through academic practices. A response-able academic practice intertwines personal reflexivity and critical analysis of the politics underlying our ways of knowing and doing in academia. Furthermore, a response-able approach requires us, as researchers, to pay attention to the consequences of our research practices through which multiple encounters are made possible (or impossible).By offering empirical examples and theoretical elaborations, this book invites students, researchers, and practitioners to find ways of embodying response-ability when generating knowledge.
Putting Daoist Thought into Practice: Happiness, Longevity, and Enlightenment
by Devin K. JoshiThis book shows how Chinese wisdom originating many centuries ago is still highly relevant to our lives today as the Daoist classics provide insightful prescriptions on how to live a life full of happiness, contentment, and healthy longevity. They also provide guidance regarding personal ethics, sustainable economics, and achieving enlightenment.The book contains reflections on how to achieve happiness drawing from the Liezi, a Daoist classic, and it examines Daoist ideas about nourishing life to achieve longevity and the marked similarity between these principles and people living in “blue zones” today with the highest concentration of centenarians. It explores Daoist views on consciousness and enlightenment in the Laozi and Zhuangzi and their close resemblance to some of the most influential “new age” teachings on the subject. It highlights the ethical character of a Daoist sage by drawing on the Daoist classic of the Wenzi and enumerates lessons for transitioning toward a sustainable economy from the Daodejing.Covering multiple dimensions of classical Daoist thought and their contemporary applications to human development and well-being, this text will usefully inform scholars, students, and researchers of Asian studies, religion, and philosophy, and individuals seeking self-improvement and personal wellness.
Exploring the Gut Microbiome in Cancer: From Biomarkers to Personalized Therapies
by Zodwa DlaminiThis book explores the relationship between the gut microbiome and cancer, illuminating various facets from fundamental roles to personalized therapies. It provides a comprehensive overview of the impact of the gut microbiome on cancer development, offering potential for innovative diagnostic and treatment approaches. The book discusses the role of dysbiosis in cancer development, the influence of the microbiome on treatment responses, and strategies to modulate the microbiome for enhanced therapies. It reviews the influence of the gut microbiome on immunotherapy resistance and chemoresistance in cancer patients. Additionally, the book presents gut microbiome biomarkers for cancer diagnosis and prognosis, the implication of the gut-brain axis on cancer development and progression, and the impact of diet and lifestyle on the microbiome. Towards the end, the book investigates the role of the gut microbiome in pediatric cancer and provides an outlook on the future challenges, technological advancements, and ethical considerations of gut microbiome research in the context of personalized cancer therapies. This book is intended for cancer researchers, medical oncologists, clinicians, pharmacologists, translational investigators, and medical students.
Olfaction in Early Childhood Research and Practice: How the Study of Smell Charts New Frontiers in Early Education
by Natalia Ingebretsen KucirkovaAn innovative exploration into the immediate and profound effects of sensory engagement, this book delves specifically into the incorporation of smell within the context of contemporary childhood experiences. Thinking to future advancements in educational technology, it is expected that digital media will eventually integrate all senses. This book outlines the convergence of children’s learning and olfaction, setting the groundwork for future-oriented early education that seamlessly integrates sensory learning with advancements in technology.Guided by child development theories and recent insights into embodiment, socio-material theories and affective literacy, chapters explore: The opportunities of olfaction in early education research and practice Developing olfactory literacies Olfaction in children’s reading and story-telling Cultural and socio-technical influences on olfaction Anticipating olfactory education futures This unique book is the first volume to communicate the power of smell in early childhood, paving the way for new approaches that empower children through innovative multisensory experiences.
Developmental Science: An Advanced Textbook
by Marc H. Bornstein Michael E. LambDevelopmental Science: An Advanced Textbook is the most complete and up-to-date advanced introduction to the field available today. Since its initial publication, the key purpose of this advanced textbook has been to furnish inclusive developmental perspectives on all theoretical, methodological, and substantive areas in developmental science. This eighth edition is no exception, as it continues to underscore the dynamic and exciting status of contemporary developmental science.In this eighth edition, Marc H. Bornstein and Michael E. Lamb have invited international experts to prepare original, comprehensive, and topical treatments of all major areas of developmental science; they are masterfully woven into a single coherent volume. The substantive chapters cover essentials of their main topics, with close attention paid to cultural, lifespan, and applied perspectives. Many chapters in this eighth edition are new, and those carried forward from the seventh edition have been extensively revised. This volume therefore represents faithfully the current status of scholarly efforts in all aspects of developmental science.Ideal for advanced undergraduate and introductory graduate courses, this advanced textbook is accompanied by two sets of supplementary materials: pedagogy files for students include chapter outlines, things to think about before reading the chapters, glossaries, and suggested readings; and ancillary files for instructors include a PowerPoint deck of tables and figures, classroom assignments, essay questions, multiple-choice questions, and short-answer questions.
Crisis Communication Cases from Asia: A Cultural Approach
by Krishnamurthy Sriramesh Su Lin YeoThis book analyzes crisis communication in Asia, focusing on how culture (broadly defined) plays a central role in the way a crisis develops and is resolved.Using the case study method, this book offers the reader glimpses of the variety of cultures in the continent, displaying the complexity of the cross-cultural process of conducting crisis communication in this diverse environment. Each of these cases addresses the onset, evolution, and resolution of the crisis. The contributors are seasoned practitioners who have done crisis communication work in this continent and have used the same framework of five environmental variables that define culture in this book: political culture, economic systems, societal culture, media systems, and activist environments.This edited volume is ideal for scholars and advanced students in public relations and strategic communication generally and crisis communication specifically.
Natural Capital Accounting and Valuation of Ecosystem Services, Karnataka State, India: Ecosystem Services
by T.V. Ramachandra Bharath Haridas Aithal Bharath Setturu S. Vinay K.S. Asulabha V. SincyThis book describes the valuation of services of ecosystems (forests, agriculture and aquatic) for Karnataka State, India, as per the validated statistical framework for natural capital accounting – SEEA: System of Environmental-Economic Accounting (SEEA.un.org). According to SEEA protocol, ecosystem services are defined as the contributions of ecosystems to the benefits that are used in economic and other human activities. The valuation of ecosystem services (VES) provides an unbiased framework to value unaccounted ecosystem benefits and helps in developing meaningful policy interventions. The approach allows for adjusted regional or national accounts which reflect the output of ecosystem services as well as the depletion of natural resources and the degradation costs (externalized costs of the loss of ecosystem services) of ecosystems in economic terms. In this perspective, the current publication, focusing on the natural capital accounting and valuation of ecosystem services in Karnataka, India, can help raise awareness and provide a quantitative tool to evaluate the sustainability of policies. The book would aid as knowledge base for many professionals, institutions and government agencies taking up the task of natural capital accounting and valuation of ecosystem services across the countries worldwide.
Sustainable Global Health Systems and Pharmaceutical Development (AAPS Advances in the Pharmaceutical Sciences Series #60)
by Bhavishya MittalStrategic decision-making focusing on economics is the fundamental requirement to generate efficiency and improve productivity in any manufacturing environment. In the 21st century, the science of drug development is an established field that requires a dedicated and synergistic partnership between various subject matter experts. Unfortunately, pharmaceutical research is complicated, time-consuming, attritive, and costly, with development costs ranging from $4 billion to $11 billion per commercialized drug. There are more than 750 biotech and big pharma companies in the US that are developing new drug products for a vast number of therapeutic indications. Due to the high attrition rate in clinical trials, a small percentage of these drugs get commercialized. Still, a very high amount of resources are being spent on drug development from a societal perspective. Despite being an economically intense activity, the current state of drug product development makes a limited effort to integrate economics into product design and development. For example, pharmaceutical scientists are excellent at a data-driven decision-making process that requires technical elements and a few strategic elements. However, there is minimal integration of financial valuation elements (commonly employed in other high-tech industries such as fine chemicals, automotive, aerospace, etc.) into pharmaceutical drug development. Unfortunately, this hurts the sustainability of the health system of which these products will be a part in the future. A desirable future state integrates fundamentals of economics in product design and development so that the decision-making is parameterized, the cost of goods can be lowered, wastage can be reduced, patient-centricity is built into the design, and manufacturing/distribution efficiencies can be gained. The financial benefits of such an approach could allow for these savings to be passed on to the stakeholders and improve the value proposition of pharmaceuticals, which is critical to maintaining the innovation potential. This book hopes to introduce the reader to this desired future state of pharmaceutical drug development.
A Little Book of Martingales (Texts and Readings in Mathematics #86)
by Arup Bose Arijit Chakrabarty Rajat Subhra HazraThis concise textbook, fashioned along the syllabus for master’s and Ph.D. programmes, covers basic results on discrete-time martingales and applications. It includes additional interesting and useful topics, providing the ability to move beyond. Adequate details are provided with exercises within the text and at the end of chapters. Basic results include Doob’s optional sampling theorem, Wald identities, Doob’s maximal inequality, upcrossing lemma, time-reversed martingales, a variety of convergence results and a limited discussion of the Burkholder inequalities. Applications include the 0-1 laws of Kolmogorov and Hewitt–Savage, the strong laws for U-statistics and exchangeable sequences, De Finetti’s theorem for exchangeable sequences and Kakutani’s theorem for product martingales. A simple central limit theorem for martingales is proven and applied to a basic urn model, the trace of a random matrix and Markov chains. Additional topics include forward martingale representation for U-statistics, conditional Borel–Cantelli lemma, Azuma–Hoeffding inequality, conditional three series theorem, strong law for martingales and the Kesten–Stigum theorem for a simple branching process. The prerequisite for this course is a first course in measure theoretic probability. The book recollects its essential concepts and results, mostly without proof, but full details have been provided for the Radon–Nikodym theorem and the concept of conditional expectation.
Conceptual Electrocardiography
by W. Barton CampbellEKG texts currently on the market present EKGs as patterns for rote memorization. This book alternatively presents a uniquely conceptual approach to the interpretation of electrocardiograms. This book contains over 140 exemplary instructive EKGs with an additional 40 self-assessment EKGs. Chapters start with an historical introduction on the nature of EKGs followed by text and illustrations regarding the conceptualization of EKG forces. Further chapters cover specific EKG abnormalities. Included are chapters covering changes which accrue from intraventricular conduction abnormalities, chamber enlargement, ischemic heart disease, COPD, pulmonary embolus, electrolyte abnormalities, basic dysrhythmias and various artifacts. The book is purposefully written to enable utilization of the superior approach of conceptual analysis of electrocardiographic forces as opposed to rote memorization of patterns. Conceptual Electrocardiography is a must-have learning resource for medical students, residents, nurse PAs, critical care and ER physicians, and cardiology fellows and attendings.
War, Hate, Propaganda and the Internet: A Dangerous Combination (SpringerBriefs in Law)
by Svitlana MazepaThe book considers how speech on social media during an armed conflict could potentially be considered a criminal offence. In doing so, it reviews the European Court of Human Rights case law on the limits of freedom of speech in an armed conflict. The author then makes recommendations on how this should be reconciled with freedom of speech in a post-conflict society. The book first outlines the propaganda cyberwar strategies being employed by the Russian Federation in the war against Ukraine. It then considers such incidents against the criminal law of Ukraine and Germany to determine when speech on social media can be considered an offence.
Eine Rundreise durch die Quantenphysik: Von der Unschärferelation bis zu Schrödingers Katze
by Wolfgang W. OsterhageSind Sie fasziniert von den Fragen der Quantenphysik und wollen Sie Beiträge in den Medien zum Thema besser verstehen können? Wolfgang Osterhage gibt Ihnen in diesem kompakten Buch den Einstieg und Überblick, den Sie dafür brauchen - auch ohne quantenphysikalisches Vorwissen! Dieses Buch lädt Sie ein, mitzudenken, und die großen Probleme der Physik des Kleinsten kennenzulernen.Eine Reise durch die Quantenphysik ist und bleibt spannend: denn obwohl die Theorie fast 85 Jahre alt und eine der erfolgreichsten Theorien der Physik ist - hat sie doch viele ihrer Grundsatzfragen bis heute nicht endgültig beantworten können. Es scheint, als habe Richard Feynmanns Ausspruch „Ich glaube mit Sicherheit behaupten zu können, daß niemand die Quantenmechanik versteht“ noch immer Bestand.Um Ihnen den Einstieg zu erleichtern, beginnt dieses Buch mit der Gedankenwelt der Quantenphysik, die manchmal quer zu den Erfahrungen der Alltagswirklichkeit zu stehen scheint. Über das Phänomen der Strahlung wird anschließend atom- und kernphysikalisches Grundwissen vermittelt, bevor es hineingeht in die fremde Welt der Operatoren, Wahrscheinlichkeiten und des Messproblems. Zuletzt münden alle Puzzelstücke in das Standardmodell der Elementarteilchen und in die Quantenfeldtheorie.In der zweiten Auflage wurde das Buch gründlich aktualisiert und u.a. durch die spannenden Themen Quantencomputer und Quanteninformation ergänzt.Eine kurz und bündige Einführung, die Ihnen den Überblick verschafft, den Sie für Ihr Weiterlesen brauchen - viel Freude bei Ihrem Studium Generale.